Quinine levels in patients with uncomplicated falciparum malaria in the Amazon region of Brazil

We examined the plasmatic concentrations of quinine in patients with uncomplicated falciparum malaria in an endemic area of the Amazon region in Brazil in a prospective clinical trial, in which a standard three-day course of oral quinine plus doxycycline was used. We measured the quinine in the plasma samples on days 0 and 3by high performance liquid chromatography. The mean concentration of quinine was 6.04 ±2.21 µg/mL in male patients and 5.98 ±1.95 µg/mL in female patients. No significant differences in quinine concentration were observed between these two groups. All samples collected before starting treatment were negative for quinine. This information could help in the development of strategies for the rational use of antimalarial drugs in Brazil

Rates of tooth movement and bone remodeling activity : self-ligating versus conventional brackets

Background: Bracket systems have been developed with the purpose of reducing frictional resistance between the archwire and accessories. The aim of this research was to compare rates of tooth movement and regions of cellular bone modeling activity along tooth root surfaces of teeth moved with conventional vs. self-ligating brackets. Material and Methods: The experiments were conducted in 20 male dogs. Bands were cemented in all intermediate incisors, with conventional brackets (Morelli) on the right side and hybrid self-ligating ones (T3-American Ortho-dontics) on the left side. A 0.019? x 0.025? stainless steel wire was inserted passively in the slot of these brackets with chain elastics (250 gf) to perform sliding mechanics. Clinical records of the orthodontic mechanics were made before and after 15 days of the tooth movement. The dental segments of the animals were prepared for light micros-copy. Statistical analysis of variance and the Tukey correction with a P value at 5% were used. Results: There were no significant differences in tooth movement rates between the two types of brackets but di-fferences, in the bone modeling activity, suggested that tooth movement with the self-ligating brackets resulted in more tipping and less translational movement than tooth movement with the conventional brackets. Conclusions: The rates of tooth movement were similar between the two systems. The histological evaluation of cellular bone modeling activity along tooth root surfaces showed more translation movement of teeth with the con-ventional brackets, and more tipping movement of teeth with self-ligating brackets

Nanostructured lipid carriers as a novel tool to deliver sclareol: physicochemical characterisation and evaluation in human cancer cell lines

Sclareol (SC) is arousing great interest due to its cytostatic and cytotoxic activities in several cancer cell lines. However, its hydrophobicity is a limiting factor for its in vivo administration. One way to solve this problem is through nanoencapsulation. Therefore, solid lipid nanoparticles (SLN-SC) and nanostructured lipid carriers (NLC-SC) loaded with SC were produced and compared regarding their physicochemical properties. NLC-SC showed better SC encapsulation than SLN-SC and was chosen to be compared with free SC in human cancer cell lines (MDA-MB-231 and HCT-116). Free SC had slightly higher cytotoxicity than NLC-SC and produced subdiploid DNA content in both cell lines. On the other hand, NLC-SC led to subdiploid content in MDA-MB-231 cells and G2/M checkpoint arrest in HCT-116 cells. These findings suggest that SC encapsulation in NLC is a way to allow the in vivo administration of SC and might alter its biological properties

Social network of sexual and gender minorities: possibilities of support in health care

The study aimed to characterize the Social Network of sexual and gender minorities and to analyze the type of social support received for health care. This was a descriptive qualitative study. The methodological theoretical framework of Social Network proposed by Lia Sanicola was used. Semi-structured interviews were analyzed based on the Content Analysis technique proposed by Bardin. The study was carried out in 2019 at a family health unit in the city of Rio de Janeiro. Results showed that the social network of the interviewees was marked by a strong relationship with friends and colleagues, while in the relationship with family members there was a greater fragility in the bonds due to the lack of knowledge or non-acceptance of these members in relation to the sexuality of the interviewees. In addition to the fragility of the family relationship, there was a difficulty and discontinuity in access to health, due to the lack of bonds stimulated by prejudice and discrimination in health services. Social networks were characterized by the bond with friends and colleagues who offered emotional support. In the context of the family and the health care network, social relationships were permeated with weaknesses and lack of support. Knowledge of the network and the type of social support received by people who are part of sexual and gender minorities makes it possible to broaden the health professional’s view of comprehensive care for this population and consequently improve the quality of care provided

A pandemia de COVID-19 e mudanças nos estilos de vida dos adolescentes brasileiros

Objective: To analyze changes in the lifestyles of Brazilian adolescents during the COVID-19 pandemic. Methods: Cross-sectional study carried out with adolescents who participated in the “Covid Adolescentes - Behavior Survey”. The indicators related to lifestyles before and during the pandemic were evaluated: consumption of healthy and unhealthy foods, physical activity and sedentary behavior, smoking and consumption of alcoholic beverages. Prevalence and 95% confidence intervals were calculated for the total population and according to sex and age group. Results: 9,470 adolescents participated in the study. During the period of social distance, there was an increase in the prevalence of consumption of vegetables (from 27.34% to 30.5%), frozen foods (from 13.26% to 17.3%), chocolates and sweets (from 48.58% to 52.51%) and time in front of screens (from 44.57% to 70.15%). On the other hand, there was a decrease in the practice of physical activity (from 28.7% to 15.74%) and in the consumption of alcoholic beverages (from 17.72% to 12.77%). Differences were observed according to sex and age group. Conclusion: The results show changes in the adolescents' lifestyles and an increase in health risk behaviors.Objetivo: Analisar as mudanças nos estilos de vida dos adolescentes brasileiros durante pandemia de COVID-19. Métodos: Estudo transversal realizado com adolescentes que participaram do inquérito “Convid Adolescentes - Pesquisa de Comportamentos”. Foram avaliados os indicadores relacionados aos estilos de vida antes e durante a pandemia: consumo de alimentos saudáveis e não saudáveis, prática de atividade física e comportamento sedentário, tabagismo e consumo de bebidas alcóolicas. Foram calculadas as prevalências e intervalos de confiança de 95% para população total e segundo sexo e faixa etária. Resultados: Participaram do estudo 9.470 adolescentes. Durante o período de distanciamento social, foi observado aumento nas prevalências de consumo de hortaliças (de 27,34% para 30,5%), de pratos congelados (de 13,26% para 17,3%), de chocolates e doces (de 48,58% para 52,51%) e do tempo em frente às telas (de 44,57% para 70,15%). Por outro lado, houve diminuição da prática de atividade física (de 28,7% para 15,74%) e do consumo de bebidas alcóolicas (de 17,72% para 12,77%). Foram observadas diferenças segundo sexo e faixa etária. Conclusão: Os resultados apontam mudanças nos estilos de vida dos adolescentes e aumento de comportamentos de risco à saúde. Objetivo: Analisar as mudanças nos estilos de vida dos adolescentes brasileiros durante pandemia de COVID-19. Métodos: Estudo transversal realizado com adolescentes que participaram do inquérito “Convid Adolescentes - Pesquisa de Comportamentos”. Foram avaliados os indicadores relacionados aos estilos de vida antes e durante a pandemia: consumo de alimentos saudáveis e não saudáveis, prática de atividade física e comportamento sedentário, tabagismo e consumo de bebidas alcóolicas. Foram calculadas as prevalências e intervalos de confiança de 95% para população total e segundo sexo e faixa etária. Resultados: Participaram do estudo 9.470 adolescentes. Durante o período de distanciamento social, foi observado aumento nas prevalências de consumo de hortaliças (de 27,34% para 30,5%), de pratos congelados (de 13,26% para 17,3%), de chocolates e doces (de 48,58% para 52,51%) e do tempo em frente às telas (de 44,57% para 70,15%). Por outro lado, houve diminuição da prática de atividade física (de 28,7% para 15,74%) e do consumo de bebidas alcóolicas (de 17,72% para 12,77%). Foram observadas diferenças segundo sexo e faixa etária. Conclusão: Os resultados apontam mudanças nos estilos de vida dos adolescentes e aumento de comportamentos de risco à saúde

Distanciamento social, sentimento de tristeza e estilos de vida da população brasileira durante a pandemia de COVID-19

The COVID-19 pandemic has had biopsychosocial impacts on individual and collective health. The aim of the study was to analyze adherence to social distance, the repercussions on mood and changes in the lifestyles of the Brazilian adult population during the beginning of the COVID-19 pandemic. This is a cross-sectional study with adult individuals living in Brazil (n = 45,161) who participated in the virtual health survey ConVid - Behavior Survey, from April 24 to May 24, 2020. Data collection was performed via web, using a self-administered questionnaire. The prevalence and 95% confidence interval of the studied variables were calculated. Of the sample studied, only 1.5% led normal lives, without any social restrictions and 75% stayed at home, of which 15% stayed strictly at home. The frequent feelings of sadness or depression (35.5%), isolation (41.2%) and anxiety (41.3%) were reported by a large part of the studied population. It was found that 17% of participants reported increased consumption of alcoholic beverages and 34% of smokers increased the number of cigarettes. There was an increase in the consumption of unhealthy foods and a reduction in the practice of physical activity in the period studied. It was concluded that there was a high adherence to social distance and an increase in feelings of sadness, depression and anxiety, as well as an increase in the consumption of unhealthy foods, use of alcoholic beverages and cigarettes and a reduction in the practice of physical activity. These changes are worrying and can result in damage to individual and collective health in the medium and long term.A pandemia de COVID-19 acarretou impactos biopsicossociais à saúde individual e coletiva. O objetivo do estudo foi analisar a adesão ao distanciamento social, as repercussões no estado de ânimo e mudanças nos estilos de vida da população adulta brasileira durante o início da pandemia da COVID-19. Trata-se de estudo transversal com indivíduos adultos residentes no Brasil (n = 45.161) que participaram do inquérito de saúde virtual ConVid - Pesquisa de Comportamentos, no período de 24 de abril a 24 de maio de 2020. A coleta de dados foi realizada via web, utilizando-se de um questionário autopreenchido. Foram calculadas as prevalências e intervalo de 95% de confiança das variáveis estudadas. Da amostra estudada, apenas 1,5% levou vida normal, sem nenhuma restrição social e 75% ficaram em casa, sendo que destes 15% ficaram rigorosamente em casa. Os sentimentos frequentes de tristeza ou depressão (35,5%), isolamento (41,2%) e ansiedade (41,3%) foram reportados por grande parte da população estudada. Verificou-se 17% dos participantes reportaram aumento do consumo de bebidas alcoólicas e de 34% dos fumantes aumentaram o número de cigarros. Observou-se aumento no consumo de alimentos não saudáveis e redução da prática de atividade física no período estudado. Conclui-se que houve elevada adesão ao distanciamento social e aumento dos sentimentos de tristeza, depressão e ansiedade, bem como aumento de consumo de alimentos não saudáveis, uso de bebidas alcóolicas e cigarros e redução da prática de atividade física. Essas mudanças são preocupantes e podem resultar em danos à saúde individual e coletiva a médio e longo prazo. &nbsp

A pandemia da COVID-19 e as mudanças no estilo de vida dos brasileiros adultos: um estudo transversal, 2020

Objective. To describe the changes in lifestyles, regarding to the consumption of tobacco and alcohol, food intake and physical activity, in the period of social restriction resulting from the pandemic of the disease by the coronavirus 2019 (COVID-19). Methods. This is a cross-sectional study conducted in Brazil with data from the virtual health survey ConVid (Behavior Survey). Changes in lifestyles were analyzed. The data were expressed in relative frequencies and a 95% confidence interval. Results. 45,161 individuals aged 18 years or more participated. During the period of social restriction, a decrease in the practice of physical activity and an increase in time in front of screens, ingestion of ultra-processed foods, the number of cigarettes smoked and the consumption of alcoholic beverages were reported. Differences were observed according to sex and age group. Conclusion. The results indicate a worsening of lifestyles and an increase in health risk behaviors.Objetivo. Descrever as mudanças nos estilos de vida, quanto ao consumo de tabaco, álcool, alimentação e atividade física, no período de restrição social consequente à pandemia da COVID-19. Métodos. Estudo transversal realizado com dados do inquérito ConVid sobre comportamentos em saúde. Os dados foram coletados por meio de questionário online autopreenchido pelos participantes. Procedimentos de pós-estratificação foram empregados para o cálculo das prevalências e intervalos de confiança de 95%. Resultados. Participaram 45.161 indivíduos com 18 ou mais anos de idade. Durante o período de restrição social, foi relatada diminuição da prática de atividade física e aumento do tempo em frente a telas, da ingestão de alimentos ultraprocessados, do número de cigarros fumados e do consumo de bebidas alcóolicas. Foram observadas diferenças segundo sexo e faixa etária. Conclusão. Os resultados apontam uma piora dos estilos de vida e aumento de comportamentos de risco à saúde

Mudanças nas condições socioeconômicas e de saúde dos brasileiros durante a pandemia de covid-19

Objective: To describe changes in socioeconomic and health conditions of Brazilians during the COVID-19 pandemic. Methodology: Cross-sectional study with data from a web-based behavioral survey data carried out from April 24 to May 24, 2020 with 45,161 participants recruited by chain sampling procedure. A descriptive analysis of the survey topics was performed: adherence to social restriction measures, diagnosis of the new coronavirus, work situation and income, difficulties in routine activities, presence of comorbidities, psychological issues, and access to health services. Prevalence and respective 95% confidence intervals were estimated. Results: Approximately 74% of Brazilians adhered to social restrictions. As for flu symptoms, 28.1% reported having at least one flu symptom, but only 5.9% underwent testing for covid-19. Regarding the socioeconomic impact, 55.1% reported a decrease in family income, and 7.0% were left without income; 25.8% of people lost their jobs, with the group of informal workers being the most affected (50.6%). As for health conditions, 29.4% reported worsening of health status; 45% having sleep problems; 40% frequently presented feelings of sadness and 52.5% of anxiety; 21.7% sought health care, and among them, 13.9% did not get care. Conclusion: The findings show the importance of controlling the covid-19 pandemic in Brazil, to mitigate the adverse effects on the socioeconomic and health conditions related to social restriction measures.Objetivo: Descrever as mudanças nas condições socioeconômicas e de saúde dos brasileiros durante a pandemia de covid-19. Metodologia: Estudo transversal com dados de pesquisa de comportamentos realizada pela internet de 24 de abril a 24 de maio, 2020 com 45.161 participantes recrutados por amostragem em cadeia. Foi realizada uma análise descritiva de temas abordados na pesquisa: adesão às medidas de restrição social, diagnóstico do novo coronavírus, situação de trabalho e rendimentos, dificuldades nas atividades de rotina, presença de comorbidades, estado de ânimo e acesso aos serviços de saúde. Foram estimadas as prevalências e intervalos de 95% de confiança. Resultados: Aproximadamente 74% dos brasileiros aderiram à restrição social. Quanto aos sintomas de gripe, 28,1% relatou ter apresentado algum sintoma, mas apenas 5,9% realizou teste para covid-19. Em relação à situação socioeconômica, 55,1% relataram diminuição do rendimento familiar, e 7,0% ficaram sem rendimento; 25,8% dos indivíduos ficaram sem trabalhar, sendo o grupo de trabalhadores informais o mais afetado (50,6%). Quanto às condições de saúde, 29,4% avaliaram que a sua saúde piorou; 45% tiveram problemas no sono, 40% apresentou, frequentemente, sentimento de tristeza e 52,5% de ansiedade/nervosismo; 21,7% procurou serviço de saúde, e, entre esses, 13,9% não conseguiu atendimento. Conclusão: Os achados mostram a importância do controle da pandemia de covid-19, no Brasil, para mitigar os efeitos adversos na situação socioeconômica e nas condições de saúde relacionados às medidas de restrição social

Relato de tristeza/depressão, nervosismo/ansiedade e problemas de sono na população adulta brasileira durante a pandemia de COVID-19

Objective. To analyze the frequency of sadness, nervousness, and sleep disorders during the COVID-19 pandemic in Brazil, identifying the most affected demographic segments. Methods. It is a cross-sectional study, with a questionnaire applied via the web to adults and the elderly, collecting information on living conditions, health and health behaviors. Prevalence and prevalence ratios were adjusted for age and sex. Results. With data from 45,161 respondents, it was found that during the pandemic 40.4% (95%CI 41,4; 46,7) of Brazilians often felt sad or depressed and 52.6% (95%CI 51,2; 54,1) often anxious or nervous; 43.5% (95%CI 41,8; 45,3) started to have a sleep problem and 48.0% (95%CI 45,6; 50,5) had a previous sleep problem aggravated. The frequencies of sadness, nervousness and change in sleep were higher in young adults, women and those with a history of depression. Conclusion. The high prevalence found indicates the need to guarantee the provision of services for mental health and quality of sleep that are adapted to the pandemic context.Objetivo. Analisar a frequência de tristeza, nervosismo e alterações do sono durante a pandemia de COVID-19 no Brasil, identificando os segmentos demográficos mais afetados. Métodos. Estudo transversal, com questionário aplicado via web a adultos e idosos, coletando informações sobre condições de vida, saúde e comportamentos de saúde. Foram estimadas prevalências e razões de prevalência ajustadas por idade e sexo. Resultados. Com dados de 45.161 respondentes, verificou-se que, durante a pandemia, 40,4% (IC95% 39,0; 41,8) dos brasileiros sentiram-se frequentemente tristes ou deprimidos e 52,6% (IC95% 51,2; 54,1) frequentemente ansiosos ou nervosos; 43,5% (IC95% 41,8; 45,3) relataram início de problemas de sono e 48,0% (IC95% 45,6; 50,5) problema de sono prévio agravado. A tristeza e o nervosismo frequentes e as alterações do sono estiveram mais presentes entre adultos jovens, mulheres e pessoas com antecedente de depressão. Conclusão. As elevadas prevalências encontradas indicam a necessidade de garantir a provisão de serviços de atenção à saúde mental e à qualidade do sono de forma adaptada ao contexto pandêmico