Influence of enhancement filters in apical bone loss measurement : a cone-beam computed tomography study

The use of cone-beam computed tomography images (CBCT) providing a better assessment of bone injuries, although the sensibility of lesions measurement might be improved by the use of enhancement filters. Objective: This study aimed to analyze the influence of enhancement filters in apical bone loss measurement. Eighteen CBCT cases randomly selected of apical bone loss were evaluated. The analyses were carried out following the evaluation in axial, coronal and sagittal protocols, using enhancement filters as Hard, Normal, and Very Sharp. The variables were statistically analyzed by Friedman and Wilcoxon test, Spearman?s rho, and intraclass correlation coefficient. The differences between filters in axial and sagittal protocols were significant (p<0.05); however, this was not observed in the coronal slice. The use of Hard filter demonstrates better results than Very Sharp and Normal filter, improving significantly the bone loss measurement. A strong, significant and positive correlation was noted for all filters (with p< 0.001), such as a strong agreement between the variables, when the Normal filter was used as a reference. The use of enhancement filters increases the sensitivity of alveolar bone loss measurement, with relative advantage for Hard filter

Validation of the Brazilian-Portuguese version of the Clinician Administered Post Traumatic Stress Disorder Scale-5

Objectives: The aim of this study was to validate CAPS-5 for the Brazilian-Portuguese language on a sample of 128 individuals from two centers (from the cities of São Paulo and Porto Alegre) who have been recently exposed to a traumatic event. Methods: We performed a reliability analysis between interviewers (with a subset of 32 individuals), an internal consistency analysis, and a confirmatory factorial analysis for the validation study. Results: The inter-rater reliability of the total PTSD symptom severity score was high [intraclass correlation coefficient =0.994, 95% CI (0.987–0.997), p < 0.001]. Cohen’s Kappa for individual items ranged between 0.759 and 1. Cronbach’s alpha coefficients indicated high internal consistency for the CAPS-5 full scale (α = 0.826) and an acceptable level of internal consistency for the four symptom clusters. The confirmatory factorial analysis for the 20-item original CAPS-5 did not fit the data well. A 15-item model with better results was then established by excluding the following CAPS-5 items: dissociative amnesia, recklessness, distorted cognitions, irritability, and hypervigilance. Conclusion: Despite the limitation of the predominance of female victims, and the high number of sexually assaulted women in our sample, the model with only 15 items provided a good fit to the data with high internal consistency (α = 0.835)

Coletanea de inovação: uma abordagem informativa

A presente coletânea&nbsp; tem como objetivo trazer conhecimento e informação ao leitor interessado na área de inovação. Os assuntos tratados são de suma importância porque foram desenvolvidos por alunos pesquisadores do mestrado profissional PROFNIT como requisito parcial da disciplina politicas de inovação ponto focal Universidade Federal do Tocantins .Com a produção deste material, espera-se que com a transmissão da informação e conhecimento&nbsp; possa orientar pessoas&nbsp; sobre&nbsp; sistema de inovação tanto em aspectos teoricos quanto práticos. Portanto, o &nbsp;desafio desta cartilha é tornar disponível o&nbsp; conhecimento e, torna-lo acessível, para que as pessoas possamconhecer e analisar as variadas formas&nbsp; e modelos de assunto relacionados o tema. Sem a intenção de esgotar o assunto, nossa tarefa foi de integrar o conhecimento existente e torná-lo disse­minado. &nbsp; Apesar das limitações, e frequentes alterações das normativas, &nbsp;é necessário buscar constantemente a atualização da legislação. Para isto, disponibilizamos sites de consulta para facilitar a busca de informação. Os elementos apresentados neste documento, tem a intenção que sejam mecanismos &nbsp;que possam auxiliar, em parte, os problemas de vulnerabilidade social existentes na sociedade

A aventura crítica da semiótica

The critical adventure of semiotics courses through the main theses about semiotics and communication that have been discussed during the first stage of the research Critical Semiotics: Towards a theory of materialities in communication. In it, the Semiotics and Communication Cultures Research Group (GPESC) discussed the potentialities and limits of a communicational perspective not only based on the founding works of semiotic research (Saussure, Peirce) and developed in its structuralist models (Jakobson, Barthes, Hjelmslev, Lotman), but also revisited by ideas that deconstructed structuralism through the postulates of this very structuralism (Derrida, Kristeva, Deleuze, Guattari). The paper presents this suggestion by means of ten deconstructions related to concepts and theoretical problems which are key to the debate around the materialities of communication: semiotics, communication, materialities, presence, phenomenon, representamen, mediums, sign and significant, structure and system. In so doing, it suggests a move from materialities towards the immanence of a micropolitical and post- human communication.A aventura crítica da semiótica percorre as principais teses sobre a semiótica e a comunicação conforme trabalhadas na primeira etapa da pesquisa Semiótica Crítica, denominada Por uma teoria das materialidades na comunicação. Nela, o Grupo de Pesquisa Semiótica e Culturas da Comunicação procurou discutir as potencialidades e limites de uma perspectiva comunicacional não somente fundamentada nos trabalhos fundadores da semiótica (Saussure, Peirce) e desenvolvida em seus modelos estruturalistas (como em Jakobson, Barthes, Hjelmslev e Lotman), mas também revisitada pelos textos que operaram uma desconstrução do estruturalismo pelo interior dos postulados deste próprio estruturalismo (Derrida, Kristeva, Deleuze, Guattari). O artigo apresenta esta proposta pelos modos como a pesquisa trabalhou com dez desconstruções ligadas a conceitos e problemas teóricos centrais ao debate das materialidades da comunicação: semiótica, comunicação, materialidades, presença, fenômeno, representâmen, meios, signo e significante, estrutura e sistema, sugerindo uma passagem das materialidades à imanência de uma comunicação micropolítica e pós-humana

A aventura crítica da semiótica

A aventura crítica da semiótica percorre as principais teses sobre a semiótica e a comunicação conforme trabalhadas na primeira etapa da pesquisa Semiótica Crítica, denominada Por uma teoria das materialidades na comunicação. Nela, o Grupo de Pesquisa Semiótica e Culturas da Comunicação procurou discutir as potencialidades e limites de uma perspectiva comunicacional não somente fundamentada nos trabalhos fundadores da semiótica (Saussure, Peirce) e desenvolvida em seus modelos estruturalistas (como em Jakobson, Barthes, Hjelmslev e Lotman), mas também revisitada pelos textos que operaram uma desconstrução do estruturalismo pelo interior dos postulados deste próprio estruturalismo (Derrida, Kristeva, Deleuze, Guattari). O artigo apresenta esta proposta pelos modos como a pesquisa trabalhou com dez desconstruções ligadas a conceitos e problemas teóricos centrais ao debate das materialidades da comunicação: semiótica, comunicação, materialidades, presença, fenômeno, representâmen, meios, signo e significante, estrutura e sistema, sugerindo uma passagem das materialidades à imanência de uma comunicação micropolítica e póshumana.The critical adventure of semiotics courses through the main theses about semiotics and communication that have been discussed during the first stage of the research Critical Semiotics: Towards a theory of materialities in communication. In it, the Semiotics and Communication Cultures Research Group (GPESC) discussed the potentialities and limits of a communicational perspective not only based on the founding works of semiotic research (Saussure, Peirce) and developed in its structuralist models (Jakobson, Barthes, Hjelmslev, Lotman), but also revisited by ideas that deconstructed structuralism through the postulates of this very structuralism (Derrida, Kristeva, Deleuze, Guattari). The paper presents this suggestion by means of ten deconstructions related to concepts and theoretical problems which are key to the debate around the materialities of communication: semiotics, communication, materialities, presence, phenomenon, representamen, mediums, sign and significant, structure and system. In so doing, it suggests a move from materialities towards the immanence of a micropolitical and posthuman communication

CK2 Phosphorylation of Schistosoma mansoni HMGB1 Protein Regulates Its Cellular Traffic and Secretion but Not Its DNA Transactions

parasite resides in mesenteric veins where fecundated female worms lay hundred of eggs daily. Some of the egg antigens are trapped in the liver and induce a vigorous granulomatous response. High Mobility Group Box 1 (HMGB1), a nuclear factor, can also be secreted and act as a cytokine. Schistosome HMGB1 (SmHMGB1) is secreted by the eggs and stimulate the production of key cytokines involved in the pathology of schistosomiasis. Thus, understanding the mechanism of SmHMGB1 release becomes mandatory. Here, we addressed the question of how the nuclear SmHMGB1 can reach the extracellular space. eggs of infected animals and that SmHMGB1 that were localized in the periovular schistosomotic granuloma were phosphorylated.We showed that secretion of SmHMGB1 is regulated by phosphorylation. Moreover, our results suggest that egg-secreted SmHMGB1 may represent a new egg antigen. Therefore, the identification of drugs that specifically target phosphorylation of SmHMGB1 might block its secretion and interfere with the pathogenesis of schistosomiasis

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio