1,183 research outputs found
Impact of regulatory safety notices on valproate prescribing and pregnancy outcome among women of child-bearing potential in Scotland: a population-based cohort study
Objective: To examine the impact of Medicines and Healthcare products Regulatory Agency (MHRA) safety alerts on valproate prescribing among women aged 14â45 years in Scotland and examine trends in pregnancies exposed to valproate. Design: Population-based cohort study. Participants: 21 983 women of all ages who received valproate between January 2011 and December 2019. Methods: All valproate prescriptions issued to women in Scotland between January 2011 and December 2019 were identified and prevalence/incidence rates per 10 000 population derived. The impact of regulatory safety alerts on prescribing was analysed using Joinpoint models. Linked pregnancy records for January 2011 to September 2019 were identified and annual rates of pregnancy per 1000 valproate-treated women aged 14â45 years were calculated for each pregnancy outcome: live birth, stillbirth, miscarriage and termination. Results: Annual prevalent and incident rates of valproate prescribing declined in women aged 14â45 years between 2011 and 2019 from 40.5 to 18.3 per 10 000 population (54.8% reduction) and 7.9 to 1.3 per 10 000 population (83.5% reduction), respectively. Statistically significant changes occurred around the times of the MHRA safety alerts. The number of valproate-exposed pregnancies conceived each year fell from 70 in 2011 to 20 in 2018, a 71.4% reduction, and the number of live births fell from 52 to 14, a 73.0% reduction. Expressed as a rate this was a 46.4% decrease from 15.3 to 8.2 per 1000 valproate-treated women aged 14â45 years in 2011 and 2018, respectively. Live birth was the most common pregnancy outcome. Conclusion: This study demonstrates, for the first time, the capabilities of national data sets to identify drug exposure and derive pregnancy outcome at scale across Scotland. Building on this as part of an evolving national/UK surveillance capability will continue efforts to minimise in-utero exposure to valproate; enabling ongoing surveillance to understand better long-term outcomes, and to inform better provision of health and wider support services
Be on TRAQ â Cross-cultural adaptation of the Transition Readiness Assessment Questionnaire (TRAQ 5.0) and pilot testing of the German Version (TRAQ-GV-15).
Objective: Transfer from pediatric care into the adult health care system is known to be a vulnerable phase in the lives of youth with special health care needs (YSHCN). Recommendations from the literature favor assessment of transition readiness rather than simply pass over YSHCN from pediatric to adult-centered care by the age of 18. Nevertheless, no validated and disease neutral assessment instrument in German exists to date. Hence, our aim was to cross-culturally adapt and to pilot-test a German version of the Transition Readiness Assessment Questionnaire (TRAQ 5.0). We wanted to provide a tool that can be applied broadly during the health care transition (HCT) process of YSHCN.
Methods: The development included translating and adapting TRAQ 5.0 to German and conducting a pilot-study with 172 YSHCN between the ages of 14 and 23.
Results: Cross-cultural adaptation resulted in the TRAQ-GV-15. Exploratory factor analysis led to a 3 factor-structure. Internal consistency for the overall score was good with a Cronbachâs alpha of 0.82. Age, in contrast to sex, had a significant effect on the TRAQ scoring. The administration of the TRAQ-GV-15 was well received and demonstrated good feasibility.
Conclusion: The TRAQ-GV-15 is an easily applicable and clinically usable instrument for assessing transition readiness in German speaking YSHCN prior to HCT
Multi-color Optical and NIR Light Curves of 64 Stripped-Envelope Core-Collapse Supernovae
We present a densely-sampled, homogeneous set of light curves of 64 low
redshift (z < 0.05) stripped-envelope supernovae (SN of type IIb, Ib, Ic and
Ic-bl). These data were obtained between 2001 and 2009 at the Fred L. Whipple
Observatory (FLWO) on Mt. Hopkins in Arizona, with the optical FLWO 1.2-m and
the near-infrared PAIRITEL 1.3-m telescopes. Our dataset consists of 4543
optical photometric measurements on 61 SN, including a combination of UBVRI,
UBVr'i', and u'BVr'i', and 2142 JHKs near-infrared measurements on 25 SN. This
sample constitutes the most extensive multi-color data set of stripped-envelope
SN to date. Our photometry is based on template-subtracted images to eliminate
any potential host galaxy light contamination. This work presents these
photometric data, compares them with data in the literature, and estimates
basic statistical quantities: date of maximum, color, and photometric
properties. We identify promising color trends that may permit the
identification of stripped-envelope SN subtypes from their photometry alone.
Many of these SN were observed spectroscopically by the CfA SN group, and the
spectra are presented in a companion paper (Modjaz et al. 2014). A thorough
exploration that combines the CfA photometry and spectroscopy of
stripped-envelope core-collapse SN will be presented in a follow-up paper.Comment: 26 pages, 17 figures, 8 tables. Revised version resubmitted to ApJ
Supplements after referee report. Additional online material is available
through http://cosmo.nyu.edu/SNYU
Tobacco angina : An electrocardiographic study
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32562/1/0000688.pd
The fast declining Type Ia supernova 2003gs, and evidence for a significant dispersion in near-infrared absolute magnitudes of fast decliners at maximum light
We obtained optical photometry of SN 2003gs on 49 nights, from 2 to 494 days
after T(B_max). We also obtained near-IR photometry on 21 nights. SN 2003gs was
the first fast declining Type Ia SN that has been well observed since SN
1999by. While it was subluminous in optical bands compared to more slowly
declining Type Ia SNe, it was not subluminous at maximum light in the near-IR
bands. There appears to be a bimodal distribution in the near-IR absolute
magnitudes of Type Ia SNe at maximum light. Those that peak in the near-IR
after T(B_max) are subluminous in the all bands. Those that peak in the near-IR
prior to T(B_max), such as SN 2003gs, have effectively the same near-IR
absolute magnitudes at maximum light regardless of the decline rate Delta
m_15(B).
Near-IR spectral evidence suggests that opacities in the outer layers of SN
2003gs are reduced much earlier than for normal Type Ia SNe. That may allow
gamma rays that power the luminosity to escape more rapidly and accelerate the
decline rate. This conclusion is consistent with the photometric behavior of SN
2003gs in the IR, which indicates a faster than normal decline from
approximately normal peak brightness.Comment: 41 pages, 13 figures, to be published in the December, 2009, issue of
the Astronomical Journa
Toward an improved design of the in-situ observing system for ocean reanalysis, analysis and forecasting: design of experiments
This report presents the work plan within the task 1.3 - Observing System Design Studie
Morally Respectful Listening and its Epistemic Consequences
What does it mean to listen to someone respectfully, that is, insofar as they are due recognition respect? This paper addresses that question and gives the following answer: it is to listen in such a way that you are open to being surprised. A specific interpretation of this openness to surprise is then defended
CfAIR2: Near Infrared Light Curves of 94 Type Ia Supernovae
CfAIR2 is a large homogeneously reduced set of near-infrared (NIR) light
curves for Type Ia supernovae (SN Ia) obtained with the 1.3m Peters Automated
InfraRed Imaging TELescope (PAIRITEL). This data set includes 4607 measurements
of 94 SN Ia and 4 additional SN Iax observed from 2005-2011 at the Fred
Lawrence Whipple Observatory on Mount Hopkins, Arizona. CfAIR2 includes JHKs
photometric measurements for 88 normal and 6 spectroscopically peculiar SN Ia
in the nearby universe, with a median redshift of z~0.021 for the normal SN Ia.
CfAIR2 data span the range from -13 days to +127 days from B-band maximum. More
than half of the light curves begin before the time of maximum and the coverage
typically contains ~13-18 epochs of observation, depending on the filter. We
present extensive tests that verify the fidelity of the CfAIR2 data pipeline,
including comparison to the excellent data of the Carnegie Supernova Project.
CfAIR2 contributes to a firm local anchor for supernova cosmology studies in
the NIR. Because SN Ia are more nearly standard candles in the NIR and are less
vulnerable to the vexing problems of extinction by dust, CfAIR2 will help the
supernova cosmology community develop more precise and accurate extragalactic
distance probes to improve our knowledge of cosmological parameters, including
dark energy and its potential time variation.Comment: 31 pages, 15 figures, 10 tables. Accepted to ApJS. v2 modified to
more closely match journal versio
Medicines in pregnancy : building a Scottish surveillance system
Some medicines have the potential to cause harm to the developing child if taken during pregnancy. In July 2020, the Cumberlege Report, âFirst do no harmâ, included examination of the harms of sodium valproate, an anti-seizure medication, during pregnancy. In March 2021, the Scottish Government published its delivery plan
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