Science and technology for the future

Dr Marc Molinari, Southampton Regional e-Science Centre, School of Engineering Sciences, looks at the increasing demand for Grid computing

High fidelity imaging in electrical impedance tomography

This thesis addresses the computational reconstruction of images using Electrical Impedance Tomography (EIT). EIT is an imaging method, in which electrical currents are injected through electrodes into a conducting volume and the resulting potential distribution is measured at surface electrodes. From these potentials, an image of the electrical conductivity can be obtained using numerical reconstruction techniques. This non-linear reconstruction is mathematically difficult and computationally intensive. Most applications in medicine and industry rely upon a fast and accurate image acquisition. The aim of this investigation is to find methods which improve the speed and accuracy of EIT by a range of improvements to the numerical methods used in the forward solution and inverse reconstruction. We investigate the impact of the finite element discretization on the performance of computing the electric field forward solution. We derive an a posteriori error estimate on the finite element mesh and implement 2D adaptive mesh refinement techniques in an optimised forward solver. Our results of this novel approach show that a speed-up of approximately an order of magnitude can be obtained. We extend the developed iterative Newton-Raphson algorithm to include image smoothness constraints and adaptive mesh refinement based on conductivity gradients in the image. The results show that the image resolution can be made independent of the underlying numerical discretization and therefore is limited only by the level of noise present in the measurements. An additional benefit of this new technique is the automatic focus of available computational resources on key regions for forward solution and inverse reconstruction. As 3D impedance imaging becomes computationally too expensive for the Newton-Raphson method, we develop a novel non-linear conjugate gradient algorithm incorporating 3D adaptive mesh refinement routines, and present results showing the decrease of memory requirements and the increase in image reconstruction performance. In addition, a Matlab software package containing optimised routines for the finite element-based computations in EIT has been developed as part of this work. Finally, we outline a method for obtaining a map for the determination of the reconstruction reliability and image correlation of an EIT algorithm. With the improvements to reconstruction accuracy and speed investigated in this thesis, we conclude that efficient non-linear 3D impedance imaging is feasibl

Integration of chargeable web services into engineering applications

We discuss an engineering case-study in which we address the issues of integration and secure consumption of a specialist software package for finite element meshing through a web service based interface. This work focuses on demonstrating the end-to-end requirements of a framework allowing the transparent integration of the web service into the design workflow of an engineering user. After detailing an example engineering problem, we discuss server-side issues and required modules such as local accounting, security and resource management which provide a sample framework for a chargeable web service. We then demonstrate how the client can easily interface to and consume the web service from within the engineering scripting language Matlab

Grid-enabled electromagnetic optimisation (GEM) for industrial use.

We have developed a tool for parametric electromagnetic design studies using industrial analysis code for the design search and optimisation of photonic crystals. This software tool allows engineering users to transparently access Grid compute components for an end-to-end design of a photonic device using computational electromagnetics. In this paper, we give an overview of the industrial application background, present some aspects of the interface developed, and discuss some of the issues involved in the computational tasks and the storage of metadata

SIOUX project: a simultaneous multiband camera for exoplanet atmospheres studies

The exoplanet revolution is well underway. The last decade has seen order-of-magnitude increases in the number of known planets beyond the Solar system. Detailed characterization of exoplanetary atmospheres provide the best means for distinguishing the makeup of their outer layers, and the only hope for understanding the interplay between initial composition chemistry, temperature-pressure atmospheric profiles, dynamics and circulation. While pioneering work on the observational side has produced the first important detections of atmospheric molecules for the class of transiting exoplanets, important limitations are still present due to the lack of sys- tematic, repeated measurements with optimized instrumentation at both visible (VIS) and near-infrared (NIR) wavelengths. It is thus of fundamental importance to explore quantitatively possible avenues for improvements. In this paper we report initial results of a feasibility study for the prototype of a versatile multi-band imaging system for very high-precision differential photometry that exploits the choice of specifically selected narrow-band filters and novel ideas for the execution of simultaneous VIS and NIR measurements. Starting from the fundamental system requirements driven by the science case at hand, we describe a set of three opto-mechanical solutions for the instrument prototype: 1) a radial distribution of the optical flux using dichroic filters for the wavelength separation and narrow-band filters or liquid crystal filters for the observations; 2) a tree distribution of the optical flux (implying 2 separate foci), with the same technique used for the beam separation and filtering; 3) an exotic solution consisting of the study of a complete optical system (i.e. a brand new telescope) that exploits the chromatic errors of a reflecting surface for directing the different wavelengths at different foci

Spectral classification of the brightest objects in the galactic star forming region W40

We present high S/N, moderate resolution near-infrared spectra, as well as 10 micron imaging, for the brightest members of the central stellar cluster in the W40 HII region, obtained using the SpeX and MIRSI instruments at NASA's Infrared Telescope Facility. Using these observations combined with archival Spitzer Space Telescope data, we have determined the spectral classifications, extinction, distances, and spectral energy distributions for the brightest members of the cluster. Of the eight objects observed, we identify four main sequence (MS) OB stars, two Herbig Ae/Be stars, and two low-mass young stellar objects. Strong HeI absorption at 1.083 micron in the MS star spectra strongly suggests that at least some of these sources are in fact close binaries. Two out of the four MS stars also show significant infrared excesses typical of circumstellar disks. Extinctions and distances were determined for each MS star by fitting model stellar atmospheres to the SEDs. We estimate a distance to the cluster of between 455 and 535 pc, which agrees well with earlier (but far less precise) distance estimates. We conclude that the late-O star we identify is the dominant source of LyC luminosity needed to power the W40 HII region and is the likely source of the stellar wind that has blown a large (~4 pc) pinched-waist bubble observed in wide field mid-IR images. We also suggest that 3.6 cm radio emission observed from some of the sources in the cluster is likely not due to emission from ultra-compact HII regions, as suggested in other work, due to size constraints based on our derived distance to the cluster. Finally, we also present a discussion of the curious source IRS 3A, which has a very strong mid-IR excess (despite its B3 MS classification) and appears to be embedded in a dusty envelope roughly 2700 AU in size.Comment: Accepted for publication in The Astronomical Journal. 29 pages, 10 figure

Knowing What the Peer Knows: The Differential Effect of Knowledge Awareness on Collaborative Learning Performance of Asymmetric Pairs

In an empirical study, we provided (or not) pairs of students working in a remote collaborative learning situation with a knowledge awareness tool that provided learner A with learner B’s level of knowledge measured through a pre-test. We analyzed the effect of the knowledge awareness tool on asymmetric pairs with regards to the prior-knowledge. Post-hoc analysis on the pairs’ knowledge level showed that the knowledge awareness tool mainly affects the learning performances of asymmetric pairs. Further analysis on the learners’ level showed that the knowledge awareness tool mainly affects the collaborative learning gain of the more-knowledgeable peers of asymmetric pairs. The results are discussed in light of socio-cognitive processes such as audience design and perspective taking

The Galactic dynamics revealed by the filamentary structure in atomic hydrogen emission

Funding: J.D.S., R.K.S., and S.C.O.G. are funded by the European Research Council via the ERC Synergy Grant “ECOGAL – Understanding our Galactic ecosystem: From the disk of the Milky Way to the formation sites of stars and planets” (project ID 855130). R.J.S. acknowledges funding from an STFC ERF (grant ST/N00485X/1) and HPC from the DiRAC facility (ST/P002293/1).We present a study of the filamentary structure in the atomic hydrogen (HI) emission at the 21 cm wavelength toward the Galactic plane using the observations in the HI4PI survey. Using the Hessian matrix method across radial velocity channels, we identified the filamentary structures and quantified their orientations using circular statistics. We found that the regions of the Milky Way's disk beyond 10 kpc and up to roughly 18 kpc from the Galactic center display HI filamentary structures predominantly parallel to the Galactic plane. For regions at lower Galactocentric radii, we found that the HI filaments are mostly perpendicular or do not have a preferred orientation with respect to the Galactic plane. We interpret these results as the imprint of supernova feedback in the inner Galaxy and Galactic rotation in the outer Milky Way. We found that the HI filamentary structures follow the Galactic warp and that they highlight some of the variations interpreted as the effect of the gravitational interaction with satellite galaxies. In addition, the mean scale height of the filamentary structures is lower than that sampled by the bulk of the HI emission, thus indicating that the cold and warm atomic hydrogen phases have different scale heights in the outer galaxy. Finally, we found that the fraction of the column density in HI filaments is almost constant up to approximately 18 kpc from the Galactic center. This is possibly a result of the roughly constant ratio between the cold and warm atomic hydrogen phases inferred from the HI absorption studies. Our results indicate that the HI filamentary structures provide insight into the dynamical processes shaping the Galactic disk. Their orientations record how and where the stellar energy input, the Galactic fountain process, the cosmic ray diffusion, and the gas accretion have molded the diffuse interstellar medium in the Galactic plane.Peer reviewe

Low-diluted Phenacetinum disrupted the melanoma cancer cell migration

Dynamic and reciprocal interactions generated by the communication between tumor cells and their matrix microenvironment, play a major role in the progression of a tumor. Indeed, the adhesion of specific sites to matrix components, associated with the repeated and coordinated formation of membrane protrusions, allow tumor cells to move along a determined pathway. Our study analyzed the mechanism of action of low-diluted Phenacetinum on murine cutaneous melanoma process in a fibronectin matrix environment. We demonstrated a reduction of dispersed cell migration, early and for as long as 24 h, by altering the formation of cell protrusions. Moreover, low-diluted Phenacetinum decreased cell stiffness highly on peripheral areas, due to a disruption of actin filaments located just under the plasma membrane. Finally, it modified the structure of the plasma membrane by accumulating large ordered lipid domains and disrupted B16 cell migration by a likely shift in the balance between ordered and disordered lipid phases. Whereas the correlation between the excess of lipid raft and cytoskeleton disrupting is not as yet established, it is clear that low-diluted Phenacetinum acts on the actin cytoskeleton organization, as confirmed by a decrease of cell stiffness affecting ultimately the establishment of an effective migration process