Study of the performance of standard RPC chambers as a function of bakelite temperature

A systematic study of the performance of the Resistive Plate Chambers as a function of the bakelite temperature is presented. The current, the rate and the efficiency were measured in the temperature range 22-40degreesC. The values of the relative humidity during the data taking were in the range 40-60%. Measurements show a strong dependence of the efficiency on bakelite temperature. (C) 2003 Elsevier Science B.V. All rights reserved

N=2 Super-Higgs, N=1 Poincare' Vacua and Quaternionic Geometry

In the context of N=2 supergravity we explain the occurrence of partial super-Higgs with vanishing vacuum energy and moduli stabilization in a model suggested by superstring compactifications on type IIB orientifolds with 3-form fluxes. The gauging of axion symmetries of the quaternionic manifold, together with the use of degenerate symplectic sections for special geometry, are the essential ingredients of the construction.Comment: 18 page

The advances of technology: A case study of two midwest academic slide libraries

This study focuses on the question of how willing and prepared slide libraries are for technological change. Many slide libraries are at various stages of development, and this fact could either facilitate or inhibit growth when it comes to implementing new technologies: in particular, digitized images in any of the available formats (CD-ROM, laser disc, or online). In this case study of two Midwest academic slide libraries, issues such as funding, size of the library, current technology usage, and knowledge of various technologies, were examined to determine their effects on advancement toward new and innovative systems. These issues were addressed in an in-depth interview process with slide librarians at two different academic institutions. Since digitized images are not yet being used in the slide libraries on which this study is based, interview questions focused on opinions, attitudes and expectations about the implementation of digitization

Structural Characterization of Cuta- and Tusavirus: Insight into Protoparvoviruses Capsid Morphology

Several members of the Protoparvovirus genus, capable of infecting humans, have been recently discovered, including cutavirus (CuV) and tusavirus (TuV). To begin the characterization of these viruses, we have used cryo-electron microscopy and image reconstruction to determine their capsid structures to ~2.9 Å resolution, and glycan array and cell-based assays to identify glycans utilized for cellular entry. Structural comparisons show that the CuV and TuV capsids share common features with other parvoviruses, including an eight-stranded anti-parallel β-barrel, depressions at the icosahedral 2-fold and surrounding the 5-fold axes, and a channel at the 5-fold axes. However, the viruses exhibit significant topological differences in their viral protein surface loops. These result in three separated 3-fold protrusions, similar to the bufaviruses also infecting humans, suggesting a host-driven structure evolution. The surface loops contain residues involved in receptor binding, cellular trafficking, and antigenic reactivity in other parvoviruses. In addition, terminal sialic acid was identified as the glycan potentially utilized by both CuV and TuV for cellular entry, with TuV showing additional recognition of poly-sialic acid and sialylated Lewis X (sLeXLeXLeX) motifs reported to be upregulated in neurotropic and cancer cells, respectively. These structures provide a platform for annotating the cellular interactions of these human pathogens

Structural Characterization of Cuta- and Tusavirus: Insight into Protoparvoviruses Capsid Morphology

Several members of the Protoparvovirus genus, capable of infecting humans, have been recently discovered, including cutavirus (CuV) and tusavirus (TuV). To begin the characterization of these viruses, we have used cryo-electron microscopy and image reconstruction to determine their capsid structures to ~2.9 Å resolution, and glycan array and cell-based assays to identify glycans utilized for cellular entry. Structural comparisons show that the CuV and TuV capsids share common features with other parvoviruses, including an eight-stranded anti-parallel β-barrel, depressions at the icosahedral 2-fold and surrounding the 5-fold axes, and a channel at the 5-fold axes. However, the viruses exhibit significant topological differences in their viral protein surface loops. These result in three separated 3-fold protrusions, similar to the bufaviruses also infecting humans, suggesting a host-driven structure evolution. The surface loops contain residues involved in receptor binding, cellular trafficking, and antigenic reactivity in other parvoviruses. In addition, terminal sialic acid was identified as the glycan potentially utilized by both CuV and TuV for cellular entry, with TuV showing additional recognition of poly-sialic acid and sialylated Lewis X (sLeXLeXLeX) motifs reported to be upregulated in neurotropic and cancer cells, respectively. These structures provide a platform for annotating the cellular interactions of these human pathogens