COVID-19: Recomendaciones técnicas sobre el correcto uso de equipos agrícolas en los espacios públicos para la aplicación de soluciones de Cloro

La evidencia actual sugiere que el COVID-19 (SARS-CoV-2) puede permanecer viable durante horas o días en la superficies de distintos tipo de materiales. La limpieza de las mismas visiblemente sucias seguida de desinfección es una medida de mejores prácticas para la prevención de COVID-19 y otras enfermedades respiratorias virales en hogares y entornos comunitarios. En tal sentido, se sugiere, el presente protocolo para el caso de utilizar pulverizadoras comerciales de fitosanitarios para la desinfección de espacios de uso público, cada vez que el Ministerio de Salud y/o sus Dependencias o Comités de Emergencia así lo decidan. Se identifica como el desinfectante de uso más común, una solución en base a hipoclorito de sodio (cloro). Al respecto y a los efectos de lograr la máxima eficacia y eficiencia en la aplicación, siendo el objetivo básico de la misma llegar al blanco (virus) en el momento adecuado, con la cantidad de producto desinfectante adecuado recomendado por las autoridades de salud competentes.Instituto de Ingeniería RuralFil: Martens, Silvia Fanny. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Agencia de Extensión Rural Tandil; ArgentinaFil: Montoya, Jorgelina. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Anguil; ArgentinaFil: Cid, Ramiro. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Ingeniería Rural; ArgentinaFil: Rivas, María del Carmen. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Suelos; Argentin

Spleen-Dependent Immune Protection Elicited by CpG Adjuvanted Reticulocyte-Derived Exosomes from Malaria Infection Is Associated with Changes in T cell Subsets' Distribution

Added corrigendum published in 2017-01-17 https://doi.org/10.3389/fcell.2016.00153Reticulocyte-derived exosomes (rex) are 30-100 nm membrane vesicles of endocytic origin released during the maturation of reticulocytes to erythrocytes upon fusion of multivesicular bodies with the plasma membrane. Combination of CpG-ODN with rex obtained from BALB/c mice infected with the reticulocyte-prone non-lethal P. yoelii 17X malaria strain (rexPy), had been shown to induce survival and long lasting protection. Here, we show that splenectomized mice are not protected upon rexPy+CpG inmunizations and that protection is restored upon passive transfer of splenocytes obtained from animals immunized with rexPy+CpG. Notably, rexPy immunization of mice induced changes in PD1- memory T cells with effector phenotype. Proteomics analysis of rexPy confirmed their reticulocyte origin and demonstrated the presence of parasite antigens. Our studies thus prove, for what we believe is the first time, that rex from reticulocyte-prone malarial infections are associated with splenic long-lasting memory responses. To try extrapolating these data to human infections, in vitro experiments with spleen cells of human transplantation donors were performed. Plasma-derived exosomes from vivax malaria patients (exPv) were actively uptaken by human splenocytes and stimulated spleen cells leading to changes in T cell subsets

Nutrition Education in Primary Education

La Educación Nutricional es la base para la salud de los niños y niñas desde la infancia hasta la edad adulta, sin patologías y especialmente, si tienen alguna relacionada con la alimentación o alguna patología relacionada con el sistema digestivo. De ahí, la importancia de inculcar hábitos saludables en alimentación desde la etapa de Educación Infantil, no por ello, olvidando la continuidad que debe tener en las posteriores etapas educativas.Nutrition education is the basis for the health of children from infancy to adulthood, without conditions and especially, if they have any food related or related to the digestive system. Hence the importance of instilling healthy eating habits from the kindergarten stage, why not forgetting the continuity that should be in later stages of education. Besides being a crosscutting issue health education, we can work session during the same day through play activities proposed in this articl

Socio-demographic situation and level of satisfaction with the training of graduates of a private university in the city of Manizales, Colombia

Esta investigación tuvo como objetivo analizar la situación sociodemográfica, el nivel de satisfacción con las competencias y el nivel de identidad institucional de los graduados. La metodología tuvo alcance descriptivo, longitudinal retrospectivo. La población estuvo conformada por 2038 graduados de las facultades de salud, ingeniería y estudios sociales y empresariales entre 2008 y 2012. Se utilizó un cuestionario de auto diligenciamiento al momento del grado. Se encontró que en la Facultad de Ingeniería la mayoría son hombres, en las tres facultades hay mayor proporción de solteros. El dominio de competencias relacionadas con el uso de la información agrupa el mayor porcentaje satisfecho en las tres facultades, con la competencia identificar y utilizar símbolos para comunicarse está satisfecho un menor porcentaje. En relación con los recursos físicos, el promedio más bajo de satisfacción se presenta con los espacios deportivos y para realizar actividades artísticas y el más alto con la biblioteca y aulas informáticas. Más del 79% está satisfecho con la formación académica, la fundamentación teórica y las relaciones interpersonales de los docentes, una menor proporción está satisfecho con el trabajo de campo. Más del 75% de los graduados de las tres facultades volvería a estudiar en la universidad, principalmente por la calidad de la formación. Finalmente los graduados tienen identidad con la institución, evidenciada en los porcentajes de satisfacción con el desarrollo de las competencias, los docentes, los recursos físicos y con algunos espacios físicos.This research aims at analyzing the socio-demographic situation, the level of satisfaction regarding the mastery of skills and the degree of institutional identity of graduates. The methodology had a descriptive, longitudinal and retrospective scope. 2038 graduates between 2008 and 2012 and who belonged to the health, engineering and social and business studies faculties participated in this research. They did a survey at the moment of their graduation. The results showed that most of the graduates from the engineering faculty were men, and there was a higher rate of singleness within the three faculties. The mastery of skills related to the satisfactory use of information gathered the highest percentage within the three faculties, whereas competences to identify and use symbols to communicate showed a lower percentage. In relation to facilities, the lowest satisfaction percentage was to sports and artistic locations, whereas the highest was for the library and computer rooms. More than 79% are satisfied with the academic training, theoretical foundations and interpersonal relationships with professors, while a smaller proportion are satisfied with fieldwork. Over 75% of graduates from the three faculties would come back to study at institution, mainly due to its quality in training. As a conclusion, graduates report to have identity with the institution. This is evident through the percentages of satisfaction with skills development, professors, physical resources and some facilities

Transversal theme: Vial Education in Early Childhood Education

La escuela pretende formar a ciudadanos que se desenvuelvan en su entorno de forma autónoma, pero no basta con el aprendizaje de conceptos y absorción de contenidos sino que hay una serie de valores que debemos trabajar de forma transversal con la rutina del día a día de la escuela y que se conectan con la vida cotidiana, mas concretamente en este texto hablaremos sobre el tema transversal de la Educación Vial y una propuesta de actividades para desarrollar una unidad didáctica sobre la misma.The school aims to train citizens in their environment unfold autonomously, but not enough learning and absorbing concepts contained but there is a set of values ​​that must work across the board in the classroom with the routine of the day day school and connect with everyday life, more specifically in this text we will discuss the cross-cutting theme of road safety education and a proposal for activities to develop a teaching unit on it

Las preguntas más frecuentes de la normalización de competencias laborales 2015 - 2020

Informe en el que se consolidan preguntas y temas relacionados con la normalización de competencias laborales que provienen de quienes están adscritos a la unidad sectorial de normalización del SENA.Report in which questions and issues related to the standardization of labor competencies that come from those who are attached to the SENA sectoral standardization unit are consolidated.Preguntas relacionadas con el análisis y mapa funcional -- Preguntas relacionadas con la estructura funcional de la ocupación -- Preguntas relacionadas con la norma sectorial de competencia laboralna12 página

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality