10 research outputs found
CCR7 as a novel therapeutic target in t-cell PROLYMPHOCYTIC leukemia
- Author
- Alfranca Arantzazu
- Andersson Emma I.
- Cuesta-Mateos Carlo
- Espartero-Santos Marina
- Faber Edgar
- Fresno Manuel
- Fuentes Patricia
- Herling Marco
- Juarez-Sanchez Raquel
- Jungherz Dennis
- Kreutzman Anna
- Loscertales Javier
- Marcos-Jimenez Ana
- Mateu-Albero Tamara
- Munoz-Calleja Cecilia
- Mustjoki Satu
- Oberbeck Sebastian
- Perez-Garcia Yaiza
- Sanchez-Lopez Blanca Andrea
- Schrader Alexandra
- Stamatakis Kostantino
- Terron Fernando
- Toribio Maria Luisa
- Urzainqui Ana
- Vega-Piris Lorena
- Wahnschaffe Linus
- Publication venue
- Publication date
- 01/01/2020
- Field of study
T-cell prolymphocytic leukemia (T-PLL) is a poor prognostic disease with very limited options of efficient therapies. Most patients are refractory to chemotherapies and despite high response rates after alemtuzumab, virtually all patients relapse. Therefore, there is an unmet medical need for novel therapies in T-PLL. As the chemokine receptor CCR7 is a molecule expressed in a wide range of malignancies and relevant in many tumor processes, the present study addressed the biologic role of this receptor in T-PLL. Furthermore, we elucidated the mechanisms of action mediated by an anti-CCR7 monoclonal antibody (mAb) and evaluated whether its anti-tumor activity would warrant development towards clinical applications in T-PLL. Our results demonstrate that CCR7 is a prognostic biomarker for overall survival in T-PLL patients and a functional receptor involved in the migration, invasion, and survival of leukemic cells. Targeting CCR7 with a mAb inhibited ligand-mediated signaling pathways and induced tumor cell killing in primary samples. In addition, directing antibodies against CCR7 was highly effective in T-cell leukemia xenograft models. Together, these findings make CCR7 an attractive molecule for novel mAb-based therapeutic applications in T-PLL, a disease where recent drug screen efforts and studies addressing new compounds have focused on chemotherapy or small molecules.Peer reviewe
Canagliflozin and renal outcomes in type 2 diabetes and nephropathy
- Author
- A Kaldun Nossuli
- Aamir Jamal
- Adalbert Schiller
- Adam Cheifetz
- Adarsh Daswani
- Adeera Levin
- Adline Ghazi
- Adrian Guinsburg
- Adriana Cif
- Adriana Gabriela Onaca
- Adriana Ilavska
- Adriana Villarino
- Agarwal R.
- Agnieszka Starzec
- Ahmed Arif
- Ahmed Awad
- Aiping Yin
- Akimichi Asano
- Alan Jackson
- Alan McMahon
- Alan Perlman
- Alberto Di Carlo
- Alberto Esquenazi
- Alejandra Oviedo
- Alejandro Valdes Depeda
- Aleksandra Kendereski
- Alex Valenzuela
- Alexander Dreval
- Alexander Gonzalez
- Alexander Shinkov
- Alexander Turchin
- Alexandre Klein
- Alfonso Soto Gonzalez
- Alfred Penfornis
- Alfredo Chew Wong
- Alfredo Wassermann
- Ali Torshizi
- Alicia Chilito
- Alina Agafyina
- Alison Dawson
- Alva Hansraj
- Amer Al-Karadsheh
- Amorin Remus Popa
- Amrendra Kumar
- Amy Sprague
- Ana Limos
- Ana Maria Cusumano
- Ana Maria Elosegui
- Anabella Amigo
- Anatoliy Kazmirchuk
- Andrea Phillips
- Andrea Stella
- Andreas Maddux
- Andrej Dzupina
- Andres Alvarisqueta
- Andrew Johnson
- Andrew O'Shaughnessy
- Andrew Steele
- Andrian Yakov
- Andrzej Januszewicz
- Andrzej Madej
- Angelina Angelova
- Anibal Gastaldi
- Anil Gupta
- Anita Bhajan Manocha
- Anjanette Tan
- Anna Kaminska
- Anna Maria Veronelli
- Anna Strzelecka
- Anna Zateyshchikova
- Anselmo Bordonava
- Antanas Navickas
- Anthony Gunstone
- Anthony Roberts
- Antonio Ceriello
- Antonio Galan Serrano
- Antonio Scafuto Scotton
- Antonio Terrelonge
- Antônio Roberto Chacra
- Anupama Gowda
- Arjun D Sinha
- Armando Perez
- Ashot Mkrtumyan
- Atanas Koundurdjiev
- Augusto Vallejos
- Aurelian-Emil Ranetti
- Ayim Akyea-Djamson
- Aysha Badat
- Bakris G.
- Baldev Singh
- Barbara Greco
- Barbara Kaczmarek
- Barbara Rewerska
- Barry M Brenner
- Belia Martin Del Camp Blanco
- Bernard Zinman
- Bertrand Cariou
- Bertrand Dussol
- Bhasker Mehta
- Bhimavarapu Sudhakar
- Björn Paschen
- Bompoint S.
- Borys Mankovskyy
- Botond Csiky
- Boyan Nonchev
- Brenner B. M.
- Brett Kissela
- Brian Nichol
- Bruce Neal
- Bruce Trippe
- Bruno Geloneze Neto
- Bull S.
- Byung-Wan Lee
- C B Keshavamurthy
- Cannon C. P.
- Capuano G.
- Carlo Giorda
- Carlos Alberto Cuneo
- Carlos Arauz-Pacheco
- Carlos Barrera
- Carlos Perez
- Carmel Hawley
- Carmen Crisan
- Carol Pollock
- Carolyn Droste
- Caroucel Chuateco
- Caryl David
- Cecilia Garcia Ballesteros
- Cecilia Jimeno
- Celso Amodeo
- Cesar Javier Zaidman
- Cesar Yoiti Hayashida
- Chamberlain Obialo
- Chang-Hsun Hsieh
- Charles Cook
- Charles Kaupke
- Charytan D. M.
- Chek Loong Loh
- Chen Leia
- Cheol-Young Park
- Chih-Ching Lin
- Christopher P Cannon
- Christy Yao
- Chu P. -L.
- Chwen-Tzuei Chang
- Chye Lee Gan
- Clara Barrios
- Claude Galphin
- Claudia Goycoa
- Claudia Moreira de Brito
- Clodoaido Caringal
- Cristian Serafinceanu
- Cristina Toarba
- Cristobal Morales Portillo
- Csaba Kovesdy
- Cynthia Bowman-Stroud
- Cynthia Christiano
- Cynthia Mustieles Rocha
- Cyrus Desouza
- Cássio Slompo Ramos
- Dagmar Bartaskova
- Dale Crawford Allison
- Dalia Kozloviene
- Dan Scharfstein
- Dana Cosma
- Daniel Coyne
- Daniel Hiser
- Daniel Kolansky
- Daniel Panarotto
- Daniel Pella
- Daniel Weiner
- Daniil Chizhov
- Dariusz Sowinski
- Darren K McGuire
- Davesh Sennik
- David C Wheeler
- David Cherney 3rd
- David Gorson
- David Johnson
- David M Charytan
- David Packham
- David Scott
- David Wheeler
- De Zeeuw D.
- Debbie Cohen-Stein
- Debbie Mascaro
- Deepak Koppolu
- Dennis Levinson
- Derek Lewis
- Detian Li
- Devasmita Dev
- Devesh Patel
- Dewan Deepak
- Dick de Zeeuw
- Diego Aizenberg
- Dinesh Jain
- Dinesh Khullar
- Diogo Belo
- Dmitry Zateyshshikov
- Domenico Santoro
- Domingos d'Avila
- Donald Brandon
- Donald Fraser
- Dong-Wan Chae
- Dora Inés Molina de Salazar
- Dorota Mlodawska-Choluj
- Doru Negru
- Edgar Arcos
- Edoardo Mannucci
- Eduardo Farias
- Edward Watson
- Edwards R.
- Egle Gaupsiene
- Egle Urbanaviciene
- Ekaterina Velichkova
- Elena Christofides
- Elena Grineva
- Elena Kolmakova
- Elena Shutemova
- Eleonora Harcsa
- Elizabeth Barranco
- Elizabeth Gelersztein
- Elizabeth Kern
- Elizete Keitel
- Eloisa Tellez Chavez
- Emanuela Orsi
- Emil Martinka
- Emyr Davies
- Enrique Gonzalez
- Eric Alamartine
- Eric Hernandez Triana
- Eric Thervet
- Erick Turcios Juarez
- Esteban Cercos
- Eugenia Galindo-Ramos
- Eva Peterfai
- Evaly Chen
- Evandro de Souza Portes
- Evgueniy Vazelov
- Fabian Otreras
- Fabiana Loss de Carvalho Contieri
- Fabio Malberti
- Fadi Saba
- Fadlo Fraige Filho
- Favio Edmundo Enriquez Sosa
- Fayzal Ahmed
- Ferdinando Carlo Sasso
- Fernanco Augusto Alves da Costa
- Fernanda Cristina Camelo Sanches
- Fernando Cereto Castro
- Fernando Flores Lozano
- Fernando Jimenez Florez
- Fernando Krynski
- Fernando M Edwin
- Fernando Thomé
- Fernando Trespalacios
- Florence Santos
- Florencia Kraft
- Fracisco Javier Gonzalez Martinez
- Fran Morren
- Franciso Jose Tinahones Madueno
- Frank Eder
- Franklin Joseph
- Franklin Paul Haase
- Frantisek Saudek
- François Dubé
- François Madore
- Freemu Varghese
- Gabriela Cecilia Coloma
- Gabriela Genova-Hristova
- Gabriele von Ingersleben
- Gaetano Serviddio
- Galina Nagibovich
- Gary Meininger
- Gema Fernandez Fresnedo
- Georg Plassmann
- George Bakris
- George Hon
- George Newman
- Gerald DaRoza
- Gerald Keightley
- Gerry Tan
- Giacomo Garibotto
- Giorgio Fuiano
- Giovanni Frascà
- Giovanni Gambaro
- Giuseppe Derosa
- Gizella Petro
- Glenn Chertow
- Gnyandev Patel
- Godwin Simon
- Goga Vukotic
- Gopal Krishna
- Grace Aquitania
- Grace Lin
- Graham Hillis
- Graziano Di Cianni
- Grazyna Orlowska-Kowalik
- Grazyna Popenda
- Greene T.
- Greg Fulcher
- Gregorio Obrador
- Gregorio Obrador Vera
- Grit Faulmann
- Guadalupe Morales Franco
- Guillermo Fragale
- Guixia Wang
- Gulam Latiff
- Gustavo Cristian Greloni
- Guy Chouinard
- Gyongyi Csecsei
- Gyorgy Paragh
- Halyna Tomashkevych
- Hans Prozesky
- Harpreet Bajaj
- Hasnain Khandwala
- Hector Rodriguez
- Heerspink H. J. L.
- Helena Oosthuizen
- Hendrik Nortje
- Henry Watson
- Hermann Haller
- Hernan Finkelstein
- Hernan Yupanqui
- Hiddo J L Heerspink
- Hiralal Maheshwari
- Hiroko Oishi
- Hiromi Aoki
- Hiromi Rodriguez Pattzi
- Hiroshi Kono
- Hitoshi Akiyama
- Holly Wang
- Hong Mao
- Hong Zhang
- Hongguang Zheng
- Hongli Lin
- Horacio Sessa
- Hugo Colombo
- Hugo Laviada Molina
- Hugo Roberto Kurtz Lisboa
- Humberto Pavon
- Hyuk-Sang Kwon
- Iain MacDougall
- Ian Fraser
- Idalia Acosta
- Ildiko Halmagyi
- In-Kyung Jeong
- Ines Bartolacci
- Ingrid Abrahamsen
- Ingrid Buganova
- Inna Kolesnyk
- Ioana Emilia Ferariu
- Irene Noronha
- Irina Glinkina
- Irina Osipova
- Iryna Dudar
- Isabel Erika Rucker Joerg
- Isabel Garcia
- Isam Marar
- Israel Hartman
- Iuliia Komisarenko
- Ivan Fushtey
- Ivan Ory
- Ivan Rychlik
- Ivan Rychlík
- Ivan Smirnov
- Ivan Topchii
- Ivan Villegas
- Iveta Smatanova
- Jaco Jurgens
- Jakkidi Reddy
- Jamal Hammoud
- James Conway
- James Januzzi
- James Welker
- Jan Culak
- Jana Babikova
- Jana Belobradkova
- Jana Dzuponova
- Janos Mucsi
- Jardine M. J.
- Jason Gaglia
- Javier Narvarte
- Javier Nieto Iglesias
- Jayameena Peringat
- Jayant Kumar
- Jean Carlo Tibes Hachmann
- Jean Welsh
- Jean-Pierre Fauvel
- Jeevren Reddy
- Jeffrey Kropp
- Jeffrey Stephens
- Jeimeen Agra
- Jelena Ignjatovic
- Jesus Cuadrado
- Jesus Egido de Los Rios
- Jian Liu
- Jiao Sun
- Jinkui Yang
- Jiri Lastuvka
- Jiri Pumprla
- Joaquin Pablo Gonzalez
- Johannes Breedt
- John Amerena
- John Baker
- John Ervin
- John Evans
- John Lentz
- John Middleton
- John Padron
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- John Updegrove
- John Wakeling
- Jonay Pantoja Perez
- Jorge Archibaldo Glenny
- Jorge Avendano
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- Jorge Hector Resk
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- Jorge Mordujovich
- Jorgelina Sala
- Jose Antonio Sánchez Arenales
- Jose Chevaile Ramos
- Jose David Gomez Rangel
- Jose Esteban Jodar Gimeno
- Jose Francisco Kerr Saraiva
- Jose Hector Sanchez Mijangos
- Jose L Górriz
- Jose Luis Accini Mendoza
- Jose Ma Portoles Perez
- Jose Osvaldo Fretes
- Jose Ricardo Correa Rotter
- Joseph Abdallah
- Joseph Aiello
- Joseph Feuerstein
- Joseph O'Hare
- Joseph Proietto
- Josier Nisnisan
- José Vicente Sanchez Polo
- João Lindolfo Cunha Borges
- João Soares Felício
- Juan Alfredo Tamayo Y Orozco
- Juan Baas Cruz
- Juan Carlos Santos
- Juan Diego Higuera
- Juan Frias
- Juan Gonzalo Godoy Jorquera
- Juan Pablo Albisu
- Juan Pablo Moreira Diaz
- Juan Peralta Calcaneo
- Juan Rosas Guzman
- Juan Villagordoa Mesa
- JungEun Lee
- Kamal Abouglila
- Karel Peterka
- Karina Hufert
- Karlton Pettis
- Katalin Keltai
- Katalin Revesz
- Katarina Halciakova
- Katarina Lalic
- Kathy Nicholls
- Kati De Brouwer
- Kazuhiro Yanagida
- Kazunori Koyama
- Kazuyuki Mizuyama
- Kee Sing Ng
- Kenneth Cohen
- Kenneth Deck
- Kenneth Hershon
- Kenneth Liss
- Kenneth W Mahaffey
- Khalid Abdul Kadir
- Khurram Wadud
- Kim Travis
- Kiril Hristozov
- Kook-Hwan Oh
- Krisztian Kiss
- Kun Ho Yoon
- Lachezar Lozanov
- Lajos Major
- Lalaine Delos Santos
- Landman Lombard
- Larisha Pillay-Ramaya
- Larry Distiller
- Larysa Pererva
- Laszlo Deak
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- Laura Akright
- Laura Coffee
- Lawrence Distiller
- Lawrence Lehrner
- Lawrence Leiter
- Lech Lazuka
- Lee-Ming Chuang
- Lenka Dohnalova
- Leslie Spry
- Levin A.
- Li Yuan Lee
- Lidia Bermudez
- Ligia Petrica
- Lilia Beatriz Schiavi
- Liliana Monica Angelescu
- Liliia Zub
- Liliya Martynyuk
- Lin Sun
- Lincoln Chapin
- Linong Ji
- Lisa Rich
- Liudmila Kvitkova
- Lori Yost
- Luca Chiovato
- Luca De Nicola
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- Ludger Rose
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- Luis Asmarats Mercadal
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- Luis Enrique Herrera Jimenez
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- Luis Isaias Juncos
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- Luis Venegas Carrillo
- Luiz Alberto Andreotti Turatti
- Luiza Despina Demian
- László Rosivall
- Ma Dovie Lallaine Ygpuara
- Mahaffey K. W.
- Manel Terns Riera
- Manish Saxena
- Manthi Hettiarachchi
- Manuel Muñoz Lopez Mendoza
- Manuel Muñoz Torres
- Manuela Schmidt
- Marc Rendell
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- Marcelo Medina Fariña
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- Marcus Gomes
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- Margo Hudson
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- Maria Florencia Fernandez
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- Mary Lawrence
- Mary Seeber
- Maryna Vlasenko
- María Alicia Fernández Montenegro
- María Angustias Quesada Simón
- Masahiko Takai
- Masahiro Koizumi
- Masakiyo Wakasugi
- Masayo Yamada
- Mastura Ismail
- Matthew Abramowitz
- Matthew Beacom
- Meg J Jardine
- Meg Jardine
- Meininger G.
- Melchor Alpizar Salazar
- Melemadathil Sreelatha
- Merce Perez Vera
- Mercedes Velo Plaza
- Michael Oliver
- Michael Robinson
- Michael Shanik
- Michael Thompson
- Michael Williams
- Michal Nowicki
- Michał Nowicki
- Michelle Zaniewski-Singh
- Mick Kumwenda
- Miguel Nazzer Hissa
- Migues Angel Reyes Rosano
- Mihaela Biscoveanu
- Mihaela-Magdalena Busegeanu
- Mihaly Dudas
- Milan Gupta
- Min Jeong Kwon
- Minara Shamkhalova
- Minghui Zhao
- Miodrag Djordjevic
- Mircea Munteanu
- Mitsuru Tsujimoto
- Mohamed El-Shahawy
- Mohamed Mookadam
- Mohamed Railey
- Mohamed Sekkarie
- Mohanram Narayanan
- Mohd Daud Che Yusof
- Mohsen El Kossi
- Mona Wahba
- Monica Alexandra Terront Lozano
- Monika Dhillon
- Moogali Arvind
- Moon-Kyu Lee
- Moon-Suk Nam
- Moustafa Moustafa
- Muhammad Shakeel
- Mukesh Joshi
- Mykola Kolesnyk
- Márcio Antônio Pereira
- Nadia Zalunardo
- Nadiya Tryshchuk
- Nan Chen
- Narayan Prasad
- Naresh Aggarwal
- Natalia Malaver
- Nataliia Pashkovska
- Natarajan Gopalakrishnan
- Navdeep Tangri
- Naveen Atray
- Neal B.
- Nebojsa Lalic
- Neil Kumar
- Nelson Kopyt
- Nelson Rodriguez Papini
- Nestor Horacio Garcia
- Ngai Wah Cheung
- Nicolae Hancu
- Nicole Li
- Nik Nur Fatnoon Nik Ahmad
- Nina Patel
- Nizar Daboul
- Noble Gracious
- Nomangesi Ngcakani
- Nonna Kravchun
- Nora Marchetta
- Norman Muirhead
- Norsiah Ali
- Oleg Legun
- Oleg Nagibovich
- Oleg Uriasyev
- Oleksandr Golovchenko
- Oleksandr Samoylov
- Oleksii Korzh
- Olga Barbarash
- Olga Barna
- Olga Barysheva
- Olga Benusova
- Olga Godlevska
- Olga Gyrina
- Olga Sazonova
- Olivert Gomez
- Oomman Abraham
- Osamu Tomonaga
- Oscar Tarsicio Moreno Loza
- Osvaldo Brusco
- Pablo Antonio Novoa
- Pablo Mele
- Pablo Raffaele
- Pablo Serrano Sanson
- Paranthaman Vengadasalam
- Patricia Del Carmen Gonzalez Colaso
- Patrick English
- Patrick Parfrey
- Paul Ainsworth
- Paul Frenk Baron
- Paul Nixon
- Paul Noonan
- Paul Rheeder
- Paulina Virginia Lanchiotti
- Pavel Weiner
- Peak Mann Mah
- Pedro Calella
- Pedro de Souza
- Pedro Velasquez-Mieyer
- Peggy Barnhill
- Peggy Lin
- Pere Alvarez Garcia
- Perkovic V.
- Peter Danos
- Peter Fulop
- Peter Van Buren
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- Petr Barton
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- Philip Home
- Philip Nicol
- Philippe Zaoui
- Phyllis August
- Piermarco Piatti
- Pierre Gourdy
- Pierre-Jean Saulnier
- Pietro Castellino
- Pilar Trueba
- Ping Tu
- Pollock C.
- Prasanth Surampudi
- Pusadee Suchinda
- Qinkai Chen
- Rachel Bregman
- Radica Alicic
- Radu Jacob
- Rafael Simo Canonge
- Raied Abdullah
- Rajendran Alappan
- Rajiv Agarwal
- Rajiv Ranjan
- Raju Sree Bhushan
- Rakesh Gulati
- Rakhi Khanna
- Rallabhandi Sankaram
- Raman Purighalla
- Ramesh Chandra Vyasam
- Ramesh Thimmaiah
- Ramon Berenguer
- Ramon Moreda
- Rangel Rangelov
- Rao K Satyanarayana
- Ravendran Govender
- Ravi Sarin
- Reddy Sreedhar
- Reginald Parker
- Rehan Symonds
- Reinhold Jerwan-Keim
- Remi Rabasa-Lhoret
- Renan Montenegro Junior
- Renata Bijata-Bronisz
- Rhea Severina Comia
- Rhonda Bentley-Lewis
- Riad Darwish
- Ricardo Alfonso Leon de la Fuente
- Ricardo Dario Dran
- Ricardo Rosero
- Riccardo Bonadonna
- Richard Ferkl
- Richard Kovar
- Richard Lindley
- Richard Orozco Castellanos
- Richard Solomon
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- Robert Cohen
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- Roberto Jorge da Silva Franco
- Roberto Pecoits Filho
- Roberto Pecoits-Filho
- Roberto Simões de Almeida
- Roberto Trevisan
- Rodica-Ioana Avram
- Rodolfo Andres Ahuad Guerrero
- Rohana Abdul Ghani
- Rohit Pankhaniya
- Rolando Zamarripa Escobedo
- Ronald Goldenberg
- Ronald Harris
- Ronald Watts
- Ronaldo Arturo Gonzalez Orellana
- Ronan Roussel
- Ronnie Aronson
- Rosa Isela Luna Ceballos
- Rosângela Milagres
- Ruben Dario Vargas Alonso
- Rury Holman
- Russell Scott
- Sacha De Serres
- Sahay Manisha
- Saiful Shahrizal Bin Shudim
- Sailaja Ventrapragada
- Salah Abusnana
- Salvatore De Cosmo
- Sam Henein
- Sam Philip
- Samuel Cohen
- Samuel Mujica Trenche
- Samy Hadjadj
- Sandor Keresztesi
- Sandor Vangel
- Sandra Berenice Saaveddra Sanchez
- Sanjeev Rastogi
- Sara Jaffer
- Sarah Olelewe
- Satoshi Ota
- Satu Pesickova
- Scott Kasner
- Secundino Cigarran Guldris
- Senan Sultan
- Serge Cournoyer
- Sergei Nedogoda
- Sergey Vorobyev
- Sergio Saul Irizar Santana
- Shahabul Arfeen
- Shahnaz Shahinfar
- Shang-Jyh Hwang
- Shelley Williams
- Shenaz Ramtoola
- Shenglian Gan
- Sherry Sussman
- Shizuo Kajiyama
- Shozo Miyauchi
- Silvia Ines Orio
- Silvia Nicolai
- Simon Davies
- Simon Roger
- Simon Young
- Sin Gon Kim
- Singhan Krishnan
- Sini George
- Slobodan Antic
- Sohan Dua
- Sonia Hermida
- Soo Kun Lim
- Sophie Borot
- Souhila Ounadjela
- Sreedhar Mandayam
- Srikanth Bellary
- Stanislav Zemek
- Stanislaw Mazur
- Stefan Dimitrov
- Stephan Maxeiner
- Stephen Grubb
- Stephen Smith
- Steven Fishbane
- Stuart Handelsman
- Suely Keiko Kohara
- Sun Kim
- Sun-Hee Park
- Sunil Sheth
- Susumu Kashine
- Svetlana Goykhman
- Svitlana D Bilyk
- Swee Win Lam
- Sylvia Rosas
- Sylvia Shaw
- Szilard Vasas
- Sérgio Alberto Cunha Vêncio
- Sérgio Yamada
- Tadashi Iitsuka
- Takamoto Kodera
- Takashi Wada
- Takayuki Watanabe
- Tamara Malek Marin
- Tamas Oroszlan
- Tara Chang
- Tareq Nassar
- Tarissa Beatrice Zanata Petry
- Tatiana Koroleva
- Tatiana Morugova
- Tatiana Raskina
- Tatyana Zykova
- Te-Lin Hsia
- Terue Sakakibara
- Tetiana Zlova
- Tetsuji Niiya
- Tetyana Pertseva
- Tiago Schuch
- Timothy Hall
- Tom Christensen
- Tom Greene
- Tomas Drasnar
- Tomas Smith Casabella
- Tonatiu Diaz Escalante
- Toshihiko Yanase
- Toshio Kawada
- Vadym Vizir
- Vanassa Ratnasingam
- Venessa Tsang
- Venkata Behara
- Vera Klokocnikova
- Vera Krane
- Veronica Anghel
- Veselka Genadieva
- Vesna Popovic-Radinovic
- Viacheslav Marasaev
- Victor Commendatore
- Victor Saavedra Gajardo
- Vijayaraman Arutchelvam
- Viktor Margaritov
- Viktor Zaviriukha
- Viktoria Andreeva
- Vimladhevi Govender
- Vincent Pichette
- Vincent Woo
- Vira Tseluyko
- Virginia Esther Visco
- Vivek Sood
- Vivekan Jha
- Vladimir Dobronravov
- Vladimir Khirmanov
- Vladimir Tesar
- Vlado Perkovic
- Volker Burst
- Volodymyr Botsyurko
- Walter Guillermo Douthat
- Walter Pharr
- Wasim Hanif
- Wataru Yumita
- Wayne H-H Sheu
- Wayne Turner
- Wei Yen Kong
- Weihong Song
- Weiping Lu
- Wendy Lane
- Wenge Li
- Wheeler D. C.
- Wladmir Saporito
- Xuemei Li
- Xueqing Yu
- Yamil Canaan
- Yan Ren
- Yannick Le Meur
- Yaozhong Kong
- Yasuro Kumeda
- Yasushi Wakida
- Yavin Y.
- Yeong Hoon Kim
- Yevgeniya Svyshchenko
- Young Min Cho
- Yulia Samoylova
- Yung-Chuan Lu
- Yuriy Mostovoy
- Yuriy Shwartz
- Yvette Ethel Yap
- Zaynab Abejuela
- Zdravko Kamenov
- Zeid Khitan
- Zhang H.
- Zinman B.
- Zishan Ali
- Zuzana Ochodnicka
- Ângela Regina Nazario Sabbag
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
Su2131 Per-Umbilical Laparoscopic Access
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Is combined colectomy and hepatectomy for synchrounous metastatic colorectal cancer more efficient than staged?
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
International Nosocomial Infection Control Consortiu (INICC) report, data summary of 43 countries for 2007-2012. Device-associated module
- Author
- Abdullah Mufareh Assiri
- Abeer Ahmed Mohmed
- Abeer Aly Omar
- Abhijeet Raha
- Abizer Nuruddin Manked
- Achilleas Gikas
- Adela Arguello Ruiz
- Adem Karbuz
- Adrian M. Puello Guerrero Glenny Mirabal
- Adriana Montanini
- Adriana Romani
- Afzal Azim
- Agamenon Alves Oliveira
- Agreta Gecaj-Gashi
- Ahmed Hakawi
- Ahmet Dilek
- Aisha Mubarak
- Ajoy Krishna Sarkar
- Alexander Molkov
- Alexander Tchekulaev
- Alfredo Lagares Guzman
- Alfredo Paucar
- Algirdas Dagys
- Ali Kaya
- Ali Metin Otkun
- Ali Omer Abdul Aziz
- Ali Pekcan Demiroz
- Aline Besen
- Aliye Yasayacak
- Alka Thool
- Alka Thool
- Alper Sener
- Altaf Ahmed
- Alysia Faye Giani
- Alzbeta Marcekova
- Amani Ali El-Kholy
- Amani Fouad Sayed
- Amaury Mielle Filho
- Ameurfina Curioso Silo
- Amine Ali Zeggwagh
- Amjad Mahboob
- Amna Mostafa Mohamed
- Amol Harshe
- Ana Lucía Bonilla Escudero
- Ana Marãa Perez Fernandez
- Ana Paula Fontes Pinheiro
- Ana Paula Vasconcelos Carneiro
- Ana Silvia Rearte
- Anahita Sanaei
- Analen Fabros Cabato
- Andrea Peña Padilla
- Andres Eduardo Mindiola Rochel
- Andres H. Corchuelo Martinez
- Andrzej Kubler
- Angel Gonzalez Vargas
- Angel Orlando Flores Alvarado
- Angelina Mendonca
- Anil Bilolikar
- Anil Karlekar
- Anirban Karmakar
- Anis Shiham Zainal Abidin
- Anju Mathew
- Anna Lesnakova
- Annalyn Amor Malificio
- Antigona Hasani
- Antonio Claudio do Amaral Baruzzi
- Antonio Martinez Mulia
- Antonio Solano Chinchilla
- Anu Kurian
- Anucha Apisarnthanarak
- Anuja Kedar Kulkarni
- Anuradha Agarwal
- Anwar Al Souheil
- Anzar Thair
- Aparajita Panda
- Aparecida Camacho
- Apsia Musa Molano
- Araceli Martinez Martinez
- Areej Dhafer Alshehri
- Arifa Hafeez
- Arjun Rajalakshmi
- Arlu Marie Casuyon Pahilanga
- Arnab Dasgupta
- Arnaldo Rodríguez-Sánchez
- Arnefelina S. Tamayo
- Arpita Bhakta
- Arpita Dwivedy
- Aseem Mahajan
- Ashoo Wadhera
- Ashraf Ali Khan
- Ashraf El Houfi
- Ashwin Kumar Mani
- Asmita Kamble
- Asmita Sagar Sakle
- Asu Ozgultekin
- Asuman Inan
- Ata Nevzat Yalcin
- Atefeh Yousefipour
- Atila Kilic
- Atilla Ramazanoglu
- Aun Raza
- Avigail M. Tan
- Ayhan Yaman
- Aynur Engin
- Ayse Danis
- Ayse Erbay
- Ayşe Willke
- Azra Parveen
- B.N. Gokul
- Babu Kuruvilla Abraham
- Baby Padmini
- Badaruddin A. Memon
- Bala Ramachandran
- Balkys Alvarez
- Banambar Ray
- Barbara Barteczko-Grajek
- Barbara Dragan
- Barkat Amina
- Basak Ceyda Meco
- Basanta Kumar Pati
- Bassel Molaeb
- Begum Atasay
- Behzad Maghsudi
- Bel Hadj Sarra
- Bhabani Shankar Pati
- Bhagyesh Shah
- Bijie Hu
- Biju John
- Bikas Mishra
- Bilge Aldemir Kocabaş
- Binesh Badyal
- Biraj Mohan Mishra
- Borgi Aida
- Bouziri Asma
- Braulio Matias De Carvalho
- Burhanuddin Qutbuddin Jawadwala
- Byambadorj Batkhuu
- Camila Almeida Silva
- Camilla Rodrigues
- Canan Aygun
- Cansu Yilmaz
- Caphiane Batista
- Carlos Alvarez-Moreno
- Carlos Enrique La Hoz Vergara
- Carlos F. Linares Calderon
- Carlos Gonzalez Fuentes
- Caroline Batista Cardoso
- Caroline Lazzarini
- Celia Flores Baldonado
- Celso Zaruma
- Cemal Bulut
- Cemal Ustun
- Cengiz Uzun
- Ceyda Necan
- Chandramouli Bhattacharya
- Chaohua Wang
- Charulata Pamnani
- Chin Seng Gan
- Christian Mendoza-Mujica
- Christianne F.V. Takeda
- Chunli Guo
- Cigdem Ataman Hatipoglu
- Cigdem Yildirim Guclu
- Clara Morales Perez
- Claudia Beatriz Dominguez
- Claudia Diaz
- Claudia Gabriela Rodriguez
- Concepcion Bran De Casares
- Cristina Mari Jean P. Llames
- Dafne Moreno
- Dagoberto Santofimio
- Daiane Casi
- Daisy A. De Moros
- Dale Fisher
- Dang Thi Van Trang
- Daniela V. Da Silva Escudero
- Danilo Amâncio Campos
- David Yepes Gomez
- Davut Ozdemir
- Dayana Aponte
- Debkishore Gupta
- Dedeepiya Devaprasad
- Deepa Ganesh Divekar
- Deepa Sasidharan Nair
- Deepesh Gokulchand Aggarwal
- Delia Muntean
- Denis Padgett
- Dennis George Maki
- Dennis Malungcot Narciso
- Devendra K. Khanna
- Diaa Abdullah Mohammed
- Diego Barahona Pinto
- Diego Marcelo Maurizi
- Diego Morocho
- Diego Morocho Tutillo
- Dileep Mane
- Dilek Arman
- Dilek Kahvecioglu
- Dimitar Georgiev Karadimov
- Dimitrios Veldekis
- Dincer Yildizdas
- Dinh Pham Phuong Anh
- Dipankar Padhihari
- Dipti Gaikwad
- Doaa Abdel-Aziz
- Doan Mai Phuong
- Doan Mai Phuong
- Dogaç Ugurcan
- Dorel Sandesc
- Doris Maribel Rivera
- Dovile Grinkeviciute
- Dragana Lekic
- Duaa Khalil Al-Awadi
- Dulce Hernandez
- Duran Yildiz
- Eduardo Alexandrino Medeiros
- Eduardo Rodriguez-Noriega
- Edwin Giovanny Chapeta Parada
- Elahe Tajeddin
- Elahe Tajeddin
- Elaine Mari Furukawa-Cinquini
- Elena Leon Sanchez
- Eleni Apostolopoulou
- Eliesel Lacerda
- Eliza Ramirez
- Elizabeth Castano
- Elizabeth Laungayan Cortez
- Elsa Margarita Trujillo Ramirez
- Elsie Cancel
- Elías García-Mayorca
- Emel Azak
- Emil D. Kostadinov
- Enrique Barbachano Rodriguez
- Erci Maria Onzi Siliprandi
- Erdal İnce
- Ergin Çiftçi
- Ernandi Dagoberto Seerig Palme
- Ertugrul Guclu
- Estuardo Salgado Yepez
- Eugenia Mejías
- Evangelina Balon Ubalde
- Evelyn Salinas
- Ever Labro
- Ewa Szewczyk
- F.E. Udwadia
- Fabio Jorge De Lima Silva
- Fabricio Picoita
- Faisal Sultan
- Farid Zand
- Fatima Mohammad Al Adwani
- Fatma Sebnem Erdinc
- Fatma Sirmatel
- Fatma Ulger
- Fco Eduardo Aguiar Leitão
- Federico Corona Jiménez
- Felcy Chacko
- Fernando Aguilera Almazán
- Fernando Martin Ramirez Wong
- Fernando Martin Ramirez Wong
- Fernando Perez
- Flavie Maria Rebello
- Florencia Maria Jerez
- Florin George Horhat
- Francisco Campos Guevara
- Francisco Kennedy Azevedo
- G.S. Gehlot
- Gabriel D. Empaire
- Gabriel Horacio Mendez
- Gabriel Munoz Gutierrez
- Gabriela Di-Silvestre
- Gabriela Martinez Falcon
- Ganshyam Jagathkar
- Gasdali Santacruz
- Gaspar Iglesias Miramontes
- Gaye Usluer
- Gazmend Spahija
- Georgina Olivarez
- Gerardo León-Garnica
- Germán Camacho Moreno
- Ghada A. Ismail
- Gilda Tolari
- Gita Nadimpalli
- Gladys Edith Correa
- Gladys Tatiana Sánchez
- Glaydson A. Ponte
- Golnar Sabetian
- Goran Ristic
- Grace Sindayen
- Greta Gailiene
- Guadalupe Aguirre-Avalos
- Guadalupe Gomez Flores
- Gul Hassan Bhutto
- Gulden Ersoz
- Gulsume Kaya
- Gunay Tuncer Ertem
- Gunes Senol
- Gustavo Jorge Chaparro
- Guxiang Ye
- H. Sunil
- Haifaa Hassan Al-Mousa
- Hakan Erdem
- Hakan Leblebicioglu
- Halil Ozdemir
- Hammad Nazeer
- Hanamant Kashinath Sale
- Hanan Balkhy
- Hanan Mesfer Al Ghamdi
- Harvinder Wasan
- Hasan Akduman
- Hasan Ayash
- Hasimah Zainol
- Hatice Cabadak
- Hava Yilmaz
- Hayrettin Akdeniz
- Hector Armando Rincon Leon
- Hector Raul Perez-Gomez
- Hector Vidal
- Heidi Johanna Munoz
- Hena Francis
- Herlidia Taboada Hernandez
- Hessa Abdullah Al Enizy
- Hilario Coronado Magaña
- Hugo Alberto Gonzalez Flores
- Hulya Sungurtekin
- Humberto Guanche Garcell
- Humeyra Zengin
- Huseyn Turgut
- Hussain Al-Rahma
- Ianick Souto Martins
- Ibrahim A.M. Al-Zaydani Asiri
- Ider Bat-Erdene
- Iftihar Koksal
- Igor Kotkov
- Ilham Bulos Abu-Khader
- Ilhan Ozgunes
- Indranil Roy
- Isaura Beatriz Sauceda Castañeda
- Islam Abdullorziz Ghazi
- Ismael A. Valderrama MarquezClaudia Linares
- Ismet Jusufi
- Ivan Utkin
- Ivar Calvo Hernandez
- J.V. Divatia
- Jaime Martínez Rodriguez
- Janet E. Pichilingue Chagray
- Javier Ospina Martinez
- Javier Soto Pastrana
- Jayant Shelgaonkar
- Jegathesan Manikavasagam
- Jehangir Soli Sorabjee
- Jelena Eremija
- Jelena Kojovic
- Jenny Jurado
- Jerlie Mae Gonzales Celiz
- Jessica C. Amor
- Jesús Alfonso Galindo Olmeda
- Jeyaganesh Veerakumaran
- Jigar Patel
- Jinzhi Zhang
- Joelene Lim
- Johanna Osorio
- Jorge Horacio Portillo-Gallo
- Jorge Ivan Marin Uribe
- Jorge Velez
- Jose Maria Harystoy
- Josephine Anne Navoa-Ng
- Juan Carlos Torres Millan
- Julia Marcia Maluf Lopes
- Julia Rosa Valdez
- Julianne Da Luz Lima
- Julio Cesar Mijangos Méndez
- Kabiri Meryem
- Kamal Berechid
- Karina Cabezas
- Karina M. Nogueira Napoles
- Karla Reyna Navarro Fuentes
- Karthikeya Varma
- Kashmira Limaye Joshi
- Katarina Furova
- Katerina Jankovska
- Katia Arruda Guimaraes
- Katja Popovska
- Katya Fernanda Aibar Yaranga
- Kavita Sandhu
- Kerinjeet Kaur
- Keyla Harten Pinto Coelho
- Keyur Parikh
- Khaldi Ammar
- Khalid Abidi
- Kotturathu Mammen Cherain
- Kushlani Jayatilleke
- Lailane D. Bergosa
- Lakshmi Ranganathan
- Lamia Jurdi
- Lamiaa Abdel-Fatteh Ahmed
- Le Thi Anh Thu
- Le Thi Diem Tuyet
- Leema Pushparaj
- Leena Steephen
- Leonardo N. Pazmino
- Leonardo Passos de Souza
- Levent Gorenek
- Li Changan
- Li Ruisheng
- Li Yimin
- Lian-Huat Tan
- Lilian Aguiar Vieira
- Lilian De Jesus Machuca
- Liliana Alina Dragomirescu
- Lilibeth G. Salvio
- Lin Meiyi
- Lindalva Pino Da Silva Neta
- Ling Zhu
- Liu Kun
- Ljubica Nikolic
- Lorena Luiza Silva Neto Avelar
- Lorena Matta Cortes
- Lorena Paola Cardena
- Lorenzo Santiago Marcos
- Lucia Ramasco
- Lucio Alberto Aguilar Angel
- Lucy Chai See-Lum
- Luis Carlos Fernandez Alvarez
- Luis E. Cuellar
- Luis E. Pedrozo-Ortiz
- Luis Gustavo De Oliveira Cardo
- Luis Isidro Castillo Bravo
- Luis Kushner Davalos
- Luis Kushner-Dávalos
- Luis Marino Cañas Giraldo
- Luis Martin Santivanez Monge
- Luis Montes Bravo
- Luiz Fernando Baqueiro Freitas
- Lul Raka
- Lusayda Sanchez Corrales
- Luz Dary Burgos Florez
- Lydia Lara
- Madhavi Latha Bommala
- Madhu Gupta
- Madhupriya Vijay Suryawanshi
- Magda Ivonne Rojas-Bonilla
- Magdalena Kosmider-Zurawska
- Mahuya Bhattacharyya
- Maithili Satish Kavathekar
- Maithili Satish Kavathekar
- Malgorzata Anna Mikaszewska-Sokolewicz
- Malik Abdo Ali
- Mammen Chandy
- Manas Roy
- Manoj Agarwal
- Mansoor Masjedi
- Manuel Jesus Mayorga Espichan
- Manuela Amaral
- Mao Pu
- Marcela Maria Sousa Colares
- Marcelo Mendonca
- Marcia Maria De Paula Bessa
- Marcia Valle
- Marco A. Trujillo Juarez
- Marco Montell Garcia
- Marco Tulio Luque Torres
- Marco Tulio Luque-Torres
- Marena Rodriguez Ferrer
- Margarete Villins
- Margarita Delgado
- Maria Angela Maretti Da Silva
- Maria C. Ferreira De Souza
- Maria Caridi
- Maria Carmen Sg Buenaflor
- Maria Catalina Pirez Garcia
- Maria Constanza Chavez
- Maria Daganou
- Maria del Rosario Vázquez Olivas
- Maria Elena Calisto Pazos
- Maria Fernanda Garcia
- Maria Fernanda Garcia
- Maria Isabel Colqui
- Maria Jose Monteiro De Assis
- Maria Kartsonaki
- Maria Laura Spadaro
- Maria Lilian Maciel Canuto
- Maria Silvia Olivieri
- Maria Teresa Blanco-Abuy
- Maria Tereza Freitas Tenório
- Maria V. Changano Rodriguez
- Mariana Andrade Oliveira Reis
- Marianina Brenda V. Valisto
- Marilou F. Trajano
- Marina Moreira
- Mario Arboleda
- Mario Cadena Zapata
- Marisa Liliana Bernan
- Marisela del Rocío González Martínez
- Marisol Sanchez Vargas
- Marius Papurica
- Marjan Rashidan
- Marlene Tasayco Ramos
- Martha Cecilia Culebro Burguet
- Martha Y. Martinez-Marroquin
- Maryam Razaghi
- Maryam Razaghi
- Marzena Zielinska
- Marãa E. Cruz Saldarriaga
- María Eugenia Guzmán Siritt
- María Guadalupe Villa González
- María Magdalena Gutierrez Castillo
- María Marcela Bovera
- Masoud Alebouyeh
- Masoud Alebouyeh
- May Abd El-Fattah
- May Osman Gamar Elanbya
- May Osman Gamar-Elanbya
- Mayra Chango
- Mayur Harshadrai Patel
- Megha Mehrotra
- Mehmet Bakir
- Mehmet Faruk Geyik
- Mehmet Oral
- Meliha Meriç Koç
- Melike Cengiz
- Menekse Ozcelik
- Mercy V. Joseph
- Michael M. Petrov
- Milena Petrovska
- Miriam de Lourdes-Dueñas
- Miriam Patricia Brito
- Misbah Rehman Aziz
- Mohamad Ftouni
- Mohamed Hassan
- Mohammad El-Dossoky Noweir
- Mohammad Mukhit Abdul Gaffar Kazi
- Mohammad Reza Sarbazi
- Mohammad Reza Zali
- Mohammed Abdullah Al Raey
- Mohd Shahnaz Hasan
- Mohit Kharbanda
- Mona Foda Salama
- Mona Mohiedden Abdel-Halim
- Monica Espinosa Valencia
- Monica Sorina Licker
- Monica Viegas
- Montri Luxsuwong
- Mrinmoy Bej
- Mrunalini Subhash Potdar
- Murali Chakravarthy
- Murali Karpagam
- Mustafa Sunbul
- Myrna T. Mendoza
- Nabeela Abdullah Al-Abdullah
- Nada Kara Zahreddine
- Nadeem Paul
- Nadia Lynette Demaisip
- Nagamani Sen
- Nagarajan Ramakrishnan
- Naheed Elahi
- Nahid Mansouri
- Namita Jaggi
- Namphon Supa
- Naoufel Madani
- Naresh Parmar
- Narinder Saini
- Nasser Yehia Aly
- Nassya Hadjieva
- Nassya Hadjieva
- Nayide Barahona Guzman
- Nazario Silva Astete
- Nazif Elaldi
- Necdet Kuyucu
- Necmettin Unal
- Nehat Baftiu
- Nejla Ben-Jaballah
- Nektarios Foteinakis
- Nelly Alquinga
- Nelson Remache
- Nelva Orozco
- Nepomuceno Mejia
- Nepomuceno Mejía
- Nesil Bayraktar
- Nevin Ince
- Ngo Quy Chau
- Nguyen Gia Binh
- Nguyen Gia Binh
- Nguyen Phuc Tien
- Nguyen Quoc Anh
- Nguyen Van Truong
- Nguyen Viet Hung
- Niketa Kaul Pawar
- Nilakshi Kumari
- Nilgün Altın
- Nirav Pandya
- Nisith Mohanty
- Nita Munshi
- Nitin Shinde
- Nonglak Suwalak
- null Dinesh
- Nurettin Erben
- Ofelia P. Javellana
- Oguz Dursun
- Oguz Karabay
- Ojan Assadian
- Olber Chavarria Ugalde
- Omer Erdeve
- Omnarayan Sarda
- Oral Oncul
- Orhan Baylan
- Osiel Requejo-Pino
- Otgon Baatar
- Ovidiu Bedreag
- Ozden Ozgur Horoz
- Ozge Turhan
- Padmalatha Raman
- Paola Andrea Rios
- Paola Deolinda Juarez
- Paola Fabiana Gallardo
- Parichart Phainuphong
- Pattabhiramarao Nadimpalli
- Paulina Alma Ulloa Camacho
- Pedro Fernández González
- Perihan Gunasan
- Phan Thi Hang
- Philip Annamma
- Pornpheth Prasan
- Prafulla Sahoo
- Pravin Kumar Nair
- Preeti Rajeev Mehta
- Priscila Botta
- Prokopis Kithreotis
- Purnima Mukherjee
- Purva Mathur
- R. Kelkar
- R. Sukanya
- Rajesh Kakkar
- Ram Gopalakrishnan
- Ramesh Venkatraman
- Ramona Severino
- Rasha Hamed Elsherif
- Ravikumar Krupanandan
- Rayo Morfin-Otero
- Regina Berba
- Reham Ali Dewdar
- Reham Hamed
- Reinaldo Salomao
- Renata Amaral De Moraes
- Reshma Naik
- Rhoda Gay Rayco
- Ricardo Arteaga Mora
- Ricardo De Souza Kuchenbecker
- Rimantas Kevalas
- Rimita Dey
- Riya Thakkar
- Roaa Hasan Basri
- Roberto Carlos Mares Morales
- Roberto Espinoza Atarama
- Rodolfo Toomey
- Rodrigo Pires Dos Santos
- Rohini Dhawale
- Rosalia Fernández-Hidalgo
- Rosana Richtmann
- Rosita Gasmin Aromin
- Ruby Jose Ramapurath
- Rungratchanee Pimathai
- Rédouane Abouqal
- S. Muralidharan
- S. Sampat
- S. Saranya
- S.K. Biswas
- S.N. Myatra
- Saadet Arsan
- Saban Esen
- Saeed Ali Al Darani
- Salih Cesur
- Sameeh Salem Ghazal
- Samir Sahu
- Samir Sahu
- Sandra Liliana Romero Torres
- Sandra Milena Bonilla
- Sanghamitra Mishra
- Sanjay Bhattacharya
- Sanjay Singhal
- Sanjeev Singh
- Sanjeev Sood
- Sankar Sengupta
- Santosh Singh
- Sarika Juneja
- Saroj Kumar Patnaik
- Sasheela Sri La Sri Ponnampala
- Saswati Sinha
- Seelas Blessymole
- Sehnaz Kaya
- Selene Manga Chavez
- Selin Bardak
- Selvi Yener Erdogan
- Senthilkumar Rajagopal
- Sergey Puzanov
- Sergio Blecher
- Sergio Esparza-Ahumada
- Serhat Unal
- Sevim Karacorlu
- Shamsher Dalal
- Sheena Binu
- Sheena Mary Sibin
- Shefali Bhattacharya
- Shirley Tenorio López
- Shobhana Kumari Kadankunnel
- Shoeb Nizamuddin Kardekar
- Shufang Wang
- Shufang Zhuo
- Sibel Bolukcu
- Silom Jamulitrat
- Simasadat Seyedjavadi
- Simone Amorim
- Siva Kumar
- Sladjana Vasiljevic
- Sneha Mary George
- Snezana Tufekcievska Guroska
- Socorro Torres Zegarra
- Sohini Arora
- Solange Regina Oliveira Castro
- Somayeh Jahani-Sherafat
- Sona Hlinkova
- Sonali Khamkar
- Sonay Incesoy Ozdemir
- Song Liqiang
- Sonia Joseph
- Soniya Thorat
- Souha Sami Kanj
- Soumya Samal
- Srdjan Pasic
- Srinivas Samavedam
- Subhash Kumar Todi
- Subodh Kumar
- Sudhir Gupta
- Sudhiranjan Misra
- Suga Thomas Varghese
- Suha Sen
- Suhas Nirkhiwale
- Sujata Malik
- Sujith Sujith
- Sujoy Mukherjee
- Sukanya Rangaswamy
- Suman Singh
- Sumana Baidya
- Sumi Nandwani
- Summiya Nizamuddin
- Sumru Ozkan
- Suneeta Sahu
- Sunil Bhamare
- Sunil Sharma
- Suo Yao
- Supriya Chabukswar
- Suresh Kumar
- Susana Gutierrez-Martinez
- Susmita Basu
- Suthinee Wanitanukool
- Suvin Shetty
- Suwara Somabutr
- Suzan Sacar
- Suzette A. Bunsay
- Swarna Banergee
- Swathy Sathish
- Sweta Shah
- Syed Faisal Mahmood
- Syed Zahid Bukhari
- Tahsine Mahfouz
- Tala Kardas
- Tamiris Moreira
- Tanıl Kendirli
- Tanja Anguseva
- Tanu Singhal
- Tao Lili
- Tarek Dendane
- Tarquino Eristidesg Sanchez
- Tatiane T. Rodrigues
- Tenzin Zompa
- Teodora Atencio-Espinoza
- Tereza De Jesus Pinheiro Gomes Bandeira
- Thara Francis
- Thejas Vini
- Tomas Kondratas
- Tomasz Lazowski
- Tran Thi My Hanh
- Tran Thi Thuy Hang
- Trudell Mapp
- Truong Anh Thu
- Tânia Mara Lima De Barros Araújo
- Ufuk Cakir
- Umesh Gupta
- V. Raut
- V.R. Ramanan
- Vaibhavi R. Subhedar
- Vaidotas Gurskis
- Valentina Tulupova
- Valter Furlan
- Vanessa A. Marquez Mondalgo
- Vanessa Bermudez
- Vatsal Kothari
- Velmira Angelova Velinova
- Velu Pandi Suresh Kumar
- Vempati Venkateshwar
- Victor Dumitrascu
- Victoria D. Villanueva
- Vikram Padbidri
- Vineya Rai
- Violeta Jivkova Dicheva
- Visanu Thamlikitkul
- Vladimir Kretov
- Vladimir Shalapuda
- Vladislav Belskiy
- Vo Thi Hong Thoa
- Víctor Daniel Rosenthal
- Walter Enrique Prudencio Leon
- Walter Enrique Prudencio Leon
- Wan Nurbayah Wan Yusoff
- Wania Vasconcelos de Freitas
- Wieslawa Duszynska
- Wilmer Villamil-Gomez
- Wong Kang Kwong
- Wu Kangxiong
- Xihua Geng
- Xiuqin Guo
- Xu Ziqin
- Xuesong Yang
- Yasemin Gelebek
- Yassir Khidir Mohammed
- Yatin Mehta
- Yazmin Leon Vega
- Yiang Shumei
- Yuet-Meng Cheong
- Yuri Mariela Perez Hernandez
- Yvis Ruiz
- Zan Mitrev
- Zaneta Bogoevska-Miteva
- Zeina Kanafani
- Zeinab Salah Seliem
- Zenaida Durán Gil De Añez
- Zeynel Gokmen
- Zeynep Kaya
- Ziad Ahmed Memish
- Zoila Rosa Diaz Tavera
- Zoila Rosa Diaz Tavera
- Çağlar Ödek
- Publication venue
- Elsevier Inc
- Publication date
- 01/09/2014
- Field of study
We report the results of an International Nosocomial Infection Control Consortium (INICC) surveillance study from January 2007-December 2012 in 503 intensive care units (ICUs) in Latin America, Asia, Africa, and Europe. During the 6-year study using the Centers for Disease Control and Prevention's (CDC) U.S. National Healthcare Safety Network (NHSN) definitions for device-associated health care–associated infection (DA-HAI), we collected prospective data from 605,310 patients hospitalized in the INICC's ICUs for an aggregate of 3,338,396 days. Although device utilization in the INICC's ICUs was similar to that reported from ICUs in the U.S. in the CDC's NHSN, rates of device-associated nosocomial infection were higher in the ICUs of the INICC hospitals: the pooled rate of central line–associated bloodstream infection in the INICC's ICUs, 4.9 per 1,000 central line days, is nearly 5-fold higher than the 0.9 per 1,000 central line days reported from comparable U.S. ICUs. The overall rate of ventilator-associated pneumonia was also higher (16.8 vs 1.1 per 1,000 ventilator days) as was the rate of catheter-associated urinary tract infection (5.5 vs 1.3 per 1,000 catheter days). Frequencies of resistance of Pseudomonas isolates to amikacin (42.8% vs 10%) and imipenem (42.4% vs 26.1%) and Klebsiella pneumoniae isolates to ceftazidime (71.2% vs 28.8%) and imipenem (19.6% vs 12.8%) were also higher in the INICC's ICUs compared with the ICUs of the CDC's NHSN
Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease: Results From the CREDENCE Trial and Meta-Analysis
- Author
- (Jay) Kropp Jeffrey
- Abdul Kadir Khalid
- Abdullah Raied
- Abraham Oomman India:
- Abramowitz Matthew
- Acosta Idalia
- Africa: Fayzal Ahmed South
- Agra Jeimeen
- Aiello Joseph
- Ainsworth Paul
- Aizenberg Diego
- Akright Laura
- Akyea-Djamson Ayim
- Al-Karadsheh Amer
- Alappan Rajendran
- Alberto Andreotti Turatti Luiz
- Alberto Berli Mario
- Alberto Cuneo Carlos
- Alberto Cunha V\ueancio S\ue9rgio
- Alberto Ramirez Roca Luis
- Alexandra Terront Lozano Monica
- Alfonso Leon de la Fuente Ricardo
- Ali Norsiah
- Ali Zishan
- Alicic Radica
- Alina Agafyina Russia:
- Alpizar Salazar Melchor
- Alva Hansraj
- Alvarisqueta Andres
- Amodeo Celso
- Andres Ahuad Guerrero Rodolfo
- Angel Reyes Rosano Miguel
- Angelova Angelina
- Anghel Veronica
- Angustias Quesada Sim\uf3n Mar\ueda
- Ant\uf4nio Pereira M\ue1rcio
- Antonia Munar Vila Maria
- Antonio Novoa Pablo
- Antonio S\ue1nchez Arenales Jose
- Aoki Hiromi
- Aquitania Grace
- Arauz-Pacheco Carlos
- Archibaldo Glenny Jorge
- Arcos Edgar
- Arfeen Shahabul
- Arif Ahmed
- Aronson Ronnie
- Arutchelvam Vijayaraman
- Arvind Moogali
- Asano Akimichi
- Asmarats Mercadal Luis
- Atray Naveen
- Augusto Alves da Costa Fernando
- Avendano Jorge
- Avram Rodica-Ioana
- Awad Ahmed
- Baas Cruz Juan
- Badat Aysha
- Bajaj Harpreet
- Bakris George
- Barbarash Olga
- Barnard Maria
- Barnhill Peggy
- Barranco Elizabeth
- Barrera Carlos
- Barrios Clara
- Bartolacci Ines
- Barton Petr
- Barysheva Olga
- Beacom Matthew
- Beatrice Zanata Petry Tarissa
- Beatriz Schiavi Lilia
- Behara Venkata
- Bellary Srikanth
- Belo Diogo
- Belobradkova Jana
- Bentley-Lewis Rhonda
- Benusova Olga
- Berenguer Ramon
- Berenice Saavedra Sanchez Sandra
- Bermudez Lidia
- Bernardo Marializa
- Bhajan Manocha Anita
- Bhushan Raju Sree
- Bilyk Svitlana D.
- Biscoveanu Mihaela
- Bordonava Anselmo
- Borot Sophie
- Botsyurko Volodymyr
- Bowman-Stroud Cynthia
- Brandon Donald
- Breedt Johannes
- Bregman Rachel
- Brusco Osvaldo
- Buganova Ingrid
- Burgos Soto Mario
- Busch Robert
- Busegeanu Mihaela-Magdalena
- Calella Pedro
- Canaan Yamil
- Caringal Clodoaido
- Cariou Bertrand
- Carlo Sasso Ferdinando
- Carlo Tibes Hachmann Jean
- Carlos Santos Juan
- Castellino Pietro
- Cecilia Cantero Maria
- Cecilia Coloma Gabriela
- Cercos Esteban
- Cereto Castro Fernando
- Ceriello Antonio
- Chandra Vyasam Ramesh
- Chen Qinkai
- Cherney David
- Chevaile Ramos Jose
- Chew Wong Alfredo
- Chilito Alicia
- Chiovato Luca
- Chizhov Daniil
- Chouinard Guy
- Christensen Tom
- Christiano Cynthia
- Christofides Elena
- Chuang Lee-Ming
- Chuateco Caroucel
- Chwen-Tzuei Chang Taiwan:
- Cif Adriana
- Cigarran Guldris Secundino
- Cohen Kenneth
- Cohen Robert
- Cohen- Stein Debbie
- Colombo Hugo
- Commendatore Victor
- Conway James
- Cook Charles
- Cosma Dana
- Cournoyer Serge
- Coyne Daniel
- Crawford Allison Dale
- Crisan Carmen
- Cristian Greloni Gustavo
- Cristina Camelo Sanches Fernanda
- Csiky Botond
- Cuadrado Jesus
- Culak Jan
- d'Avila Domingos
- Daboul Nizar
- Danos Peter
- Dario Dran Ricardo
- Dario Vargas Alonso Ruben
- DaRoza Gerald
- Darwish Riad
- Daswani Adarsh
- Daud Che Yusof Mohd
- David Gomez Rangel Jose
- Davies Emyr
- Davies Mark
- Davies Simon
- Dawson Alison
- De Cosmo Salvatore
- De Nicola Luca
- De Serres Sacha
- de Souza Portes Evandro
- de Souza Pedro
- Deak Laszlo
- Deck Kenneth
- del Carmen Gonzalez Colaso Patricia
- Delos Santos Lalaine
- Derosa Giuseppe
- Desouza Cyrus
- Despina Demian Luiza
- Dev Devasmita
- Dewan Deepak
- Dhillon Monika
- Di Carlo Alberto
- Di Cianni Graziano
- Diaz Escalante Tonatiu
- Diego Higuera Juan
- Dimitrov Stefan
- Distiller Lawrence
- Djordjevic Miodrag
- Dobronravov Vladimir
- Dohnalova Lenka
- Dominguez Lopez Marta
- Dovie Lallaine Ygpuara Ma.
- Drasnar Tomas
- Dreval Alexander
- Droste Carolyn
- Dua Sohan
- Dub\ue9 Fran\ue7ois
- Dudar Iryna
- Dudas Mihaly
- Dussol Bertrand
- Dzupina Andrej
- Dzuponova Jana
- Eder Frank
- Edmundo Enriquez Sosa Favio
- Edwin Fernando M.
- Egido de los Rios Jesus
- Egle Gaupsiene Lithuania:
- El Kossi Mohsen
- El-Shahawy Mohamed
- Emilia Ferariu Ioana
- English Patrick
- Enrique Herrera Jimenez Luis
- Eric Alamartine France:
- Erika Rucker Joerg Isabel
- Ernesto Andres Diaz Ruiz Jorge
- Ervin John
- Esquenazi Alberto
- Esteban Jodar Gimeno Jose
- Esther Visco Virginia
- Ethel Yap Yvette
- Evans John
- Faghih Markus
- Farias Eduardo
- Faulmann Grit
- Fauvel Jean-Pierre
- Ferkl Richard
- Fernandez Fresnedo Gema
- Fernando Flota Cervera Luis
- Finkelstein Hernan
- Fishbane Steven
- Florencia Fernandez Maria
- Flores Lozano Fernando
- Fragale Guillermo
- Fraige Filho Fadlo
- Francisco Kerr Saraiva Jose
- Frasc\ue0 Giovanni
- Fraser Donald
- Fraser Ian
- Frenk Baron Paul
- Frias Juan
- Fuiano Giorgio
- Fulop Peter
- Fushtey Ivan
- Gabriela Onaca Adriana
- Galan Serrano Antonio
- Galindo-Ramos Eugenia
- Galphin Claude
- Gambaro Giovanni
- Gan Shenglian
- Garcia Ballesteros Cecilia
- Garcia Isabel
- Garibotto Giacomo
- Gastaldi Anibal
- Gelersztein Elizabeth
- Geloneze Neto Bruno
- Genadieva Veselka
- Genova-Hristova Gabriela
- Ghazi Adline
- Giorda Carlo
- Glinkina Irina
- Gnudi Luigi
- Godlevska Olga
- Goldenberg Ronald
- Golovchenko Oleksandr
- Gomes Marcus
- Gomez Olivert
- Gon Kim Sin
- Gonzalez Alexander
- Gonzalez Enrique
- Gonzalo Godoy Jorquera Juan
- Gopalakrishnan Natarajan
- Gorson David
- Gourdy Pierre
- Govender Ravendran
- Govender Vimladhevi
- Gowda Anupama
- Goycoa Claudia
- Gracious Noble
- Greco Barbara
- Grineva Elena
- Grubb Stephen
- Guillermo Douthat Walter
- Guinsburg Adrian
- Gulati Rakesh
- Gunstone Anthony
- Gupta Anil
- Gupta Milan
- Gyongyi Csecsei Hungary:
- Gyrina Olga
- H-H Sheu Wayne
- Halciakova Katarina
- Hall Timothy
- Haller Hermann
- Halmagyi Ildiko
- Hammoud Jamal
- Hancu Nicolae
- Handelsman Stuart
- Hanif Wasim
- Harcsa Eleonora
- Hartman Israel
- Hector Resk Jorge
- Hector Sanchez Mijangos Jose
- Henein Sam
- Henrique Canani Luis
- Hermida Sonia
- Hernandez Triana Eric
- Hernando Garcia Ortiz Luis
- Hershon Kenneth
- Hiser Daniel
- Hitoshi Akiyama Japan:
- Ho Yoon Kun
- Hon George
- Hoon Kim Yeong
- Horacio Garcia Nestor
- Hotlos Lucyna
- Hristozov Kiril
- Hsia Te-Lin
- Hsieh Chang-Hsun
- Hwang ShangJyh
- Iitsuka Tadashi
- Ilavska Adriana
- In\ue9s Molina de Salazar Dora
- Ines Orio Silvia
- Isabel Klyver Maria
- Isaias Juncos Luis
- Isela Luna Ceballos Rosa
- Ismail Mastura
- Jackson Alan
- Jacob Radu
- Jaime Maria
- Jain Dinesh
- Jamal Aamir
- Jana Babikova Slovakia:
- Januszewicz Andrzej
- Javier Gonzalez Martinez Francisco
- Javier Zaidman Cesar
- Jeong Kwon Min
- Jeong In-Kyung
- Jerwan-Keim Reinhold
- Jimenez Flores Fernando
- Jimeno Cecilia
- Johnson Andrew
- Johnson David
- Jorge da Silva Franco Roberto
- Jose Luis Accini Mendoza Colombia:
- Jose Tinahones Madueno Francisco
- Joseph Franklin
- Joshi Mukesh
- Jurgens Jaco
- Kaczmarek Barbara
- Kajiyama Shizuo
- Kaldun Nossuli A.
- Kamenov Zdravko
- Kaminska Anna
- Kashine Susumu
- Kaupke Charles
- Kawada Toshio
- Kazmirchuk Anatoliy
- Keightley Gerald
- Keiko Kohara Suely
- Keitel Elizete
- Keltai Katalin
- Kendereski Aleksandra
- Keresztesi Sandor
- Kern Elizabeth
- Keshavamurthy C. B.
- Khandwala Hasnain
- Khanna Rakhi
- Khirmanov Vladimir
- Khitan Zeid
- Khullar Dinesh
- Kim Sun
- Kingdom: Kamal Abouglila United
- Kiss Krisztian
- Klein Alexandre
- Klokocnikova Vera
- Kodera Takamoto
- Kolesnyk Mykola
- Kolmakova Elena
- Komisarenko Iuliia
- Kong Yaozhong
- Kono Hiroshi
- Konyves Laszlo
- Kopyt Nelson
- Korea: Dong-Wan Chae South
- Koroleva Tatiana
- Korzh Oleksii
- Koundurdjiev Atanas
- Kovar Richard
- Kovesdy Csaba
- Koyama Kazunori
- Kozloviene Dalia
- Kraft Florencia
- Kravchun Nonna
- Krishna Gopal
- Krishnan Singhan
- Krynski Fernando
- Kumar Amrendra
- Kumar Jayant
- Kumar Neil
- Kumeda Yasuro
- Kumwenda Mick
- Kun Lim Soo
- Kusnir Jorge
- Kvitkova Liudmila
- Kwon Hyuk-Sang
- Lalic Katarina
- Lalic Nebojsa
- Lane Wendy
- Lastuvka Jiri
- Latiff Gulam
- Laviada Molina Hugo
- Lawrence Mary
- Lazuka Lech
- Le Meur Yannick
- Lee Gan Chye
- Lee Byung-Wan
- Lee JungEun
- Lee Moon-Kyu
- Legun Oleg
- Lehrner Lawrence
- Leiter Lawrence
- Lentz John
- Levin Adeera
- Levinson Dennis
- Lewis Derek
- Li Detian
- Li Wenge
- Li Xuemei
- Liliana Monica Angelescu Romania:
- Lin Chih-Ching
- Lin Hongli
- Lindolfo Cunha Borges Jo\ue3o
- Liss Kenneth
- Liu Jian
- Lombard Landman
- Loong Loh Chek
- Lopez Mendoza Manuel
- Loss de Carvalho Contieri Fabiana
- Lozanov Lachezar
- Lu Weiping
- Lu Yung-Chuan
- Luis David Abraira Munoz Mexico:
- Lukac Martin
- M\uf4nica Deboni Luciane
- Ma Portoles Perez Jose
- MacDougall Iain
- Maddux Andreas
- Madej Andrzej
- Madore Fran\ue7ois
- Maheshwari Hiralal
- Major Lajos
- Malaver Natalia
- Malberti Fabio
- Malek Marin Tamara
- Mandayam Sreedhar
- Mandreoli Marcora
- Mankovskyy Borys
- Mann Mah Peak
- Mannucci Edoardo
- Mao Hong
- Mar\ueda Alicia Fern\ue1ndez Montenegro Chile:
- Marar Isam
- Marasaev Viacheslav
- Marchetta Nora
- Margaritov Viktor
- Maria Cusumano Ana
- Maria Elosegui Ana
- Maria Veronelli Anna
- Martin del Campo Blanco Belia
- Martinka Emil
- Martynyuk Liliya
- Maxeiner Stephan
- Mazur Stanislaw
- Mc- Mahon Alan
- Medina Fari\uf1a Marcelo
- Mehta Bhasker
- Mele Pablo
- Melemadathil Sreelatha
- Middleton John
- Milagres Ros\ue2ngela
- Mileder Margit
- Min Cho Young
- Miyauchi Shozo
- Mizuyama Kazuyuki
- Mkrtumyan Ashot
- Mlodawska-Choluj Dorota
- Mohamed Railey United Arab Emirates: Salah Abusnana
- Molnar Marta
- Montenegro Junior Renan
- Mookadam Mohamed
- Morales Franco Guadalupe
- Morales Portillo Cristobal
- Mordujovich Jorge
- Moreda Ramon
- Moreira de Brito Claudia
- Morugova Tatiana
- Mostovoy Yuriy
- Moustafa Moustafa
- Mu\uf1oz Torres Manuel
- Mucsi Janos
- Muirhead Norman
- Mujica Trenche Samuel
- Munteanu Mircea
- Mustieles Rocha Cynthia
- Nagibovich Galina
- Nagibovich Oleg
- Nam Moon-Suk
- Nan Chen China:
- Narayanan Mohanram
- Naresh Aggarwal Canada:
- Narvarte Javier
- Nassar Tareq
- Nasser Hissa Miguel
- Navickas Antanas
- Nedogoda Sergei
- Negru Doru
- Newman George
- Ngai Wah Cheung Australia:
- Ngcakani Nomangesi
- Nichol Brian
- Nicholls Kathy
- Nicol Philip
- Nicolai Silvia
- Nieto Iglesias Javier
- Niiya Tetsuji
- Nisnisan Josier
- Nixon Paul
- Nonchev Boyan
- Noonan Paul
- Noronha Irene
- Nortje Hendrik
- Nowicki Michal
- Nur Fatnoon Nik Ahmad Nik
- O'Hare Joseph
- O'Shaughnessy Andrew
- Obialo Chamberlain
- Obrador Vera Gregorio
- Ochodnicka Zuzana
- Oh Kook-Hwan
- Oishi Hiroko
- Olelewe Sarah
- Olga Barna Ukraine:
- Oliver Michael
- Oosthuizen Helena
- Orlowska-Kowalik Grazyna
- Oroszlan Tamas
- Orozco Castellanos Ricardo
- Orsi Emanuela
- Ory Ivan
- Osipova Irina
- Osvaldo Fretes Jose
- Ota Satoshi
- Otreras Fabian
- Oviedo Alejandra
- Pablo Albisu Juan
- Pablo Gonzalez Joaquin
- Pablo Moreira Diaz Juan
- Packham David
- Padron John
- Panarotto Daniel
- Pankhaniya Rohit
- Pantoja Perez Jonay
- Paragh Gyorgy
- Park Cheol-Young
- Park Sun-Hee
- Parker Reginald
- Paschen Bj\uf6rn
- Pashkovska Nataliia
- Patel Devesh
- Patel Gnyandev
- Patel Nina
- Paul Haase Franklin
- Pavon Humberto
- Pecoits Filho Roberto
- Pella Daniel
- Penfornis Alfred
- Peralta Calcaneo Juan
- Pere Alvarez Garcia Spain:
- Pererva Larysa
- Perez Vera Merce
- Perez Armando
- Perez Carlos
- Peringat Jayameena
- Perlman Alan
- Pertseva Tetyana
- Pesickova Satu
- Peterfai Eva
- Peterka Karel
- Petrica Ligia
- Petro Gizella
- Pettis Karlton
- Pharr Walter
- Philip Sam
- Phillips Andrea
- Piatti Piermarco
- Pichette Vincent
- Pillay-Ramaya Larisha
- Plassmann Georg
- Popenda Grazyna
- Popovic-Radinovic Vesna
- Prasad Narayan
- Proietto Joseph
- Prozesky Hans
- Pumprla Jiri
- Purighalla Raman
- Quesada-Suarez Luis
- Rabasa-Lhoret Remi
- Raffaele Pablo
- Ramtoola Shenaz
- Ranetti Aurelian-Emil
- Rangelov Rangel
- Ranjan Rajiv
- Raskina Tatiana
- Rastogi Sanjeev
- Ratnasingam Vanassa
- Reddy Jakkidi
- Reddy Jeevren
- Reddy Sreedhar
- Regina Nazario Sabbag \uc2ngela
- Remus Popa Amorin
- Ren Yan
- Renata Bijata-Bronisz Poland:
- Rendell Marc
- Republic: Dagmar Bartaskova Czech
- Revesz Katalin
- Rewerska Barbara
- Rheeder Paul
- Ricardo Correa Rotter Jose
- Riccardo Bonadonna Italy:
- Rich Lisa
- Rista Lucas
- Roberto Abr\ue3o Raduan Brazil:
- Roberto Chacra Ant\uf4nio
- Roberto Kurtz Lisboa Hugo
- Roberts Anthony
- Robinson Michael
- Rodolfo Cartasegna Luis
- Rodriguez Papini Nelson
- Rodriguez Pattzi Hiromi
- Rodriguez Hector
- Roger Simon
- Rohana Abdul Ghani Malaysia:
- Ronaldo Arturo Gonzalez Orellana Guatemala:
- Rosa Ulla Maria
- Rosas Guzman Juan
- Rosas Sylvia
- Rose Ludger
- Rosero Ricardo
- Roussel Ronan
- Rychlik Ivan
- Saavedra Gajardo Victor
- Saba Fadi
- Sahay Manisha
- Sakakibara Terue
- Sala Jorgelina
- Samoylov Oleksandr
- Samoylova Yulia
- Sankaram Rallabhandi
- Santoro Domenico
- Santos Florence
- Saporito Wladmir
- Sarin Ravi
- Satyanarayana Rao K.
- Saudek Frantisek
- Saul Irizar Santana Sergio
- Saulnier Pierre-Jean
- Saxena Manish
- Sazonova Olga
- Scafuto Scotton Antonio
- Schreiman Robert
- Schuch Tiago
- Scott David
- Scott Russell
- Seeber Mary
- Sekkarie Mohamed
- Sennik Davesh
- Sensenbrenner John
- Serafinceanu Cristian
- Serrano Sanson Pablo
- Serviddio Gaetano
- Sessa Horacio
- Severina Comia Rhea
- Shahrizal Bin Shudim Saiful
- Shakeel Muhammad
- Shamkhalova Minara
- Shanik Michael
- Shaw Sylvia
- Shinkov Alexander
- Shutemova Elena
- Shwartz Yuriy
- Sim\uf5es de Almeida Roberto
- Simo Canonge Rafael
- Simon Godwin
- Sing Ng Kee
- Singh Baldev
- Slobodan Antic Serbia:
- Slompo Ramos C\ue1ssio
- Smatanova Iveta
- Smirnov Ivan
- Smith Casabella Tomas
- Smith Stephen
- Soares Fel\uedcio Jo\ue3o
- Solomon Richard
- Song Weihong
- Soto Gonzalez Alfonso
- Sowinski Dariusz
- Sprague Amy
- Spry Leslie
- States: Joseph Abdallah United
- Steele Andrew
- Stella Andrea
- Stephens Jeffrey
- Strzelecka Anna
- Suchinda Pusadee
- Sudhakar Bhimavarapu
- Sultan Senan
- Sun Jiao
- Sun Lin
- Surampudi Prasanth
- Sussman Sherry
- Svyshchenko Yevgeniya
- Symonds Rehan
- Takacs Robert
- Takai Masahiko
- Tan Anjanette
- Tan Gerry
- Tangri Navdeep
- Tarsicio Moreno Loza Oscar
- Tellez Chavez Eloisa
- Temelkova Margarita
- Teresa Zanella Maria
- Terns Riera Manel
- Terrelonge Antonio
- Tesar Vladimir
- Thervet Eric
- Thom\ue9 Fernando
- Thompson Michael
- Toarba Cristina
- Tolentino Marsha
- Tomashkevych Halyna
- Tomonaga Osamu
- Topchii Ivan
- Torshizi Ali
- Trespalacios Fernando
- Trevisan Roberto
- Trippe Bruce
- Trueba Pilar
- Tryshchuk Nadiya
- Tsang Venessa
- Tseluyko Vira
- Tsujimoto Mitsuru
- Tu Ping
- Turcios Juarez Erick
- Turner Wayne
- Twahirwa Marcel
- Updegrove John
- Urbanaviciene Egle
- Uriasyev Oleg
- Valderrama Cometa Luis
- Valdes Cepeda Alejandro
- Valdez Maria
- Valenzuela Alex
- Valis Martin
- Vallejos Augusto
- Van Buren Peter
- Vangel Sandor
- Vannorsdall Mark
- Varghese Freemu
- Vasas Szilard
- Vejar Margarita
- Velasquez-Mieyer Pedro
- Velichkova Ekaterina
- Velo Plaza Mercedes
- Venegas Carrillo Luis
- Vengadasalam Paranthaman
- Ventrapragada Sailaja
- Vicente Sanchez Polo Jos\ue9
- Viktoria Andreeva Bulgaria:
- Villagordoa Mesa Juan
- Villarino Adriana
- Villegas Ivan
- Virginia Lanchiotti Paulina
- Vizir Vadym
- Vlasenko Maryna
- Volker Burst Germany:
- Vorobyev Sergey
- Vukotic Goga
- Wada Takashi
- Wadud Khurram
- Wahba Mona
- Wakasugi Masakiyo
- Wakeling John
- Wakida Yasushi
- Walker Robert
- Wang Guixia
- Warren Mark
- Wassermann Alfredo
- Watanabe Takayuki
- Watson Edward
- Watson Henry
- Watts Ronald
- Weiner Daniel
- Weiner Pavel
- Welker James
- Welsh Jean
- Wheeler David
- Williams Michael
- Williams Shelley
- Win Lam Swee
- Winocour Peter
- Woo Vincent
- y Orozco Juan Alfredo Tamayo
- Yakov Andrian
- Yamada Masayo
- Yamada S\ue9rgio
- Yanagida Kazuhiro
- Yanase Toshihiko
- Yang Jinkui
- Yao Christy
- Yen Kong Wei
- Yin Aiping
- Yoiti Hayashida Cesar
- Young Simon
- Yu Xueqing
- Yuan Lee Li
- Yumita Wataru
- Yupanqui Hernan
- Zalunardo Nadia
- Zamarripa Escobedo Rolando
- Zaniewski-Singh Michelle
- Zanoli Luca
- Zaoui Philippe
- Zateyshchikova Anna
- Zateyshshikov Dmitry
- Zaynab Abejuela Philippines:
- Zealand: John Baker New
- Zemek Stanislav
- Zhao Minghui
- Zheng Hongguang
- Zlova Tetiana
- Zsom Marianna
- Zub Liliia
- Zykova Tatyana
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2021
- Field of study
BACKGROUND AND PURPOSE: Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus.METHODS: CREDENCE randomized 4401 participants with type 2 diabetes mellitus and chronic kidney disease to canagliflozin or placebo. Post hoc, we estimated effects on fatal or nonfatal stroke, stroke subtypes, and intermediate markers of stroke risk including AF/AFL. Stroke and AF/AFL data from 3 other completed large CVOTs and CREDENCE were pooled using random-effects meta-analysis.RESULTS: In CREDENCE, 142 participants experienced a stroke during follow-up (10.9/1000 patient-years with canagliflozin, 14.2/1000 patient-years with placebo; hazard ratio [HR], 0.77 [95% CI, 0.55-1.08]). Effects by stroke subtypes were: ischemic (HR, 0.88 [95% CI, 0.61-1.28]; n=111), hemorrhagic (HR, 0.50 [95% CI, 0.19-1.32]; n=18), and undetermined (HR, 0.54 [95% CI, 0.20-1.46]; n=17). There was no clear effect on AF/AFL (HR, 0.76 [95% CI, 0.53-1.10]; n=115). The overall effects in the 4 CVOTs combined were: total stroke (HRpooled, 0.96 [95% CI, 0.82-1.12]), ischemic stroke (HRpooled, 1.01 [95% CI, 0.89-1.14]), hemorrhagic stroke (HRpooled, 0.50 [95% CI, 0.30-0.83]), undetermined stroke (HRpooled, 0.86 [95% CI, 0.49-1.51]), and AF/AFL (HRpooled, 0.81 [95% CI, 0.71-0.93]). There was evidence that SGLT2i effects on total stroke varied by baseline estimated glomerular filtration rate (P=0.01), with protection in the lowest estimated glomerular filtration rate (<45 mL/min/1.73 m2]) subgroup (HRpooled, 0.50 [95% CI, 0.31-0.79]).CONCLUSIONS: Although we found no clear effect of SGLT2i on total stroke in CREDENCE or across trials combined, there was some evidence of benefit in preventing hemorrhagic stroke and AF/AFL, as well as total stroke for those with lowest estimated glomerular filtration rate. Future research should focus on confirming these data and exploring potential mechanisms. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02065791
Kidney and Cardiovascular Effects of Canagliflozin According to Age and Sex: A Post Hoc Analysis of the CREDENCE Randomized Clinical Trial
- Author
- Abdallah Joseph
- Abdul Ghani Rohana
- Abdullah Raied
- Abejuela Zaynab
- Abouglila Kamal
- Abraham Oomman
- Abraira Munoz Luis David
- Abramowitz Matthew
- Abusnana Salah
- Acosta Idalia
- Agafyina Alina
- Agarwal Rajiv
- Agarwal Rajiv
- Aggarwal Naresh
- Agra Jeimeen
- Ahmad Nik Nur Fatnoon Nik
- Ahmed Fayzal
- Aiello Joseph
- Ainsworth Paul
- Aizenberg Diego
- Aizenberg Diego
- Akiyama Hitoshi
- Akright Laura
- Akyea-Djamson Ayim
- Al-Karadsheh Amer
- Alamartine Eric
- Alappan Rajendran
- Albisu Juan Pablo
- Alexandra Terront Lozano Monica
- Ali Norsiah
- Ali Zishan
- Alicic Radica
- Allison Dale Crawford
- Alvarisqueta Andres
- Amodeo Celso
- Andreeva Viktoria
- Angelescu Liliana Monica
- Angelova Angelina
- Anghel Veronica
- Antic Slobodan
- Aoki Hiromi
- Aquitania Grace
- Arauz-Pacheco Carlos
- Arcos Edgar
- Arfeen Shahabul
- Arif Ahmed
- Arnott Clare
- Aronson Ronnie
- Arutchelvam Vijayaraman
- Arvind Moogali
- Asano Akimichi
- Atray Naveen
- Avendano Jorge
- Avram Rodica-Ioana
- Awad Ahmed
- Babikova Jana
- Badat Aysha
- Bajaj Harpreet
- Baker John
- Bakris George
- Bakris George
- Bakris George
- Ballesteros Cecilia Garcia
- Barbarash Olga
- Barna Olga
- Barnard Maria
- Barnhill Peggy
- Baron Paul Frenk
- Barranco Elizabeth
- Barrera Carlos
- Barrios Clara
- Bartaskova Dagmar
- Bartolacci Ines
- Barton Petr
- Barysheva Olga
- Beacom Matthew
- Behara Venkata
- Bellary Srikanth
- Belo Diogo
- Belobradkova Jana
- Bentley-Lewis Rhonda
- Benusova Olga
- Berenguer Ramon
- Berli Mario Alberto
- Bermudez Lidia
- Bernardo Marializa
- Bhushan Raju Sree
- Bijata-Bronisz Renata
- Bilyk Svitlana D.
- Biscoveanu Mihaela
- Bonadonna Riccardo
- Bordonava Anselmo
- Borges João Lindolfo Cunha
- Borot Sophie
- Botsyurko Volodymyr
- Bowman-Stroud Cynthia
- Brandon Donald
- Breedt Johannes
- Bregman Rachel
- Brenner Barry M.
- Brusco Osvaldo
- Buganova Ingrid
- Burst Volker
- Busch Robert
- Busegeanu Mihaela-Magdalena
- Calcaneo Juan Peralta
- Calella Pedro
- Canaan Yamil
- Canani Luis Henrique
- Cannon Christopher P.
- Cannon Christopher P.
- Canonge Rafael Simo
- Cantero Maria Cecilia
- Cardoza Kathryn
- Caringal Clodoaido
- Cariou Bertrand
- Carrillo Luis Venegas
- Cartasegna Luis Rodolfo
- Casabella Tomas Smith
- Castellanos Ricardo Orozco
- Castellino Pietro
- Castro Fernando Cereto
- Cepeda Alejandro Valdes
- Cercos Esteban
- Ceriello Antonio
- Chacra Antônio Roberto
- Chae Dong-Wan
- Chae Dong-Wan
- Chandra Vyasam Ramesh
- Chang Chwen-Tzuei
- Chang Tara
- Charytan David M.
- Charytan David M.
- Charytan David M.
- Chavez Eloisa Tellez
- Che Yusof Mohd Daud
- Chen Nan
- Chen Qinkai
- Cherney David
- Cherney David
- Chertow Glenn
- Cheung Ngai Wah
- Chilito Alicia
- Chiovato Luca
- Chizhov Daniil
- Cho Young Min
- Chouinard Guy
- Christensen Tom
- Christiano Cynthia
- Christofides Elena
- Chuang Lee-Ming
- Chuateco Caroucel
- Cif Adriana
- Cohen Kenneth
- Cohen Robert
- Cohen-Stein Debbie
- Colaso Patricia del Carmen Gonzalez
- Coloma Gabriela Cecilia
- Colombo Hugo
- Cometa Luis Valderrama
- Comia Rhea Severina
- Commendatore Victor
- Contieri Fabiana Loss de Carvalho
- Conway James
- Cook Charles
- Correa Rotter Jose Ricardo
- Cosma Dana
- Costa Fernando Augusto Alves da
- Cournoyer Serge
- Coyne Daniel
- Crisan Carmen
- Cruz Juan Baas
- Csecsei Gyongyi
- Csiky Botond
- Cuadrado Jesus
- Culak Jan
- Cuneo Carlos Alberto
- Cusumano Ana Maria
- Daboul Nizar
- Danos Peter
- DaRoza Gerald
- Darwish Riad
- Daswani Adarsh
- David null
- Davies Emyr
- Davies Mark
- Davies Simon
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- de Almeida Roberto Simões
- de Brito Claudia Moreira
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- De Nicola Luca
- De Nicola Luca
- de Salazar Dora Inés Molina
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- de Souza Pedro
- de Zeeuw Dick
- de Zeeuw Dick
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- Deepak Dewan
- del Campo Blanco Belia Martin
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- Derosa Giuseppe
- Desouza Cyrus
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- Di Carlo Alberto
- Di Cianni Graziano
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- Diaz Ruiz Jorge Ernesto Andres
- Dimitrov Stefan
- Distiller Larry
- Distiller Lawrence
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- Douthat Walter Guillermo
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- Egido de los Rios Jesus
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- Evans John
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- Farias Eduardo
- Fariña Marcelo Medina
- Faulmann Grit
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- Filho Roberto Pecoits
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- Heerspink Hiddo J. L.
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- Wada Takashi
- Wada Takashi
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- Wakasugi Masakiyo
- Wakeling John
- Wakida Yasushi
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- Watanabe Takayuki
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- Watson Henry
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- Weiner Daniel
- Weiner Pavel
- Welker James
- Welsh Jean
- Wheeler C.
- Wheeler David
- Wheeler David C.
- Wheeler David C.
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- Williams Shelley
- Winocour Peter
- Wong Alfredo Chew
- Woo Vincent
- Yakov Andrian
- Yamada Masayo
- Yamada Sérgio
- Yanagida Kazuhiro
- Yanase Toshihiko
- Yang Jinkui
- Yao Christy
- Yap Yvette Ethel
- Yi Tae Won
- Yin Aiping
- Yoon Kun Ho
- Young Simon
- Yu Xueqing
- Yumita Wataru
- Yupanqui Hernan
- Zaidman Cesar Javier
- Zalunardo Nadia
- Zanella Maria Teresa
- Zaniewski-Singh Michelle
- Zanoli Luca
- Zaoui Philippe
- Zateyshchikova Anna
- Zateyshshikov Dmitry
- Zemek Stanislav
- Zhang Hong
- Zhang Hong
- Zhang Hong
- Zhao Minghui
- Zheng Hongguang
- Zinman Bernard
- Zinman Bernard
- Zlova Tetiana
- Zsom Marianna
- Zub Liliia
- Zykova Tatyana
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Rationale & Objective: It is unclear whether the effect of canagliflozin on adverse kidney and cardiovascular events in those with diabetic kid-ney disease varies by age and sex. We assessed the effects of canagliflozin among age group categories and between sexes in the Canagli-flozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) study.Study Design: Secondary analysis of a random-ized controlled trial. Setting & Participants: Participants in the CREDENCE trial. Intervention: Participants were randomly assigned to receive canagliflozin 100 mg/d or placebo.Outcomes: Primary composite outcome of kid-ney failure, doubling of serum creatinine con-centration, or death due to kidney or cardiovascular disease. Prespecified secondary and safety outcomes were also analyzed. Out-comes were evaluated by age at baseline (<60, 60-69, and >_70 years) and sex in the intention-to-treat population using Cox regression models.Results: The mean age of the cohort was 63.0 & PLUSMN; 9.2 years, and 34% were female. Older age and female sex were independently associ-ated with a lower risk of the composite of adverse kidney outcomes. There was no evidence that the effect of canagliflozin on the primary outcome (acomposite of kidney failure, a doubling of serum creatinine concentration, or death from kidney or cardiovascular causes) differed between age groups (HRs, 0.67 [95% CI, 0.52-0.87], 0.63 [0.4 8-0.82], and 0.89 [0.61-1.29] for ages <60, 60-69, and >_70 years, respectively; P = 0.3 for interaction) or sexes (HRs, 0.71 [95% CI, 0.5 4-0.95] and 0.69 [0.56-0.8 4] in women and men, respectively; P = 0.8 for interaction). No differences in safety outcomes by age group or sex were observed.Limitations: This was a post hoc analysis with multiple comparisons.Conclusions: Canagliflozin consistently reduced the relative risk of kidney events in people with diabetic kidney disease in both sexes and across age subgroups. As a result of greater background risk, the absolute reduction in adverse kidney outcomes was greater in younger participants.Funding: This post hoc analysis of the CREDENCE trial was not funded. The CREDENCE study was sponsored by Janssen Research and Development and was conducted collaboratively by the sponsor, an academic-led steering committee, and an academic research organization, George Clinical.Trial Registration: The original CREDENCE trial was registered at ClinicalTrials.gov with study number NCT02065791
International Nosocomial Infection Control Consortium report, data summary of 50 countries for 2010-2015: Device-associated module
- Author
- A. Ahmad Zaatari
- A. Ahmed
- A. Alves De Oliveira
- A. Anirban Karmakar
- A. Anwar Al Souheil
- A. Argüello-Ruiz
- A. Azim
- A. Bat-Erdene
- A. Bhakta
- A. Borgi
- A. Bouziri
- A. Cerero-Gudino
- A. Chawla
- A. Dagys
- A. Dilek
- A. Dwivedy
- A. Engin
- A. Flores-Alvarado
- A. Florin-Rogobete
- A. Gashi
- A. Gunduz
- A. Kaya
- A. Kubler
- A. Lagares-Guzmán
- A. Lesnakova
- A. Martínez
- A. Molkov
- A. Mubarak
- A. Oncul
- A. Ozgultekin
- A. Palaoro
- A. Patil
- A. Poojary
- A. Ramazanoglu
- A. Romani
- A. Romario-Mendes
- A. Sasidharan
- A. Simic
- A. Solano-Chinchilla
- A. Thakur
- A. Willke
- A. Zamores-Pedroza
- A.A. Zeggwagh
- A.C. Bianchi
- A.M. Elansary
- A.M. Mathew
- A.M. Mohamed
- A.M. Montanini
- A.M. Ríos
- A.N. Manked
- A.N. Yalcin
- A.P. González
- A.R. Vargas-García
- A.S.K. Rillorta
- A.V. Dharan
- Aamer Ikram
- Abd El Moniem Moustafa
- Abdulrahim Al Khamis
- Abeer A. Omar
- Abeera Ahmed
- Adnan Soliman Alsaadi
- Ahmad Mahmoud Ali
- Ahmed Abdoh Al-Jarie
- Ahmed Hasanin
- Ainul Auzani Othman
- Aisha Hassan Mutwalli
- Alejandra Sepulveda-Chavez
- Ali Pekcan Demiroz
- Aliza Mohamad Yusof
- Amani Ali El-Kholy
- Ameena Isa Alsayegh
- Ana Marcela Quesada-Mora
- Ana P. Dy
- Anahita Sanaei
- Anamma Philip
- Andrew Trotter
- Anil Kumar Bilolikar
- Anis Siham Zainal Abidin
- Anjeela Koirala
- Anna Lyn N. Tajanlangit
- Antoine Abdel Messih
- Anucha Apisarnthanarak
- Anuja Kulkarni
- Anumol Thomas
- Anuradha Agarwal
- Anuradha Sriram
- Arnab Dasgupta
- Arnefelina S. Tamayo
- Arul Rose Suganya
- Arwa Ramadan
- Ashraf Elhoufi
- Ashraf Kelany
- Ashwin Kumar Mani
- Asmita Sakle
- Asuman Inan
- Athena Manao
- Aun Raza
- Azra Parveen
- B. Barteczko-Grajek
- B. Cano-Munoz
- B. Dragan
- B. Herrera
- B. Ramachandran
- B.A. El Awady
- B.E. Hernandez-Chena
- Babu K. Abraham
- Baby Padmini
- Banambar Ray
- Basak Ceyda Meco
- Basanta Kumar Pati
- Bat Erdene Ider
- Batsaikhan Narankhuu
- Batsuren Choijamts
- Battsetseg Tuvdennyam
- Behzad Maghsudi
- Bhaskar Narayan Chaudhury
- Bijie Hu
- Biraj Mohan Mishra
- Braulio Matias De Carvalho
- Burhan Q. Jawadwala
- Byambadorj Batkhuu
- C. Aygun
- C. Becerik
- C. Bulut
- C. Cevallos
- C. Daliborca Vlad
- C. Domínguez
- C. Díaz
- C. Fernandes-Valente
- C. Linares
- C. Pelaez
- C. Rodrigues
- C. Santos
- C. Uzun
- C. Wang
- C. Ávila-Acosta
- C.C. Carreon-Martinez
- C.E. La Hoz Vergara
- C.F. Linares-Calderon
- C.G. Rodríguez
- C.G. Silva
- Carlos Alvarez-Moreno
- Chin Seng Gan
- Chirag Modi
- Chirag Patel
- Cigdem Ataman Hatipoglu
- Cigdem Yildirim Guclu
- Cristina Mari Jean P. Llames
- D. Azevedo-Ferreira Lima
- D. Azevedo-Pereira
- D. Enkhtsetseg
- D. Escudeiro
- D. Galishevskiy
- D. Grinkeviciute
- D. Lekic
- D. Moreno
- D. Muntean
- D. Ozdemir
- D. Sandesc
- D. Santofimio
- D. Ugurcan
- D. Yepes-Gomez
- D. Yildizdas
- D.A. Marin-Tobar
- D.K. Khanna
- D.M. Hassan
- D.M. Maurizi
- D.M. Rivera
- D.P. Mazo-Elorza
- D.Q. Quintana
- Daisy Aguilar de Moros
- Dale Fisher
- Dang Thi Van Trang
- Dao Quang Minh
- Dao Xuan Co
- Dedeepiya Devaprasad
- Deepa Divekar
- Deepesh G. Aggarwal
- Denis Padgett
- Dhaffer Moghram Alamri
- Dinh Pham Phuong Anh
- Doaa Abd El Aziz
- Dolatsinh Zala
- E. Alcala-Martinez
- E. Azak
- E. Bogdanowicz
- E. Garcia-Mayorca
- E. Gonzalez-Diaz
- E. Guclu
- E. Hristozova
- E. Jara
- E. Ramirez
- E. Rodriguez-Noriega
- E. Sachez
- E.A. Medeiros
- E.B. Santiago
- E.D. Kostadinov
- E.E. Coello-Gordon
- E.G. Castaño
- E.G. Chapeta-Parada
- E.M. Onzi-Siliprandi
- E.P. Cruzpero
- Edwin Pathrose
- Eleni Apostolopoulou
- Esmeray Mutlu Yilmaz
- Estuardo Salgado-Yepez
- Ever Labro
- F. Aguiar-Leitao
- F. Corona-Jimenez
- F. Perez
- F. Picoita
- F. Sebnem-Erdinc
- F. Serpa-Maia
- F. Sirmatel
- F. Ulger
- F. Valencia
- F.M. Guerra-Infante
- F.M. Guerrero-Toapant
- F.M. Ramírez Wong
- F.M. Rebello
- F.O. Riera
- Fadzlina Abdul Aziz
- Fahad Ahmed Sawan
- Faisal Sultan
- Farid Zand
- Fatema Hasan Yaseen
- Fatima Abdullah Al Qasmah
- Fazil Abubakar
- Felcy Chacko
- Ferhat Sari
- Filiz Kizilates
- Florin George Horhat
- Foong Kit Weng
- G. Aguirre-Avalos
- G. Arteaga-Troncoso
- G. Assuncao-Ponte
- G. Batjargal
- G. Bayasgalan
- G. Benchetrit
- G. Camacho-Moreno
- G. Ceylan
- G. Ersoz
- G. Kaya
- G. Leon-Garnica
- G. Martinez-Falcon
- G. Ristic
- G. Santacruz
- G. Senol
- G. Song
- G. Spahija
- G. Usluer
- G. Ye
- G. Álvarez
- G.A. Muñoz-Gutierrez
- G.D. Empaire
- G.E. Roncancio-Vill
- G.J. Chaparro
- G.M. Montenegro-Orrego
- G.S. Gehlot
- G.Y. Ramos-Ortiz
- Gabriela Di Silvestre
- Gautam Khanna
- Gloria Y. Ramos-Ortiz
- Golnar Sabetian
- Gortap Sitohang
- Gunay Tuncer Ertem
- H. Ayash
- H. Coronado-Magana
- H. Gonzalez
- H. Turgut
- H. Vidal
- H. Yilmaz
- H. Yu
- H.A. Delgado-Aguirre
- H.K. Sale
- H.R. Perez-Gomez
- H.R. Sandoval-Castillo
- Haeel Alabdaly
- Haifaa Hassan Almousa
- Hail M. Al-Abdely
- Hajer Am Al-Dossary
- Hakan Leblebicioglu
- Hala Ahmed
- Hala Hamza
- Hala Mounir Agha
- Hala Roshdi
- Halima Yahia Al-Alkami
- Hana Hanafi
- Hasan Agin
- Hasimah Zainol
- Hassan Eisa Ammari
- Hatem Mohd Al Hani
- Hatice Cabadak
- Hector Miguel Telechea
- Hindra Irawan Satari
- Hulya Sungurtekin
- Humberto Guanche-Garcell
- Humeyra Zengin
- Hussain Alrahma
- I. Calvo-Hernández
- I. Devrim
- I. Erdem
- I. Ozgunes
- I. Perez
- I. Zeid
- I.A. Valderrama-Marquez
- I.E. Sosa-Gonzalez
- Ibrahim A.M. Alzaydani Asiri
- Indranil Roy
- Inşa Gul Ekiz Işcanlı
- Islam Abdullorziz Ghazi
- J. Dos Anjos-Lima
- J. ElKholy
- J. Eremija
- J. Kojovic
- J. Mueras-Quevedo
- J. Olszewski
- J. Osorio
- J. Pichilingue-Chagray
- J. Rodriguez-Pacheco
- J. Tannous
- J. Vimercati
- J.A. Galindo-Olmeda
- J.A. Lopez-Pulgarin
- J.A. Navoa-Ng
- J.C. López
- J.C. Mijangos-Mendez
- J.D. Fortin
- J.E. Desse
- J.E. Ruiz-Gallardo
- J.I. Marín-Uribe
- J.J. Ayala-Gaytan
- J.L. Moreno-Castillo
- J.M. Ballinas-Aquino
- J.O. Ospina-Martínez
- J.P. Stagnaro
- J.P. Stagnaro
- J.R. Rojas
- J.V. Divatia
- Jayant Shelgaonkar
- Jeffrey Asidera Mendoza
- Jehangir Sorabjee
- Jincy Eappen
- Jomol Philipose
- Joy Ola Selga
- Justin Mathew
- Jyotishka Pal
- K. Abidi
- K. Angelova
- K. Berechid
- K. Gomez-Nieto
- K. Harten Pinto Coelho
- K. Liu
- K.F. Aibar-Yaranga
- K.H. Chuluunchimeg
- Kamal Bashar Abu Bakar
- Karthikeya Varma
- Kashmira Limaye Joshi
- Katarina Furova
- Katerina Jankovska
- Katja Popovska
- Kavita Sandhu
- Khalid Mohammed Ghalilah
- Kushlani Jayatilleke
- L. Josph
- L. Lara
- L. Maroto-Vargas
- L. Meneses-Ovallos
- L. Montes-Bravo
- L. Nikolic
- L. Pushparaj
- L. Ramasco
- L. Song
- L. Zamorano-Flores
- L.D. Bergosa
- L.D. Burgos-Florez
- L.F. Alves De Lima
- L.G. Salvio
- L.I. Castillo-Bravo
- L.M. Canas-Giraldo
- L.M. Santivanez-Monge
- L.N. Pazmino
- L.S. Marcos
- L.Y.M. Rincon
- Lakshmi Ranganathan
- Lateefa Fardan Hani
- Le Thi Anh Thu
- Le Thi Diem Tuyet
- Le Thi Thu Nguyet
- Leide Shyrine Redito
- Lucy Chai See Lum
- Luis Kushner-Davalos
- Lul Raka
- M. Al-Alawi
- M. Altindis
- M. Amaral-Almeida Costa
- M. Andrade-Oliveira-Reis
- M. Arboleda
- M. Bernan
- M. Bhattacharyya
- M. Bjelovic
- M. Bri Saibala
- M. Caridi
- M. Cengiz
- M. Chakravarthy
- M. De Guzman
- M. Dorj
- M. Furman
- M. Girvan
- M. Gonzalez-Martinez
- M. Karpagam
- M. Kasten-Monges
- M. Lascano
- M. Licker
- M. Lopez-Hurtado
- M. Lozano
- M. Mansour
- M. Mehmet Bakir
- M. Mendonca
- M. Meric
- M. Mikaszewska-Sokolewicz
- M. Moreira
- M. Oral
- M. Ozcelik
- M. Papurica
- M. Ramírez
- M. Rodriguez
- M. Sanchez-Vargas
- M. Sunbul
- M. Valverde-Hernandez
- M. Vargas
- M. Ximenes-Rocha Batista
- M. Zielinska
- M. Zurawska
- M.A. Altuzar-Figueroa
- M.A. Cureno-Diaz
- M.A. Zuniga
- M.C. Culebro-Burguet
- M.C. Oyola
- M.C. Rodríguez
- M.C. Sg-Buenaflor
- M.E. Gomez
- M.E. Guzman Siritt
- M.E. Sanchez-Castuera
- M.F. Garcia
- M.F. Geyik
- M.F. Trajano
- M.G. Manuel
- M.G. Miranda-Novales
- M.I. Rojas-Bonilla
- M.J. Mayorga-Espichan
- M.L. Maciel-Canuto Amaral
- M.L. Spadaro
- M.L.G. Rosario-Tueros
- M.M. Bovera
- M.M.A. Haleim
- M.N. Sivakumar
- M.O. Gamar-Elanbya
- M.S. Olivieri
- M.T. Mendoza
- M.T. Tenorio
- M.V. Changano-Rodriguez
- Madhav Lavate
- Madhavi Latha
- Madhupriya Suryawanshi
- Maithili Kavathekar
- Manal Mansour Al-Gethamy
- Manoj Kumar Agarwal
- Mansoor Masjedi
- Maria Carmen S.G. Buenaflor
- Maria Khan
- Marjory Madco
- Marzida Mansor
- Masoud Alebouyeh
- May Abdel Fattah
- May Osman Gamar Elanbya
- Mayur Patel
- Mazuin Kamarul Zaman
- Mehul Shah
- Mervat Aldalaton
- Mervat Elanany
- Michael M. Petrov
- Milena Petrovska
- Modhi Alkhamaly
- Mohamad Fadhil Hadi Jamaluddin
- Mohammad Masfar
- Mohammed Ahmed Ali Karrar
- Mohd Shahnaz Hasan
- Mohit Kharbanda
- Mona Foda Salama
- Mrinmoy Bej
- Mrunalini Potdar
- Munayfa Musallam Al Azmi
- Myrna Lim Quisai
- Myrna Misador Torres
- N. Al Zharani
- N. Al-Abdullah
- N. Alquinga
- N. Baftiu
- N. Barahona-Guzmán
- N. Ben-Jaballah
- N. Elaldi
- N. Gad
- N. Gita
- N. Jaggi
- N. Kuyucu
- N. Madani
- N. Navarrete
- N. Orozco
- N. Oztoprak
- N. Ramakrishnan
- N. Saini
- N. Sen
- N. Unal
- N. Yasar
- N.E. Salazar-Ramirez
- N.K. Pawar
- N.K. Zahreddine
- N.P. Rao
- Nadeem Paul
- Nader Ahmed Tawfic
- Naglaa Mahmoud Abdo
- Naheed Elahi
- Najla Ben Jaballah
- Namphon Supa
- Naranpurev Mendsaikhan
- Nargis Daud
- Nashwa Elsayed
- Nawal Salah Abdulkhalik
- Nehad Abdulshakour Bugis
- Neilia Cardinal Ariola
- Nepomuceno Mejia
- Nesreen Alghosn
- Ngo uy Chau
- Nguyen Gia Binh
- Nguyen Phuc Tien
- Nguyen Quoc Anh
- Nguyen Viet Hung
- Nidal Tashkandi
- Nikhil Modi
- Nirav Pandya
- Nisith Mohanty
- null Kehkashan
- null Sijo
- null Tsuyanga
- null Velupandi
- Nurettin Erben
- Nuri Bayram
- O. Chavarria-Ugalde
- O. Coskun
- O. Mancera-Paez
- O.G. Ramires
- O.P. Javellana
- O.S. Espinosa
- Oguz Dursun
- Oguz Karabay
- Otgon Baatar
- Ovidiu Horea Bedreag
- Ozden Ozgur Horoz
- Ozge Turhan
- Ozlem Sarac Sandal
- P. Botta
- P. Mathur
- P. Saul
- P. Suvderdene
- P.A. De Vera
- P.A. Rios-Arana
- P.D. Juarez
- Phan Thi Hang
- Pooja Thakkar
- Pornpheth Prasan
- Pradnya Joshi
- Prafulla Kumar Sahoo
- Pravin Kumar Nair
- Priyadarshini Senthil Kumar
- Priyanka Patil
- Purnima Mukherjee
- Purvi Shah
- R. Abouqal
- R. Ahmadieh
- R. Amaral De Moraes
- R. Cabrera-Montesino
- R. De Leon-Escobedo
- R. Fouda
- R. Kelkar
- R. Kevalas
- R. Li
- R. Ortega
- R. Penuliar
- R. Popescu
- R. Rocha-Vasconcelos Carneiro
- R. Ruiz-Rendon
- R. Salas-Flores
- R. Sukanya
- R.H. Pérez
- R.R. Maglente
- R.S. Campos-Uchoa
- R.V. Lozada
- Radhika Krishnan
- Raed Hassan Al Shehri
- Raha Abdul Rahman
- Rajalakshmi Arjun
- Rajesh Chawla
- Ram Gopalakrishnan
- Ramesh Venkataraman
- Rasha Hamed El-Sherif
- Rasha Nour Aldeen Jaha
- Rashmi Giri
- Ravikumar Krupanandan
- Rayo Morfin Otero
- Recep Tekin
- Reham H.A. Yousef
- Reny Thomas
- Reshma Tejam
- Retno Kadarsih
- Rhea Lynn Cresencia
- Rhendra Hardy Mohamad Zaini
- Richa Misra
- Ritesh Debroy
- Rosliza Zhazali
- Rungratchanee Pimathai
- S. Al Qahtani
- S. Baigalmaa
- S. Basu
- S. Bekeit
- S. Biswas
- S. Esparza-Ahumada
- S. Gerah
- S. Gualtero
- S. Hlinkova
- S. Petersen-Morfin
- S. Raut
- S. Sahu
- S. Saranya
- S. Shah
- S. Shetty
- S. Singh
- S. Singh
- S. Valderrama
- S. Vega-Gonzalez
- S.A. Aguirre-Diaz
- S.C. Do Nascimento
- S.D. Grecu
- S.J. Ramos
- S.K. Patnaik
- S.K. Todi
- S.L. Romero-Torres
- S.M. George
- S.M. Pulido-Leon
- S.N. Myatra
- S.S. Dalal
- Saban Esen
- Safa A Aziz AlKhawaja
- Sajith Narayanan
- Saleh Fakher Sowar
- Samana Sainju
- Sameh Twfik
- Sana Yusuf
- Sanghamitra Mishra
- Sanjith Saseedharan
- Sankar Sengupta
- Sarah Hassan Al Faraj
- Sasheela Sri La Sri Ponnampala
- Saswati Sinha
- Seelas Blessymole
- Seema Rohra
- Selvi Yener Erdogan
- Senthilkumar Rajagopal
- Serhat Unal
- Sevim Karacorlu
- Shanta Mukherjee
- Sharmila Sengupta
- Sheeba John
- Shefali Bhattacharya
- Sherin El-Sherbiny
- Sinchan Bhattacharyya
- Siti Jhulmina B. Alih
- Snezana Tufekcievska Guroska
- Soad Khamis
- Solita Briones
- Somayeh Jahani Sherafat
- Sonali Vadi
- Soo Lin Chuah
- Souha Sami Kanj
- Subhash Prasad Acharya
- Subodh Kumar
- Sudha Kansal
- Sudhjan Misra
- Sudipta Bhattacharyya
- Suha Sen
- Suha Sen
- Suhas Nirkhiwale
- Suja Thomas
- Sujit Kar Purkayastha
- Sujoy Mukherjee
- Summiya Nizamuddin
- Sunil Sharma
- Suresh Kumar
- Suthinee Wanitanukool
- Suwara Somabutr
- Suzan Sacar
- Syed Zahid Bukhari
- T. De Jesus Pinheiro-Bandeira
- T. Kardas
- T. Khajidmaa
- T. Kondratas
- T. Liu
- T. Mahfouz
- T. Mapp
- T. Moreira-Matos
- T. Singhal
- T. Sohanlal
- T.M. Lima-De Barros Araujo
- Tahira Anwar Magray
- Tanja Anguseva
- Tarek Dendane
- Tariq Saad Abdulhadi Alotaibi
- Thara Francis
- Thejasvini Anand
- Tran Thi My Hanh
- Tran Thi Thuy Hang
- Truong Anh Thu
- Tsolmon Begzjav
- Uma Gopal
- Umesh Gupta
- Usha Nair
- V. Bayani
- V. Bermudez
- V. Chediack
- V. De Iturrado
- V. Delgado
- V. Dumitrascu
- V. Gaona-Flores
- V. Kothari
- V. Ramírez
- V. Tanzi
- V. Venkateshwar
- V.A. Marquez-Mondalgo
- V.A. Monroy-Colin
- V.A. Velinova
- V.J. Dicheva
- V.L. Machado-Silva
- V.M. Moreno-Mejia
- Vaidotas Gurskis
- Valsa Thomas
- Vesna Mioljevic
- Vineya Rai
- Vini Kantroo
- Vladislav Belskiy
- Vo Thi Hong Thoa
- Volkan Yarar
- Víctor Daniel Rosenthal
- W. Chilon
- W. Raigoza-Martinez
- W. Villamil-Gomez
- W.M. Santos Monteiro
- Wael Abdulrahman Abdulatif
- Waleed Mohd Hussain
- Walter Enrique Prudencio Leon
- Wan Fadzlina Wan Mohd Shukeri
- Wan Nazaruddin Wan Hassan
- Wan Nurbayah Wan Yusoff
- Wan Rahiza Wan Mat
- Wieslawa Duszynska
- Wynndale Mae Demotica
- X. Guo
- X. Yang
- Y. Arreza-Galapia
- Y. Ruiz
- Y. Yang
- Y.A. Pardo-Lopez
- Y.M. Abdelhamid
- Y.S. Elkholy
- Yassir Khidir Mohamed
- Yatin Mehta
- Yeliz Oruc
- Yusuf Sahip
- Z. Ariyasuren
- Z. Cruz-Rivera
- Z. Duran-Gil De Anez
- Z. Hammoud
- Z. Kanafani
- Zan Mitrev
- Zaneta Bogoevska Miteva
- Zeinab Salah
- Zeynep Kaya
- Publication venue
- Elsevier Inc
- Publication date
- 01/12/2016
- Field of study
•We report INICC device-associated module data of 50 countries from 2010-2015.•We collected prospective data from 861,284 patients in 703 ICUs for 3,506,562 days.•DA-HAI rates and bacterial resistance were higher in the INICC ICUs than in CDC-NHSN's.•Device utilization ratio in the INICC ICUs was similar to CDC-NHSN's.
Background: We report the results of International Nosocomial Infection Control Consortium (INICC) surveillance study from January 2010-December 2015 in 703 intensive care units (ICUs) in Latin America, Europe, Eastern Mediterranean, Southeast Asia, and Western Pacific.
Methods: During the 6-year study period, using Centers for Disease Control and Prevention National Healthcare Safety Network (CDC-NHSN) definitions for device-associated health care-associated infection (DA-HAI), we collected prospective data from 861,284 patients hospitalized in INICC hospital ICUs for an aggregate of 3,506,562 days.
Results: Although device use in INICC ICUs was similar to that reported from CDC-NHSN ICUs, DA-HAI rates were higher in the INICC ICUs: in the INICC medical-surgical ICUs, the pooled rate of central line-associated bloodstream infection, 4.1 per 1,000 central line-days, was nearly 5-fold higher than the 0.8 per 1,000 central line-days reported from comparable US ICUs, the overall rate of ventilator-associated pneumonia was also higher, 13.1 versus 0.9 per 1,000 ventilator-days, as was the rate of catheter-associated urinary tract infection, 5.07 versus 1.7 per 1,000 catheter-days. From blood cultures samples, frequencies of resistance of Pseudomonas isolates to amikacin (29.87% vs 10%) and to imipenem (44.3% vs 26.1%), and of Klebsiella pneumoniae isolates to ceftazidime (73.2% vs 28.8%) and to imipenem (43.27% vs 12.8%) were also higher in the INICC ICUs compared with CDC-NHSN ICUs.
Conclusions: Although DA-HAIs in INICC ICU patients continue to be higher than the rates reported in CDC-NSHN ICUs representing the developed world, we have observed a significant trend toward the reduction of DA-HAI rates in INICC ICUs as shown in each international report. It is INICC's main goal to continue facilitating education, training, and basic and cost-effective tools and resources, such as standardized forms and an online platform, to tackle this problem effectively and systematically
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
- Abdel-Aziz Amal Kamal
- Abdelfatah Sara
- Abdellatif Mahmoud
- Abdoli Asghar
- Abel Steffen
- Abeliovich Hagai
- Abildgaard Marie H
- Abudu Yakubu Princely
- Acevedo-Arozena Abraham
- Adamopoulos Iannis E
- Adeli Khosrow
- Adolph Timon E
- Adornetto Annagrazia
- Aflaki Elma
- Afshar Elham Ghasemipour
- Agam Galila
- Agarwal Anupam
- Aggarwal Bharat B
- Agnello Maria
- Agostinis Patrizia
- Agrewala Javed N
- Agrotis Alexander
- Aguilar Patricia V
- Ahmad S Tariq
- Ahmed Zubair M
- Ahumada-Castro Ulises
- Aits Sonja
- Aizawa Shu
- Akkoc Yunus
- Akoumianaki Tonia
- Akpinar Hafize Aysin
- Al-Abd Ahmed M
- Al-Akra Lina
- Al-Bari M Abdul Alim
- Al-Gharaibeh Abeer
- Alaoui-Jamali Moulay A
- Alberti Simon
- Alcocer-Gomez Elisabet
- Alcon Soledad Porte
- Alessandri Cristiano
- Ali Muhammad
- Aliwaini Saeb
- Alizadeh Javad
- Almacellas Eugenia
- Almasan Alexandru
- Alonso Alicia
- Alonso Guillermo D
- Altan-Bonnet Nihal
- Altieri Dario C
- Alvarez Elida MC
- Alves Sara
- Alzaharna Mazen M
- Amadio Marialaura
- Amantini Consuelo
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- Ammanathan Veena
- An Zhenyi
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- Andrabi Shaida A
- Andrade-Silva Magaiver
- Andres Allen M
- Angelini Sabrina
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- Anton Zurine
- Anwar Tahira
- Apetoh Lionel
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- Araki Yasuhiro
- Arasaki Kohei
- Araujo Thais Fenz
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- Vega-Rubin-de-Celis Silvia
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- Verdier Mireille
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- Wang Maggie Haitian
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- Wang Yu
- Wang Yuqi
- Wang Zhe
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- Xiao Hengyi
- Xiao Hong-tao
- Xiao Jian
- Xiao Lan
- Xiao Shi
- Xiao Yin
- Xie Baoming
- Xie Chuan-Ming
- Xie Min
- Xie Yuxiang
- Xie Zhiping
- Xie Zhonglin
- Xilouri Maria
- Xu Congfeng
- Xu En
- Xu Haoxing
- Xu Jing
- Xu JinRong
- Xu Liang
- Xu Wen Wen
- Xu Xiulong
- Xue Yu
- Yakhine-Diop Sokhna MS
- Yamaguchi Masamitsu
- Yamaguchi Osamu
- Yamamoto Ai
- Yamashina Shunhei
- Yan Shengmin
- Yan Shian-Jang
- Yan Zhen
- Yanagi Yasuo
- Yang Chuanbin
- Yang Dun-Sheng
- Yang Huan
- Yang Huang-Tian
- Yang Hui
- Yang Jin-Ming
- Yang Jing
- Yang Jingyu
- Yang Ling
- Yang Liu
- Yang Ming
- Yang Pei-Ming
- Yang Qian
- Yang Seungwon
- Yang Shu
- Yang Shun-Fa
- Yang Wannian
- Yang Wei Yuan
- Yang Xiaoyong
- Yang Xuesong
- Yang Yi
- Yang Ying
- Yao Honghong
- Yao Shenggen
- Yao Xiaoqiang
- Yao Yong-Gang
- Yao Yong-Ming
- Yasui Takahiro
- Yazdankhah Meysam
- Yen Paul M
- Yi Cong
- Yin Xiao-Ming
- Yin Yanhai
- Yin Zhangyuan
- Yin Ziyi
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- Yoshida Kiyotsugu
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- Yoshimori Tamotsu
- Yousefi Bahman
- Yu Boxuan
- Yu Haiyang
- Yu Jun
- Yu Jun
- Yu Li
- Yu Ming-Lung
- Yu Seong-Woon
- Yu Victor C
- Yu W Haung
- Yu Zhengping
- Yu Zhou
- Yuan Junying
- Yuan Ling-Qing
- Yuan Shilin
- Yuan Shyng-Shiou F
- Yuan Yanggang
- Yuan Zengqiang
- Yue Jianbo
- Yue Zhenyu
- Yun Jeanho
- Yung Raymond L
- Zacks David N
- Zaffagnini Gabriele
- Zambelli Vanessa O
- Zanella Isabella
- Zang Qun S
- Zanivan Sara
- Zappavigna Silvia
- Zaragoza Pilar
- Zarbalis Konstantinos S
- Zarebkohan Amir
- Zarrouk Amira
- Zeitlin Scott O
- Zeng Jialiu
- Zeng Ju-deng
- Zerovnik Eva
- Zhan Lixuan
- Zhang Bin
- Zhang Donna D
- Zhang Hanlin
- Zhang Hong
- Zhang Hong
- Zhang Honghe
- Zhang Huafeng
- Zhang Huaye
- Zhang Hui
- Zhang Hui-Ling
- Zhang Jianbin
- Zhang Jianhua
- Zhang Jing-Pu
- Zhang Kalin YB
- Zhang Leshuai W
- Zhang Lin
- Zhang Lisheng
- Zhang Lu
- Zhang Luoying
- Zhang Menghuan
- Zhang Peng
- Zhang Sheng
- Zhang Wei
- Zhang Xiangnan
- Zhang Xiao-Wei
- Zhang Xiaolei
- Zhang Xiaoyan
- Zhang Xin
- Zhang Xinxin
- Zhang Xu Dong
- Zhang Yang
- Zhang Yanjin
- Zhang Yi
- Zhang Ying-Dong
- Zhang Yingmei
- Zhang Yuan-Yuan
- Zhang Yuchen
- Zhang Zhe
- Zhang Zhengguang
- Zhang Zhibing
- Zhang Zhihai
- Zhang Zhiyong
- Zhang Zili
- Zhao Haobin
- Zhao Lei
- Zhao Shuang
- Zhao Tongbiao
- Zhao Xiao-Fan
- Zhao Ying
- Zhao Yongchao
- Zhao Yongliang
- Zhao Yuting
- Zheng Guoping
- Zheng Kai
- Zheng Ling
- Zheng Shizhong
- Zheng Xi-Long
- Zheng Yi
- Zheng Zu-Guo
- Zhivotovsky Boris
- Zhong Qing
- Zhou Ao
- Zhou Ben
- Zhou Cefan
- Zhou Gang
- Zhou Hao
- Zhou Hong
- Zhou Hongbo
- Zhou Jie
- Zhou Jing
- Zhou Jing
- Zhou Jiyong
- Zhou Kailiang
- Zhou Rongjia
- Zhou Xu-Jie
- Zhou Yanshuang
- Zhou Yinghong
- Zhou Yubin
- Zhou Zheng-Yu
- Zhou Zhou
- Zhu Binglin
- Zhu Changlian
- Zhu Guo-Qing
- Zhu Haining
- Zhu Hongxin
- Zhu Hua
- Zhu WeiGuo
- Zhu Yanping
- Zhu Yushan
- Zhuang Haixia
- Zhuang Xiaohong
- Zientara-Rytter Katarzyna
- Zimmermann Christine M
- Ziviani Elena
- Zoladek Teresa
- Zong Wei-Xing
- Zorov Dmitry B
- Zorzano Antonio
- Zou Weiping
- Zou Zhen
- Zou Zhengzhi
- Zuryn Steven
- Zwerschke Werner
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field