Measuring Damages to Marine Natural Resources from Pollution Incidents under CERCLA: Applications of an Integrated Ocean Systems/Economic Model

Several pieces of federal environmental regulation establish strict liability for damages from spills of oil and hazardous substances. This paper discusses the Natural Resource Damage Assessment Model for Coastal and Marine Environments (NRDAMICME), which is to be used for assessing damages from spills of oil or hazardous substances in coastal and marine environments under CERCLA and the Clean Water Act, as amended. The approach employs an integrated ocean systems/economic model to simulate the physical fates and biological effects of a spill and to measure the resulting economic damages. To illustrate application of the model, selected results are presented for hypothetical spills of a number of substances in a variety of environments. The results show that the damage function depends on the physical and chemical properties of the substance spilled, the season, and the environment in which the spill occurs.Environmental Economics and Policy, Research Methods/ Statistical Methods, Resource /Energy Economics and Policy, Risk and Uncertainty,

An Entropy Loss Approach for a Meanline Bladerow Model With Coupling to Test Data and 3D CFD Results

ABSTRACT A methodology which couples a computational fluid dynamics simulation and a 1D meanline bladerow model employing entropy-based loss terms is presented. A 3D APNASA CFD flow solution of the GE90-94B was used to provide input to the 1D bladerow model, which computed entropy-generation terms from the flow state. These terms accounted for losses in mixing of leakage and cooling flow, and gross aerodynamics using bladerow entropy loss coefficients as defined by Denton. A description of the 1D model is presented. The 1D bladerow model was implemented in the NPSS system making it possible to easily construct N-stage component simulations. The 1D model was used to generate partial performance maps of the HPT and LPT for use in a coupled 0D-3D simulation of the full GE90 engine. To validate the approach, a data match of the GE EEE HPT at the design point has been made and presented. An extrapolation of the model to off-design points has compared favorably to the experimental data

Framing of sustainable agricultural practices by the farming press and its effect on adoption

There is growing political pressure for farmers to use more sustainable agricultural practices to protect people and the planet. The farming press could encourage farmers to adopt sustainable practices through its ability to manipulate discourse and spread awareness by changing the salience of issues or framing topics in specific ways. We sought to understand how the UK farming press framed sustainable agricultural practices and how the salience of these practices changed over time. We combined a media content analysis of the farming press alongside 60 qualitative interviews with farmers and agricultural advisors to understand whether the farming press influenced farmers to try more sustainable practices. Salience of sustainable agricultural practices grew between 2009 and 2020. Many of the practices studied were framed by the press around economic and agronomic aspects, and farmer respondents said the most common reasons for trying sustainable agricultural practices were for economic and agronomic reasons. The farming press tended to use more positive rather than negative tones when covering sustainable agricultural practices. Respondents used the farming press as a source of information, though many did not fully trust these outlets as they believed the farming press were mouthpieces for agribusinesses. Whilst a minority of farmers stated they were motivated to try a new sustainable agricultural practice after learning about it in the farming press, this was rare. Instead, the farming press was used by respondents to raise their awareness about wider agricultural topics. We reflect on the role and power given to agribusinesses by the farming press and what this means for agricultural sustainability.</p

Natural resource education: Getting forest products workers into the flow

The forest products industry employs over 1.4 million people in the U.S.; it ranks among the top ten manufacturing employers in 46 states. Surprisingly, a recent survey of U.S. forest products workers revealed substantial ignorance and misperceptions about forests and forestry issues. Despite this, few educational programs are targeted at this audience. The Oregon Forest Resources Institute has teamed up with Oregon State University\u27s Forestry Media Center to fill this gap with Project FLOW (Forestry Learning Opportunities for Workers). Phase one of this project, completed in summer 1997, analyzed current status of forestry educational opportunities for forest workers in Oregon: existing educational activities, opportunities for new programs, and obstacles to implementing new programs. A mail-in survey, sent to human resource officers or chief executives of 590 forest products businesses in Oregon, indicated that it was important for forest workers to have reliable information about forestry topics. However, fewer than half those responding said that their company currently distributes educational materials or provides on-the-job learning opportunities. Principal obstacles cited were lack of time during the workday, lack of staff, and lack of relevant and effective educational materials. Phase two of this project will use the survey data, as well as information collected from focus groups, site visits, and telephone conversations with key stakeholders, to develop and pilot-test learning materials in various formats. We anticipate that materials developed through this project will have wide application throughout the United States-and that better-informed workers are likely to become better individual decision makers and more effective ambassadors for sound forest management

Mejoramiento de los procesos en el quirófano mediante la aplicación de la metodología Lean de Toyota

ResumenEl sector de la atención en salud está necesitando un cambio fundamental a fin de mejorar significativamente los resultados y limitar al mismo tiempo los costos. Los métodos Lean desarrollados inicialmente en la industria manufacturera han demostrado mejorar realmente la calidad, la productividad y la seguridad, a la vez que permiten utilizar menos recursos en la gestión de la salud. Estas herramientas, prácticas gerenciales y filosofías se han adaptado con éxito en los servicios de cirugía del SC. Pueden transformar el sistema y la cultura mediante el compromiso del personal de asistencia para el desarrollo de un servicio que mejora continuamente y permite obtener mejores resultados clínicos duraderos.AbstractHealthcare is in need of fundamental change if we are going to make significant improvements in outcomes while limiting costs. Lean methods, initially developed in the manufacturing industry, have been shown to deliver real improvements in quality, productivity, and safety while using fewer resources in healthcare service settings. These tools, management practices and philosophies have been successfully adapted in operative services at SC. They can transform your system and culture through engagement of frontline staff into a continuously improving service with real and sustainable enhancements in clinical outcomes

Sodium Bicarbonate Ingestion Improves Time-to-Exhaustion Cycling Performance and Alters Estimated Energy System Contribution:A Dose-Response Investigation

This study investigated the effects of two sodium bicarbonate (NaHCO3) doses on estimated energy system contribution and performance during an intermittent high-intensity cycling test (HICT), and time-to-exhaustion (TTE) exercise. Twelve healthy males (stature: 1.75 ± 0.08 m; body mass: 67.5 ± 6.3 kg; age: 21.0 ± 1.4 years; maximal oxygen consumption: 45.1 ± 7.0 ml.kg.min-1) attended four separate laboratory visits. Maximal aerobic power (MAP) was identified from an incremental exercise test. During the three experimental visits, participants ingested either 0.2 g.kg-1 BM NaHCO3 (SBC2), 0.3 g.kg-1 BM NaHCO3 (SBC3), or 0.07 g.kg-1 BM sodium chloride (placebo; PLA), 60 minutes pre-exercise. The HICT involved 3 x 60 s cycling bouts (90%, 95%, 100% MAP) interspersed with 90 s recovery, followed by TTE cycling at 105% MAP. Blood lactate was sampled after each cycling bout to calculate estimates for glycolytic contribution to exercise. Gastrointestinal (GI) upset was quantified at baseline, 30 minutes and 60 minutes post-ingestion, and 5 minutes post-exercise. Cycling TTE increased for SBC2 (+20.2 s; p =0.045) and SBC3 (+31.9 s; p =0.004) compared to PLA. Glycolytic contribution increased during the TTE protocol for SBC2 (+7.77 kJ; p =0.10) and SBC3 (+7.95 kJ; p =0.07) compared to PLA. GI upset was exacerbated post-exercise after SBC3 for nausea compared to SBC2 and PLA (p 0.05). Both NaHCO3 doses enhanced cycling performance and glycolytic contribution, however, higher doses may maximise ergogenic benefits

Pain Coping Skills Training for Patients Who Catastrophize About Pain Prior to Knee Arthroplasty: A Multisite Randomized Clinical Trial

BACKGROUND: Pain catastrophizing has been identified as a prognostic indicator of poor outcome following knee arthroplasty. Interventions to address pain catastrophizing, to our knowledge, have not been tested in patients undergoing knee arthroplasty. The purpose of this study was to determine whether pain coping skills training in persons with moderate to high pain catastrophizing undergoing knee arthroplasty improves outcomes 12 months postoperatively compared with usual care or arthritis education. METHODS: A multicenter, 3-arm, single-blinded, randomized comparative effectiveness trial was performed involving 5 university-based medical centers in the United States. There were 402 randomized participants. The primary outcome was the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Scale, measured at baseline, 2 months, 6 months, and 12 months following the surgical procedure. RESULTS: Participants were recruited from January 2013 to June 2016. In 402 participants, 66% were women and the mean age of the participants (and standard deviation) was 63.2 ± 8.0 years. Three hundred and forty-six participants (90% of those who underwent a surgical procedure) completed a 12-month follow-up. All 3 treatment groups had large improvements in 12-month WOMAC pain scores with no significant differences (p > 0.05) among the 3 treatment arms. No differences were found between WOMAC pain scores at 12 months for the pain coping skills and arthritis education groups (adjusted mean difference, 0.3 [95% confidence interval (CI), -0.9 to 1.5]) or between the pain coping and usual-care groups (adjusted mean difference, 0.4 [95% CI, -0.7 to 1.5]). Secondary outcomes also showed no significant differences (p > 0.05) among the 3 groups. CONCLUSIONS: Among adults with pain catastrophizing undergoing knee arthroplasty, cognitive behaviorally based pain coping skills training did not confer pain or functional benefit beyond the large improvements achieved with usual surgical and postoperative care. Future research should develop interventions for the approximately 20% of patients undergoing knee arthroplasty who experience persistent function-limiting pain. LEVEL OF EVIDENCE: Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence

Presyncope Is Associated with Intensive Care Unit Admission in Emergency Department Patients with Acute Pulmonary Embolism

Introduction: Syncope is common among emergency department (ED) patients with acute pulmonary embolism (PE) and indicates a higher acuity and worse prognosis than in patients without syncope. Whether presyncope carries the same prognostic implications has not been established. We compared incidence of intensive care unit (ICU) admission in three groups of ED PE patients: those with presyncope; syncope; and neither.Methods: This retrospective cohort study included all adults with acute, objectively confirmed PE in 21 community EDs from January 2013–April 2015. We combined electronic health record extraction with manual chart abstraction. We used chi-square test for univariate comparisons and performed multivariate analysis to evaluate associations between presyncope or syncope and ICU admission from the ED, reported as adjusted odds ratios (aOR) with 95% confidence intervals (CI).Results: Among 2996 PE patients, 82 (2.7%) had presyncope and 109 (3.6%) had syncope. ICU admission was similar between groups (presyncope 18.3% vs syncope 25.7%) and different than their non-syncope counterparts (either 22.5% vs neither 4.7%; p&lt;0.0001). On multivariate analysis, both presyncope and syncope were independently associated with ICU admission, controlling for demographics, higher-risk PE Severity Index (PESI) class, ventilatory support, proximal clot location, and submassive and massive PE classification: presyncope, aOR 2.79 (95% CI, 1.40, 5.56); syncope, aOR 4.44 (95% CI 2.52, 7.80). These associations were only minimally affected when excluding massive PE from the model. There was no significant interaction between either syncope or presyncope and PESI, submassive or massive classification in predicting ICU admission.Conclusion: Presyncope appears to carry similar strength of association with ICU admission as syncope in ED patients with acute PE. If this is confirmed, clinicians evaluating patients with acute PE may benefit from including presyncope in their calculus of risk assessment and site-of-care decision-making

Discovery of macrocyclic inhibitors of apurinic/apyrimidinic endonuclease 1

Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential base excision repair enzyme that is upregulated in a number of cancers, contributes to resistance of tumors treated with DNA-alkylating or -oxidizing agents, and has recently been identified as an important therapeutic target. In this work, we identified hot spots for binding of small organic molecules experimentally in high resolution crystal structures of APE1 and computationally through the use of FTMAP analysis (http://ftmap.bu.edu/). Guided by these hot spots, a library of drug-like macrocycles was docked and then screened for inhibition of APE1 endonuclease activity. In an iterative process, hot-spot-guided docking, characterization of inhibition of APE1 endonuclease, and cytotoxicity of cancer cells were used to design next generation macrocycles. To assess target selectivity in cells, selected macrocycles were analyzed for modulation of DNA damage. Taken together, our studies suggest that macrocycles represent a promising class of compounds for inhibition of APE1 in cancer cells.This work was supported by grants from the National Institutes of Health (Grant R01CA205166 to M.R.K. and M.M.G. and Grant R01CA167291 to M.R.K.) and by the Earl and Betty Herr Professor in Pediatric Oncology Research, Jeff Gordon Children's Foundation, and the Riley Children's Foundation (M.R.K.). Work at the BU-CMD (J.A.P., L.E.B., R.T.) is supported by the National Institutes of Health, Grant R24 GM111625. D.B. and S.V. were supported by the National Institutes of Health, Grant R35 GM118078. (R35 GM118078 - National Institutes of Health; R01CA205166 - National Institutes of Health; R01CA167291 - National Institutes of Health; R24 GM111625 - National Institutes of Health; Earl and Betty Herr Professor in Pediatric Oncology Research; Jeff Gordon Children's Foundation; Riley Children's Foundation)Accepted manuscriptSupporting documentatio