Compatibility of the large quasar groups with the concordance cosmological model

We study the compatibility of large quasar groups with the concordance cosmological model. Large quasar groups are very large spatial associations of quasars in the cosmic web, with sizes of 50–250 h−1 Mpc. In particular, the largest large quasar group known, named Huge-LQG, has a longest axis of ∼860 h−1 Mpc, larger than the scale of homogeneity (∼260 Mpc), which has been noted as a possible violation of the cosmological principle. Using mock catalogues constructed from the Horizon Run 2 cosmological simulation, we found that large quasar groups size, quasar member number and mean overdensity distributions in the mocks agree with observations. The Huge-LQG is found to be a rare group with a probability of 0.3 per cent of finding a group as large or larger than the observed, but an extreme value analysis shows that it is an expected maximum in the sample volume with a probability of 19 per cent of observing a largest quasar group as large or larger than Huge-LQG. The Huge-LQG is expected to be the largest structure in a volume at least 5.3 ± 1 times larger than the one currently studied

A 3D Voronoi+Gapper Galaxy Cluster Finder in Redshift Space to z∼ 0.2 I: an Algorithm Optimized for the 2dFGRS

This paper is the first in a series, presenting a new galaxy cluster finder based on a three-dimensional Voronoi Tesselation plus a maximum likelihood estimator, followed by gapping-filtering in radial velocity(VoML+G). The scientific aim of the series is a reassessment of the diversity of optical clusters in the local universe. A mock galaxy database mimicking the southern strip of the magnitude(blue)-limited 2dF Galaxy Redshift Survey (2dFGRS), for the redshift range 0.009 N g ≥ 5, and 14% with N g < 5. The ensemble of VoML+G clusters has a ~59% completeness and a ~66% purity, whereas the subsample with N g ≥ 10, to z ~ 0.14, has greatly improved mean rates of ~75% and ~90%, respectively. The VoML+G cluster velocity dispersions are found to be compatible with those corresponding to "Millennium clusters" over the 300–1000 km s−1 interval, i.e., for cluster halo masses in excess of ~3.0 × 1013 M ⊙ h −1

Coffee capsule impacts and recovery techniques: A literature review

The recently developing coffee market has been characterized by profound changes caused by new solutions and technologies for coffee preparation. The polylaminate materials that compose most popular capsules make them a type of waste that is difficult to manage and recycle. This paper analyses the scientific references that deal with studying and improving the management processes of waste coffee capsules, as well as the studies that have analysed their environmental impact. Through a bibliographic review, some encouraging aspects emerged in the recovery of materials that can be adequately recycled (plastics and metals), as well as their possible use for the production of biogas and energy recovery. The need to manually separate the components that make up the capsule still represents one of the main challenges. Many efforts are still needed to favour the environmental sustainability of this waste from a strategic, technological and consumer empowerment point of view

Effectiveness of dolutegravir-based regimens as either first-line or switch antiretroviral therapy: data from the Icona cohort

Introduction: Concerns about dolutegravir (DTG) tolerability in the real-life setting have recently arisen. We aimed to estimate the risk of treatment discontinuation and virological failure of DTG-based regimens from a large cohort of HIV-infected individuals. Methods: We performed a multicentre, observational study including all antiretroviral therapy (ART)-naïve and virologically suppressed treatment-experienced (TE) patients from the Icona (Italian Cohort Naïve Antiretrovirals) cohort who started, for the first time, a DTG-based regimen from January 2015 to December 2017. We estimated the cumulative risk of DTG discontinuation regardless of the reason and for toxicity, and of virological failure using Kaplan–Meier curves. We used Cox regression model to investigate predictors of DTG discontinuation. Results: About 1679 individuals (932 ART-naïve, 747 TE) were included. The one- and two-year probabilities (95% CI) of DTG discontinuation were 6.7% (4.9 to 8.4) and 11.5% (8.7 to 14.3) for ART-naïve and 6.6% (4.6 to 8.6) and 7.6% (5.4 to 9.8) for TE subjects. In both ART-naïve and TE patients, discontinuations of DTG were mainly driven by toxicity with an estimated risk (95% CI) of 4.0% (2.6 to 5.4) and 2.5% (1.3 to 3.6) by one year and 5.6% (3.8 to 7.5) and 4.0% (2.4 to 5.6) by two years respectively. Neuropsychiatric events were the main reason for stopping DTG in both ART-naïve (2.1%) and TE (1.7%) patients. In ART-naïve, a concomitant AIDS diagnosis predicted the risk of discontinuing DTG for any reason (adjusted relative hazard (aRH)&nbsp;=&nbsp;3.38, p&nbsp;=&nbsp;0.001), whereas starting DTG in combination with abacavir (ABC) was associated with a higher risk of discontinuing because of toxicity (aRH&nbsp;=&nbsp;3.30, p&nbsp;=&nbsp;0.009). TE patients starting a DTG-based dual therapy compared to a triple therapy had a lower risk of discontinuation for any reason (adjusted hazard ratio (aHR)&nbsp;=&nbsp;2.50, p&nbsp;=&nbsp;0.037 for ABC-based triple-therapies, aHR&nbsp;=&nbsp;3.56, p&nbsp;=&nbsp;0.012 for tenofovir-based) and for toxicity (aHR&nbsp;=&nbsp;5.26, p&nbsp;=&nbsp;0.030 for ABC-based, aHR&nbsp;=&nbsp;6.60, p&nbsp;=&nbsp;0.024 for tenofovir-based). The one- and two-year probabilities (95% CI) of virological failure were 1.2% (0.3 to 2.0) and 4.6% (2.7 to 6.5) in the ART naïve group and 2.2% (1.0 to 3.3) and 2.9% (1.5 to 4.3) in the TE group. Conclusions: In this large cohort, DTG showed excellent efficacy and optimal tolerability both as first-line and switching ART. The low risk of treatment-limiting toxicities in ART-naïve as well as in treated individuals reassures on the use of DTG in everyday clinical practice

Symphonic Winds

Center for the Performing Arts March 23, 2018 Friday Evening 8:00p.m

Weak and Strong Sustainability of Irrigation: A Framework for Irrigation Practices Under Limited Water Availability

Agriculture strongly relies on irrigation. While irrigated land accounts for roughly 20% of the global cultivated area, it contributes to about 40% of crop production. In the last few decades, the growing demand for agricultural commodities has translated into an increasing pressure on the global freshwater resources, often leading to their unsustainable use. Here we investigate the sustainability of irrigation, balancing farmers' profit generation objectives and the needs of ecological systems. We ask the question “sustainability of what?” to stress how the sustainability of irrigation is often evaluated with respect the opposing needs of humans and nature. While from the farmers' perspective irrigation is sustainable when it provides uninterrupted access to water resources at a price not exceeding the marginal revenue they generate (clearly without accounting for environmental externalities), from the standpoint of water resources, irrigation is sustainable if it does not deplete freshwater stocks or environmental flows. We invoke the notions of “weak” and “strong” sustainability to develop a novel framework for the evaluation of tradeoffs between human needs and the conservation of natural capital. Through the analysis of criteria of performance, we relate water deficit and irrigation overuse to the reliability and resilience of irrigation. This approach is applied to the case of Australia, a major agricultural country affected by water scarcity. The application of the framework to the case of Australia shows how this approach can be used to highlight areas in which irrigation contributes to a weakly sustainable use of water resources with impacts on environmental flows and groundwater stocks. Solutions, such as increasing efficiencies or reducing water applications through the adoption of deficit irrigation, can enhance water sustainability in some water scarce locations

efficacy of biofeedback and cognitive behavioural therapy in psoriatic patientsa single blind randomized and controlled study with added narrow band ultraviolet b therapy

n/

Wind Symphony

Center for the Performing Arts April 28, 2018 Saturday Evening 8:00p.m