A Spitzer view of protoplanetary disks in the gamma Velorum cluster

We present new Spitzer Space Telescope observations of stars in the young ~5 Myr gamma Velorum stellar cluster. Combining optical and 2MASS photometry, we have selected 579 stars as candidate members of the cluster. With the addition of the Spitzer mid-infrared data, we have identified 5 debris disks around A-type stars, and 5-6 debris disks around solar-type stars, indicating that the strong radiation field in the cluster does not completely suppress the production of planetesimals in the disks of cluster members. However, we find some evidence that the frequency of circumstellar primordial disks is lower, and the IR flux excesses are smaller than for disks around stellar populations with similar ages. This could be evidence for a relatively fast dissipation of circumstellar dust by the strong radiation field from the highest mass star(s) in the cluster. Another possibility is that gamma Velorum stellar cluster is slightly older than reported ages and the the low frequency of primordial disks reflects the fast disk dissipation observed at ~5 Myr.Comment: Accepted for publication in the Astrophysical Journal: 32 pages; 11 Figure

Material-driven fibronectin assembly for high-efficiency presentation of growth factors

Growth factors (GFs) are powerful signaling molecules with the potential to drive regenerative strategies, including bone repair and vascularization. However, GFs are typically delivered in soluble format at supraphysiological doses because of rapid clearance and limited therapeutic impact. These high doses have serious side effects and are expensive. Although it is well established that GF interactions with extracellular matrix proteins such as fibronectin control GF presentation and activity, a translation-ready approach to unlocking GF potential has not been realized. We demonstrate a simple, robust, and controlled material-based approach to enhance the activity of GFs during tissue healing. The underlying mechanism is based on spontaneous fibrillar organization of fibronectin driven by adsorption onto the polymer poly(ethyl acrylate). Fibrillar fibronectin on this polymer, but not a globular conformation obtained on control polymers, promotes synergistic presentation of integrin-binding sites and bound bone morphogenetic protein 2 (BMP-2), which enhances mesenchymal stem cell osteogenesis in vitro and drives full regeneration of a nonhealing bone defect in vivo at low GF concentrations. This simple and translatable technology could unlock the full regenerative potential of GF therapies while improving safety and cost-effectiveness

Smelling Nano Aerial Vehicle for Gas Source Localization and Mapping

This paper describes the development and validation of the currently smallest aerial platform with olfaction capabilities. The developed Smelling Nano Aerial Vehicle (SNAV) is based on a lightweight commercial nano-quadcopter (27 g) equipped with a custom gas sensing board that can host up to two in situ metal oxide semiconductor (MOX) gas sensors. Due to its small form-factor, the SNAV is not a hazard for humans, enabling its use in public areas or inside buildings. It can autonomously carry out gas sensing missions of hazardous environments inaccessible to terrestrial robots and bigger drones, for example searching for victims and hazardous gas leaks inside pockets that form within the wreckage of collapsed buildings in the aftermath of an earthquake or explosion. The first contribution of this work is assessing the impact of the nano-propellers on the MOX sensor signals at different distances to a gas source. A second contribution is adapting the 'bout' detection algorithm, proposed by Schmuker et al. (2016) to extract specific features from the derivative of the MOX sensor response, for real-time operation. The third and main contribution is the experimental validation of the SNAV for gas source localization (GSL) and mapping in a large indoor environment (160 m²) with a gas source placed in challenging positions for the drone, for example hidden in the ceiling of the room or inside a power outlet box. Two GSL strategies are compared, one based on the instantaneous gas sensor response and the other one based on the bout frequency. From the measurements collected (in motion) along a predefined sweeping path we built (in less than 3 min) a 3D map of the gas distribution and identified the most likely source location. Using the bout frequency yielded on average a higher localization accuracy than using the instantaneous gas sensor response (1.38 m versus 2.05 m error), however accurate tuning of an additional parameter (the noise threshold) is required in the former case. The main conclusion of this paper is that a nano-drone has the potential to perform gas sensing tasks in complex environments

Phosphomannosylation and the functional analysis of the extended Candida albicans MNN4-like gene family

We thank Luz A. López-Ramírez (Universidad de Guanajuato) for technical assistance. This work was supported by Consejo Nacional de Ciencia y Tecnología (ref. CB2011/166860; PDCPN2014-247109, and FC 2015-02-834), Universidad de Guanajuato (ref. 000025/11; 0087/13; ref. 1025/2016; Convocatoria Institucional para Fortalecer la Excelencia Académica 2015; CIFOREA 89/2016), Programa de Mejoramiento de Profesorado (ref. UGTO-PTC-261), and Red Temática Glicociencia en Salud (CONACYT-México). NG acknowledges the Wellcome Trust (086827, 075470, 101873, and 200208) and MRC Centre for Medical Mycology for funding (N006364/1). KJ was supported by a research visitor grant to Aberdeen from China Scholarship Council (CSC No. 201406055024). The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fmicb.2017.02156/full#supplementary-materialPeer reviewedPublisher PD

Combining non selective gas sensors on a mobile robot for identification and mapping of multiple chemical compounds

In this paper, we address the task of gas distribution modeling in scenarios where multiple heterogeneous compounds are present. Gas distribution modeling is particularly useful in emission monitoring applications where spatial representations of the gaseous patches can be used to identify emission hot spots. In realistic environments, the presence of multiple chemicals is expected and therefore, gas discrimination has to be incorporated in the modeling process. The approach presented in this work addresses the task of gas distribution modeling by combining different non selective gas sensors. Gas discrimination is addressed with an open sampling system, composed by an array of metal oxide sensors and a probabilistic algorithm tailored to uncontrolled environments. For each of the identified compounds, the mapping algorithm generates a calibrated gas distribution model using the classification uncertainty and the concentration readings acquired with a photo ionization detector. The meta parameters of the proposed modeling algorithm are automatically learned from the data. The approach was validated with a gas sensitive robot patrolling outdoor and indoor scenarios, where two different chemicals were released simultaneously. The experimental results show that the generated multi compound maps can be used to accurately predict the location of emitting gas sources

Validation of the Spanish version of the Problem Areas in Diabetes (PAID-SP) Scale

This study aimed to assess the psychometric properties of the Spanish version of the Problem Areas in Diabetes (PAID-SP) Scale. Data were collected from patients with type 1 and type 2 diabetes. The findings suggested that the PAID-SP is a reliable and valid measure of diabetes-specific emotional problems

A Linear Time Algorithm for Counting #2SAT on Series-Parallel Formulas

Capítulo de libroAn O(m + n) time algorithm is presented for counting the number of models of a two Conjunctive Normal Form Boolean Formula whose constrained graph is represented by a Series-Parallel graph, where n is the number of variables and m is the number of clauses. To the best of our knowledge, no linear time algorithm has been developed for counting in this kind of formulas

A Study of the Transient Response of Duct Junctions: Measurements and Gas-Dynamic Modeling with a Staggered Mesh Finite Volume Approach

[EN] Duct junctions play a major role in the operation and design of most piping systems. The objective of this paper is to establish the potential of a staggered mesh finite volume model as a way to improve the description of the effect of simple duct junctions on an otherwise one-dimensional flow system, such as the intake or exhaust of an internal combustion engine. Specific experiments have been performed in which different junctions have been characterized as a multi-port, and that have provided precise and reliable results on the propagation of pressure pulses across junctions. The results obtained have been compared to simulations performed with a staggered mesh finite volume method with different flux limiters and different meshes and, as a reference, have also been compared with the results of a more conventional pressure loss- based model. The results indicate that the staggered mesh finite volume model provides a closer description of wave dynamics, even if further work is needed to establish the optimal calculation settings.Manuel Hernandez is partially supported through contract FPI-S2-2015-1064 of Programa de Apoyo para la Investigacin y Desarrollo (PAID) of Universitat Politecnica de Valencia.Torregrosa, AJ.; Broatch, A.; García-Cuevas González, LM.; Hernández-Marco, M. (2017). A Study of the Transient Response of Duct Junctions: Measurements and Gas-Dynamic Modeling with a Staggered Mesh Finite Volume Approach. Applied Sciences. 7(5):1-25. https://doi.org/10.3390/app7050480S12575Payri, F., Reyes, E., & Galindo, J. (2000). Analysis and Modeling of the Fluid-Dynamic Effects in Branched Exhaust Junctions of ICE. Journal of Engineering for Gas Turbines and Power, 123(1), 197-203. doi:10.1115/1.1339988Tang, S. K. (2004). Sound transmission characteristics of Tee-junctions and the associated length corrections. The Journal of the Acoustical Society of America, 115(1), 218-227. doi:10.1121/1.1631830Harrison, M. F., De Soto, I., & Rubio Unzueta, P. L. (2004). A linear acoustic model for multi-cylinder IC engine intake manifolds including the effects of the intake throttle. Journal of Sound and Vibration, 278(4-5), 975-1011. doi:10.1016/j.jsv.2003.12.009Karlsson, M., & Åbom, M. (2011). Quasi-steady model of the acoustic scattering properties of a T-junction. Journal of Sound and Vibration, 330(21), 5131-5137. doi:10.1016/j.jsv.2011.05.012Karlsson, M., & Åbom, M. (2010). Aeroacoustics of T-junctions—An experimental investigation. Journal of Sound and Vibration, 329(10), 1793-1808. doi:10.1016/j.jsv.2009.11.024Corberán, J. M. (1992). A New Constant Pressure Model for N-Branch Junctions. Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering, 206(2), 117-123. doi:10.1243/pime_proc_1992_206_167_02Schmandt, B., & Herwig, H. (2015). The head change coefficient for branched flows: Why «losses» due to junctions can be negative. International Journal of Heat and Fluid Flow, 54, 268-275. doi:10.1016/j.ijheatfluidflow.2015.06.004Shaw, C. T., Lee, D. J., Richardson, S. H., & Pierson, S. (2000). Modelling the Effect of Plenum-Runner Interface Geometry on the Flow Through an Inlet System. SAE Technical Paper Series. doi:10.4271/2000-01-0569Pérez-García, J., Sanmiguel-Rojas, E., Hernández-Grau, J., & Viedma, A. (2006). Numerical and experimental investigations on internal compressible flow at T-type junctions. Experimental Thermal and Fluid Science, 31(1), 61-74. doi:10.1016/j.expthermflusci.2006.02.001Naeimi, H., Domiry, G., Gorji, M., Javadirad, G., & Keshavarz, M. (2011). A parametric design of compact exhaust manifold junction in heavy duty diesel engine using CFD. Thermal Science, 15(4), 1023-1033. doi:10.2298/tsci100417041nSakowitz, A., Mihaescu, M., & Fuchs, L. (2014). Turbulent flow mechanisms in mixing T-junctions by Large Eddy Simulations. International Journal of Heat and Fluid Flow, 45, 135-146. doi:10.1016/j.ijheatfluidflow.2013.06.014Bassett, M. D., Winterbone, D. E., & Pearson, R. J. (2001). Calculation of steady flow pressure loss coefficients for pipe junctions. Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, 215(8), 861-881. doi:10.1177/095440620121500801Hager, W. H. (1984). An Approximate Treatment of Flow in Branches and Bends. Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, 198(1), 63-69. doi:10.1243/pime_proc_1984_198_088_02Paul, J., Selamet, A., Miazgowicz, K. D., & Tallio, K. V. (2007). Combining Flow Losses at Circular T-Junctions Representative of Intake Plenum and Primary Runner Interface. SAE Technical Paper Series. doi:10.4271/2007-01-0649Pérez-García, J., Sanmiguel-Rojas, E., & Viedma, A. (2010). New coefficient to characterize energy losses in compressible flow at T-junctions. Applied Mathematical Modelling, 34(12), 4289-4305. doi:10.1016/j.apm.2010.05.005Wang, W., Lu, Z., Deng, K., & Qu, S. (2014). An experimental study of compressible combining flow at 45° T-junctions. Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, 229(9), 1600-1610. doi:10.1177/0954406214546678Peters, B., & Gosman, A. D. (1993). Numerical Simulation of Unsteady Flow in Engine Intake Manifolds. SAE Technical Paper Series. doi:10.4271/930609Bingham, J. F., & Blair, G. P. (1985). An Improved Branched Pipe Model for Multi-Cylinder Automotive Engine Calculations. Proceedings of the Institution of Mechanical Engineers, Part D: Transport Engineering, 199(1), 65-77. doi:10.1243/pime_proc_1985_199_140_01William-Louis, M. J. P., Ould-El-Hadrami, A., & Tournier, C. (1998). On the calculation of the unsteady compressible flow through an N-branch junction. Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, 212(1), 49-56. doi:10.1243/0954406981521033Bassett, M. D., Pearson, R. J., Fleming, N. P., & Winterbone, D. E. (2003). A Multi-Pipe Junction Model for One-Dimensional Gas-Dynamic Simulations. SAE Technical Paper Series. doi:10.4271/2003-01-0370Pearson, R. J., Bassett, M. D., Batten, P., Winterbone, D. E., & Weaver, N. W. E. (1999). Multi-Dimensional Wave Propagation in Pipe Junctions. SAE Technical Paper Series. doi:10.4271/1999-01-1186Bassett, M. D., Winterbone, D. E., & Pearson, R. J. (2000). Modelling Engines with Pulse Converted Exhaust Manifolds Using One-Dimensional Techniques. SAE Technical Paper Series. doi:10.4271/2000-01-0290Montenegro, G., Onorati, A., Piscaglia, F., & D’Errico, G. (2007). Integrated 1D-MultiD Fluid Dynamic Models for the Simulation of I.C.E. Intake and Exhaust Systems. SAE Technical Paper Series. doi:10.4271/2007-01-0495Onorati, A., Montenegro, G., D’Errico, G., & Piscaglia, F. (2010). Integrated 1D-3D Fluid Dynamic Simulation of a Turbocharged Diesel Engine with Complete Intake and Exhaust Systems. SAE Technical Paper Series. doi:10.4271/2010-01-1194Montenegro, G., Onorati, A., & Della Torre, A. (2013). The prediction of silencer acoustical performances by 1D, 1D–3D and quasi-3D non-linear approaches. Computers & Fluids, 71, 208-223. doi:10.1016/j.compfluid.2012.10.016Morel, T., Silvestri, J., Goerg, K.-A., & Jebasinski, R. (1999). Modeling of Engine Exhaust Acoustics. SAE Technical Paper Series. doi:10.4271/1999-01-1665Sapsford, S. M., Richards, V. C. M., Amlee, D. R., Morel, T., & Chappell, M. T. (1992). Exhaust System Evaluation and Design by Non-Linear Modeling. SAE Technical Paper Series. doi:10.4271/920686Montenegro, G., Della Torre, A., Onorati, A., Fairbrother, R., & Dolinar, A. (2011). Development and Application of 3D Generic Cells to the Acoustic Modelling of Exhaust Systems. SAE Technical Paper Series. doi:10.4271/2011-01-1526Payri, F., Desantes, J. M., & Broatch, A. (2000). Modified impulse method for the measurement of the frequency response of acoustic filters to weakly nonlinear transient excitations. The Journal of the Acoustical Society of America, 107(2), 731-738. doi:10.1121/1.428256Torregrosa, A. J., Broatch, A., Fernández, T., & Denia, F. D. (2006). Description and measurement of the acoustic characteristics of two-tailpipe mufflers. The Journal of the Acoustical Society of America, 119(2), 723. doi:10.1121/1.2159228Torregrosa, A. J., Broatch, A., Arnau, F. J., & Hernández, M. (2016). A non-linear quasi-3D model with Flux-Corrected-Transport for engine gas-exchange modelling. Journal of Computational and Applied Mathematics, 291, 103-111. doi:10.1016/j.cam.2015.03.034Montenegro, G., Della Torre, A., Onorati, A., & Fairbrother, R. (2013). A Nonlinear Quasi-3D Approach for the Modeling of Mufflers with Perforated Elements and Sound-Absorbing Material. Advances in Acoustics and Vibration, 2013, 1-10. doi:10.1155/2013/546120CMT—Motores Térmicos, Universitat Politècnica de Valènciahttp://www.openwam.org/Ikeda, T., & Nakagawa, T. (1979). On the SHASTA FCT Algorithm for the Equation ∂ρ ∂t + ∂ ∂x (υ(ρ)ρ) = 0. Mathematics of Computation, 33(148), 1157. doi:10.2307/2006453Toro, E. F., Spruce, M., & Speares, W. (1994). Restoration of the contact surface in the HLL-Riemann solver. Shock Waves, 4(1), 25-34. doi:10.1007/bf01414629Van Leer, B. (1979). Towards the ultimate conservative difference scheme. V. A second-order sequel to Godunov’s method. Journal of Computational Physics, 32(1), 101-136. doi:10.1016/0021-9991(79)90145-

Parton-to-kaon fragmentation revisited

We revisit the global QCD analysis of parton-to-kaon fragmentation functions at next-to-leading-order accuracy using the latest experimental information on single-inclusive kaon production in electron-positron annihilation, lepton-nucleon deep-inelastic scattering, and proton-proton collisions. An excellent description of all data sets is achieved, and the remaining uncertainties in parton-to-kaon fragmentation functions are estimated and discussed based on the Hessian method. Extensive comparisons to the results from our previous global analysis are made.Instituto de Física La Plat