Efficacy of a Fixed Combination of Tetracycline, Chloramphenicol, and Colistimethate Sodium for Treatment of Candida albicans Keratitis

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Ocurrencia de Ceresa nigripectus (Hemiptera: Membracidae) en vides de la región cuyana de Argentina

En la provincia de Mendoza se han observado ninfas y adultos de una chicharra, que al alimentarse de los órganos de la vid (Vitis vinifera L.) causa lesiones y sintomatologías producto de la respuesta de la planta. Dada su similitud con otras afecciones, el cuadro sintomatológico muchas veces no es reconocido por los viticultores. En esta contribución se da a conocer a C. nigripectus como el membrácido que afecta los viñedos mendocinos y se destaca su importancia por ser una especie nativa ampliamente distribuida en el país, que ha demostrado tener capacidad infestiva en alfalfares y ser potencial vector del fitoplasma ArAWB, agente causal de la “escoba de bruja de la alfalfa”. Asimismo, se marcan los rasgos diagnósticos más relevantes y se caracterizan las lesiones y sintomatologías observadas en la vid producto de la alimentación del insecto, para que sean fácilmente reconocidas a campo.In Mendoza province, which belongs to Argentina ‛Cuyo’ region, has been seen treehopper nymphs and adults, which feed leaves, branches and clusters of the vine causing a symptomatology product of the plant’s response. The symptoms are not often recognized by the winegrowers due to the similarity to other grapevine disorders. In this contribution C. nigripectus is identified as the Membracidae that causes injuries in vineyards and its importance is highlighted because it is a common native species in alfalfa crop and potential vector of ArAWB phytoplasma causing “alfalfa witches broom”. Also are provided the most relevant diagnostic features and symptoms occurred in the vineyard to be easily recognized in the field.Gerencia de Comunicación Institucional, DG SICyP, INTAFil: Vicchi, Franco R. Promotor asesor de Cambio Rural. Actividad vitivinícola; ArgentinaFil: Marino de Remes Lenicov, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. División Entomología; Argentin

Chronic Overlapping Pain Conditions and Long-Term Opioid Treatment

OBJECTIVES: One in 5 people in the United States lives with chronic pain. Many patients with chronic pain experience a subset of specific co-occurring pain conditions that may share a common pain mechanism and that have been designated as chronic overlapping pain conditions (COPCs). Little is known about chronic opioid prescribing patterns among patients with COPCs in primary care settings, especially among socioeconomically vulnerable patients. This study aims to evaluate opioid prescribing among patients with COPCs in US community health centers and to identify individual COPCs and their combinations that are associated with long-term opioid treatment (LOT). STUDY DESIGN: Retrospective cohort study. METHODS: We conducted analyses of more than 1 million patients 18 years and older based on electronic health record data from 449 US community health centers across 17 states between January 1, 2009, and December 31, 2018. Logistic regression models were used to assess the relationship between COPCs and LOT. RESULTS: Individuals with COPCs were prescribed LOT 4 times more often than individuals without a COPC (16.9% vs 4.0%). The presence of chronic low back pain, migraine headache, fibromyalgia, or irritable bowel syndrome combined with any of the other COPCs increased the odds of LOT prescribing compared with the presence of a single COPC. CONCLUSIONS: Although LOT prescribing has declined over time, it remains relatively high among patients with certain COPCs and for those with multiple COPCs. These study findings suggest target populations for future interventions to manage chronic pain among socioeconomically vulnerable patients

Transcriptomic indices of fast and slow disease progression in two mouse models of amyotrophic lateral sclerosis

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Fungal model systems and the elucidation of pathogenicity determinants

Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.Peer reviewedPublisher PD

The Gaia-ESO survey: Radial metallicity gradients and age-metallicity relation of stars in the milky way disk

We study the relationship between age, metallicity, and α-enhancement of FGK stars in the Galactic disk. The results are based upon the analysis of high-resolution UVES spectra from the Gaia-ESO large stellar survey. We explore the limitations of the ob

Prevalent Multimorbidity Combinations Among Middle-Aged and Older Adults Seen in Community Health Centers

BACKGROUND: Multimorbidity (≥ 2 chronic diseases) is associated with greater disability and higher treatment burden, as well as difficulty coordinating self-management tasks for adults with complex multimorbidity patterns. Comparatively little work has focused on assessing multimorbidity patterns among patients seeking care in community health centers (CHCs). OBJECTIVE: To identify and characterize prevalent multimorbidity patterns in a multi-state network of CHCs over a 5-year period. DESIGN: A cohort study of the 2014-2019 ADVANCE multi-state CHC clinical data network. We identified the most prevalent multimorbidity combination patterns and assessed the frequency of patterns throughout a 5-year period as well as the demographic characteristics of patient panels by prevalent patterns. PARTICIPANTS: The study included data from 838,642 patients aged ≥ 45 years who were seen in 337 CHCs across 22 states between 2014 and 2019. MAIN MEASURES: Prevalent multimorbidity patterns of somatic, mental health, and mental-somatic combinations of 22 chronic diseases based on the U.S. Department of Health and Human Services Multiple Chronic Conditions framework: anxiety, arthritis, asthma, autism, cancer, cardiac arrhythmia, chronic kidney disease (CKD), chronic obstructive pulmonary disease (COPD), congestive heart failure, coronary artery disease, dementia, depression, diabetes, hepatitis, human immunodeficiency virus (HIV), hyperlipidemia, hypertension, osteoporosis, post-traumatic stress disorder (PTSD), schizophrenia, substance use disorder, and stroke. KEY RESULTS: Multimorbidity is common among middle-aged and older patients seen in CHCs: 40% have somatic, 6% have mental health, and 24% have mental-somatic multimorbidity patterns. The most frequently occurring pattern across all years is hyperlipidemia-hypertension. The three most frequent patterns are various iterations of hyperlipidemia, hypertension, and diabetes and are consistent in rank of occurrence across all years. CKD-hyperlipidemia-hypertension and anxiety-depression are both more frequent in later study years. CONCLUSIONS: CHCs are increasingly seeing more complex multimorbidity patterns over time; these most often involve mental health morbidity and advanced cardiometabolic-renal morbidity

Helium enhanced stars and multiple populations along the horizontal branch of NGC 2808: Direct spectroscopic measurements

We present an abundance analysis of 96 horizontal branch (HB) stars in NGC 2808, a globularcluster exhibiting a complex multiple stellar population pattern. These stars are distributed indifferent portions of the HB and cover a wide range of temperature

Screening Feline Blood Donors for Bartonella henselae Infection: Comparison between Indirect Immunofluorescent Antibody Test (IFAT) and Polymerase Chain Reaction (PCR) Results

In order to minimize pathogen transmission, all blood do- nors should be appropriately screened for infectious agents. Screening for Bartonella spp. infection in feline blood donors is a recommended practice in veterinary blood banks across the world. The aim of this study was to compare results of an indirect immunofluorescence antibody test (IFAT) in identifying Bartonella henselae antibodies with the results of PCR amplification of Bartonella spp. DNA to establish the best IFAT cut off to identify non-bacteremic cats. A secondary aim of this study was to evaluate demographic and clinicopathologic factors that may be associated with Bartonella henselae infection status. From a population of stray cats in Milan city, 82 serum samples were evaluated by IFAT for Bartonella henselae antibodies and PCR was performed on 90 whole blood samples for amplification of Bartonella spp. DNA. A total of 14/82 (17.1%) samples were seropositive with an IFAT titer 651:64 (cut-off for infection). Bartonella spp. DNA was identified in 11/90 (12.2%) samples by PCR. Overall 20/90 (22.2%) infected cats were identified by either IFAT 651:64 and/or PCR-positive results. Hyperbetaglobulinemia (P=0.02) and originating from zone 2 of Milan city (P=0.03) were statistically associated with positive Bartonella infection status. The overall IFAT sensitivity was 50.0%, specificity 87.5%, positive predictive value 35.7% and negative predictive value was 92.65%. The ROC analysis showed that the area under the curve was 0.747 (P=0.0032) and that an IFAT cut off<1:32 had the highest sensitivity in identifying Bartonella PCR-negative cats. When feline blood donors undergo serological screening for Bartonella henselae infection an IFAT cut off <1:32 has the highest sensitivity for identifying non-bacteremic cats. However some serologically negative cats could be bacteremic and therefore screening of a feline blood donor using a combination of IFAT and PCR is recommended. Protein electrophoresis should be performed in all potential donor cats