A Model for Successful Reutilization of a Military Installation: A Case Study of Gentile Air Force Station

Previous research concerning base closure and reutilization focused on the roles of government agencies and the assistance they provided. This study looks at the community and the impact of installation closure. The process of planning for reuse of an installation is difficult and confusing. The guidance provided by the government has changed drastically since the first closures announced in the 1988 Base Realignment and Closure Committee recommendations. This study focuses on the strategy employed by Kettering, OH to successfully reuse Gentile AFS upon closure. As the final part in a longitudinal study, the research focus was lessons learned and implementation challenges for the city of Kettering. Research findings indicated Kettering would be successful in their attempts to reuse Gentile AFS as a business park. Recommendations were to locate a liaison on site to deal with the daily operations of conveying the facilities and property to the local community. This liaison should be employed by the local community to represent the community\u27s interests. Further, the model used by Kettering could be adapted for any installation and help the local community break down the enormous task of reutilization into several tasks of more manageable size

Modeling spectral changes in singing voice for pitch modification

We present an advanced method to achieve natural modifications when applying a pitch shifting process to singing voice by modifying the spectral envelope of the audio ex- cerpt. To this end, an all-pole spectral envelope model has been selected to describe the global variations of the spectral envelope with the changes of the pitch. We performed a pitch shifting process of some sustained vowels with the envelope processing and without it, and compared both by means of a survey open to volunteers in our website.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. This work has been funded by the Ministerio de Economía y Competitividad of the Spanish Government under Project No. TIN2013-47276-C6-2-R and by the Junta de Andalucía under Project No. P11-TIC-7154

Autophagy in Pancreatic Cancer

Pancreatic adenocarcinoma (PDAC) is a devastating disease with an extremely poor life expectancy and no effective treatment. Autophagy is a process of degradation of cytoplasmic component capable of recycling cellular components or eliminate specific targets. The presence of autophagy in PDAC has been demonstrated. However, the implicated cellular pathways are not fully understood and, more importantly, the role of autophagy in PDAC is matter of intensive debate. This review summarizes recently published data in an attempt to clarify the importance of autophagy in this disease and try to reconcile apparently contradictory results

Prevalência de consumo de suplementos alimentares nos profissionais do Instituto Politécnico de Bragança

Atualmente, o estilo de vida da sociedade, nem sempre permite a ingestão de refeições equilibradas, o que despoleta os indivíduos a recorrer a suplementos alimentares para compensar a deficiente ingestão de certas substâncias, assim como prevenir diversas patologias.(1) Os suplementos alimentares são definidos como géneros alimentícios que se destinam a complementar e ou suplementar o regime alimentar normal e que constituem fontes concentradas de determinadas substâncias, nutrientes ou outras com efeito nutricional ou fisiológico, estremes ou combinadas, comercializadas em forma doseada, tais como cápsulas, pastilhas, comprimidos, pílulas e outras formas semelhantes, saquetas de pó, ampolas de líquido, frascos com conta-gotas e outras formas similares de líquidos ou pós que se destinam a ser tomadas em unidades medidas de quantidade reduzida

Bioavailability of orange juice (poly)phenols: the impact of short-term cessation of training by male endurance athletes

Background: Physical exercise has been reported to increase the bioavailability of citrus flavanones. Objective: To investigate the bioavailability of orange juice (OJ) (poly)phenols in endurance-trained men before and after cessation of training for 7 days. Design: Ten fit endurance-trained males, with a maximal oxygen consumption of 58.2 ± 5.3 mL/kg/min, followed a low (poly)phenol diet for 2 d before drinking 500 mL of OJ, containing 398 µmol of (poly)phenols of which 330 µmol were flavanones. After the volunteers stopped training for 7 days the feeding study was repeated. Urine samples were collected 12 h pre- and 24 h post-OJ orange consumption. Bioavailability was assessed by the quantitative analysis of urinary flavanone metabolites and (poly)phenol catabolites using HPLC-HR-MS. Results: While training, 0-24 h urinary excretion of flavanone metabolites, mainly hesperetin-3-O-glucuronide, hesperetin-3´-sulfate, naringenin-4´-O-glucuronide, naringenin-7-O-glucuronide, was equivalent to 4.2% of OJ flavanone intake. This increased significantly to 5.2% when OJ was consumed after the volunteers stopped training for 7 days. Overall, this trend, although not significant, was also observed with OJ-derived colonic catabolites which after supplementation in the trained state were excreted in amounts equivalent to 51% of intake compared to 59% after cessation of training. However, urinary excretion of three colonic catabolites of bacterial origin, most notably, 3-(3´-hydroxy-4´-methoxyphenyl)hydracrylic acid, did increase significantly when OJ was consumed post- compared to pre-cessation of training. Data were also obtained on inter-individual variations in flavanone bioavailability. Conclusion: A 7-day cessation of endurance training enhanced, rather than reduced, the bioavailability of OJ flavanones. The biological significance of these differences and, whether or not they extend to the bioavailability of other dietary (poly)phenols, remains to be determined. Hesperetin-3´-O-glucuronide and the colonic microbiota-derived catabolite 3-(3´-hydroxy-4´-methoxyphenyl)hydracrylic acid are key biomarkers of the consumption of hesperetin-O-glycoside-containing OJ and other citrus products

Profile of cancer patients requiring dental and oral-maxillofacial prostheses in a Brazilian subpopulation

The aim of the present study was to identify the profile of cancer patients in need of rehabilitation with dental and/or oral-maxillofacial prostheses and evaluate possible reasons for not concluding the rehabilitation process. A retrospective observati

Reinforcement of the Plasmon–phonon Coupling in Α-Quartz Via Deposition of Gold Nanoparticles in Etched Ion Tracks

This study reports a large reinforcement of the plasmon–phonon coupling in alpha quartz achieved through the controlled deposition of gold nanoparticles into nano templates produced through chemical etching of ion tracks. Preferential agglomeration of nanoparticles within the etched ion tracks (nano wells) was observed in Scanning Electron Microscopy and Atomic Force Microscopy images. Raman characterization of quartz substrates with different nanoparticle concentrations revealed a relationship between the plasmon–phonon coupling intensity and nanoparticle concentration. Reinforcement of the plasmon–phonon coupling was observed as an increase in the Raman intensity with increasing concentration of deposited nanoparticles. The intensity initially increased linearly with nanoparticle concentration up to about 4 x 106 nps/µL where a saturation regime was identified. In the saturation regime, a roughly 200-fold increase in the scattering intensity was measured in the first micron of the specimen. At higher nanoparticle concentrations, the Raman intensity decreased exponentially following the Beer–Lambert Law. The reduction in the Raman intensity is attributed to increased laser absorption with increasing nanoparticle layer thickness. Comparatively weak reinforcement of Raman scattering was observed when nanoparticles were deposited on unirradiated and unetched samples, suggesting that the reinforcement of plasmon–phonon coupling may be favored by the anisotropic geometry of the nano wells. In particular, the etched tracks promote nanoparticles agglomeration likely promoting the formation of plasmon hotspots

Nuclear phenotype changes after heat shock in Panstrongylus megistus (Burmeister)

The nuclear phenotypes of Malpighian tubule epithelial cells of male nymphs of the blood-sucking insect, Panstrongylus megistus, subjected to short- and long-duration heat shocks at 40ºC were analyzed immediately after the shock and 10 and 30 days later. Normal nuclei with a usual heterochromatic body as well as phenotypes indicative of survival (unravelled heterochromatin, giants) and death (apoptosis, necrosis) responses were observed in control and treated specimens. However, all nuclear phenotypes, except the normal ones, were more frequent in shocked specimens. Similarly altered phenotypes have also been reported in Triatoma infestans following heat shock, although at different frequencies. The frequency of the various nuclear phenotypes observed in this study suggests that the forms of cell survival observed were not sufficient or efficient enough to protect all of the Malpighian tubule cells from the deleterious effects of stress. In agreement with studies on P. megistus survival following heat shock, only long-duration shock produced strongly deleterious effects.27127