Effect of fixed orthodontic appliances on salivary microbial parameters at 6 months:a controlled observational study

Objective: The aim of this study was to assess the microbial changes in children with fixed orthodontic appliances compared with a control group of children without orthodontic treatment. Material and Methods: Ninety-five children, aged between 12 and 16 years, participated in this study. Forty-eight subjects were fitted with fixed orthodontic appliances and forty-seven were free of any such appliances. The follow-up was 6 months for all children. The association between orthodontic appliances and high levels of Streptococcus mutans and Lactobacillus spp was assessed with logistic regression models, taking age, sex, pH and buffer capacity into account. Results: Differences at baseline between the two groups were not statistically significant. We found that wearing a fixed orthodontic appliance was associated with high levels of Streptococcus mutans and Lactobacillus spp (adjusted OR: 6.65, 95% CI [1.98-22.37]; 9.49, 95% CI [2.57-35.07], respectively), independently of other variables. Conclusion: The originality of the present epidemiological study was to evaluate the evolution of salivary microbial parameters in a population of children with fixed orthodontic appliances. Our results show an increase of Streptococcus mutans and Lactobacillus spp values during the follow-up. The whole dental workforce should be aware that preventive measures are of paramount importance during orthodontic treatment

Le bilan de thrombophilie au diagnostic de leucémie aiguë lymphoblastique chez l'enfant (étude rétrospective au CHU de Bordeaux)

BORDEAUX2-BU Santé (330632101) / SudocSudocFranceF

[Prevention of venous perioperative thromboembolism in ENT and maxillofacial surgery]

International audienceThere are few studies of poor methodological quality on the risk of thromboembolism in head and neck surgery. The incidence of symptomatic deep vein thrombosis is estimated between, 0.1% and 0.6%. The patient's risk factors (cancer, alcoholism, smoking, malnutrition) determine for the assessment of the potential benefit of thromboembolism prophylaxis. No method can be recommended based on the literature. In patients receiving anticoagulant therapy undergoing superficial head and neck surgery or dental extraction, the literature suggest to continue anticoagulation throughout the perioperative period

[Thromboprophylaxis in neurosurgery and head trauma]

International audienceThe incidence of deep vein thrombosis (DVT) is between 20 and 35% using contrast venography, with a rate of symptomatic DVT between 2.3 and 6% in neurosurgery without any prophylaxis. The risk of DVT is poorly evaluated in head injured patients but is around 5%. Specific risk factors in neurosurgery are: a motor deficit, a meningioma or malignant tumour, a large tumour, age over 60 years, surgery lasting more than 4 hours, a chemotherapy. The benefit of mechanical methods or low molecular weight heparin (LMWH) for the prevention of DVP in neurosurgery is demonstrated (grade A). Each method decreases the risk by about 50%. A postoperative prophylaxis with a LMWH does not seem to increase the risk of intracranial bleeding (grade C). There is no demonstrated benefit to begin a prophylaxis with LMWH before the intervention. The duration of the prophylaxis is 7 to 10 days but this has not been scientifically determined

Recent Changes in the ISBA-CTRIP Land Surface System for Use in the CNRM-CM6 Climate Model and in Global Off-Line Hydrological Applications

International audienceIn recent years, significant efforts have been made to upgrade physical processes in the ISBA-CTRIP land surface system for use in fully coupled climate studies using the new CNRM-CM6 climate model or in stand-alone mode for global hydrological applications. Here we provide a thorough description of the new and improved processes implemented between the CMIP5 and CMIP6 versions of the model and evaluate the hydrology and thermal behavior of the model at the global scale. The soil scheme explicitly solves the one-dimensional Fourier and Darcy laws throughout the soil, accounting for the dependency of hydraulic and thermal soil properties on soil organic carbon content. The snowpack is represented using a multilayer detailed internal-process snow scheme. A two-way dynamic flood scheme is added in which floodplains interact with the soil hydrology through reinfiltration of floodwater and with the overlying atmosphere through surface free-water evaporation. Finally, groundwater processes are represented via a two-dimensional diffusive unconfined aquifer scheme allowing upward capillarity rises into the superficial soil. This new system has been evaluated in off-line mode using two different atmospheric forcings and against a large set of satellite estimates and in situ observations. While this study is not without weaknesses, its results show a real advance in modeling the physical aspects of the land surface with the new ISBA-CTRIP version compared to the previous system. This increases our confidence that the model is able to represent the land surface physical processes accurately across the globe and in turn contribute to several important scientific and societal issues

Decline in C-reactive protein after successful ablation of long-lasting persistent atrial fibrillation

Copyright © 2006 American College of Cardiology FoundationMartin Rotter, Pierre Jaïs, Marie-Christine Vergnes, Paquita Nurden, Yoshihide Takahashi, Prashanthan Sanders, Thomas Rostock, Mélèze Hocini, Fréderic Sacher and Michel Haïssaguerrehttp://www.elsevier.com/wps/find/journaldescription.cws_home/505766/description#descriptio

Novel risk factors for premature peripheral arterial occlusive disease in non-diabetic patients: a case-control study.

BACKGROUND: This study aimed to determine the prevalence of genetic and environmental vascular risk factors in non diabetic patients with premature peripheral arterial disease, either peripheral arterial occlusive disease or thromboangiitis obliterans, the two main entities of peripheral arterial disease, and to established whether some of them are specifically associated with one or another of the premature peripheral arterial disease subgroups. METHODS AND RESULTS: This study included 113 non diabetic patients with premature peripheral arterial disease (diagnosis <45-year old) presenting either a peripheral arterial occlusive disease (N = 64) or a thromboangiitis obliterans (N = 49), and 241 controls matched for age and gender. Both patient groups demonstrated common traits including cigarette smoking, low physical activity, decreased levels of HDL-cholesterol, apolipoprotein A-I, pyridoxal 5'-phosphate (active form of B6 vitamin) and zinc. Premature peripheral arterial occlusive disease was characterized by the presence of a family history of peripheral arterial and carotid artery diseases (OR 2.3 and 5.8 respectively, 95% CI), high lipoprotein (a) levels above 300 mg/L (OR 2.3, 95% CI), the presence of the factor V Leiden (OR 5.1, 95% CI) and the glycoprotein Ia(807T,837T,873A) allele (OR 2.3, 95% CI). In thromboangiitis obliterans group, more patients were regular consumers of cannabis (OR 3.5, 95% CI) and higher levels in plasma copper has been shown (OR 6.5, 95% CI). CONCLUSIONS: According to our results from a non exhaustive list of study parameters, we might hypothesize for 1) a genetic basis for premature peripheral arterial occlusive disease development and 2) the prevalence of environmental factors in the development of thromboangiitis obliterans (tobacco and cannabis). Moreover, for the first time, we demonstrated that the 807T/837T/873A allele of platelet glycoprotein Ia may confer an additional risk for development of peripheral atherosclerosis in premature peripheral arterial occlusive disease