The Durotriges Project, Phase Two: an interim statement

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Common Data Elements: Critical Assessment of Harmonization between Current Multi-Center Traumatic Brain Injury Studies

Standardization and harmonization of data collection in studies on traumatic brain injury (TBI) is of paramount importance for meta-analyses across studies. Nearly 10 years ago, the first set of Common Data Elements for TBI (TBI-CDEs v1) were introduced to achieve these goals. The TBI-CDEs version 2 wer

The role of Delta(1700) excitation and rho production in double pion photoproduction

Recent information on invariant mass distributions of the $\gamma p\to\pi^+\pi^0 n$ reaction, where previous theoretical models had shown deficiencies, have made more evident the need for new mechanisms, so far neglected or inaccurately included. We have updated a previous model to include new necessary mechanisms. We find that the production of the $\rho$ meson, and the $\Delta(1700)$ excitation, through interference with the dominant terms, are important mechanisms that solve the puzzle of the $\gamma p\to\pi^+\pi^0 n$ reaction without spoiling the early agreement with the $\gamma p\to\pi^+\pi^- p$ and $\gamma p\to\pi^0\pi^0 p$ reactions.Comment: 39 pages, 13 figures (ps files). Final version. To be published in Nucl. Phys.

Leading for gold: social identity leadership processes at the London 2012 Olympic Games

© 2014, © 2014 Taylor & Francis. This paper adopted a social identity approach to explore the media data of leadership figures at the London 2012 Olympic Games. Media data in the form of interviews, speeches/team announcements, and blog posts from leaders integral to the London 2012 Olympic Games were analysed from 100 days prior to, during, and for 30 days following, the Olympic Games. Leaders included Lord Seb Coe, Andy Hunt, and performance directors of TeamGB athletics (Charles van Commenee), cycling (Sir David Brailsford), rowing (David Tanner) and swimming (Michael Scott). An inductive and deductive thematic analysis identified five higher order themes: creation of team identities, team values, team vision, performance consequences and ‘we’ achieved. The analysis makes a contribution to extant leadership literature by highlighting novel contextually relevant themes surrounding leadership at the London 2012 Olympic Games. Thus, opportunities for future research and application are outlined

Uncovering precision phenotype-biomarker associations in traumatic brain injury using topological data analysis

Background: Traumatic brain injury (TBI) is a complex disorder that is traditionally stratified based on clinical signs and symptoms. Recent imaging and molecular biomarker innovations provide unprecedented opportunities for improved TBI precision medicine, incorporating patho-anatomical and molecular mechanisms. Complete integration of these diverse data for TBI diagnosis and patient stratification remains an unmet challenge. Methods and findings: The Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Pilot multicenter study enrolled 586 acute TBI patients and collected diverse common data elements (TBI-CDEs) across the study population, including imaging, genetics, and clinical outcomes. We then applied topology-based data-driven discovery to identify natural subgroups of patients, based on the TBI-CDEs collected. Our hypothesis was two-fold: 1) A machine learning tool known as topological data analysis (TDA) would reveal data-driven patterns in patient outcomes to identify candidate biomarkers of recovery, and 2) TDA-identified biomarkers would significantly predict patient outcome recovery after TBI using more traditional methods of univariate statistical tests. TDA algorithms organized and mapped the data of TBI patients in multidimensional space, identifying a subset of mild TBI patients with a specific multivariate phenotype associated with unfavorable outcome at 3 and 6 months after injury. Further analyses revealed that this patient subset had high rates of post-traumatic stress disorder (PTSD), and enrichment in several distinct genetic polymorphisms associated with cellular responses to stress and DNA damage (PARP1), and in striatal dopamine processing (ANKK1, COMT, DRD2). Conclusions: TDA identified a unique diagnostic subgroup of patients with unfavorable outcome after mild TBI that were significantly predicted by the presence of specific genetic polymorphisms. Machine learning methods such as TDA may provide a robust method for patient stratification and treatment planning targeting identified biomarkers in future clinical trials in TBI patients

Clinical predictors of 3- and 6-month outcome for mild traumatic brain injury patients with a negative head CT scan in the emergency department: A TRACK-TBI pilot study

Aconsiderable subset of mild traumatic brain injury (mTBI) patients fail to return to baseline functional status at or beyond 3 months postinjury. Identifying at-risk patients for poor outcome in the emergency department (ED) may improve surveillance strategies and referral to care. Subjects with mTBI (Glasgow Coma Scale 13–15) and negative ED initial head CT < 24 h of injury, completing 3- or 6-month functional outcome (Glasgow Outcome Scale-Extended; GOSE), were extracted from the prospective, multicenter Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Pilot study. Outcomes were dichotomized to full recovery (GOSE = 8) vs functional deficits (GOSE < 8). Univariate predictors with p < 0.10 were considered for multivariable regression. Adjusted odds ratios (AOR) were reported for outcome predictors. Significance was assessed at p < 0.05. Subjects who completed GOSE at 3- and 6-month were 211 (GOSE < 8: 60%) and 185 (GOSE < 8: 65%). Risk factors for 6-month GOSE < 8 included less education (AOR = 0.85 per-year increase, 95% CI: (0.74–0.98)), prior psychiatric history (AOR = 3.75 (1.73–8.12)), Asian/minority race (American Indian/Alaskan/Hawaiian/Pacific Islander) (AOR = 23.99 (2.93–196.84)), and Hispanic ethnicity (AOR = 3.48 (1.29–9.37)). Risk factors for 3-month GOSE < 8 were similar with the addition of injury by assault predicting poorer outcome (AOR = 3.53 (1.17–10.63)). In mTBI patients seen in urban trauma center EDs with negative CT, education, injury by assault, Asian/minority race, and prior psychiatric history emerged as risk factors for prolonged disability

eta-prime Meson Production in Nucleon-Nucleon Collisions Near The Threshold

The production of $\eta'$ mesons in the reactions $pp\to pp\eta'$ and $pn\to pn\eta'$ at threshold-near energies is analyzed within a covariant effective meson-nucleon theory. The description of cross section and angular distributions of the available data in this kinematical region in the $pp$ channel is accomplished by including meson currents and nucleon currents with the resonances $S_{11}(1650)$, $P_{11}(1710)$ and $P_{13}(1720)$. Predictions for the $pn$ channel are given. The di-electron production from subsequent $\eta'$ Dalitz decay $\eta' \to \gamma \gamma^* \to\gamma e^+e^-$ is also calculated and numerical results are presented for intermediate energy and kinematics of possible experiments with HADES, CLAS and KEK-PS