7 research outputs found
Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2
- Author
- AbellĂĄn Javier
- Acosta-isaac René
- Aguado Jose MarĂa
- Aguilar Carlos
- Aguilera-albesa Sergio
- Ahmadi Sabbagh Abdolah
- Alba Jorge
- Albu Sergiu
- AlcalĂĄ-gallardo Karla A. M.
- Alcoba-florez Julia
- Alcolea Batres Sergio
- Algarin-lara Holmes Rafael
- Almadana Virginia
- Almeida Julia
- Almoguera Berta
- Alonso MarĂa R.
- Andreu-bernabeu Ălvaro
- Antonijoan Maria Rosa
- Arana-arri Eunate
- Aranda Carlos
- Arango Celso
- Araque Carolina
- Araujo Izabel M. T.
- Araujo Nathalia K.
- Arcanjo Ana C.
- Arnaiz Ana
- Arnalich FernĂĄndez Francisco
- Arranz MarĂa J.
- Arribas López José Ramón
- Artiga Maria-jesĂșs
- Avello-malaver Yubelly
- Ayuso Carmen
- Balagué-dobón Laura
- Baldion Ana MarĂa
- Ballina MartĂn BelĂ©n
- Baptista-rosas RaĂșl C.
- Barranco-dĂaz Andrea
- Barreda-sĂĄnchez MarĂa
- Barrera-penagos Viviana
- Belhassen-garcia Moncef
- Bernal Enrique
- Bernal-bello David
- Bezerra Joao F.
- Bezerra Marcos A. C.
- Blanca-lĂłpez Natalia
- Blancas Rafael
- Boix-palop LucĂa
- Borobia Alberto
- Bravo Elsa
- Brion MarĂa
- Brochado-kith Ăscar
- Brugada RamĂłn
- Bustos Matilde
- Cabello Alfonso
- Calbo Esther
- CalderĂłn Enrique J.
- Camacho Shirley
- Campos Marcela C.
- Carbonell Cristina
- Cardona-huerta Servando
- Carioca Antonio Augusto F.
- Carpio Segura Carlos
- Carracedo Ăngel
- Carratto ThĂĄssia M. T.
- Carrillo-avila José Antonio
- Carvalho Maria C. C.
- Casasnovas Carlos
- Castaño Carlos F.
- Castaño Luis
- Castelao Jose E.
- Castellano Candalija Aranzazu
- Castillo MarĂa A.
- Cañadas Yolanda
- Ceballos Francisco C.
- Chaux Jessica G.
- Chaves-santiago Walter G.
- Chiquillo-gĂłmez Sylena
- Cid-lĂłpez Marco A.
- Cienfuegos-jimĂ©nez Ăscar
- Conde-vicente Rosa
- Cordero-lorenzana M. Lourdes
- Corella Dolores
- Corrales Almudena
- Corton Marta
- Cortés-sånchez Jose L.
- Costa Tatiana X.
- Cruz Marina S.
- Cruz Raquel
- Cuesta Luisa
- Cunha Gabriela C. R.
- CĂĄceres Alejandro
- CĂĄceres-agra Juan J.
- Dalmau David
- Dantas-komatsu Raquel C. S.
- Darnaude M. Teresa
- De Andrés Raimundo
- De AraĂșjo JĂ©ssica N. G.
- De Juan Carmen
- De La Cruz Troca Juan J.
- De La Horra Carmen
- De La Hoz Ana B.
- De Martino-rodrĂguez Alba
- De Sousa Alves Neri Julianna Lys
- Del Campo-pérez Victor
- Delgado-cuesta Juan
- Diaz De Bustamante Aranzazu
- Dietl Beatriz
- Diz-de Almeida Silvia
- Do Monte Alves Manoella
- DomĂnguez-garrido Elena
- Dos Santos Katiusse A.
- Duarte Alice L.
- DĂaz-caneja Covadonga M.
- DĂaz-pĂ©rez Anderson
- Echave-sustaeta Jose
- Eiros RocĂo
- Enciso-olivera CĂ©sar O.
- Escudero Gabriela
- Esko Tonu
- España Pedro Pablo
- Estigarribia Sanabria Gladys
- Fariñas MarĂa Carmen
- Fernandes Marianne R.
- Fernandez-nestosa MarĂa J.
- FernĂĄndez MartĂnez Yolanda
- FernĂĄndez RamĂłn
- FernĂĄndez Ruth
- FernĂĄndez-caballero Lidia
- FernĂĄndez-capitĂĄn Carmen
- FernĂĄndez-cruz Ana
- FernĂĄndez-ferrero Silvia
- FernĂĄndez-robelo UxĂa
- FernĂĄndez-rodrĂguez Amanda
- FernĂĄndez-sampedro Marta
- FernĂĄndez-villa Tania
- Flores Carlos
- Flores-pérez Patricia
- Friaza Vicente
- Fuenmayor-hernĂĄndez LĂĄcides
- Fuertes-nĂșñez Marta
- FumadĂł Victoria
- Gadea Ignacio
- Gagliardi Lidia
- Gago-domĂnguez Manuela
- Gallego Natalia
- Galoppo Cristina
- Garcia-garcĂa Josefina
- GarcĂa TorrejĂłn MarĂa Carmen
- GarcĂa InĂ©s
- GarcĂa Leticia
- GarcĂa Mercedes
- GarcĂa-cerrada Carlos
- GarcĂa-de-vicuña Aitor
- GarcĂa-garcĂa Irene
- GarcĂa-ibarbia Carmen
- GarcĂa-montero AndrĂ©s C.
- GarcĂa-soidĂĄn Ana
- GarcĂa-vĂĄzquez Elisa
- Garza-frias Emiliano
- Gentile Angela
- Gil-fournier Belén
- Gonzalez-sagrado Manuel
- Gonzalo-benito Hugo
- GonzĂĄlez Bernaldo De QuirĂłs FernĂĄn
- GonzĂĄlez Ălvarez Beatriz
- GonzĂĄlez Juan R.
- GonzĂĄlez Juan R.
- GonzĂĄlez-montelongo Rafaela
- GonzĂĄlez-neira Anna
- Gonzålez-peñas Javier
- Gorgojo-galindo Oscar
- Guaragna Florencia
- Guegel Genilson P.
- GuillĂ©n-guĂo Beatriz
- Guillén-navarro Encarna
- Guisado-vasco Pablo
- Gutiérrez-bautista Juan F.
- Gutiérrez-castañeda Luz D.
- GĂłmez Carrera Luis
- GĂłmez GarcĂa MarĂa
- GĂłmez SacristĂĄn Ăngela
- GĂłmez-arrue Javier
- GĂłmez-duque Mario
- GĂłrgolas Miguel
- Heili-frades Sara
- HernĂĄndez Estefania
- HernĂĄndez-moro Cristina
- HernĂĄndez-ortega Luis D.
- Hernåndez-pérez Guillermo
- HernĂĄndez-vaquero Rebeca
- Herranz M. Teresa
- Herrera MarĂa
- Herrero MarĂa JosĂ©
- Herrero-gonzĂĄlez Antonio
- Herråez Belén
- Horcajada Juan P.
- Imaz-ayo Natale
- Intxausti-urrutibeaskoa Maider
- Jacomo Rafael H.
- Jara Rubén
- Jiménez Pilar
- JimĂ©nez Ăngel
- Jiménez-alfaro Ignacio
- JimĂ©nez-sousa MarĂa A.
- Jordan Iolanda
- Laguna-goya RocĂo
- Laorden Daniel
- Lapunzina Pablo
- Lasa-lĂĄzaro MarĂa
- Lattig MarĂa Claudia
- Lauriente Ailen
- Liger Borja Anabel
- Llanos LucĂa
- Lopez-garcia Esther
- Lopez-rodriguez Rosario
- Lorente Leonardo
- Lorenzo-salazar José M.
- Lozano José E.
- Lozano-espinosa MarĂa
- Luchessi Andre D.
- LĂłpez De Heredia Miguel
- LĂłpez De Heredia Miguel
- LĂłpez-bernĂșs Amparo
- LĂłpez-granados Eduardo
- LĂłpez-ruz Miguel A.
- Mahillo Ignacio
- Mancebo Esther
- Mar Carmen
- Marcelo Calvo Cristina
- Marcos Miguel
- Marcos-delgado Alba
- Mariscal-aguilar Pablo
- Martin-fernandez Marta
- Martin-pedraza Laura
- Martinez Amalia
- Martinez-paz Pedro
- MartĂn MarĂa Dolores
- MartĂn MarĂa M.
- MartĂn Vicente
- MartĂn-lĂłpez Caridad
- MartĂn-oterino JosĂ©-Ăngel
- MartĂn-vicente MarĂa
- MartĂnez Juan JosĂ©
- MartĂnez Ricardo
- MartĂnez Silvia
- MartĂnez-aquino Eleno
- MartĂnez-gonzĂĄlez Ăscar
- MartĂnez-lĂłpez Iciar
- MartĂnez-nieto Ăscar
- MartĂnez-pĂ©rez Ăngel
- MartĂnez-ramas Andrea
- MartĂnez-resĂ©ndez Michel F.
- MartĂnez-robles Violeta
- Marzal Laura
- MarĂn-candĂłn Alicia
- Maya BelĂ©n RodrĂguez
- Mazzeu Juliana F.
- Medeiros Jeane F. P.
- Medeiros Kelliane A.
- Medrano Francisco J.
- Meijome Xose M.
- Mejuto-montero Natalia
- Mendes Ingrid
- Mendoza Charris Humberto
- Merayo MacĂas Eleuterio
- Mercadillo FĂĄtima
- Mercado-sesma Arieh R.
- Molina Antonio J. J.
- Molina-roldĂĄn Elena
- Montoya Juan José
- Moraes Vitor M. S.
- Moreira-escriche Patricia
- Morelos-arnedo Xenia
- Moreno Cuerda VĂctor
- Moreno FernĂĄndez Alberto
- Moreno RocĂo
- Moreno-docĂłn Antonio
- Moreno-escalante Junior
- Morilla Rubén
- Muñoz GarcĂa Patricia
- MĂ©ndez-echevarrĂa Ana
- MĂnguez Pablo
- Neira Pablo
- Nevado JuliĂĄn
- Nieto-gañån Israel
- Nunes Joana F. R.
- Nuñez-torres RocĂo
- Obrador-hevia AntĂČnia
- Ocejo-vinyals J. Gonzalo
- Olivar Virginia
- Oliveira Silviene F.
- Olivera MarĂa Rubio
- Ondo Lorena
- Orfao Alberto
- Ortega Luis
- Ortega-paino Eva
- Ortiz-flores Fernando
- Ortiz-lĂłpez RocĂo
- Oteo José A.
- Pacheco Manuel
- Pacheco-miranda Fredy Javier
- Padilla-conejo Irene
- Panadero-fajardo Sonia
- Parellada Mara
- Pariente-rodrĂguez Roberto
- Paz-artal Estela
- Peces-barba GermĂĄn
- Pedromingo Kus Miguel S.
- Perales Celia
- Perucho Teresa
- Pichardo Lisbeth A.
- Pinho Susana M. T.
- Pinsach-abuin Mel·lina
- PinzĂłn Luz Adriana
- Pita Guillermo
- Pla-juncĂ Francesc
- Planas-serra Laura
- Pompa-mera Ericka N.
- Porras-hurtado Gloria L.
- Pujol Aurora
- PĂ©rez Alexandra
- PĂ©rez CĂ©sar
- PĂ©rez MarĂa JazmĂn
- PĂ©rez Patricia
- PĂ©rez-de-nanclares Gustavo
- PĂ©rez-garcĂa Felipe
- PĂ©rez-jurado Luis A.
- PĂ©rez-matute Patricia
- PĂ©rez-tomĂĄs M. Elena
- Quevedo-chĂĄvez MarĂa Eugenia
- Quijada Maria Angeles
- Quintela Inés
- Quintela Inés
- Ramiro-leĂłn Soraya
- Rascado Sedes Pedro
- Recalde Delia
- Recio-fernĂĄndez Emma
- Resino Salvador
- Riancho José A.
- Ribeiro Adriana P.
- Rivadeneira-chamorro Carlos S.
- Roa-agudelo Diana
- Robelo Pardo Montserrat
- Rodriguez Marilyn Johanna
- Rodriguez-nicolas Antonio
- Rodriguez-palmero AgustĂ
- Rodriguez-urrego Paula A.
- RodrĂguez-artalejo Fernando
- RodrĂguez-ferrer Marena
- RodrĂguez-gallego Carlos
- RodrĂguez-garcĂa JosĂ© A.
- RodrĂguez-hernĂĄndez MarĂa A.
- RodrĂguez-novoa German Ezequiel
- RodrĂguez-ruiz Emilio
- Rojas-martinez Augusto
- Rojo Federico
- Romero-coronado Andrea
- RondĂłn-garcĂa Filomeno
- Rosa Lidia S.
- Rosales-castillo Antonio
- Rubio Cladelis
- Ruiz Montserrat
- Ruiz-cabello Francisco
- Ruiz-casares Eva
- Ruiz-cubillan Juan J.
- Ruiz-hornillos Javier
- Ryan Pablo
- Salamanca Hector D.
- Salazar-garcĂa Lorena
- Salgueiro-origlia Giorgina Gabriela
- Sancho-sainz Cristina
- Sande Esther
- Sangil Anna
- Santos Arnoldo
- Santos Ney P. C.
- SchlĂŒter Agatha
- Scourge Cohort Group
- Segovia Sonia
- Serra-llovich Alex
- Sevil-puras Fernando
- Sevilla-porras Marta
- Sicolo Miguel A.
- Silbiger Vivian N.
- Silva Fabiola T. C.
- Silva Gabriela V.
- Silva Nayara S.
- SilvĂĄn-fuentes Cristina
- Solé-violån Jordi
- Soria José Manuel
- SorlĂ Jose V.
- Sousa Renata R.
- Souto Juan Carlos
- Souza Karla S. C.
- Souza Vanessa S.
- Sprockel John J.
- Suårez-rama José Javier
- SuĂĄrez-zamora David A.
- SĂĄnchez LĂłpez Antonio J.
- SĂĄnchez Pedro-luis
- SĂĄnchez-carpintero Abad MarĂa
- SĂĄnchez-pablo Clara
- SĂĄnchez-pernaute Olga
- SĂĄnchez-prados MarĂa ConcepciĂłn
- SĂĄnchez-real Javier
- SĂĄnchez-redondo Jorge
- Taboada-fraga Xiana
- Tamayo Eduardo
- Tamayo-velasco Alvaro
- Taracido-fernĂĄndez Juan Carlos
- Tavares Nathali A. C.
- TellerĂa Carlos
- Tenorio-castaño Jair Antonio
- Teper Alejandro
- Torres-gutiérrez Ronald P.
- Torres-macho Juan
- Torres-tobar Lilian
- Troya JesĂșs
- Urioste Miguel
- Valencia-ramos Juan
- Valido AgustĂn
- Vargas-gallo Juan Pablo
- Varón Belén
- Vasconcelos Romero H. T.
- Vega Tomas
- Velasco-quirce Santiago
- Vidån-estévez Julia
- Vieitez-santiago Miriam
- Vilches Carlos
- Villalobos Lavinia
- Villar Felipe
- Villar-garcia Judit
- Villaverde Cristina
- Villoslada-blanco Pablo
- Virseda-berdices Ana
- VĂ©lez-santamarĂa Valentina
- VĂctor Virginia
- Yåñez Zuleima
- Zapatero-gaviria Antonio
- Zarate Ruth
- Zazo Sandra
- Ălvarez Nuria
- Ălvarez-benĂtez Yady
- Ălvarez-navia Felipe
- Ălvarez-sala Walther Rodolfo
- Ăñigo-campos Antonio
- Ăñiguez MarĂa
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 08/05/2024
- Field of study
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality
Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs
- Author
- Abe-jones Yumiko
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abolhassani Hassan
- Abou Tayoun Ahmad
- Achille Cristian
- Ailioaie Oana
- Aiuti Alessandro
- Al-muhsen Saleh
- Al-mulla Fahd
- Aliberti Anna
- Allavena Clotilde
- Allende Luis M.
- Altamirano Luz Torres
- Anderson Mark S.
- Anderson Mark S.
- Andreakos Evangelos
- Andreakos Evangelos
- Andrejak Claire
- Angelini Micol
- Angoulvant François
- AntolĂ Arnau
- Arias Andrés A.
- Arroyo-sĂĄnchez Daniel
- Asthana Saurabh
- Aytekin Gokhan
- Azoulay Cecile
- Bachelet Delphine
- Bair Rebecca
- Bal Antonin
- Baldanti Fausto
- Bartoli Marie
- Basmaci Romain
- Bastard Paul
- Behilill Sylvie
- Belot Alexandre
- Belot Alexandre
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Bergami Federica
- Bezzi Michela
- Bhavsar Krishna
- Bhide Sharvari
- Biggs Catherine M.
- Bitker Laurent
- Bizien Lucy
- Bogunovic Dusan
- Bolze Alexandre
- Bompoil Thierry
- Bondarenko Anastasia
- Bondarenko Anastasiia
- Borghesi Alessandro
- Bouadma Lila
- Bouscambert Maude
- Bousfiha Ahmed A.
- Boutboul David
- Boyarchuk Oksana
- Brodin Petter
- Bryceson Yenan
- Burrel Sonia
- Bustamante Carlos D.
- Butte Manish J.
- Calfee Carolyn S.
- Carrillo Sidney A.
- Casanova Jean-laurent
- Casari Giorgio
- Cassaniti Irene
- Catherinot Emilie
- Cervantes-gonzalez Minerva
- Chair Anissa
- Chak Suzanna
- Chirouze Catherine
- Christodoulou John
- Clément Bénédicte
- Cobat Aurélie
- Coelho Alexandra
- Collins Zachary
- Comet Consortium
- Condino-neto Antonio
- Constantinescu Stefan N.
- Conti Francesca
- Cooper Megan A.
- Cordel Hugues
- Couffignal Camille
- Couffin-cadiergues Sandrine
- Covid Hge Consortium
- Dalgard Clifton L.
- Danielson Jeffrey
- De Diego Rebeca Perez
- De Montmollin Etienne
- Debard Alexa
- Debray Marie-pierre
- Delaunay Clarisse
- Deplanque Dominique
- Derisi Joseph L.
- Desai Murkesh
- Descamps Diane
- Desvallée Mathilde
- Diallo Alpha
- Diehl Jean-luc
- Diouf Alphonsine
- Dorgham Karim
- Dorival CĂ©line
- Drolet Beth A.
- Dubos François
- Duval Xavier
- Duvlis Sotirija
- Dâortenzio Eric
- El Baghdadi Jamila
- Eloy Philippine
- Enouf Vincent
- Epaulard Olivier
- Ergun Dilek
- Ergun Recai
- Erle David J.
- Esperou HĂ©lĂšne
- Espinosa-padilla Sara
- Esposito-farese Marina
- Etienne Manuel
- Fekkar Arnaud
- Feldman Hagit Baris
- Fellay Jacques
- Flores Carlos
- Fragiadakis Gabriela K.
- Franco José Luis
- French Covid Study Group
- Froidure Antoine
- Gagro Alenka
- Garot Denis
- Garzaro Margaux
- Garçon Pierre
- Gault Nathalie
- Gaymard Alexandre
- Gervais Adrian
- Ghale Rajani
- Ghirardello Stefano
- Ghosn Jade
- Gigante Tristan
- Gilg Morgane
- Goehringer François
- Gorochov Guy
- Gregersen Peter K.
- Grimbacher Bodo
- Guedj Jérémie
- Haerynck Filomeen
- Hagin David
- Halwani Rabih
- Halwani Rabih
- Hammarström Lennart
- Hatipoglu Nevin
- Heath James R.
- Hendrickson Carolyn M.
- Henrickson Sarah E.
- Hernu Romain
- Hoctin Alexandre
- Hoffmann Isabelle
- Houas Ikram
- Hsieh Elena W.y.
- Hulot Jean-sébastien
- Husebye Eystein
- Imai Kohsuke
- Imberti Luisa
- Itan Yuval
- Jaafoura Salma
- Jarvis Erich D.
- Jauregui Alejandra
- Jeziorski Eric
- Jouanguy Emmanuelle
- Kafif Ouifiya
- Kaguelidou Florentia
- Kali Sabrina
- Kanat Fikret
- Kangelaris Kirsten N.
- Karamitros Timokratis
- Keles Sevgi
- Keles Sevgi
- Kenney Heather
- Kerroumi Younes
- Khalil Antoine
- Khan Coralie
- Kimmoun Antoine
- Kisand Kai
- Kopcha Vasyl
- Korda Mykhaylo
- Krummel Matthew F.
- Ku Cheng-lung
- Laine Fabrice
- Langelier Charles R.
- Laouenan CĂ©dric
- Laouénan Cédric
- Laribi Samira
- Lau Yu-lung
- Laurie Matthew T.
- Le Bris Cyril
- Le Gac Sylvie
- Le Hingrat Quentin
- Le Mestre Soizic
- Le Nagard Hervé
- Le Turnier Paul
- Le Voyer Tom
- Le Minh
- Lea Tasha
- Lee Deanna
- Leligdowicz Aleksandra
- Lemaignen Adrien
- Lemee VĂ©ronique
- Leroux Carolyn
- Lescure François-xavier
- Letrou Sophie
- Levy Yves
- Lhuillier Marine
- Lina Bruno
- Ling Yun
- Lingas Guillaume
- Liu Jamin
- Lota Raphael
- Lucas Carrie L.
- Lucet Jean Christophe
- Machado MoĂŻse
- Mahevas Matthieu
- Malvy Denis
- Mambert Marina
- Maniatis Tom
- Manry Jérémy
- Mansouri Davood
- Manuel Aldric
- Martinez-picado Javier
- MarĂłdi LĂĄszlĂł
- Matthay Michael
- Mentré France
- Meyts Isabelle
- Meziane Amina
- Milner Joshua D.
- Mironska Kristina
- Mitchell Anthea M.
- Mogensen Trine H.
- Mojoli Francesco
- Monneret Guillaume
- Morandeira Francisco
- Morbieu Caroline
- Morio Tomohiro
- Mouquet Hugo
- Mullaert Jimmy
- Nagl Laurenz
- Neant NadĂšge
- Neuville Mathilde
- Neven Bénédicte
- Ng Lisa F. P.
- Ng Lisa F.p.
- Nguyen Duc
- Nguyen Viet
- Noret Marion
- Notarangelo Luigi D.
- Notarangelo Luigi D.
- Novelli Antonio
- Novelli Antonio
- Novelli Giuseppe
- Novelli Giuseppe
- O'farrelly Cliona
- Okada Satoshi
- Okamoto Keisuke
- Ozcelik Tayfun
- Ozcelik Tayfun
- Pagani Michele
- Pan-hammarström Qiang
- Pan-hammarström Qiang
- Papadopoulos Aurélie
- Pape Jean W.
- Patel Ravi
- Paul Christelle
- Paz Artal Estela
- Paz Pauline Caraux
- Peiffer-smadja Nathan
- Peigne Vincent
- Perani Cristiano
- Perlin David S.
- Pesole Graziano
- Pession Andrea
- Petrov-sanchez Ventzislava
- Peytavin Gilles
- Pham Huong
- Philippot Quentin
- Picone Olivier
- Pierce Logan
- Piquard Valentine
- Piralla Antonio
- Planas Anna M.
- Poissy Julien
- Poulakou Garyphallia
- Prando Carolina
- Prasad Priya
- Puel Anne
- Pujol Aurora
- Pujol Aurora
- Puéchal Oriane
- Quaresima Virginia
- Quintana-murci Lluis
- Raffi François
- Ramaswamy Sathishkumar
- Rao Arjun Arkal
- Rashid Ahmad
- Renia Laurent
- Renia Laurent
- Resnick Igor
- Reyes Luis Felipe
- Rigo-bonnin RaĂșl
- Rocamora-blanch Gemma
- Rodriguez Nicklaus
- RodrĂguez-gallego Carlos
- RodrĂguez-gallego Carlos
- Rosa-calatrava Manuel
- Rosain Jérémie
- Rossignol Bénédicte
- Rossignol Patrick
- Roussel Lucie
- Roy Carine
- Rubio Luis
- Sahanic Sabina
- Saker Kahina
- Salagianni Maria
- Samad Bushra
- Sancho-shimizu Vanessa
- Schneider Marion
- Sediva Anna
- SeppÀnen Mikko R.j.
- Shahrooei Mohammed
- Sharif-askari Narjes Saheb
- Shaw Cole
- Shcherbina Anna
- Sigman Austin
- Siouti Eleni
- Slaby Ondrej
- Snow Andrew L.
- Solanich Xavier
- Soler-palacĂn Pere
- Sottini Alessandra
- Spaan AndrĂĄs N.
- Stepanovskyy Yurii
- Su Richa
- Tancevski Ivan
- Tancevski Ivan
- Tandjaoui-lambiotte Yacine
- Tang Kevin
- Tangye Stuart G.
- Tardivon Coralie
- Teixeira Carla
- Tellier Marie-capucine
- Terrier Olivier
- Thompson Leslie M.
- Timsit Jean-françois
- Trouillet-assant Sophie
- Troya Jesus
- Tual Christelle
- Tubiana Sarah
- Tulek Baykal
- Turvey Stuart E.
- Téoulé François
- Uddin K M Furkan
- Uddin Mohammed
- Van Der Werf Sylvie
- Vanel Noémie
- Vazquez Sara
- Veislinger Aurélie
- Venet Fabienne
- Vinh Donald C.
- Visseaux Benoit
- Volokha Alla
- Wang Chung Yu
- Ward Alyssa
- Weiss GĂŒnter
- Wiedemann Aurélie
- Willmore Andrew
- Willmore Andrew
- Wilson Michael
- Wilson Michael R
- Woodruff Prescott G.
- Yazdanpanah Yazdan
- Ye Chun Jimmie
- Zamecnik Colin
- Zhang Qian
- Zhang Shen-ying
- Zhang Yu
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 13/04/2023
- Field of study
Life-threatening `breakthrough' cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS- CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals ( age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto- Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-a2 and IFN-., while two neutralized IFN-omega only. No patient neutralized IFN-ss. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population
Uso de tarjeta universitaria y tecnologĂa mĂłvil para el control de acceso a instalaciones universitarias y su posterior anĂĄlisis en tĂ©rminos de rendimiento acadĂ©micos y control de asistencia en clase = Use of university card and mobile technology to study and improve academic performance and class attendance control
- Author
- Alejandro RodrĂguez-GonzĂĄlez
- Angel Garcia-Pedrero
- Consuelo Gonzalo
- Diego Fernandez Peces-Barba
- Ernestina Menasalvas
- Francisco Borja Lorenzo-Gomez
- Francisco Borja Lorenzo-Gomez
- Francisco Borja Lorenzo-Gomez
- Juan L. Esteban Uceda
- Luis Pulido Garcia-Duarte
- Maria Boyer Lagos
- Maria I. Domecq Urquijo
- Maria J. Carrillo Troya
- Victor Robles
- Publication venue
- E.T.S. de Ingenieros InformĂĄticos (UPM)
- Publication date
- 01/01/2017
- Field of study
Hoy en dĂa es habitual que las universidades ofrezcan a sus alumnos carnĂ©s que los identifican con el fin de poder hacer uso de las instalaciones universitarias, asĂ como de identificarse como estudiantes fuera del ĂĄmbito universitario. De igual modo, es cada vez mĂĄs frecuente que dichos carnĂ©s incorporen las Ășltimas tecn ologĂas, como las contactless NFC o RFID para hacer un uso mĂĄs dinĂĄmico del carnĂ©. El presente artĂculo explora el desarrollo de un nuevo servicio a implantar en las universidades mediante el uso del carnĂ© con tecnologĂa contactless y, dispositivos mĂłviles . Concretamente los objetivos del servicio son, por una parte, permitir el control de acceso de los usuarios potenciales de las bibliotecas, y por otra parte, su aplicaciĂłn en las aulas de clases como medio de control de asistencia para sustituir a los pro cedimientos basados en firmas. Finalmente, el proyecto presenta mĂșltiples posibles explotaciones y casos de uso adicionales que pueden ser aplicados en base a la explotaciĂłn de los datos recogidos y que permitirĂĄn analizar y fomentar un mejor rendimiento a cadĂ©mico, por parte de los estudiantes, asĂ como una mejor gestiĂłn de las instalaciones universitarias. El caso de estudio de aplicaciĂłn del proyecto descrito en el presente artĂculo es la Universidad PolitĂ©cnica de Madrid (UPM).
---ABSTRACT---
hat those cards incorporate the last technologies such as NFC or RFID (contactless technologies) to allow a more dynamic use of the card. This paper explores the development a new service to be implemented in the univer sities by means of using identity cards with contactless technologies and mobile devices. The goal of the service is twofold: on one hand it aims to control the access of the users to the university libraries; on the other hand it aims to be used in the classroom to control the attendance. Finally, the project has several other exploitations and additional use cases focused on analysing and encouraging the academic performance. The project is under implementation in Universidad Politécnica de Madrid (UPM)
Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs
- Author
- Abe-Jones Yumiko
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abolhassani Hassan
- Abou Tayoun Ahmad
- Achille Cristian
- Ailioaie Oana
- Aiuti Alessandro
- Al-Muhsen Saleh
- Al-Mulla Fahd
- Aliberti Anna
- Allavena Clotilde
- Allende Luis, M
- Altamirano Luz, Torres
- Anderson Mark, S
- Anderson Mark, S
- Andreakos Evangelos
- Andreakos Evangelos
- Andrejak Claire
- Angelini Micol
- Angoulvant François
- AntolĂ Arnau
- Arias Andrés, A
- Arroyo-SĂĄnchez Daniel
- Asthana Saurabh
- Aytekin Gokhan
- Azoulay Cecile
- Bachelet Delphine
- Bair Rebecca
- Bal Antonin
- Baldanti Fausto
- Bartoli Marie
- Basmaci Romain
- Bastard Paul
- Behilill Sylvie
- Belot Alexandre
- Belot Alexandre
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Bergami Federica
- Bezzi Michela
- Bhavsar Krishna
- Bhide Sharvari
- Biggs Catherine, M
- Bitker Laurent
- Bizien Lucy
- Bogunovic Dusan
- Bolze Alexandre
- Bompoil Thierry
- Bondarenko Anastasia
- Bondarenko Anastasiia
- Borghesi Alessandro
- Bouadma Lila
- Bouscambert Maude
- Bousfiha Ahmed, A
- Boutboul David
- Boyarchuk Oksana
- Brodin Petter
- Bryceson Yenan
- Burrel Sonia
- Bustamante Carlos, D
- Butte Manish, J
- Calfee Carolyn, S
- Carrillo Sidney, A
- Casanova Jean-Laurent
- Casari Giorgio
- Cassaniti Irene
- Catherinot Emilie
- Cervantes-Gonzalez Minerva
- Chair Anissa
- Chak Suzanna
- Chirouze Catherine
- Christodoulou John
- Clément Bénédicte
- Cobat Aurélie
- Coelho Alexandra
- Collins Zachary
- Condino-Neto Antonio
- Constantinescu Stefan, N
- Conti Francesca
- Cooper Megan, A
- Cordel Hugues
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Dalgard Clifton, L
- Danielson Jeffrey
- de Diego Rebeca, Perez
- de Montmollin Etienne
- Debard Alexa
- Debray Marie-Pierre
- Delaunay Clarisse
- Deplanque Dominique
- Derisi Joseph, L
- Desai Murkesh
- Descamps Diane
- Desvallée Mathilde
- Diallo Alpha
- Diehl Jean-Luc
- Diouf Alphonsine
- Dorgham Karim
- Dorival CĂ©line
- Drolet Beth, A
- Dubos François
- Duval Xavier
- Duvlis Sotirija
- Dâortenzio Eric
- El Baghdadi Jamila
- Eloy Philippine
- Enouf Vincent
- Epaulard Olivier
- Ergun Dilek
- Ergun Recai
- Erle David, J
- Esperou HĂ©lĂšne
- Espinosa-Padilla Sara
- Esposito-Farese Marina
- Etienne Manuel
- Fekkar Arnaud
- Feldman Hagit, Baris
- Fellay Jacques
- Flores Carlos
- Fragiadakis Gabriela, K
- Franco José, Luis
- Froidure Antoine
- Gagro Alenka
- Garot Denis
- Garzaro Margaux
- Garçon Pierre
- Gault Nathalie
- Gaymard Alexandre
- Gervais Adrian
- Ghale Rajani
- Ghirardello Stefano
- Ghosn Jade
- Gigante Tristan
- Gilg Morgane
- Goehringer François
- Gorochov Guy
- Gregersen Peter, K
- Grimbacher Bodo
- Guedj Jérémie
- Haerynck Filomeen
- Hagin David
- Halwani Rabih
- Halwani Rabih
- Hammarström Lennart
- Hatipoglu Nevin
- Heath James, R
- Hendrickson Carolyn, M
- Henrickson Sarah, E
- Hernu Romain
- Hoctin Alexandre
- Hoffmann Isabelle
- Houas Ikram
- Hsieh Elena, W Y
- Hulot Jean-SĂ©bastien
- Husebye Eystein
- Imai Kohsuke
- Imberti Luisa
- Itan Yuval
- Jaafoura Salma
- Jarvis Erich, D
- Jauregui Alejandra
- Jeziorski Eric
- Jouanguy Emmanuelle
- Kafif Ouifiya
- Kaguelidou Florentia
- Kali Sabrina
- Kanat Fikret
- Kangelaris Kirsten, N
- Karamitros Timokratis
- Keles Sevgi
- Keles Sevgi
- Kenney Heather
- Kerroumi Younes
- Khalil Antoine
- Khan Coralie
- Kimmoun Antoine
- Kisand Kai
- Kopcha Vasyl
- Korda Mykhaylo
- Krummel Matthew, F
- Ku Cheng-Lung
- Laine Fabrice
- Langelier Charles, R
- Laouenan CĂ©dric
- Laouénan Cédric
- Laribi Samira
- Lau Yu-Lung
- Laurie Matthew, T
- Le Bris Cyril
- Le Gac Sylvie
- Le Hingrat Quentin
- Le Mestre Soizic
- Le Nagard Hervé
- Le Turnier Paul
- Le Voyer Tom
- Le Minh
- Lea Tasha
- Lee Deanna
- Leligdowicz Aleksandra
- Lemaignen Adrien
- Lemee VĂ©ronique
- Leroux Carolyn
- Lescure François-Xavier
- Letrou Sophie
- Levy Yves
- Lhuillier Marine
- Lina Bruno
- Ling Yun
- Lingas Guillaume
- Liu Jamin
- Lota Raphael
- Lucas Carrie, L
- Lucet Jean, Christophe
- Machado MoĂŻse
- Mahevas Matthieu
- Malvy Denis
- Mambert Marina
- Maniatis Tom
- Manry Jérémy
- Mansouri Davood
- Manuel Aldric
- Martinez-Picado Javier
- MarĂłdi LĂĄszlĂł
- Matthay Michael
- Mentré France
- Meyts Isabelle
- Meziane Amina
- Milner Joshua, D
- Mironska Kristina
- Mitchell Anthea, M
- Mogensen Trine, H
- Mojoli Francesco
- Monneret Guillaume
- Morandeira Francisco
- Morbieu Caroline
- Morio Tomohiro
- Mouquet Hugo
- Mullaert Jimmy
- Nagl Laurenz
- Neant NadĂšge
- Neuville Mathilde
- Neven Bénédicte
- Ng Lisa, F P
- Ng Lisa, F P
- Nguyen Duc
- Nguyen Viet
- Noret Marion
- Notarangelo Luigi, D
- Notarangelo Luigi, D
- Novelli Antonio
- Novelli Antonio
- Novelli Giuseppe
- Novelli Giuseppe
- O'Farrelly Cliona
- Okada Satoshi
- Okamoto Keisuke
- Ozcelik Tayfun
- Ozcelik Tayfun
- Pagani Michele
- Pan-Hammarström Qiang
- Pan-Hammarström Qiang
- Papadopoulos Aurélie
- Pape Jean, W
- Patel Ravi
- Paul Christelle
- Paz Artal Estela
- Paz Pauline, Caraux
- Peiffer-Smadja Nathan
- Peigne Vincent
- Perani Cristiano
- Perlin David, S
- Pesole Graziano
- Pession Andrea
- Petrov-Sanchez Ventzislava
- Peytavin Gilles
- Pham Huong
- Philippot Quentin
- Picone Olivier
- Pierce Logan
- Piquard Valentine
- Piralla Antonio
- Planas Anna, M
- Poissy Julien
- Poulakou Garyphallia
- Prando Carolina
- Prasad Priya
- Puel Anne
- Pujol Aurora
- Pujol Aurora
- Puéchal Oriane
- Quaresima Virginia
- Quintana-Murci Lluis
- Raffi François
- Ramaswamy Sathishkumar
- Rao Arjun, Arkal
- Rashid Ahmad
- Renia Laurent
- Renia Laurent
- Resnick Igor
- Reyes Luis, Felipe
- Rigo-Bonnin RaĂșl
- Rocamora-Blanch Gemma
- Rodriguez Nicklaus
- RodrĂguez-Gallego Carlos
- RodrĂguez-Gallego Carlos
- Rosa-Calatrava Manuel
- Rosain Jérémie
- Rossignol Bénédicte
- Rossignol Patrick
- Roussel Lucie
- Roy Carine
- Rubio Luis
- Sahanic Sabina
- Saker Kahina
- Salagianni Maria
- Samad Bushra
- Sancho-Shimizu Vanessa
- Schneider Marion
- Sediva Anna
- SeppÀnen Mikko, R J
- Shahrooei Mohammed
- Sharif-Askari Narjes, Saheb
- Shaw Cole
- Shcherbina Anna
- Sigman Austin
- Siouti Eleni
- Slaby Ondrej
- Snow Andrew, L
- Solanich Xavier
- Soler-PalacĂn Pere
- Sottini Alessandra
- Spaan AndrĂĄs, N
- Stepanovskyy Yurii
- Su Richa
- Tancevski Ivan
- Tancevski Ivan
- Tandjaoui-Lambiotte Yacine
- Tang Kevin
- Tangye Stuart, G
- Tardivon Coralie
- Teixeira Carla
- Tellier Marie-Capucine
- Terrier Olivier
- Thompson Leslie, M
- Timsit Jean-François
- Trouillet-Assant Sophie
- Troya Jesus
- Tual Christelle
- Tubiana Sarah
- Tulek Baykal
- Turvey Stuart, E
- Téoulé François
- Uddin K, M Furkan
- Uddin Mohammed
- van der Werf Sylvie
- Vanel Noémie
- Vazquez Sara
- Veislinger Aurélie
- Venet Fabienne
- Vinh Donald, C
- Visseaux Benoit
- Volokha Alla
- Wang Chung, Yu
- Ward Alyssa
- Weiss GĂŒnter
- Wiedemann Aurélie
- Willmore Andrew
- Willmore Andrew
- Wilson Michael, R
- Wilson Michael, R
- Woodruff Prescott, G
- Yazdanpanah Yazdan
- Ye Chun, Jimmie
- Zamecnik Colin
- Zhang Qian
- Zhang Shen-Ying
- Zhang Yu
- Publication venue
- American Association for the Advancement of Science (AAAS)
- Publication date
- 14/06/2022
- Field of study
International audienceLife-threatening âbreakthroughâ cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS-CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals (age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto-Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-α2 and IFN-Ï, while two neutralized IFN-Ï only. No patient neutralized IFN-ÎČ. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
- Author
- Abad Jorge
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Accordino Giulia
- Achille Cristian
- Acosta-Ampudia Yeny
- Agra Juan José Cåceres
- Aguilera-Albesa Sergio
- AguilĂł-Cucurull Aina
- Aiuti Alessandro
- Aiuti Alessandro
- Aiuti Alessandro
- Akcan Ăzge Metin
- Al-Muhsen Saleh
- Al-Mulla Fahd
- Alavoine Loubna
- Albert Matthew
- Albisures Jonathan Antonio Roblero
- Alcover Andres
- Aldave Juan
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- Alkhater Suzan
- Alkhater Suzan
- Allardet-Servent Jerome
- Allavena Clotilde
- Allende Luis
- Alonso-Arias Rebeca
- Alshahrani Mohammed
- Alsina Laia
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Amador-Borrero Blanca
- Amat Karine
- Amoura Zahir
- Anaya Juan-Manuel
- Anderson Mark
- Anderson Mark
- Andreakos Evangelos
- Andreakos Evangelos
- Andrejak Claire
- Andrés Ana De
- Anglicheau Dany
- Angoulvant François
- Annereau Jean-Philippe
- AntolĂ Arnau
- Appelman Brent
- Arias Andrés
- Arias Andrés Augusto
- Arkin Lisa
- Arquero Miguel Fernandez
- Arranz MarĂa JesĂșs
- Arrestier Romain
- Arrestier Romain
- Asano Takaki
- Aschard Hugues
- Aubart MĂ©lodie
- Auguet Teresa
- Avramenko Iryna
- Aytekin Gökhan
- Aytekin Selma Erol
- Azot Axelle
- Azoulay Cecile
- Bachelet Delphine
- Bahram Seiamak
- Bajolle Fanny
- Baldanti Fausto
- Baldolli Aurélie
- Ballester Maite
- Baris-Feldman Hagit
- Barreiros Lucila
- Barrou Benoit
- Bartoli Marie
- Barzaghi Federica
- Basmaci Romain
- Basso Sabrina
- Bastard Paul
- Batten Isabella
- Bauters Fré
- Bax Diane
- Bayhan Gulsum Iclal
- Behillil Sylvie
- Behillill Sylvie
- Bellani Giacomo
- Belot Alexandre
- Belot Alexandre
- Belot Alexandre
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Beretta Ilaria
- Bergin Colm
- Bertholon Frédérique
- Bettini Laura Rachele
- Beudel Martijn
- Bezrodnik Liliana
- Bhavsar Krishna
- Biggs Catherine
- Biggs Catherine
- Bilbao Agurtzane
- Bilguvar Kaya
- Biondi Andrea
- Bitker Laurent
- Bizien Lucy
- Blanchard-Rohner Geraldine
- Blanco Ignacio
- BlandiniĂšres Adeline
- Bleibtreu Alexandre
- Bloomfield Marketa
- BlĂĄzquez-Gamero Daniel
- Bogaard Harm Jan
- Bogunovic Dusan
- Boisson Bertrand
- Bolivar-Prados Mireia
- Bolze Alexandre
- Bomers Marije
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bonfanti Paolo
- Bonneaudeau Brigitte
- Bonta Peter
- Borghesi Alessandro
- Borie Raphael
- Borrero Blanca Amador
- Bos Lieuwe
- Bosteels CĂ©dric
- Botdhlo-Nevers Elisabeth
- Botelho-Nevers Elisabeth
- Botta Michela
- Bouadma Lila
- Bouadma Lila
- Boucherit Soraya
- Boudhabhay Idris
- Bouiller KĂ©vin
- Boulanger CĂ©cile
- Bourgeois Fleur Le
- Bourgeon Marilou
- Bourke Nollaig
- Bourke Nollaig
- Bourke Nollaig
- Bouscambert-Duchamp Maude
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousquet Aurore
- Bousso Philippe
- Boutolleau David
- Bouvattier Claire
- Boyarchuk Oksana
- Boyarchuk Oksana
- Bozdemir Ćefika Elmas
- Bravais Juliette
- Briones M. Luisa
- Briseño-Roa Luis
- Brodin Petter
- Brodin Petter
- Brouwer Matthijs
- Bruhns Pierre
- Bruneau LĂ©a
- Brunner Marie-Eve
- Bruno Raffaele
- Bryceson Yenan
- Bueno Maria Rita P.
- Bugiani Marianna
- Buis David
- Bukhari Huda
- Bulle Esther
- Burdet Charles
- Burdet Charles
- Burrel Sonia
- Bustamante Carlos
- Bustamante Jacinta
- Butte Manish
- BĂ©ziat Vivien
- Cannet Dorothée
- Capra Ruggero
- Carapito Raphael
- Carrabba Maria
- Carrillo Jorge
- Casanova Jean-Laurent
- Casanova Jean-Laurent
- Casari Giorgio
- Casari Giorgio
- Casari Giorgio
- Casasnovas Carlos
- Caseris Marion
- Cassaniti Irene
- Castagnoli Riccardo
- Castelle Martin
- Castelli Francesco
- Castro Mateus
- Catherinot Emilie
- Cazzaniga Marina
- Celik Jale Bengi
- Cerf-Bensussan Nadine
- Cervantes-Gonzalez Minerva
- Ceschi Alessandro
- Chahine Abir
- Chair Anissa
- Chakravorty Samya
- Chalumeau Martin
- Charbit Bruno
- Charpentier Charlotte
- Chauvineau-Grenier Angélique
- Chen Jie
- Cheng Matthew
- Chirouze Catherine
- Chirouze Catherine
- Chouchane Osoul
- Chrabieh Maya
- Christodoulou John
- Ciceri Fabio
- Citerio Giuseppe
- Clavé Pere
- Clercq Jozefien De
- Cloherty Alex
- Clotet Bonaventura
- Cobat Aurélie
- Codina Anna
- Coelho Alexandra
- Coeuret-Pellicer Mireille
- Cognasse Fabrice
- Cognasse Fabrice
- Cohen Yves
- Colobran Roger
- Colobran Roger
- Comarmond Cloé
- Combes Alain
- Comoli Patrizia
- Condino-Neto Antonio
- Condino-Neto Antonio
- Conlon Niall
- Connolly Emma
- Constantinescu Stefan
- Conti Francesca
- Contro Ernesto
- Cooper Megan
- Cordel Hugues
- Correales Luisa Paola Duarte
- Corsico Angelo
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Couffin-Cadiergues Sandrine
- Coulongeat Matthieu
- CoĆkuner Taner
- Cruz InĂ©s MarĂn
- Cuadros Esmeralda Nuñez
- Cumano Ana
- Cvetkovski Aleksandar
- Cyrus Cyril
- Daganou Maria
- Dalgard Clifton
- Dalgard Clifton
- Dalmau David
- Dalmau David
- Danielson Jeffrey
- Danion François
- Darazam Ilad Alavi
- Darley David Ross
- Das Vincent
- Dauby Nicolas
- Dauger Stéphane
- de Brabander Justin
- de Bree Godelieve
- de Bruin Sanne
- de Chambrun Marc Pineton
- de Diego Rebeca Perez
- de Jong Menno
- de la Chapelle Aliénor
- de Lamballerie Xavier
- de Montmollin Etienne
- de Munter Paul
- de Pontual Loic
- de Prost Nicolas
- de Rotte Maurits
- de Vera MartĂn Castillo
- de Vries Heder
- Debard Alexa
- Debette Stéphanie
- Debette Stéphanie
- Debray Marie-Pierre
- Dechanet Aline
- Dehban Amin
- Delmonte Ottavia
- Delplancq Geoffroy
- Demar Magalie
- Demirkol Yasemin Kendir
- Demoule Alexandre
- Deplanque Dominique
- Deplanque Dominique
- Deriano Ludovic
- Desai Murkesh
- Descamps Diane
- Descamps Diane
- Desguerre Isabelle
- Desille-Dugast Mireille
- Desmarets Maxime
- Desvallée Mathilde
- Di Sabatino Antonio
- Di Santo James
- Diallo Alpha
- Diego Rebeca PĂ©rez De
- Diehl Jean-Luc
- Diehl Jean-Luc
- Dijkstra Mirjam
- Dillies Marie-AgnĂšs
- Ding Li
- Dinh Khoa Manh
- Diouf Alphonsine
- Djossou FĂ©lix
- Dobbelaere Stephanie
- Dobbs Kerry
- Dominguez-Garrido Elena
- DomĂnguez-Garrido Elena
- Dongelmans Dave
- Dorgham Karim
- Dorival CĂ©line
- Drolet Beth
- Dromer Françoise
- Dubos François
- Dubost Clément
- Duffy Darragh
- Duffy Darragh
- Dufouil Carole
- Dujardin Romein
- Dunne Jean
- Dupont Annabelle
- Duval Xavier
- Duval Xavier
- Duvlis Sotirija
- Dyer Adam
- Dâangio Mariella
- Dâenfert Christophe
- Dâortenzio Eric
- Eberl GĂ©rard
- Ecobichon Jean-Luc
- Ekwall Olov
- El Baghdadi Jamila
- El Bakkouri Jalila
- Elbers Paul
- Elnagdy Marwa
- Eloy Philippine
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- Stilma Willemke
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- Su Helen
- Su Helen
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- SĂĄnchez-RamĂłn Silvia
- SĂ€rekannu Karita
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- SĂžrensen Erik
- Taccone Fabio
- Talouarn Estelle
- Tanaka Junko
- Tancevski Ivan
- Tancevski Ivan
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- Tandjaoui-Lambiotte Yacine
- Tangy Frédéric
- Tangye Stuart
- Tangye Stuart
- Tardivon Coralie
- Tardy Bernard
- Taupin Jean-Luc
- Tavernier Simon
- Tayoun Ahmad Abou
- Tellier Marie-Capucine
- Terrier Benjamin
- Terrier Olivier
- Teunissen Charlotte
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- Tiberghien Pierre
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- Tipu Imran
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- Tolstrup Martin
- Tomasoni Gabriele
- Toubert Antoine
- Toubiana Julie
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- Townsend Liam
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- Trouillet-Assant Sophie
- Trouillet-Assant Sophie
- Troya JesĂșs
- Troya JesĂșs
- Tsang Owen
- Tserel Liina
- Tso Eugene
- Tsonas Anissa
- Tsumura Miyuki
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- Tubiana Sarah
- Tubiana Sarah
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- Tuinman Pieter
- Turvey Stuart
- Tzourio Christophe
- Téoulé François
- Uddin K.
- Uddin Mohammed
- Ungeheuer Marie-Noëlle
- Ursini Matilde Valeria
- Utsumi Takanori
- Uzunhan Yurdagul
- Vabres Pierre
- Valencia-Ramos Juan
- Valsecchi Maria Grazia
- van Agtmael Michiel
- van Baarle Frank
- van Braeckel Eva
- van de Beek Diederik
- van de Beek Diederik
- van de Beek Diederik
- van den Rym Ana Maria
- van der Poll Tom
- van der Valk Marc
- van der Werf Sylvie
- van der Werf Sylvie
- van Mourik Niels
- van Praet Jens
- van Vugt MichĂšle
- Vanderlinden Dimitri
- Vandernoot Isabelle
- Vanel Noémie
- Vasse Marc
- Veelo Denise
- Veislinger Aurélie
- Velez-Santamaria Valentina
- Veliz Silvia Patricia Zuniga
- Venet Fabienne
- Vergara José Alejandro Daza
- Vidaur Loreto
- Vidaur Loreto
- Vidigal Mateus
- Vidigal Mateus
- Viel SĂ©bastien
- Vignali Valérie
- Vilaire-Meunier Marie
- Villain CĂ©dric
- Villar-GarcĂa Judit
- Vincent Audrey
- Vinh Donald
- Vinh Donald
- Visseaux Benoit
- Visseaux Benoit
- Vlaar Alexander
- Vogt Guillaume
- Voiriot Guillaume
- Volleman Carolien
- Volokha Alla
- von Bernuth Horst
- von Stemann Jakob Hjorth
- Vught Lonneke
- Vuotto Fanny
- VĂ©lez VerĂłnica Posada
- Waucquier Nawal
- Wauters Els
- Wauters Joost
- Wauters Joost
- Wauters Joost
- Wiedemann Aurélie
- Wiersinga W. Joost
- Wouters Dorien
- Wu Alan
- Wu Tak-Chiu
- YahĆi Aysun
- Yang Rui
- Yasar Kadriye Kart
- Yazdanpanah Yazdan
- Yazdanpanah Yazdan
- Yepes Jairo David Torres
- Yesilbas Osman
- Yildiz Mehmet
- Young Barnaby
- YĂŒkselmiĆ Ufuk
- Zatz Mayana
- Zatz Mayana
- Zatz Mayana
- Zawadzki Pawel
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Yu
- Zimmer Christophe
- Zins Marie
- Zins Marie
- Zuccaro Valentina
- Zwinderman A.
- Ăñigo-Campos Antonio
- Ăz Ćadiye KĂŒbra TĂŒter
- Ăzkan Esra AkyĂŒz
- Ăzçelik Tayfun
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 24/05/2022
- Field of study
International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
- Author
- Abad Jorge
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Accordino Giulia
- Achille Cristian
- Acosta-Ampudia Yeny
- Agra Juan José Cåceres
- Aguilera-Albesa Sergio
- AguilĂł-Cucurull Aina
- Aiuti Alessandro
- Aiuti Alessandro
- Aiuti Alessandro
- Akcan Ăzge Metin
- Al-Muhsen Saleh
- Al-Mulla Fahd
- Alavoine Loubna
- Albert Matthew
- Albisures Jonathan Antonio Roblero
- Alcover Andres
- Aldave Juan
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- Alkhater Suzan
- Alkhater Suzan
- Allardet-Servent Jerome
- Allavena Clotilde
- Allende Luis
- Alonso-Arias Rebeca
- Alshahrani Mohammed
- Alsina Laia
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Amador-Borrero Blanca
- Amat Karine
- Amoura Zahir
- Anaya Juan-Manuel
- Anderson Mark
- Anderson Mark
- Andreakos Evangelos
- Andreakos Evangelos
- Andrejak Claire
- Andrés Ana De
- Anglicheau Dany
- Angoulvant François
- Annereau Jean-Philippe
- AntolĂ Arnau
- Appelman Brent
- Arias Andrés
- Arias Andrés Augusto
- Arkin Lisa
- Arquero Miguel Fernandez
- Arranz MarĂa JesĂșs
- Arrestier Romain
- Arrestier Romain
- Asano Takaki
- Aschard Hugues
- Aubart MĂ©lodie
- Auguet Teresa
- Avramenko Iryna
- Aytekin Gökhan
- Aytekin Selma Erol
- Azot Axelle
- Azoulay Cecile
- Bachelet Delphine
- Bahram Seiamak
- Bajolle Fanny
- Baldanti Fausto
- Baldolli Aurélie
- Ballester Maite
- Baris-Feldman Hagit
- Barreiros Lucila
- Barrou Benoit
- Bartoli Marie
- Barzaghi Federica
- Basmaci Romain
- Basso Sabrina
- Bastard Paul
- Batten Isabella
- Bauters Fré
- Bax Diane
- Bayhan Gulsum Iclal
- Behillil Sylvie
- Behillill Sylvie
- Bellani Giacomo
- Belot Alexandre
- Belot Alexandre
- Belot Alexandre
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Beretta Ilaria
- Bergin Colm
- Bertholon Frédérique
- Bettini Laura Rachele
- Beudel Martijn
- Bezrodnik Liliana
- Bhavsar Krishna
- Biggs Catherine
- Biggs Catherine
- Bilbao Agurtzane
- Bilguvar Kaya
- Biondi Andrea
- Bitker Laurent
- Bizien Lucy
- Blanchard-Rohner Geraldine
- Blanco Ignacio
- BlandiniĂšres Adeline
- Bleibtreu Alexandre
- Bloomfield Marketa
- BlĂĄzquez-Gamero Daniel
- Bogaard Harm Jan
- Bogunovic Dusan
- Boisson Bertrand
- Bolivar-Prados Mireia
- Bolze Alexandre
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- van de Beek Diederik
- van de Beek Diederik
- van den Rym Ana Maria
- van der Poll Tom
- van der Valk Marc
- van der Werf Sylvie
- van der Werf Sylvie
- van Mourik Niels
- van Praet Jens
- van Vugt MichĂšle
- Vanderlinden Dimitri
- Vandernoot Isabelle
- Vanel Noémie
- Vasse Marc
- Veelo Denise
- Veislinger Aurélie
- Velez-Santamaria Valentina
- Veliz Silvia Patricia Zuniga
- Venet Fabienne
- Vergara José Alejandro Daza
- Vidaur Loreto
- Vidaur Loreto
- Vidigal Mateus
- Vidigal Mateus
- Viel SĂ©bastien
- Vignali Valérie
- Vilaire-Meunier Marie
- Villain CĂ©dric
- Villar-GarcĂa Judit
- Vincent Audrey
- Vinh Donald
- Vinh Donald
- Visseaux Benoit
- Visseaux Benoit
- Vlaar Alexander
- Vogt Guillaume
- Voiriot Guillaume
- Volleman Carolien
- Volokha Alla
- von Bernuth Horst
- von Stemann Jakob Hjorth
- Vught Lonneke
- Vuotto Fanny
- VĂ©lez VerĂłnica Posada
- Waucquier Nawal
- Wauters Els
- Wauters Joost
- Wauters Joost
- Wauters Joost
- Wiedemann Aurélie
- Wiersinga W. Joost
- Wouters Dorien
- Wu Alan
- Wu Tak-Chiu
- YahĆi Aysun
- Yang Rui
- Yasar Kadriye Kart
- Yazdanpanah Yazdan
- Yazdanpanah Yazdan
- Yepes Jairo David Torres
- Yesilbas Osman
- Yildiz Mehmet
- Young Barnaby
- YĂŒkselmiĆ Ufuk
- Zatz Mayana
- Zatz Mayana
- Zatz Mayana
- Zawadzki Pawel
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Yu
- Zimmer Christophe
- Zins Marie
- Zins Marie
- Zuccaro Valentina
- Zwinderman A.
- Ăñigo-Campos Antonio
- Ăz Ćadiye KĂŒbra TĂŒter
- Ăzkan Esra AkyĂŒz
- Ăzçelik Tayfun
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 24/05/2022
- Field of study
International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population
Characteristics and predictors of death among 4035 consecutively hospitalized patients with COVID-19 in Spain
- Author
- AdoraciĂłn Valiente
- Adriana HernĂĄndez Belmonte
- Adriana SĂĄnchez Serrano
- AdriĂĄn SĂĄnchez MontalvĂĄ
- AgustĂn Rojas-Vieyra
- Aida GutiĂ©rrez GarcĂa
- Aina Gabarrell Pascuet
- Aina Gomila Grange
- Ainhoa Urrutia Losada
- Alba Alastrué Violeta
- Alba Bergas
- Alba Rueda LĂłpez
- Albert Sabater Gil
- Alberto Arranz Caso
- Alberto Bahamonde Carrasco
- Alberto Delgado-Iribarren
- Alberto Oreja
- Alberto Serrano MartĂnez
- Alejandra Duarte Borges
- Alejandra PĂ©rez GarcĂa
- Alejandro Aguirre Vila-Cora
- Alejandro Callejas DĂaz
- Alejandro GarcĂa GarcĂa
- Alejandro SuĂĄrez-Benjumea
- Alex Smithson Amat
- Alex Soriano
- Alexander Rombauts
- Alexandre PĂ©rez GonzĂĄlez
- Alexia Costanza Espiño Ălvarez
- Alexy Inciarte
- Alfonso Cabello Ăbeda
- Alfredo Mican
- Alicia HernĂĄndez Torres
- Almudena Villa MartĂ
- AlĂ Martakoush
- Amparo Blasco Claramunt
- Amparo LĂłpez-Bernus
- Ana Alguacil
- Ana Barrios Blandino
- Ana CamĂłn
- Ana del Cielo Pérez Jaén
- Ana Escoresca
- Ana FernĂĄndez Cruz
- Ana Ferrer Ribera
- Ana GonzĂĄlez-CordĂłn
- Ana Isabel Cañabate
- Ana Isabel PelĂĄez Ballesta
- Ana Josefa Tebar MartĂnez
- Ana LĂ©rida Urteaga
- Ana Mariño Callejo
- Ana MartĂnez Sapiña
- Ana MarĂa Garijo Saiz
- Ana Milagro Beamonte
- Ana Such Diaz
- Ana Vegas Serrano
- Ander GonzĂĄlez Sarria
- Andrea Espigares Correa
- Andrea PĂ©rez RodrĂguez
- André Barbosa Ventura
- Andrés Canut Blasco
- Andrés Felipe Cardona Arias
- Andrés Javier Ruiz Fernåndez
- Anna Ferrer Santolaria
- Antonio GarcĂa Pardo
- Antonio Oteo Revuelta José
- Antonio Ramos MartĂnez
- Antonio Rezusta LĂłpez
- Arantzazu Mera Fidalgo
- ArĂĄnzazu Villasante de la Puente
- Asier Aranguren Arostegui
- AsunciĂłn DĂaz
- Beatriz Dietl GĂłmez-Luengo
- Beatriz Loureiro RodrĂguez
- Beatriz MarĂa Sanjuan
- Beatriz Mestre GĂłmez
- Beatriz PĂ©rez-Monte MĂnguez
- Beatriz RodrĂguez-Alonso
- Beatriz Ălvarez Zapatero
- Beatriz Ălvarez Ălvarez
- Belén Alejos
- Belén Gutiérrez-Gutiérrez
- BelĂ©n Loeches YagĂŒe
- Benito Almirante
- Berta Torres
- Blanca Alonso
- Blanca MartĂnez Cifre
- Blanca Marzo
- Camilo Sanz Zamudio
- Carlos Bea Serrano
- Carlos Iniesta
- Carlos JesĂșs Dueñas GutiĂ©rrez
- Carlos RodrĂguez Franco
- Carlos Ruiz MartĂnez
- Carlota Gudiol
- Carmen Ardanuy
- Carmen Busca Arenzana
- Carmen Herrero RodrĂguez
- Carmen Infante
- Carmen MartĂnez Cilleros
- Carmen Quereda
- Carmen SĂĄez BarberĂĄ
- Carmen Yera Bergua
- Carmen Yllera Gutiérrez
- Carmina Oltra
- Carolina HernĂĄndez Carballo
- Carolina RoldĂĄn Fontana
- Cecilia Tortajada Alamilla
- Celia Salamanca
- Chen
- Chen
- Chiara Fanciulli
- Cintia MarĂa MartĂnez Mateu
- Clara Muñoz Aguirre
- Clara Sala Jofre
- Claudia GonzĂĄlez Rico
- Claudio Bueno
- ConcepciĂłn Amador Prous
- ConcepciĂłn GarcĂa GarcĂa
- Conchita PĂ©rez-Jorge Peremarch
- Constanza Muñoz Hornero
- Covadonga Morcate FernĂĄndez
- Cristina Carbonell
- Cristina Cervera Acedo
- Cristina Chico Chumillas
- Cristina DĂez
- Cristina GĂłmez-Ayerbe
- Cristina HernĂĄn GarcĂa
- Cristina Hernåndez Gutiérrez
- Cristina LĂłpez Mestanza
- Cristina Morales GarcĂa
- Cristina Moreno
- Cristina Roca
- CristĂłbal Manuel RodrĂguez Leal
- Cummings
- Daniel Molina Morant
- Daniel Podzamczer
- Daniel Roger Zapata
- Daniel Useros Brañas
- David Alonso Menchén
- David Roa
- David Vinuesa GarcĂa
- Delia Quilez Ăgreda
- Docherty
- Domingo GarcĂa-JimĂ©nez
- Eduardo Malmierca Corral
- Efrén Sånchez Vidal
- Elena Chamarro MartĂ
- Elena Isaba Ares
- Elena LĂłpez TizĂłn
- Elena MarĂa Aranda Rife
- Elena Morcillo RodrĂguez
- Elena Morte
- Elena MĂșñez Rubio
- Elena Resino Foz
- Elena Salamanca
- Elena Trigo Esteban
- Elena Ălvaro Alonso
- Elisa Cordero-MatĂa
- Elisa GarcĂa VĂĄzquez
- Elisabet Delgado SĂĄnchez
- Elizabet Petkova Saiz
- Elsa Izquierdo GarcĂa
- EncarnaciĂłn Moral Escudero
- Enrique MĂguez Rey
- Enrique Peral
- Esperanza Bejarano Tello
- Esteban MartĂnez
- Estel Pons Viñas
- Ester SĂĄez de Adana ArrĂłniz
- Esther Aznar Muñoz
- Esther ExpĂłsito Palomo
- Esther Fraile Villarejo
- Esther GarcĂa AlmodĂłvar
- Eva Jiménez Gonzålez de Buitrago
- Eva MarĂa LeĂłn JimĂ©nez
- Eva MarĂa Romay Lema
- Eva Pilar GarcĂa Villalba
- Eva Talavera GarcĂa
- Eva Van den Eynde Otero
- Felipe Villar Ălvarez
- Fernando de la Calle Prieto
- Fernando GonzĂĄlez-Romo
- Francesc AlbertĂ
- Francesca Gioia
- Francesca Norman
- Francisco AlcĂĄntara NicolĂĄs
- Francisco Arnaiz de las Revillas
- Francisco Javier Membrillo de Novales
- Francisco Mora GĂłmez
- Francisco Muñoz Beamud
- Francisco Parras
- Francisco RodrĂguez GĂłmez
- Francisco Tejerina
- Fåtima Brañas Baztån
- Félix Gutiérrez Rodero
- Gabriel Gaspar Alonso-Vega
- Gabriela Abelenda-Alonso
- Gema Barbeito Castiñeiras
- Gema DomĂnguez de Pablos
- Gema Muñiz
- GermĂĄn RamĂrez-Olivencia
- Ginger Giorgiana Cabrera Tejada
- Goyal
- Grasselli
- Guan
- Guillermo Cuervo
- Guillermo Cuevas Tascon
- Guillermo Estrada FernĂĄndez
- Guillermo JimĂ©nez Ălvarez
- Guillermo Maestro de la Calle
- Guillermo MartĂn
- Harris
- Helem Haydee Vilchez
- Helena Mozas Moriñigo
- Henar Calvo SĂĄnchez
- Hernando Knobel
- Huang
- Huang
- HĂ©ctor Meijide MĂguez
- Ianire Virto Peña
- Ignacio De los Santos Gil
- Inmaculada JarrĂn
- Inmaculada JarrĂn
- Inmaculada MartĂn PĂ©rez
- Inmaculada Poquet Catala
- Inés Fernåndez Jiménez
- Inés Pérez Zapata
- InĂ©s SuĂĄrez-GarcĂa
- Irene Carrillo Acosta
- Irene DĂaz de la Torre
- Irene MartĂn Rubio
- Iris Pedrola Gorrea
- Isabel A. PĂ©rez HernĂĄndez
- Isabel Barrio LĂłpez
- Isabel Gutiérrez
- Isabel JimĂ©nez MartĂnez
- Isabel PĂ©rez-Tamayo
- Isabel RĂĄbago Lorite
- Ismail Zakariya-Yousef Breval
- Itziar Diego YagĂŒe
- Ivette Abascal Cambras
- IvĂĄn Castro HernĂĄndez
- IvĂĄn Navas Clemente
- IvĂĄn PelegrĂn Senent
- Ivån Piñero
- Jamil Cedeño
- Jara Llenas GarcĂa
- Javier Coy Coy
- Javier De la Torre Lima
- Javier Nieto Arana
- Javier Oliver Ortega
- Javier SĂĄnchez-Lora
- JerĂłnimo PachĂłn
- JerĂłnimo PachĂłn
- Jessica Abadia Otero
- JesĂșs Rodriguez Baño
- JesĂșs RodrĂguez-Baño
- JesĂșs Ruiz AragĂłn
- JesĂșs Santos GonzĂĄlez
- JesĂșs Sanz Sanz
- JesĂșs Sojo
- JesĂșs SĂĄnchez-GĂłmez
- JesĂșs Troya GarcĂa
- Jhon Rojas
- Joan GĂłmez-Junyent
- JoaquĂn LĂłpez-Contreras GonzĂĄlez
- Jon Ugalde Espiñeira
- Jonathan CĂĄmara FernĂĄndez
- Jordi CarratalĂ
- Jordi CarratalĂ
- Jordi Mancebo Cortés
- Jordi NiubĂł
- Jorge Alba FernĂĄndez
- Jorge Anel Pedroche
- Jorge CalderĂłn Parra
- Jorge Calvo
- Jorge MartĂnez JordĂĄn
- Jorge Parra Ruiz
- Jorge Valencia de la Rosa
- Jose David Ampuero Martinich
- Joseba Portu Zapirain
- Josefa Serralta Buades
- Josefina GarcĂa GarcĂa
- Josune Goikoetxea Agirre
- José Antonio Peregrina
- José Antonio Pérez de León
- José Bravo-Ferrer
- José Hernåndez Quero
- José Ignacio Bernardino de la Serna
- José Luis Blanco
- JosĂ© Luis DĂaz de Tuesta del Arco
- JosĂ© Luis GarcĂa Fogeda
- José Luis Velasco Garrido
- JosĂ© LuĂs Del Pozo LeĂłn
- José M. Azcona Gutiérrez
- José Manuel Våzquez Comendador
- JosĂ© MarĂa Aguado
- JosĂ© MarĂa MarimĂłn Ortiz de ZĂĄrate
- JosĂ© MarĂa Milicua Muñoz
- José Miguel Cisneros
- JosĂ© MÂȘ GarcĂa de Lomas Guerrero
- José R. Blanco Ramos
- José Ramón Arriba
- José Ramón Arribas López
- José Romån Muñoz del Rey
- José Sanz Moreno
- José Tomas Algado Rabasa
- Juan Berenguer
- Juan Berenguer
- Juan CantĂłn de Seoane
- Juan Carlos Abad Almendro
- Juan Carlos Gainzarain Arana
- Juan Carlos LĂłpez
- Juan Carlos Ramos Ramos
- Juan Cuadros GonzĂĄlez
- Juan Emilio Losa GarcĂa
- Juan Espinosa Pereiro
- Juan Pablo Avilés
- Juan Pablo Horcajada
- Juan Salillas Hernando
- Juan Torres Macho
- Judit Villar-GarcĂa
- Julen Cadiñaños Loidi
- Julia Pareja Coca
- Julia Praena
- Julio GarcĂa RodrĂguez
- Justo Menéndez
- JĂșlia SellarĂ©s
- Karim Mohamed RamĂrez
- Kass
- Klein
- Kuderer
- Kwong
- Lagunas-Rangel
- Laia Lorenzo-Esteller
- Lara Montes AndĂșjar
- Laura Castelo Corral
- Laura Iglesias Llorente
- Laura Mao MartĂn
- Laura Muñoz López
- Laura Prieto PĂ©rez
- Leire Balerdi Sarasola
- Leire PĂ©rez-Latorre
- Liang
- Lidia MartĂn
- Lighter
- Liu
- Lorea Arteche Eguizabal
- Lorena De la Mora
- Loreto Vidaur Tello
- Lourdes Herrera Pacheco
- Lucia Boix Palop
- Lucia Cajuela
- Lucia SuĂĄrez PĂ©rez
- Lucio GarcĂa-Fraile
- Lucy Abella VĂĄzquez
- LucĂa FernĂĄndez de Orueta
- LucĂa GĂłmez GarcĂa
- LucĂa MarĂn-Barrera
- LucĂa Ramos Merino
- Luis Alberto Nieto FernĂĄndez del Campo
- Luis E. López-Cortés
- Luis Falgueras LĂłpez
- Luis Force SanmartĂn
- Luis Metola SacristĂĄn
- Luis Puente
- Luisa Sorli RedĂČ
- Lydia GĂĄlvez-BenĂtez
- Lydia MartĂn GonzĂĄlez
- M. Teresa PĂ©rez-RodrĂguez
- Maialen Ibarguren Pinilla
- Manuel Cervantes GarcĂa
- Manuela Aguilar-Guisado
- Mar MasiĂĄ Canuto
- Mar Mosquera
- Marcelino Hayek Peraza
- Marco Antonio Sempere Alcocer
- Marcos DĂez MartĂnez
- Marcos LĂłpez Dosil
- Margarita RamĂrez-Schacke
- Maria Ălvarez de Castro
- Maribel Zamora Cintas
- Marina Pacheco MartĂnez-Atienza
- Mario FernĂĄndez-Ruiz
- Mario José Rodriguez Dominguez
- Mario Pérez Butragueño
- Marta Alvarado Blasco
- Marta Arsuaga Vicente
- Marta DĂaz MenĂ©ndez
- Marta Lamata Subero
- Marta Miarons
- Marta Mora Rillo
- Marta Navarro VilasarĂł
- Marta Rava
- Marta Rico RodrĂguez
- Marta Robledo del Prado
- Marta Ruiz-Alguero
- Marta Santos Peña
- Marta VizcaĂno CallejĂłn
- MarĂa Aroca Ferri
- MarĂa ArĂĄnzazu Galindo MartĂn
- MarĂa Carmen Fariñas Ălvarez
- MarĂa Cecilia CĂĄnepa
- MarĂa de la Luz Padilla Salazar
- MarĂa del Carmen Navarro SĂĄez
- MarĂa del Mar Alonso Socas
- MarĂa Dolores AvilĂ©s
- MarĂa E. GarcĂa-Leoni
- MarĂa Isabel Quijano Contreras
- MarĂa JesĂșs DomĂnguez Santalla
- MarĂa JosĂ© Blanco Vidal
- MarĂa JosĂ© Ruiz RodrĂguez
- MarĂa Larrosa
- MarĂa LorĂ©n Vargas
- MarĂa Luisa Machado Sicilia
- MarĂa LĂłpez-JĂłdar
- MarĂa Milagro Montero
- MarĂa Novella Mena
- MarĂa Paz GarcĂa Butenegro
- MarĂa Pilar GarcĂa GarcĂa
- MarĂa Rexach Fumaña
- MarĂa Roca Toda Savall
- MarĂa RodrĂguez MahĂa
- MarĂa SimĂłn SacristĂĄn
- MarĂa Yllescas
- MarĂa Ăngeles DomĂnguez
- MarĂa Ăngeles Garcinuño
- Melania Ăñigo Pestaña
- Melchor Riera Jaume
- Melchor Ălvarez de Mon Soto
- Melissa Carreres Candela
- Merce Cardona Rivera
- Merce Sirisi
- Mercedes Clemente Presas
- Mercedes GuillamĂłn SĂĄnchez
- Mercedes San Franco
- Mercedes Villarreal GarcĂa-Lomas
- MercĂš GurguĂ Ferrer
- Miguel Cervero
- Miguel Corral Saracho
- Miguel FernĂĄndez-Huerta
- Miguel GĂłrgolas HernĂĄndez-Mora
- Miguel Pedromingo Kus
- Miguel Salavert LletĂ
- Miguel Sampedro NĂșñez
- Miguel Torralba GonzĂĄlez de Suso
- Miguel VillamarĂn
- Miguel Ăngel Moran RodrĂguez
- Mikel del Ălamo MartĂnez de Lagos
- Ministerio de Sanidad
- Miquel Pujol
- Mireia Puig Campmany
- Miriam Estébanez Muñoz
- Miriam GarcĂa GĂłmez
- Miriam Latorre-MillĂĄn
- Moncef Belhassen-GarcĂa
- Montaña JimĂ©nez Ălvaro
- Montserrat Laguno
- Montserrat Sanmarti Vilamala
- MÂȘ Antonia SepĂșlveda Berrocal
- MÂȘ Carmen SĂĄnchez Arenas
- MÂȘ del Mar Lago NĂșñez
- MÂȘ Ăngeles Marcos
- MĂłnica GonzĂĄlez Bardanca
- MĂłnica Gozalo
- Mónica Liébana Gómez
- Natalia Carrasco Fons
- Natividad Benito HernĂĄndez
- Nerea Carrasco AntĂłn
- Nicolas Merchante Gutiérrez
- Nieves Valcarce Pardeiro
- Noelia Arenal Andrés
- Nora Izko Gartzia
- Nuria FernĂĄndez
- Nuria Parra Arribas
- Nuria Rabella GarcĂa
- NĂșria Trullen
- Olalla MartĂnez Macias
- Oriol Gasch Blasi
- Oscar del RĂo PĂ©rez
- Oscar Sanz PelĂĄez
- Pablo FernĂĄndez-GonzĂĄlez
- Pablo Marguenda Contreras
- Pablo Pascual Alonso
- Pablo Ryan
- Pablo Ryan
- Paloma Merino Amador
- Patricia Gonzålez Muñiz
- Patricia GonzĂĄlez- Ruano
- Patricia MartĂnez MartĂn
- Patricia PĂ©rez-Palacios
- Patricia SornĂ Moreno
- Paula Runza Buznego
- Paula Santibåñez Såenz
- Paula SĂĄez Escolano
- Paula Villares FernĂĄndez
- Pedro Gil Divasson
- Pere Comas Casanova
- Pere Domingo Pedrol
- Pilar CatalĂĄn
- Pilar HernĂĄndez MachĂn
- Pilar Retamar
- Pilar Toledano Sierra
- Pilar Vizcarra
- Rafael CantĂłn Moreno
- Rafael PadrĂłs Selma
- Rafael Silvariño Fernåndez
- Rafael Torres Perea
- RamĂłn PĂ©rez Tanoira
- Raquel Aranega
- Raquel BarrĂłs GonzĂĄlez
- Raquel Elisa RodrĂguez Tarazona
- Raquel MartĂnez Goñi
- Raquel Ălvarez Franco
- Rebeca Izquierdo
- Remedios AlemĂĄn Valls
- Ricardo FernĂĄndez Roblas
- Richard Rojas
- Richardson
- Robert Torres SĂĄnchez del Arco
- Roberto GĂŒerri-FernĂĄndez
- Roberto Vates GĂłmez
- RocĂo MartĂnez AvilĂ©s
- Rodrigo Alonso Navarro
- Rodrigo Sierra RodrĂguez
- Roi SuĂĄrez Gil
- Rosa de Miguel Buckley
- Rosana Rouco Esteves Marques
- Ruth Brea Aparicio
- Ruth Figueroa CerĂłn
- Sadaf Zafar Iqubal-Mirza
- Salvador Ălvarez Martin
- Sandra PĂ©rez-Recio
- Santos Del Campo
- Sara FernĂĄndez RodrĂguez
- Sara Heili Frades
- Sara Lidia Kamal
- Sara Medrano Pardo
- Sara Rodrigo GonzĂĄlez
- Sarah Caro Bragado
- Schiffrin
- Sergio España Cueto
- Sergio Gilaberte ReyzĂĄbal
- Sergio PĂ©rez Pinto
- Silvana Fiorante
- Silvia Castañeda Espinosa
- Silvia HernĂĄez Crespo
- Silvia Loscos
- Silvia Paulos Viñas
- Silvia SuĂĄrez Diaz
- Silvia Valero Rovira
- Silvia Ălvarez Kaelis
- Simonnet
- Singh
- Sonia Calzado Isbert
- Sonia GarcĂa
- Sonia GarcĂa Calvo
- Sonia Vega Molpeceres
- Susana Casas RodrĂguez
- Tamara Manso GĂłmez
- Teresa AldabĂł
- Teresa AldĂĄmiz-EchevarrĂa
- Teresa GarcĂa Delange
- Teresa Ălvarez de Espejo Montiel
- TomĂĄs Tosco NĂșñez
- Valvanera Ibarra CucalĂłn
- Vanessa Alende Castro
- VerĂłnica Cano Llorente
- Vicente Boix
- Vicente Ferrer DĂaz de Brito FernĂĄndez
- Victoria Hernando
- Violeta Ramos Sesma
- Virginia FernĂĄndez Espinilla
- Virginia Molina Peinado
- Virginia Naranjo Velasco
- Virginia Pomar Solchaga
- Virginia Pérez Doñate
- VĂctor Asensi Ălvarez
- VĂctor J. Moreno Cuerda
- Wadhera
- World Health Organization
- Xabier Kortajarena Urkola
- Xavier Bonfill Cosp
- Yang
- Yolanda MartĂnez MartĂnez
- Yolanda Meije
- Yolanda Posada Franco
- Young
- Zaira R. Palacios
- Zeltia Valcarce GonzĂĄlez
- Zhou
- Zhou
- Zineb Karroud
- Zuriñe Ortiz de Zårate Ibarra
- Ălvaro Navarro Batet
- Ălvaro Varela Plaza
- Ăngeles GarcĂa Flores
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study