Muscle strength and balance as mediators in the association between physical activity and health-related quality of life in community-dwelling older adults

Lower extremity muscle strength (LEMS) and body balance (BB) are essential for older adults to maintain an upright posture and autonomously perform their basic activities of daily living. This study aimed to examine whether LEMS and BB mediate the relationship between physical activity (PA) and health-related quality of life (HRQoL) in a large sample of community-dwelling older adults. This is a cross-sectional study carried out with 802 individuals, 401 males and 401 females (69.8 ± 5.6 years), residents of the Autonomous Region of Madeira, Portugal. PA and HRQoL were assessed by the Baecke Questionnaire and e SF-36, respectively. LEMS was assessed by the Senior Fitness Test and BB by the Fullerton Advance Balance (FAB). The serial mediation pathway model pointed out that LEMS and BB partially mediated the association between PA and HRQoL in approximately 39.6% and 47%, respectively. The total variance in HRQoL explained by the entire model was 98%. Our findings may indicate the role that LEMS and BB play in the relationship between PA and HRQoL in the older population.info:eu-repo/semantics/publishedVersio

The use of remote labs to contextualize learning and teaching in engineering mathematics

Interdisciplinary education is an important aspect of critical thinking development in engineering students, as they prepare for their careers. This study reports the didactic experiences of the integration of remote experiment, simulations and calculations for learning and teaching higher education mathematics. These are the first experiences of the use of the remote electronics laboratory VISIR (Virtual Instrument Systems in Reality) in a didactic implementation in the engineering subjects of Calculus and Statistics. The strategy used in Calculus is to study a real electric circuit modeled by differential equations, covering 20% of the topics in the syllabus. In statistics, real experiments are used to collect, organise and interpret data, covering around 40% of the syllabus. The results show that students who benefited from this implementation not only feel more engaged and interested in engineering mathematics, but are also likely to develop new skills and achieve higher in mathematics subjects.N/

Light-emitting diode therapy (LEDT) before matches prevents increase in creatine kinase with a light dose response in volleyball players

Low-level laser (light) therapy (LLLT) has been applied over skeletal muscles before intense exercise (muscular pre-conditioning) in order to reduce fatigue and muscle damage (measured by creatine kinase, CK) in clinical trials. However, previous exercise protocols do not exactly simulate the real muscle demand required in sports. For this reason, the aim of this randomized and double-blind placebo-controlled trial was to investigate whether light-emitting diode therapy (LEDT) applied over the quadriceps femoris muscles, hamstrings, and triceps surae of volleyball players before official matches could prevent muscle damage (CK) with a dose response, establishing a therapeutic window. A professional male volleyball team (12 athletes) was enrolled in this study, and LEDT was applied before 4 matches during a national championship. LEDT used an array of 200 light-emitting diodes (LEDs) arranged in 25 clusters of 4 infrared LEDs (850 ± 20 nm; 130 mW) and 25 clusters of 4 red LEDs (630 ± 10 nm; 80 mW). Athletes were randomized to receive one of four different total doses over each muscle group in a double-blind protocol: 105 J (20 s), 210 J (40 s), 315 J (60 s), and placebo (no light for 30 s). CK in blood was assessed 1 h before and 24 h after each match. LEDT at 210 J avoided significant increases in CK (+10 %; P = 0.993) as well as 315 J (+31 %, P = 0.407). Placebo (0 J) allowed a significant increase in CK (+53 %; P = 0.012) as well as LEDT at 105 J (+59 %; P = 0.001). LEDT prevented significant increases of CK in blood in athletes when applied before official matches with a light dose response of 210–315 J, suggesting athletes might consider applying LEDT before competition.National Institutes of Health (U.S.) (Grant R01AI050875

Como não “Reinventar a Roda”?: a Anterioridade Tecnológica como base para o Desenvolvimento Tecnológico

Os avanços tecnológicos necessitam que as empresas sejam mais flexíveis e dinâmicas, possuindo capacidade de aprender e inovar para serem competitivas. Dada a inovação como algo novo, há a necessidade de se realizar estudos de anterioridade tecnológica antes do início das pesquisas, pois assim é possível conhecer as tecnologias existentes e desenvolver algo com potencial mercadológico. Assim, o objetivo deste artigo foi investigar os estudos de anterioridade tecnológica das patentes relacionadas a kits de diagnóstico para leishmaniose. Caracterizada como qualitativa e descritiva, a pesquisa foi baseada em dados secundários obtidos a partir de estratégias de buscas no banco de patentes Thomson Innovation, que possui uma vasta cobertura de patentes em todo o mundo e reúne ferramentas essenciais para a análise de propriedades intelectuais. Os resultados demonstraram que dos 44 documentos recuperados, 26 citaram ou foram citados por outros estudos. Das 412 citações realizadas,76% referem-se à Non-patents, principalmente artigos científicos, e 24% à Backwards, ou seja, patentes. Das Backwards, 53% referem-se a citações de invenções dos próprios países, demonstrando uma aproximação regional. Com relação à Forward, apenas 3 tecnologias foram referenciadas por estudos posteriores, o que pressupõe a importância dessas tecnologias para a evolução da ciência. Assim, evidenciou-se a relevância da anterioridade tecnológica, que vem sendo utilizada na realização de mapeamentos tecnológicos precedentes e no subsídio de estudos futuros

The VISIR+ Project – Helping Contextualize Math in an Engineering Course

The long-term goal of engineering education is to prepare students to work as engineers. Being a practical profession, laboratories play a crucial role in illustrating concepts and principles as well as improving technical skills. In the last decades the use of online resources (simulators and remote labs) has been growing, either as a complementary and/or as an alternative way of developing experimental competences. In the scope of the VISIR+ Project, this work presents the first results of a didactical implementation using simultaneously the remote laboratory VISIR (Virtual Instrument Systems in Reality), simulation and calculus in a Math Course at the Federal University of Santa Catarina (UFSC). The preliminary results indicate that the use of several resources increases students’ performance, boosting their learning and competence development.info:eu-repo/semantics/publishedVersio

Noise modeling and variance stabilization of a computed radiography (CR) mammography system subject to fixed-pattern noise

In this work we model the noise properties of a computed radiography (CR) mammography system by adding an extra degree of freedom to a well-established noise model, and derive a variance-stabilizing transform (VST) to convert the signal-dependent noise into approximately signal-independent. The proposed model relies on a quadratic variance function, which considers fixed-pattern (structural), quantum and electronic noise. It also accounts for the spatial-dependency of the noise by assuming a space-variant quantum coefficient. The proposed noise model was compared against two alternative models commonly found in the literature. The first alternative model ignores the spatial-variability of the quantum noise, and the second model assumes negligible structural noise. We also derive a VST to convert noisy observations contaminated by the proposed noise model into observations with approximately Gaussian noise and constant variance equals to one. Finally, we estimated a look-up table that can be used as an inverse transform in denoising applications. A phantom study was conducted to validate the noise model, VST and inverse VST. The results show that the space-variant signal-dependent quadratic noise model is appropriate to describe noise in this CR mammography system (errors< 2.0% in terms of signal-to-noise ratio). The two alternative noise models were outperformed by the proposed model (errors as high as 14.7% and 9.4%). The designed VST was able to stabilize the noise so that it has variance approximately equal to one (errors< 4.1%), while the two alternative models achieved errors as high as 26.9% and 18.0%, respectively. Finally, the proposed inverse transform was capable of returning the signal to the original signal range with virtually no bias.acceptedVersionPeer reviewe

Percutaneous vs. surgical treatment of patent ductus arteriosus in children and adolescents

INTRODUÇÃO: Estudos comparando os métodos percutâneo e cirúrgico no tratamento da persistência do canal arterial (PCA) são raros na literatura. Nosso objetivo foi realizar análise comparativa entre os dois métodos de tratamento da PCA, enfatizando os aspectos de eficácia e morbidade. MÉTODOS: Estudo observacional com 2 coortes de crianças e adolescentes &gt; 5 kg e < 14 anos, portadores de PCA, tratados durante um projeto de avaliação de incorporação de novas tecnologias ao Sistema Único de Saúde (SUS), realizado em um hospital cardiológico de excelência, em parceria com o Ministério da Saúde do Brasil. Foi feita análise prospectiva no grupo percutâneo entre 2009 e 2011 e retrospectiva no grupo cirúrgico entre 2006 e 2011. RESULTADOS: Foram incluídos 80 pacientes no grupo percutâneo (60% do sexo feminino) e 39 no grupo cirúrgico (51% do sexo feminino; P = 0,37). A mediana de idade e de peso dos grupos percutâneo e cirúrgico foi de 39,4 meses vs. 25,5 meses (P = 0,04) e de 14 kg vs. 11,1 kg (P = 0,052), respectivamente. No grupo percutâneo, 78 pacientes (92%) tinham PCA do tipo A e o diâmetro mínimo do canal à angiografia foi de 2,5 ± 1,2 mm. As próteses mais utilizadas foram Amplatzer®, molas de Gianturco e CeraTM. A técnica cirúrgica mais utilizada foi a clipagem. A taxa de sucesso dos procedimentos foi de 100% nos dois grupos. O grupo cirúrgico apresentou maiores taxas de complicação, incluindo quilotórax, infecções, necessidade de hemoderivados, hipertensão arterial sistêmica e uso de opioides, como também maior necessidade de terapia intensiva. A mediana do tempo de internação foi de 1,3 dia no grupo percutâneo e de 7,9 dias no grupo cirúrgico (P < 0,01). À alta hospitalar, as taxas de oclusão foram semelhantes nos dois grupos (91% no grupo percutâneo e 87% no grupo cirúrgico; P = 0,71). CONCLUSÕES: Em decorrência da menor morbidade, do menor tempo de internação e da igual eficácia, o tratamento percutâneo da PCA deve ser considerado a modalidade terapêutica de escolha para pacientes selecionados

Essential oils from leaves of cryptocarya spp from the atlantic rain forest

The essential oils from leaves of four Cryptocarya spp endemic in the Brazilian Atlantic rain forest were obtained by hydrodistillation and shown by GC-MS analysis to contain mono and sesquiterpenes. The major components of the oil of Cryptocarya moschata were linalool (34.3%), a-terpinene (17.0%), g-terpinene (10.4%), 1,8-cineole (5.8%) and trans-ocimene (4.8%), whilst those of C. botelhensis were a-pinene (22.7%), b-pinene (9.2%), trans-verbenol (8.4%), trans-pinocarveol (5.5%) and myrtenal (5.4%). The principal compounds of C. mandioccana oil were b-caryophyllene (13.8%), spathulenol (10.2%), caryophyllene oxide (7.8%), d-cadinene (6.9%) and bicyclogermacrene (6.4%), whilst those of C. saligna were germacrene D (15.5%), bicyclogermacrene (13.8%), spathulenol (11.8%) and germacrene B (5.7%)