Clustering COVID-19 ARDS patients through the first days of ICU admission. An analysis of the CIBERESUCICOVID Cohort

Background Acute respiratory distress syndrome (ARDS) can be classified into sub-phenotypes according to different inflammatory/clinical status. Prognostic enrichment was achieved by grouping patients into hypoinflammatory or hyperinflammatory sub-phenotypes, even though the time of analysis may change the classification according to treatment response or disease evolution. We aimed to evaluate when patients can be clustered in more than 1 group, and how they may change the clustering of patients using data of baseline or day 3, and the prognosis of patients according to their evolution by changing or not the cluster.Methods Multicenter, observational prospective, and retrospective study of patients admitted due to ARDS related to COVID-19 infection in Spain. Patients were grouped according to a clustering mixed-type data algorithm (k-prototypes) using continuous and categorical readily available variables at baseline and day 3.Results Of 6205 patients, 3743 (60%) were included in the study. According to silhouette analysis, patients were grouped in two clusters. At baseline, 1402 (37%) patients were included in cluster 1 and 2341(63%) in cluster 2. On day 3, 1557(42%) patients were included in cluster 1 and 2086 (57%) in cluster 2. The patients included in cluster 2 were older and more frequently hypertensive and had a higher prevalence of shock, organ dysfunction, inflammatory biomarkers, and worst respiratory indexes at both time points. The 90-day mortality was higher in cluster 2 at both clustering processes (43.8% [n = 1025] versus 27.3% [n = 383] at baseline, and 49% [n = 1023] versus 20.6% [n = 321] on day 3). Four hundred and fifty-eight (33%) patients clustered in the first group were clustered in the second group on day 3. In contrast, 638 (27%) patients clustered in the second group were clustered in the first group on day 3.Conclusions During the first days, patients can be clustered into two groups and the process of clustering patients may change as they continue to evolve. This means that despite a vast majority of patients remaining in the same cluster, a minority reaching 33% of patients analyzed may be re-categorized into different clusters based on their progress. Such changes can significantly impact their prognosis

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Protocolo de Inmunoensayo ELisa indirecto para detección de molécula modelo BSA

Evidencias del semillero 2022_1Estudiar las bases moleculares de los inmunoensayos de afinidad y su aplicación en el diagnóstico de enfermedades. Caso de estudio, detección de BSA como molécula modeloTecnología para la detección de Biomarcadores y Biomateriae

Simposio Internacional de Investigación Educativa y Pedagógica

El 4º. Simposio Internacional de Investigación Educativa y Pedagógica de la Red SUE Caribe, es un encuentro que reúne periódicamente a académicos nacionales y extranjeros de reconocida presencia y trayectoria, a estudiantes de maestría y doctorado y a maestros investigadores, que se concentran durante las jornadas agendadas del evento. Se constituye así un escenario propicio para la socialización de resultados de investigación, la reflexión y el debate alrededor de asuntos actuales en educación, pedagogía, psicología del aprendizaje, sobre las didácticas emergentes tecnología aplicada a la gestión de la enseñanza y el aprendizaje y en relación con el desarrollo humano y social.Presentación 12Líneas temáticas por mesas de trabajo 14Mesa 1. Didáctica, Mediación pedagógica y tecnologías en contextos vulnerables 15Percepciones sobre la influencia de un programa apoyado en TIC en relación con las prácticas de actividad física y deportiva de estudiantes de la Institución Educativa Rancho Grande de Montería. María Julia Caldera Quintero - Yina Paola Pérez Siyag 16Aplicación de estrategias cognitivas y metacognitivas en el uso del castellano escrito en estudiantes con discapacidad auditiva. Mercedes del Carmen Pico Aycardi 18Aprendizaje colaborativo con ambientes de liderazgo en el desarrollo del componente geométrico métrico. Lenis Judith Sierra Llorente – Juana Raquel Robles González 20Escenario de construcción conjunta del conocimiento mediado por las TIC en el área de filosofía en la Institución Educativa Normal Superior de Sahagún-Córdoba. Dayro Ruiz Araujo - Andrés Mercado Herazo 22Programa de formación docente para el mejoramiento de la lectura crítica de estudiantes de pregrado: una intervención formativa con docentes de la Universidad de Córdoba. Ibeth Morales Escobar – Arnaldo Peinado Méndez - Sonia Jerez Rodríguez 24Las prácticas de enseñanza. Un estudio interpretativo en las instituciones de la subregión sabanas del Departamento de Sucre, Colombia. Edy Luz Castro De Rodríguez 26Modelos pedagógicos y factores identitarios en las prácticas de enseñanza en contextos emergentes. Adriana Cristina Pérez Aguilar 28Rol del tutor durante los diálogos de reflexión desarrollados con futuros docentes mediatizados con video. Ceferina Cabrera Félix - Jesús Salcedo –Martha Serrata Taveras 30Desarrollo del pensamiento aleatorio a través de la utilización de un entorno virtual de aprendizaje en estudiantes de básica secundaria. Anny Leidys Valero Peña – Francisco Antonio Avilez Aguas – Juana Raquel Robles González 32Efectos de un programa de géneros textuales y la incidencia de factores sociodemográficos en los desempeños de lectura crítica. Diana Arroyo -Tatiana Becerra Posada – Antonio Oviedo Acosta 34El conocimiento glocal para alentar la confianza al hablar inglés: investigación-acción en una secundaria de Cartagena. Maryuris Vanessa Pérez Salcedo 36Los textos multimodales una estrategia didáctica para la inclusión educativa. Maura Paola Hoyos Carvajal - María Fernanda Martínez Garcés - Ludwig Isabel Segura Bermúdez 38Didáctica Ecoformadora para el desarrollo de la comprensión lectora de una lengua extranjera. Zaily Patricia Del Toro García 40Desarrollo de la competencia científica “indagación” a partir de la vivencia filosófica en los educandos de Básica Primaria. Un análisis desde sus fundamentos teóricos. Dina Villar Ortega - Nataly López Conde 42La estrategia metacognitiva y didáctica “Bitácora MAP” para el desarrollo del aprendizaje significativo en ciencias naturales en estudiantes del Alto San Jorge- Córdoba. Diana Sofía Blanquicet Arrieta - José Pantaleón Barrera Sierra 44Las concepciones del currículo y las prácticas curriculares de los docentes. Una revisión sistemática de literatura. Brianda Isabel Vergara Ibarra - Yisenia Lucía Vergara Vergara 46Implementación de metodologías activas en el fortalecimiento de competencias comunicativas en escenarios vulnerables. Liana Álvarez Cantero – José Antonio Sánchez Sánchez 48Estrategia pedagógica discursiva interactiva para el mejoramiento de la comprensión textual de estudiantes de básica primaria. Osvaldo Enrique Manjarrez Villalba - Ibeth Del Rosario Morales Escobar 50Proyecto pedagógico para mejorar la lectoescritura en los estudiantes de grado 5º aula multigrado. Miriam Albán Villarreal – María Dorila Díaz Valentierra 52La Oratoria como escenario pedagógico para el desarrollo de habilidades de pensamiento crítico: una apuesta en la virtualidad. María Andrea Baquero Escobar – Rudy Doria Correa 54Mesa 2. Pedagogía social, ética y desarrollo humano 56Prácticas discursivas en torno a la enseñanza de la Educación Religiosa: una perspectiva desde el educando. Cetty Carlos Benjumea Loaiza - Jesús Andrés Vélez Vélez 57Transversalidad de la formación en valores en las prácticas de enseñanza de docentes de básica secundaria en la institución etnoeducativa Los Córdobas. Emilio Elis Cogollo – Ezequías Balaguera Ortiz 59Mediaciones pedagógicas para el fortalecimiento de la convivencia escolar entre estudiantes, una revisión en el contexto educativo hispano parlante. Jesús Alberto Peñaranda Bastidas – José Tomas Fragozo Soto – Miladys Paola Redondo Marin 61La mediación como estrategia de convivencia escolar en la Institución Educativa Técnica Agropecuaria La Buena Esperanza del municipio de Turbaco – Bolívar. Cinthya Inés Martínez Mendoza 63Formación de maestros educadores para la paz desde la didáctica del conflicto para la inclusión educativa. Dilia Elena Mejía Rodríguez – Liris Múnera Cavadía 65Educación en derechos humanos desde el reconocimiento y humanismo del otro. Ledys Alcira Arrieta Perez – María Alejandra Taborda Caro 67Educación para la convivencia y la paz: Una mirada crítica desde la intervención docente. Decired Ojeda Pertuz 69El clima escolar en el diseño curricular: Una perspectiva que favorece la enseñanza - aprendizaje en instituciones educativas rurales de Cartagena de Indias, Colombia. Neisa del Carmen Gómez Diaz - Alexander Javier Montes Miranda 71La danza folclórica cómo satisfactor sinérgico de necesidades humanas en los estudiantes del grupo de danzas folclóricas sede Montería de la Universidad de Córdoba. Elaine Patricia Parra Martínez - Fernando De La Espriella Arenas 73La música, una estrategia didáctica para el fortalecimiento de las competencias ciudadanas. Marta Guerra Muñoz – Rosa Beatriz Gómez -Yamira Rodríguez 74Convivencia escolar desde la pedagogía de paz: estrategia didáctica a través de la lúdica. Hna. Olga Lucia Canchila Salcedo - Martha Pacheco Lora 76Mesa 3. Innovación educativa y pedagógica 78Mesa 3. Innovación educativa y pedagógica 78Objetos virtuales de aprendizaje para la formación profesional: una mirada desde los estudiantes de la Universidad del Atlántico. Mirna Patricia Bernal Martínez - Roberto Enrique Figueroa Molina - Melba Rosa Cuadrado Galán 80Las apuestas investigativas y el desarrollo profesional de los egresados de la Maestría en Educación SUE Caribe Universidad de Cartagena. Nadia Mallarino Miranda – Katia Martínez Morad 82Investigación y desarrollo profesional de los egresados de la Maestría en Educación SUE Caribe. Universidad de Cartagena, 2006-2018. Clara Inés Sagre Hernández 84Aprendizaje Invertido: autoinstrucción, evaluación formativa y desempeños de comprensión. Esteban Rodríguez Garrido 86Transformación de la praxis docente durante un programa de formación en Pedagogía de Géneros Textuales para la enseñanza de la lectura crítica. José David Herazo Rivera – Paula García Montes - Pedro Guerra Meza 88Estrategias didácticas basadas en laboratorios virtuales y presenciales en el aprendizaje de las leyes de Newton. Alberto Iriarte Pupo – Yessica Ortega Pérez - Lizeth Estrada Soto 90Impacto del uso de la estrategia "Leo y argumento" para el desarrollo de las habilidades del pensamiento crítico. Dairo de Jesus Bustamante de Hoyos – Paulo Emilio Fúnez Chávez 92Impacto de la mediación pedagógica virtual como contingencia ante situación de pandemia Covid-19 en la Institución de Educación Superior ITFIP. Mauren Andrés Guayara Ramírez - Luis Antonio Herrán Cardoso -Jimmy Alexander Vergara Rodríguez 94Origem da Escola Doméstica Dona Júlia e a influência do Grêmio Literário Júlia Lopes De Almeida no proceso implementação da instituição em Cuiabá/MT (1946-1947). Gabriella Moura da Silva – Nilce Vieira Campos Ferreira 96Uso de Tecnologías de la Información y la Comunicación (TIC) por docentes de educación primaria en atención a estudiantes en confinamiento por pandemia. Leida de la Rosa Rosa 98Resignificación de la praxis educativa para favorecer la competencia lectora desde la sistematización de experiencias docentes. Elia Marina Santuario Rada - Jorge Carlos Peinado Ballesteros 100Relación entre competencias mediáticas y saberes digitales en la formación de maestros. Claudia Saavedra - Dijibath Matallana Rodríguez – Karen Medina Jaime 102Las concepciones de evaluación de los docentes de ciencias naturales. Gina Violeta Verbel González 104Estrategias para la mejora del aprendizaje autónomo del alumnado de la Licenciatura en Educación Física. Sandy Portorreal - Atlas Osiris Sosa - Rudy Gilberto López 106Escuelas Normales: Instituciones formadoras de profesoras rurales en Cundinamarca 1950-1970. Nataly Rojas - Nilce Vieira Campos Ferreira 108Perspectivas teóricas del liderazgo escolar: una resignificación pedagógica del liderazgo transformacional y su contribución a la calidad educativa. Amalfi Rosales - Alexander Montes - Vladimir Figueroa Gutiérrez 110Gestión de prácticas educativas innovadoras desde un enfoque educativo STEM+A. Arnovis Alemán - Rainer Villarreal Contreras – Daniel Salas Álvarez 112La investigación, un camino para la transformación de las prácticas pedagógicas. Belkis Vergara Pérez 113Processo Histórico De Denominação Da Escola Estadual Da Polícia Militar “Tiradentes”. Junior Cézar Lopes dos Santos – Nilce Vieira Campos Ferreira 115Modelos de mediación para el análisis de datos educativos: Más allá de los modelos cuantitativos típicamente usados en las tesis de postgrado en Educación en Colombia. Claudia Patricia Ovalle Ramirez 117Mesa 4. Perspectivas neurocientíficas y abordajes psicosociales contemporáneos en educación 119Análisis de la relación entre inteligencia emocional y estrategias de afrontamiento en situaciones de acoso y cyberbullyng en universitarios. María Fernanda Méndez Losada - Isabel Alicia Sierra Pineda 121Emoción y academia: historias no contadas de las estancias doctorales. Harold Castañeda Peña - Pilar Méndez - Carmen Helena Guerrero 123La conciencia fonológica en la enseñanza de la lectura en estudiantes de grado primero de la Institución Educativa Santa María Goretti en Montería. María Victoria González Zapa 125Estrategias educativas para promover competencias socioemocionales en los estudiantes articulando procesos pedagógicos y evaluativos. Becky Román Pérez 127La competencia docente de análisis de idoneidad didáctica en futuros profesores de matemáticas al planificar la enseñanza. Juan Alberto Barboza Rodríguez - Walter Fernando Castro Gordillo 129Pensamiento pedagógico en la Educación Superior del departamento de Córdoba 1951-2019. Carolina Castellanos Ramos 131Concepciones y Creencias de futuros profesores de matemáticas sobre la enseñanza y evaluación al planificar clases en el componente geométrico métrico. José Luis Acosta Pérez - Juan Alberto Barboza Rodríguez 133Comprensión de la incidencia formativa de un grupo de maestros de Ciencias Sociales a través de narrativas biográficas en el departamento de Córdoba. María Andrea Acosta García - Daniel David Chimá Arroyo 135Percepciones de los docentes de una institución privada de Montería, sobre la implementación del modelo pedagógico institucional, incluyendo sus prácticas de aula. Keila Paola Ramos Buelvas 137Indagación narrativa de la identidad profesional del docente de Tecnología e Informática: Tensiones y reflexiones en la construcción cotidiana del currículo. Atahualpa Villadiego Alvarez 139Autopercepción de los docentes sobre neurociencia y transferencia a la didáctica de las ciencias: un estudio fenomenográfico. Claudia Patricia Mercado Aguado - Isabel Alicia Sierra Pineda 140Mesa 5. Multiculturalidad, diversidad y educación inclusiva 142Formación inclusiva: concepciones y prácticas pedagógicas en docentes de educación superior. Roberto Figueroa Molina – Mirna Patricia Bernal Martínez - Roberto Thorné Torné 144La Escuela: Un lugar en la cartografía y en los imaginarios de las Ciencias Sociales. Daniel Antonio Pérez Cerro – Luis Alfredo González Monroy – Iván Manuel Sánchez Fontalvo 146Lineamientos para incorporar la política de inclusión social en los planes de acción del plan de desarrollo en el municipio de El Charco de Nariño. Aura Pérez Caicedo - Delia De la Hoz – Robinson Rafael Peña Almeida 148Inclusión de estudiantes en situación de discapacidad en una Institución Educativa: visiones desde la ruralidad. Leidy Sofía Peñata Doria 150Percepciones sobre la discapacidad física en las clases de educación física en Montería. Heider Ramiro Díaz Better - Cleiber Eusse López 152Framework basado en gestión de conocimiento para la salvaguarda de la lengua embera. Ernesto Llerena García – Manuel Caro Piñeres 154Educación inclusiva: una oportunidad para la transformación de la escuela rural. Liliana María Escobar Guerra - Isabel Hernández Arteaga – Henry David Uribe Londoño 156Ciudadanía Planetaria. Una mirada desde la multiculturalidad y la interculturalidad. Milton Fabián Badel Gómez 158Nivel de apropiación de la Competencia Tic e Intercultural en docentes de básica primaria del departamento del Atlántico. Nathaly Sofía Daza Morales 160El sistema pictográfico como medio para fomentar la comunicación de estudiantes con Síndrome de Down en el entorno escolar. Evis Danith Ariza Jiménez 162Literatura infantil y deporte inclusivo: estrategias didácticas para fomentar la inclusión, el respeto a la diferencia y a la diversidad en la educación infantil. Jesús Kerguelén - Luisa Fernanda Llorente Vergara - Luis Pacheco Lora 164Modelos de enseñanza de los docentes de música Vallenata en la Facultad de Bella Artes, Universidad Popular del Cesar. Juan De La Rosa López – Camilo Andrés Andrade Guerra – Martha Guerra Muñoz 166Enseñando fracciones desde un aula inclusiva: fracciones para no fraccionarnos. Silvia Madera - Nasly Ruíz – Ángel Viloria - Heidy Esperanza Gordillo 168Escenarios para la apropiación patrimonial con tecnologías digitales en Santa Cruz de Lorica. Jacob Vargas Arteaga 1701 Edició

Study of Bc+→χcπ+B_c^+ \rightarrow \chi_c \pi^+ decays

International audienceA study of $B_c^+ \rightarrow \chi_c \pi^+$ decays is reported using proton-proton collision data, collected with the LHCb detector at centre-of-mass energies of 7, 8, and 13 TeV, corresponding to an integrated luminosity of 9fb$^{-1}$. The decay $B_c^+ \rightarrow \chi_{c2} \pi^+$ is observed for the first time, with a significance exceeding seven standard deviations. The relative branching fraction with respect to the $B_c^+ \rightarrow J/\psi \pi^+$ decay is measured to be $$\frac{\mathcal{B}_{B_c^+ \rightarrow \chi_{c2} \pi^+}} {\mathcal{B}_{B_c^+ \rightarrow J/\psi \pi^+}} = 0.37 \pm 0.06 \pm 0.02 \pm 0.01 ,$$ where the first uncertainty is statistical, the second is systematic, and the third is due to the knowledge of the $\chi_c \rightarrow J/\psi \gamma$ branching fraction. No significant $B_c^+ \rightarrow \chi_{c1} \pi^+$ signal is observed and an upper limit for the relative branching fraction for the $B_c^+ \rightarrow \chi_{c1} \pi^+$ and $B_c^+ \rightarrow \chi_{c2} \pi^+$ decays of $$\frac{\mathcal{B}_{B_c^+ \rightarrow \chi_{c1} \pi^+}} {\mathcal{B}_{B_c^+ \rightarrow \chi_{c2} \pi^+}} < 0.49$$ is set at the 90% confidence level

Determination of short- and long-distance contributions in B0→K∗0μ+μ−B^{0}\to K^{*0}\mu^+\mu^- decays

International audienceAn amplitude analysis of the $B^0 \to K^{*0} \mu^+\mu^-$ decay is presented. The analysis is based on data collected by the LHCb experiment from proton-proton collisions at $\sqrt{s} = 7,\,8$ and $13$ TeV, corresponding to an integrated luminosity of $4.7$ fb$^{-1}$. For the first time, Wilson coefficients and non-local hadronic contributions are accessed directly from the unbinned data, where the latter are parameterised as a function of $q^2$ with a polynomial expansion. Wilson coefficients and non-local hadronic parameters are determined under two alternative hypotheses: the first relies on experimental information alone, while the second one includes information from theoretical predictions for the non-local contributions. Both models obtain similar results for the parameters of interest. The overall level of compatibility with the Standard Model is evaluated to be between 1.8 and 1.9 standard deviations when looking at the $\mathcal{C}_9$ Wilson coefficient alone, and between 1.3 and 1.4 standard deviations when considering the full set of $\mathcal{C}_9, \, \mathcal{C}_{10}, \, \mathcal{C}_9^\prime$ and $\mathcal{C}_{10}^\prime$ Wilson coefficients. The ranges reflect the theoretical assumptions made in the analysis