180 research outputs found
In Vivo confocal endomicroscopy of small intestinal mucosal morphology in dogs
Background: Confocal endomicroscopy (CEM) is an endoscopic technology that permits in vivo cellular and subcellular imaging of the gastrointestinal mucosa. Objective: To determine the feasibility of CEM to evaluate small intestinal mucosal topologic morphology in dogs and to characterize the appearance in healthy dogs. Animals: Fourteen clinically healthy research colony dogs. Methods: Experimental study. Dogs were anesthetized for standard endoscopic evaluation of the small intestine followed by CEM. Two fluorophores were used to provide contrast: fluorescein (10% solution, 15 mg/kg IV) before administration of topical acriflavine (0.05% solution) via an endoscopy spray catheter. A minimum of 5 sites within the small intestine were assessed and at each location, sequential adjustment of imaging depth allowed collection of a three-dimensional volume equivalent to an 'optical biopsy'. CEM-guided pinch biopsies were obtained for histologic examination. Results: CEM provided high-quality in vivo cellular and subcellular images. Intravenous administration of fluorescein provided sufficient contrast to allow assessment of the vasculature, cellular cytoplasmic features and goblet cell numbers, and distribution. Topical application of acriflavine preferentially stained cellular nucleic acids, allowing evaluation of nuclear morphology. Quality of captured images was occasionally affected by motion artifact, but improved with operator experience. Conclusion and Clinical Importance: CEM provides in vivo images that allow for cellular and subcellular assessment of intestinal mucosal morphology during endoscopy. This has implications for aiding in vivo diagnosis of gastrointestinal disease. \ua9 2013 by the American College of Veterinary Internal Medicine
Myocardial injury in major aortic surgery
AbstractPurpose: The purpose of this study was to examine the effects of major aortic surgery and its associated oxidative stress and injury on the myocardium. Methods: Plasma from 27 patients who underwent thoracoabdominal aortic aneurysm (TAAA) repair and 17 patients who underwent infrarenal aortic aneurysm (AAA) repair was collected at incision, aortic crossclamping, and reperfusion and 1, 8, and 24 hours thereafter. Samples were assayed for the myocardial specific protein troponin-T, total antioxidant status, and lipid hydroperoxides. Results: Ten patients experienced cardiac dysfunction in the first 24 hours after surgery (eight patients in the TAAA group and two patients in the AAA group). Immediately after reperfusion, total antioxidant status levels dropped in all patients with TAAA and with AAA; this was more marked in patients with TAAA, leading to a significant difference between the two groups at this time point and for up to 1 hour thereafter (P <.01). Patients with TAAA showed a sharp rise in lipid hydroperoxide levels immediately after reperfusion, and levels were significantly higher than in patients with AAA (P =.0007). In patients with AAA, no significant change in troponin-T was observed throughout the study period; whereas in patients with TAAA, levels were significantly elevated at 8 and 24 hours after reperfusion (P <.01). Troponin-T levels significantly correlated with total antioxidant status (r = –0.5) and lipid hydroperoxides (r = 0.78) but not with systolic blood pressure. Conclusion: Supracoeliac aortic crossclamping is associated with a significant release of the myocardial injury marker troponin-T. This seems to correlate with the severity of oxidative rather than hemodynamic stresses. Ameliorating oxidative injury during TAAA surgery may therefore have a cardioprotective effect. (J Vasc Surg 2000;31:742-50.
Classification and nondegeneracy of Toda system with singular sources
We consider the following Toda system \Delta u_i + \D \sum_{j = 1}^n
a_{ij}e^{u_j} = 4\pi\gamma_{i}\delta_{0} \text{in}\mathbb R^2, \int_{\mathbb
R^2}e^{u_i} dx -1\delta_0a_{ij}\gamma_i=0\forall \;1\leq i\leq n\gamma_i+\gamma_{i+1}+...+\gamma_j \notin \mathbb Z1\leq i\leq
j\leq nu_i$ is \textit{radially symmetric} w.r.t. 0.
(iii) We prove that the linearized equation at any solution is
\textit{non-degenerate}. These are fundamental results in order to understand
the bubbling behavior of the Toda system.Comment: 28 page
Inclusive One Jet Production With Multiple Interactions in the Regge Limit of pQCD
DIS on a two nucleon system in the regge limit is considered. In this
framework a review is given of a pQCD approach for the computation of the
corrections to the inclusive one jet production cross section at finite number
of colors and discuss the general results.Comment: 4 pages, latex, aicproc format, Contribution to the proceedings of
"Diffraction 2008", 9-14 Sep. 2008, La Londe-les-Maures, Franc
A retrospective multi‐center study of treatment, outcome, and prognostic factors in 34 dogs with disseminated aspergillosis in Australia
Background
Disseminated aspergillosis (DA) in dogs has a guarded prognosis and there is a lack of a gold standard treatment protocol.
Objective
To retrospectively assess survival times and factors influencing survival times.
Animals
Dogs diagnosed with DA from January 2007 to June 2017.
Methods
Disseminated aspergillosis case data were retrieved from 13 Australian veterinary referral centers, with a diagnosis confirmed with culture or PCR. Factors influencing survival time after diagnosis were quantified using a Cox proportional hazards regression model.
Results
Thirty-four dogs met the study inclusion criteria. Twenty-two dogs were treated with antifungal treatment and 12 dogs received no antifungal treatment. Accounting for censoring of dogs that were either still alive on the date of data collection or were loss to follow-up, dogs treated with itraconazole alone (n = 8) had a median survival time (MST) of 63 (95% CI: 20−272) days compared to 830 (95% CI: 267-1259) days for the n = 14 dogs that received multimodal antifungal therapy
Symmetries of a class of nonlinear fourth order partial differential equations
In this paper we study symmetry reductions of a class of nonlinear fourth
order partial differential equations \be u_{tt} = \left(\kappa u + \gamma
u^2\right)_{xx} + u u_{xxxx} +\mu u_{xxtt}+\alpha u_x u_{xxx} + \beta u_{xx}^2,
\ee where , , , and are constants. This
equation may be thought of as a fourth order analogue of a generalization of
the Camassa-Holm equation, about which there has been considerable recent
interest. Further equation (1) is a ``Boussinesq-type'' equation which arises
as a model of vibrations of an anharmonic mass-spring chain and admits both
``compacton'' and conventional solitons. A catalogue of symmetry reductions for
equation (1) is obtained using the classical Lie method and the nonclassical
method due to Bluman and Cole. In particular we obtain several reductions using
the nonclassical method which are no} obtainable through the classical method
Modelling Effects of Tariff Liberalisation on India’s Key Export Sectors: Analysis of the EU–India Free Trade Agreement
Trade agreements are increasingly being negotiated between developed and emerging economy partners. An example is the EU–India Free Trade Agreement (FTA) for which negotiations began in 2007. There has been a debate on the potential effects of the proposed FTA and how this can impact on India’s key export sectors. Our study addresses this aspect from a global computable general equilibrium (CGE) modelling perspective. Using the Global Trade Analysis Project (GTAP) framework, we analyse trade and welfare impacts of the proposed FTA between the EU and India. Two scenarios are modelled: first, complete and immediate elimination of tariff on all goods traded and second, selective tariff elimination on textiles, wearing apparel and leather goods—products in which India has a comparative advantage. Results under both scenarios show that India enjoys positive welfare effects though there is a possibility of trade diversion. Under scenario 1, India loses due to a negative terms of trade (ToT) effect. Under scenario 2, with selective sectoral liberalisation, gains are mainly concentrated in the textiles, wearing apparel and leather sectors. There is a positive output effect from change in demand for factors of production, suggesting that the proposed FTA could lead to relocation of labour-intensive production to India
Laparoendoscopic Single-Site Surgery na realização de criptorquidectomia laparoscópica em um gato
Produção e composição do leite de vacas em pastagem de capim-elefante (Pennisetum purpureum) suplementado com diferentes fontes de carboidratos
On the mechanisms governing gas penetration into a tokamak plasma during a massive gas injection
A new 1D radial fluid code, IMAGINE, is used to simulate the penetration of gas into a tokamak plasma during a massive gas injection (MGI). The main result is that the gas is in general strongly braked as it reaches the plasma, due to mechanisms related to charge exchange and (to a smaller extent) recombination. As a result, only a fraction of the gas penetrates into the plasma. Also, a shock wave is created in the gas which propagates away from the plasma, braking and compressing the incoming gas. Simulation results are quantitatively consistent, at least in terms of orders of magnitude, with experimental data for a D 2 MGI into a JET Ohmic plasma. Simulations of MGI into the background plasma surrounding a runaway electron beam show that if the background electron density is too high, the gas may not penetrate, suggesting a possible explanation for the recent results of Reux et al in JET (2015 Nucl. Fusion 55 093013)
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