ENHANCED PRESENTATION EXPERIENCE FOR COLOR BLIND MEETING ATTENDEES

Techniques are described for adding support to an online meeting client or collaboration infrastructure, which allows a presentation media stream in an online meeting to be converted to a color blind friendly palette in real-time. A configuration wizard would be included in the online meeting client, which would guide the color blind attendee to select the palette best suited for their individual experience

INTELLIGENT MEETING GRAPH

Presented herein is a calendaring/collaboration application that displays a meeting graph with pin representation used to represent meeting attendee and room availability in order to facilitate meeting scheduling when multiple locations and time-zones are involved. The application will also suggest best available timeslots based on attendee and room locations

Mode-Locking of High-Power Resonant-Optical-Waveguide Diode Laser Arrays

We report the first mode-locked operation of a resonant optical waveguide (ROW semiconductor laser array. Pulsewidths as short as 23 ps and peak powers of over 1W are generated in a single-lobed beam

Priority setting: women’s health topics in multiple sclerosis

Cancer; Multiple sclerosis; Women’s healthCàncer; Esclerosi múltiple; Salut de la donaCáncer; Esclerosis múltiple; Salud de la mujerBackground: A scoping review found that most studies on women’s health in multiple sclerosis (MS) focused on pregnancy, fetal/neonatal outcomes and sexual dysfunction. Few studies addressed menopause, contraception, gynecologic cancers/cancer screening. However, the perceived relative importance of these knowledge gaps to people living with MS and other partners is unknown. We engaged a range of partners, including people living with MS, health care providers, researchers, and patient advocacy groups, to set priorities for future research in women’s health in MS. Methods: We employed a three-step global engagement process. First, we identified which broad research topics relevant to women’s health in MS were of highest priority using two surveys. Second, we developed specific research questions within these topics using focus groups. Finally, we prioritized the research questions with a third survey. Results: Overall, 5,266 individuals responded to the initial surveys [n = 1,430 global survey, mean (SD) age 50.0 (12.6), all continents; n = 3,836 North American Research Committee on Multiple Sclerosis survey, mean (SD) age 64.8 (9.6), United States]. Menopause, sexual dysfunction, pregnancy, gynecologic cancer/cancer screening, hormones and parenthood were identified as the most important topics. Focus groups generated 80 potential research questions related to these topics. In the final survey 712 individuals prioritized these questions. The highest priority questions in each research topic were: (i) How do perimenopause and menopause affect disease activity, course, response to disease-modifying treatment and quality of life in MS; (ii) What are the most effective strategies for managing issues around sexual intimacy, including related to low sexual desire, changes in physical function, and MS symptoms; (iii) Are there long-term effects of disease-modifying therapies on the children of persons with MS; (iv) What are the short and long-term effects of disease-modifying drugs on gynecologic cancer risk, particularly for high efficacy disease-modifying drugs and hematopoietic stem cell transplantation; (v) Are there hormone related treatments that can stabilize fluctuations in MS symptoms; and (vi) How does MS fatigue impact parenting strategies. Conclusion: Priorities for research relating to women’s health issues for persons with MS have been delineated using a collaborative process with key partners. Alignment of future research with these priorities should be monitored.The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The International Advisory Committee on Clinical Trials in MS is sponsored by the European Committee for Treatments and Research in MS and the National Multiple Sclerosis Society. NARCOMS is a project of the Consortium of Multiple Sclerosis Centers (CMSC). NARCOMS is funded in part by the CMSC and the Foundation of the CMSC. The study was also supported in part by the Waugh Family Chair in Multiple Sclerosis (to RM). The funding source(s) had no role in the study design, collection, analysis or interpretation of the data, nor in the decision to submit the article for publication

Faraday rotation and polarization gradients in the jet of 3C~120: Interaction with the external medium and a helical magnetic field?

We present a sequence of 12 monthly polarimetric 15, 22, and 43 GHz VLBA observations of the radio galaxy 3C 120 revealing a systematic presence of gradients in Faraday rotation and degree of polarization across and along the jet. The degree of polarization increases with distance from the core and toward the jet edges, and has an asymmetric profile in which the northern side of the jet is more highly polarized. The Faraday rotation measure is also stratified across the jet width, with larger values for the southern side. We find a localized region of high Faraday rotation measure superposed on this structure between approximately 3 and 4 mas from the core, with a peak of about 6000 rad/m^2. Interaction of the jet with the external medium or a cloud would explain the confined region of enhanced Faraday rotation, as well as the stratification in degree of polarization and the flaring of superluminal knots when crossing this region. The data are also consistent with a helical field in a two-fluid jet model, consisting of an inner, emitting jet and a sheath containing nonrelativistic electrons. However, this helical magnetic field model cannot by itself explain the localized region of enhanced Faraday rotation. The polarization electric vectors, predominantly perpendicular to the jet axis once corrected for Faraday rotation, require a dominant component parallel to the jet axis (in the frame of the emitting plasma) for the magnetic field in the emitting region.Comment: Accepted for publication in ApJ Letters. 4 pages (including 5 figures

Identification and Characterization of Wheat Streak Mosaic Virus Isolates in Wheat-Growing Areas in Brazil

Wheat streak mosaic virus (WSMV—Potyviridae, Tritimovirus), transmitted by the eriophyid mite Aceria tosichella Keifer (Acari: Eriophyidae), was considered a quarantine pest in South America. Since the first report of virus in Argentina, the vector has been found in Argentina, Uruguay and Brazil. The objective of this work was to determine the occurrence of WSMV in Brazil and characterize isolates from wheat-growing areas. Between 2009 and 2011, a total of 40 samples collected in wheat (Triticum aestivum) growing areas, where the presence of the mite was previously related, were tested by RT-PCR for virus detection. Six isolates of WSMV were obtained and characterized by sequencing. Two of them had their host range determined. The Brazilian WSMV isolates clustered in clade D are closely related to the Argentine isolate Arg2 (FJ348359). As expected, isolates were unable to infect dicotyledons plants. They caused mosaic in Triticum aestivum, Hordeum vulgare, Secale cereale, ×Triticosecale, and Zea mays, and they were also able to infect Avena sativa. The presence of WSMV in wheat-growing areas of the Brazilian state Rio Grande do Sul was confirmed, possibly having been introduced from a common source and/or direct vector bearing virus migration from Argentina

Extremely high frequency RF effects on electronics.

The objective of this work was to understand the fundamental physics of extremely high frequency RF effects on electronics. To accomplish this objective, we produced models, conducted simulations, and performed measurements to identify the mechanisms of effects as frequency increases into the millimeter-wave regime. Our purpose was to answer the questions, 'What are the tradeoffs between coupling, transmission losses, and device responses as frequency increases?', and, 'How high in frequency do effects on electronic systems continue to occur?' Using full wave electromagnetics codes and a transmission-line/circuit code, we investigated how extremely high-frequency RF propagates on wires and printed circuit board traces. We investigated both field-to-wire coupling and direct illumination of printed circuit boards to determine the significant mechanisms for inducing currents at device terminals. We measured coupling to wires and attenuation along wires for comparison to the simulations, looking at plane-wave coupling as it launches modes onto single and multiconductor structures. We simulated the response of discrete and integrated circuit semiconductor devices to those high-frequency currents and voltages, using SGFramework, the open-source General-purpose Semiconductor Simulator (gss), and Sandia's Charon semiconductor device physics codes. This report documents our findings

Antithetic effect of interferon-α on cell-free and cell-to-cell HIV-1 infection

In HIV-1-infected individuals, transmitted/founder (TF) virus contributes to establish new infection and expands during the acute phase of infection, while chronic control (CC) virus emerges during the chronic phase of infection. TF viruses are more resistant to interferon-alpha (IFN-α)-mediated antiviral effects than CC virus, however, its virological relevance in infected individuals remains unclear. Here we perform an experimental-mathematical investigation and reveal that IFN-α strongly inhibits cell-to-cell infection by CC virus but only weakly affects that by TF virus. Surprisingly, IFN-α enhances cell-free infection of HIV-1, particularly that of CC virus, in a virus-cell density-dependent manner. We further demonstrate that LY6E, an IFN-stimulated gene, can contribute to the density-dependent enhancement of cell-free HIV-1 infection. Altogether, our findings suggest that the major difference between TF and CC viruses can be explained by their resistance to IFN-α-mediated inhibition of cell-to-cell infection and their sensitivity to IFN-α-mediated enhancement of cell-free infection

Mobility of Transgenic Nucleic Acids and Proteins within Grafted Rootstocks for Agricultural Improvement

Grafting has been used in agriculture for over 2000 years. Disease resistance and environmental tolerance are highly beneficial traits that can be provided through use of grafting, although the mechanisms, in particular for resistance, have frequently been unknown. As information emerges that describes plant disease resistance mechanisms, the proteins, and nucleic acids that play a critical role in disease management can be expressed in genetically engineered (GE) plant lines. Utilizing transgrafting, the combination of a GE rootstock with a wild-type (WT) scion, or the reverse, has the potential to provide pest and pathogen resistance, impart biotic and abiotic stress tolerance, or increase plant vigor and productivity. Of central importance to these potential benefits is the question of to what extent nucleic acids and proteins are transmitted across a graft junction and whether the movement of these molecules will affect the efficacy of the transgrafting approach. Using a variety of specific examples, this review will report on the movement of organellar DNA, RNAs, and proteins across graft unions. Attention will be specifically drawn to the use of small RNAs and gene silencing within transgrafted plants, with a particular focus on pathogen resistance. The use of GE rootstocks or scions has the potential to extend the horticultural utility of grafting by combining this ancient technique with the molecular strategies of the modern era

On the source of Faraday rotation in the jet of the radio galaxy 3C120

The source of Faraday rotation in the jet of the radio galaxy 3C120 is analyzed through Very Long Baseline Array observations carried out between 1999 and 2007 at 86, 43, 22, 15, 12, 8, 5, 2, and 1.7 GHz. Comparison of observations from 1999 to 2001 reveals uncorrelated changes in the linear polarization of the underlying jet emission and the Faraday rotation screen: while the rotation measure (RM) remains constant between approximately 2 and 5 mas from the core, the RM-corrected electric vector position angles (EVPAs) of two superluminal components are rotated by almost 90 degrees when compared to other components moving through similar jet locations. On the other hand, the innermost 2 mas experiences a significant change in RM -- including a sign reversal -- but without variations in the RM-corrected EVPAs. Similarly, observations in 2007 reveal a double sign reversal in RM along the jet, while the RM-corrected EVPAs remain perpendicular to the jet axis. Although the observed coherent structure and gradient of the RM along the jet supports the idea that the Faraday rotation is produced by a sheath of thermal electrons that surrounds the emitting jet, the uncorrelated changes in the RM and RM-corrected EVPAs indicate that the emitting jet and the source of Faraday rotation are not closely connected physically and have different configurations for the magnetic field and/or kinematical properties. Furthermore, the existence of a region of enhanced RM whose properties remain constant over three years requires a localized source of Faraday rotation, favoring a model in which a significant fraction of the RM originates in foreground clouds.Comment: 12 pages, 11 figures; Accepted for publication in Ap