2,669 research outputs found
Cyanobacterial Toxins as Allelochemicals with Potential Applications as Algaecides, Herbicides and Insecticides
Cyanobacteria (“blue-green algae”) from marine and freshwater habitats are known to produce a diverse array of toxic or otherwise bioactive metabolites. However, the functional role of the vast majority of these compounds, particularly in terms of the physiology and ecology of the cyanobacteria that produce them, remains largely unknown. A limited number of studies have suggested that some of the compounds may have ecological roles as allelochemicals, specifically including compounds that may inhibit competing sympatric macrophytes, algae and microbes. These allelochemicals may also play a role in defense against potential predators and grazers, particularly aquatic invertebrates and their larvae. This review will discuss the existing evidence for the allelochemical roles of cyanobacterial toxins, as well as the potential for development and application of these compounds as algaecides, herbicides and insecticides, and specifically present relevant results from investigations into toxins of cyanobacteria from the Florida Everglades and associated waterways
Optimality of private quantum channels
We addressed the question of optimality of private quantum channels. We have
shown that the Shannon entropy of the classical key necessary to securely
transfer the quantum information is lower bounded by the entropy exchange of
the private quantum channel and von Neumann entropy of the ciphertext
state . Based on these bounds we have shown that decomposition
of private quantum channels into orthogonal unitaries (if exists) is optimizing
the entropy. For non-ancillary single qubit PQC we have derived the optimal
entropy for arbitrary set of plaintexts. In particular, we have shown that
except when the (closure of the) set of plaintexts contains all states, one bit
key is sufficient. We characterized and analyzed all the possible single qubit
private quantum channels for arbitrary set of plaintexts. For the set of
plaintexts consisting of all qubit states we have characterized all possible
approximate private quantum channels and we have derived the relation between
the security parameter and the corresponding minimal entropy.Comment: no commen
Introgression of peanut smut resistance from landraces to elite peanut cultivars (\u3ci\u3eArachis hypogaea\u3c/i\u3e L.)
Smut disease caused by the fungal pathogen Thecaphora frezii Carranza & Lindquist is threatening the peanut production in Argentina. Fungicides commonly used in the peanut crop have shown little or no effect controlling the disease, making it a priority to obtain peanut varieties resistant to smut. In this study, recombinant inbred lines (RILs) were developed from three crosses between three susceptible peanut elite cultivars (Arachis hypogaea L. subsp. hypogaea) and two resistant landraces (Arachis hypogaea L. subsp. fastigiata Waldron). Parents and RILs were evaluated under high inoculum pressure (12000 teliospores g-1 of soil) over three years. Disease resistance parameters showed a broad range of variation with incidence mean values ranging from 1.0 to 35.0% and disease severity index ranging from 0.01 to 0.30. Average heritability (h2) estimates of 0.61 to 0.73 indicated that resistance in the RILs was heritable, with several lines (4 to 7 from each cross) showing a high degree of resistance and stability over three years. Evidence of genetic transfer between genetically distinguishable germplasm (introgression in a broad sense) was further supported by simple-sequence repeats (SSRs) and Insertion/Deletion (InDel) marker genotyping. This is the first report of smut genetic resistance identified in peanut landraces and its introgression into elite peanut cultivars
Dead Zones around Young Stellar Objects: Dependence on Physical Parameters
Angular momentum is transported outwards through an accretion disc by
magnetohydrodynamical (MHD) turbulence thus allowing material to accrete on to
the central object. The magneto-rotational instability (MRI) requires a minimum
ionisation fraction to drive turbulence in a disc. The inner parts of the disc
around a young stellar object are sufficiently hot to be thermally ionised.
Further out, cosmic rays ionise the surface layers and a dead zone forms at the
mid-plane where the disc is too cool for the MRI to operate. The surface
density in the turbulent active layer is often assumed to be constant with
radius because the cosmic rays penetrate a constant layer. However, if a
critical magnetic Reynolds number, Re_{M,crit}, is used to determine the extent
of the dead zone, the surface density in the layer generally increases with
radius. For small critical magnetic Reynolds number of order 1, the constant
layer approximation may be a reasonable fit. However, MHD simulations suggest
the critical magnetic Reynolds number may be much larger, of order 10^4.
Analytical fits for the surface density in the magnetic active layer show that
\Sigma_m \propto Re_{M,crit}^{-2} R^{9/2} T^{\,2}$, at temperature T and radius
R, are a good fit for higher critical magnetic Reynolds number. For the
metallicity variation between our galaxy, the LMC and the SMC, there should be
no significant difference in the extent of the dead zone. Observations suggest
an increase in the lifetime of the disc with decreasing metallicity that cannot
be explained by the dead zone structure (ignoring possible differences in dust
abundances).Comment: Accepted for publication in MNRA
combined pik3ca and fgfr inhibition with alpelisib and infigratinib in patients with pik3ca mutant solid tumors with or without fgfr alterations
PURPOSE Concurrent PIK3CA mutations and fibroblast growth factor receptor (FGFR) alterations occur in multiple cancer types, including estrogen receptor–positive breast cancer, bladder cancer, and endometrial cancer. In this first-in-human combination trial, we explored safety and preliminary efficacy of combining the PI3Kα selective inhibitor alpelisib with the FGFR1-4 selective inhibitor infigratinib. PATIENTS AND METHODS Patients with PIK3CA-mutant advanced solid tumors, with or without FGFR1-3 alterations, were enrolled in the dose escalation or one of three molecular-defined dose-expansion cohorts. The primary end point was the maximum tolerated dose. Secondary end points included safety, pharmacokinetics, and response. Archival tumor samples were sequenced to explore genomic correlates of response. RESULTS In combination, both agents were escalated to full, single-agent recommended doses (alpelisib, 300 mg per day continuously; infigratinib, 125 mg per day 3 weeks on followed by 1 week off). The toxicity profile of the combination was consistent with the established safety profile of each agent, although 71% of all patients required at least one treatment interruption or dose reduction. Molecularly selected dose expansions in breast cancer and other solid tumors harboring PIK3CA mutations, alone or in combination with FGFR alterations, identified sporadic responses, predominately in tumor types and genotypes previously defined to have sensitivity to these agents. CONCLUSION The combination of alpelisib and infigratinib can be administered at full single-agent doses, although the high rate of dose interruption or reduction suggests long-term tolerability may be challenging. In exploratory signal-seeking cohorts of patients harboring dual PIK3CA and FGFR1-3 alterations, no clear evidence of synergistic activity was observed
The scattering of SH waves by a finite crack with a superposition based diffraction technique
The problem of diffraction of cylindrical and plane SH waves by a finite crack is revisited -- We construct an approximate solution by the addition of independent diffracted terms -- We start with the derivation of the fundamental case of a semi-infinite crack obtained as a degenerate case of generalized wedge -- This building block is then used to compute the diffraction of the main incident waves -- The interaction between the opposite edges of the crack is then considered one term at a time until a desired tolerance is reached -- We propose a recipe to determine the number of required interactions as a function of frequency -- The solution derived with the superposition technique can be applied at low and high frequencie
Association of bronchial steroid inducible methylation quantitative trait loci with asthma and chronic obstructive pulmonary disease treatment response
Elimination of onchocerciasis in Ecuador: findings of post-treatment surveillance.
BACKGROUND: The Esmeraldas focus of onchocerciasis in Ecuador expanded geographically during the 1980s and was associated with severe ocular and skin disease. Mass drug administration (MDA) with ivermectin started in 1991, initially once but later twice a year, in the principle endemic focus followed by all satellite foci. Treatment was stopped in 2009 when entomological assessments determined that transmission of Onchocerca volvulus had been interrupted. METHODS: Three years after the cessation of ivermectin treatment in 2012, as defined by the WHO guidelines for onchocerciasis elimination, blackfly collections were done in four sentinel sites in former hyperendemic areas. The presence of infective larvae in local vectors, Simulium exiguum and Simulum quadrivittatum, was assessed by detection of O. volvulus DNA by PCR. Additional flies captured in four extra-sentinel sites located in former hyper- and mesoendemic dispersed isolated areas were also assessed. RESULTS: The results from 68,310 captured blackflies, 40,114 from four sentinel villages in the previously hyperendemic areas (Corriente Grande, El Tigre, San Miguel on Río Cayapas and Naranjal on Río Canandé) and 28,197 from extra-sentinel locations, were all negative for the presence of O. volvulus. These extra-sentinel sites (Hualpí on Río Hoja Blanca, Capulí on Río Onzole, La Ceiba on Río Tululví and Medianía on Río Verde) were included to provide additional evidence of the impact of MDA on the transmission of O. volvulus in isolated endemic areas. CONCLUSIONS: Our data indicate that transmission of O. volvulus has been stopped in all endemic areas in Ecuador, including all satellite foci outside the main focus. These findings indicate that a strategy of ivermectin distribution twice a year to over 85% of the treatment-eligible population was effective in eliminating the infection from Ecuador in a focus with a highly competent primary vector, S. exiguum, and where the infection rates were equal to or greater than observed in many onchocerciasis foci in Africa
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