Tobacco Usage among Males in Rural Tamil Nadu, India: A Cross-sectional Study

Background: Knowing the prevalence of tobacco use and the socio-demographic profile of users might prove useful in further strengthening the information, education, communication and regulatory activities, thereby decreasing tobacco use. The objective was to study the prevalence and pattern of tobacco use among men aged 18 years and above in rural area of Tamil Nadu. Methods: A cross sectional study was performed among 714 males aged 18 years and above in Vadagarai village of Tamil Nadu during 2010 and interviewed with a pretested questionnaire. Systematic random sampling was used to select the participants. Results: Prevalence of smoking was found to be 36.7%. Cigarette smoking was more common than beedi and smokeless tobacco.Conclusion: Strict enforcement of anti-tobacco legislation and awareness measures targeting ill-effects of tobacco can be intensified to reduce tobacco related morbidity and mortality

FRUGAL INNOVATIONS: THE FUTURE OF AFFORDABLE HEALTH CARE

Frugal innovations are cost-conscious innovations developed to meet the needs in resource-poor settings, withoutcompromising quality. While there have been various innovations in the field of health care in the past decades, there is avast difference in the distribution and utilization of these innovations between developed and developing countries. Frugalinnovations can play a potential role in bridging the gap between countries and ensure affordable health care for all

Double burden of malnutrition among elderly population of Delhi

Background: Nutritional status is an important determinant for elderly, directly influencing their susceptibility to diseases, adversely affecting their quality of life.  Aim & Objective: To assess the nutritional status of elderly persons aged ?60 years residing in an urban resettlement colony of Delhi. Materials and Methods: A community-based cross-sectional study was conducted in a resettlement colony in Delhi. Cluster random sampling was used. Three out of ten blocks were selected randomly. All elderly persons present in the selected blocks were included.  Information on socio-demographic variables was collected. Arm span and weight were measured by trained investigators. Data was entered in MS Excel 2007 and analyzed in Stata 11.0. Multiple logistic regression was done to determine the association between nutritional status and socio-demographic variables Results: A total of 711 elderly persons were recruited. About half (53.2%) had normal nutritional status, 20.8% were underweight and 19.4% were overweight and 6.6% were obese. Under-nutrition was significantly associated with gender, while overweight/obesity was found to be significantly associated with age (p<0.001), gender (p<0.001), occupation (p<0.001) and economic dependency (p< 0.001). Conclusion: Dual burden of malnutrition was seen, so there is a need to promote healthy eating and lifestyle to address both spectrum of malnutrition

Determinantes de los intervalos genésicos en tamil nadu (india): desarrollando modelos de riesgos de cox con validaciones y predicciones

Este estudio utiliza datos de la Encuesta Nacional de Salud Familiar (International Institute for Population Sciences 1995) realizada en el estado de Tamil Nadu, India. Se desarrollaron modelos de Cox para analizar el efecto de la lactancia materna cuando varía en el tiempo y el factor tiempo depende de los intervalos genésicos. La lactancia materna sólo mejora la probabilidad de acceder a un nivel más alto en cada intervalo de nacimiento. Otros factores que entraron en los modelos fueron en el intervalo del primer parto: nivel educativo de la madre (secundaria y superior) y trabajo de la madre; en el intervalo del segundo parto: nivel de supervivencia en el índice de vida infantil y nivel educativo del padre (secundaria y superior), y en el intervalo del tercer parto: lactancia materna más 22 meses. Cada uno de los anteriores es un factor protector para ampliar el intervalo entre nacimientos en el estudio. Además, este estudio confirma los modelos desarrollados en los servicios públicos de predicción para los intervalos genésicos.The present study uses data from National Family Health Survey (NFHS-1) 1992-93 (International Institute for Population Sciences 1995) conducted in the state of Tamil Nadu, India. Cox models were developed to analyze the effect of breastfeeding as time varying and time dependent factor on birth intervals. Breastfeeding alone improved the log likelihood up to a higher level in each birth interval. Other factors that entered into the models were: at first birth interval, women’s education (high school and amp; above) and working status of women; at second birth interval, survival status of index child alive and husband’s education (high school and amp; above), and at third birth interval, breastfeeding more than 22 month were found to be protective factors for next births. Validation of the developed models was done through bootstrapping to predict birth intervals

Chikungunya Infection in India: Results of a Prospective Hospital Based Multi-Centric Study

Chikungunya (CHIKV) has recently seen a re-emergence in India with high morbidity. However, the epidemiology and disease burden remain largely undetermined. A prospective multi-centric study was conducted to evaluate clinical, epidemiological and virological features of chikugunya infection in patients with acute febrile illness from various geographical regions of India.A total of 540 patients with fever of up to 7days duration were enrolled at Karnataka Institute of Medical Sciences (KIMS), Karnataka (South); Sawai Man Singh Medical College (SMS) Rajasthan (West), and All India Institute of Medical Sciences (AIIMS) New Delhi (North) from June 2008 to May 2009. Serum specimens were screened for chikungunya infection concurrently through RT-PCR and serology (IgM). Phylogenetic analysis was performed using Bioedit and Mega2 programs. Chikungunya infection was detected in 25.37% patients by RT-PCR and/or IgM-ELISA. Highest cases were detected in south (49.36%) followed by west (16.28%) and north (0.56%) India. A difference in proportion of positives by RT-PCR/ELISA with regard to duration of fever was observed (p<0.05). Rashes, joint pain/swelling, abdominal pain and vomiting was frequently observed among chikungunya confirmed cases (p<0.05). Adults were affected more than children. Anti-CHIK antibodies (IgM) were detected for more than 60days of fever onset. Phylogenetic analysis based on E1 gene from KIMS patients (n = 15) revealed ∼99% homology clustering with Central/East African genotype. An amino acid change from lysine to glutamine at position 132 of E1 gene was frequently observed among strains infecting children.The study documented re-emergence of chikungunya in high frequencies and severe morbidity in south and west India but rare in north. The study emphasizes the need for continuous surveillance for disease burden using multiple diagnostic tests and also warrants the need for an appropriate molecular diagnostic for early detection of chikungunya virus

Respiratory viral infections detected by multiplex PCR among pediatric patients with lower respiratory tract infections seen at an urban hospital in Delhi from 2005 to 2007

<p>Abstract</p> <p>Background</p> <p>Acute lower respiratory tract infections (ALRI) are the major cause of morbidity and mortality in young children worldwide. Information on viral etiology in ALRI from India is limited. The aim of the present study was to develop a simple, sensitive, specific and cost effective multiplex PCR (mPCR) assay without post PCR hybridization or nested PCR steps for the detection of respiratory syncytial virus (RSV), influenza viruses, parainfluenza viruses (PIV1–3) and human metapneumovirus (hMPV). Nasopharyngeal aspirates (NPAs) were collected from children with ALRI ≤ 5 years of age. The sensitivity and specificity of mPCR was compared to virus isolation by centrifugation enhanced culture (CEC) followed by indirect immunofluorescence (IIF).</p> <p>Results</p> <p>From April 2005–March 2007, 301 NPAs were collected from children attending the outpatient department or admitted to the ward of All India Institute of Medical Sciences hospital at New Delhi, India. Multiplex PCR detected respiratory viruses in 106 (35.2%) of 301 samples with 130 viruses of which RSV was detected in 61, PIV3 in 22, PIV2 in 17, hMPV in 11, PIV1 in 10 and influenza A in 9 children. CEC-IIF detected 79 viruses only. The sensitivity of mPCR was 0.1TCID₅₀for RSV and influenza A and 1TCID₅₀for hMPV, PIV1, PIV2, PIV3 and Influenza B. Mixed infections were detected in 18.8% of the children with viral infections, none detected by CEC-IIF. Bronchiolitis was significantly associated with both total viral infections and RSV infection (p < 0.05). History of ARI in family predisposed children to acquire viral infection (p > 0.05).</p> <p>Conclusion</p> <p>Multiplex PCR offers a rapid, sensitive and reasonably priced diagnostic method for common respiratory viruses.</p

HİNDİSTAN’DA KUDUZ HASTALIĞI: İHMAL EDİLEN YAYGIN HASTALIĞA YENİDEN BİR BAKIŞ

Rabies is a tropical zoonotic disease, transmitted to human being by carnivorous animals. Majority of human rabies cases were reported from Asia and African countries. India recorded more deaths from rabies than any other country in the world. There is no effective treatment for rabies; it can only be prevented by vaccination. It needs multiple levels of interventions at human and animal level. World Health Organization’s target is to eliminate the disease by 2020 in endemic South-East Asian countries which include India. Key challenges in control of rabies in India are lack of intersectoral coordination, weak surveillance system on rabies, inadequate rabies research and lack of sustainability. To conclude, breaking the rabies cycle in a sustained manner is necessary to eliminate rabies from this part of the world