Gastronomic events in the function of creating a brand of a tourist destination: The example of strudel festival in Dolovo

Gastronomic events in recent years represent a very significant segment for the development of tourism. There are numerous events traditionally taking place in Vojvodina. Each of these events is unique and represents a rich variety of customs, culture and traditions. The authentic gastronomic offer, which is promoted through these events, is an important segment for creating a brand of a particular place and tourist destination. The aim of this study is to investigate the recognizability of the Strudel festival in Dolovo, as well as the authenticity of this gastronomic event, in terms of creating a brand of the tourist destination. The research was carried out using the survey method, through a questionnaire, on a sample of 150 respondents. Based on the collected data, using statistical methods of binary logistic regression, chi-square and Fisher's test, the analysis was performed and the results were presented. The results of the research show that the Strudel festival in Dolovo and its brand - strudels - have a high level of recognizability among visitors. However, the Strudel festival in Dolovo should be promoted more intensively, as it is currently recognized locally, and has the potential to attract more tourists.Publishe

Development of an 18F radiolabeling method using solid phase chemistry

New radiotracers are constantly being developed to expand the clinical applications of positron emission tomography (PET). One of the challenges in the development of PET tracers is the incorporation of a positron emitting isotope. Short half-lives combined with added safety measures when working with radioactive materials require a fast and simple synthesis. This project describes a solid phase fluorine-18 (t1/2 = 110 min) radiolabeling procedure that allows removal of impurities through filtration. The synthesis takes an indirect approach by first labeling a small molecule with F-18 and then coupling this molecule to an amine containing compound using solid phase dichlorotriazine (DCT). This procedure has been used to label various compounds containing primary and secondary amine groups without the need for an additional purification step. The total synthesis time required is approximately 80 min from the from delivery of the [ 18F]fluoride, with a decay corrected radiochemical yield of 3% for the example tested (yield will likely vary depending on the substrate). This demonstrates the potential of solid phase reagents like DCT to be used in radiolabeling, but further development is required to improve yields for this reaction

Do events contribute to the brand of Novi Sad?: A millennials' perspective

In the era of the global economy and more expressed need for obtaining a competitive advantage, strong brands and the branding process itself gain importance, which is why brand management principles are being applied even to geographical areas and destinations. Events and festivals represent an important element of brand destination, i.e. of cities worldwide, whereas in strategic documents related to the tourism both of the Republic of Serbia and of the city of Novi Sad, they are recognised as priority tourist products. The topic of this research is the analysis of importance of festivals for the "city of festivals" i.e. Novi Sad, but from the point of view of population that had little attention of researchers – millennials. Millennials, i.e. those born in the 1990's, are the largest generation humankind ever had and their attitudes are dominating on the market. The research conducted in May 2018 on a sample of 102 students in Novi Sad has shown absolute domination of Exit festival in all aspects, but also some other interesting characteristics of Novi Sad brand.Publishe

Autentičnost gastronomskih manifestacija u funkciji brendiranja destinacije

The promotion of authentic food and beverages in Vojvodina is most commonly carried out in gastronomic events. Vojvodina is rich in gastronomic products coming from the households of different nations that inhabit its territory. Gastronomic events with their authenticity can contribute to the creation of the destination brand. The aim of the present study is to explore the authenticity of gastronomic events, which could contribute to a better promotion of Vojvodina and the creation of a recognizable brand of this tourist destination. The research was conducted through the method of survey, using a questionnaire on a sample of 150 respondents. Using statistical methods of binary logistic regression, Chi - square and Fisher's test, the analysis was performed and the results were presented. The findings of the research indicate that the authenticity of gastronomic events is recognized by the tourists; however, this should be better utilized in destination branding, as this feature could be the key in attracting tourists.Publishe

Effect of intrathecal morphine on pain score in total hip arthroplasty

Introduction: The advantage of intrathecal morphine is due to its delivery into the subarachnoid space with direct access to opiate receptors and ion channels, while clinical duration of action can be as long as 20 hours. Joint replacement surgery is reported to be one of the most painful surgical procedures. The key factor for short postoperative length of stay and rapid functional recovery is pre-operative, intraoperative and postoperative analgesia. Spinal anaesthesia incorporating intrathecal morphine has been used as a systemic opioid-sparing technique. The most frequently investigated dose of intrathecal morphine was 100 μg. Materials and Methods: In this study, spinal anaesthesia with the addition of morphine for intrathecal administration at a dose of 200 μg and 250 μg was administered to patients who underwent surgery for total hip arthroplasty and VAS pain scale was monitored postoperatively in the next 24 hours. The study group was compared to a group of patients who received standard intravenous analgesia postop- eratively. Results: Intrathecal application of morphine improves pain management in the first 24 postoperative hours in comparison to a control group who has received a systemic combination of opioid and non- opioid analgesics as part of postoperative analgesia. Conclusions: The use of intrathecal morphine at a dose of 200 μg or 250 μg is an extremely good anal- gesic method in the postoperative period after surgery for total hip arthroplasty

Effect of intrathecal morphine on pain score in total hip arthroplasty

Introduction: The advantage of intrathecal morphine is due to its delivery into the subarachnoid space with direct access to opiate receptors and ion channels, while clinical duration of action can be as long as 20 hours. Joint replacement surgery is reported to be one of the most painful surgical procedures. The key factor for short postoperative length of stay and rapid functional recovery is pre-operative, intraoperative and postoperative analgesia. Spinal anaesthesia incorporating intrathecal morphine has been used as a systemic opioid-sparing technique. The most frequently investigated dose of intrathecal morphine was 100 μg. Materials and Methods: In this study, spinal anaesthesia with the addition of morphine for intrathecal administration at a dose of 200 μg and 250 μg was administered to patients who underwent surgery for total hip arthroplasty and VAS pain scale was monitored postoperatively in the next 24 hours. The study group was compared to a group of patients who received standard intravenous analgesia postop- eratively. Results: Intrathecal application of morphine improves pain management in the first 24 postoperative hours in comparison to a control group who has received a systemic combination of opioid and non- opioid analgesics as part of postoperative analgesia. Conclusions: The use of intrathecal morphine at a dose of 200 μg or 250 μg is an extremely good anal- gesic method in the postoperative period after surgery for total hip arthroplasty

Studija uticaja pandemije COVID-19 na ponašanje i očekivanja turista - slučaj Srbije

Due to the spread of COVID-19 and the closing of the borders of a large number of countries, tourists’ interest in domestic tourist destinations has grown. The objective of this paper is to identify future behaviour patterns of tourists and to propose measures that would affect the interest of domestic tourists in domestic destinations after COVID-19. The study starts with an analysis of the impact of COVID-19 on global tourism, then focuses on trends in the tourism market in Serbia and ends by examining citizens' attitudes towards key factors for domestic tourism development. It is estimated that tourism can benefit from an essential understanding of tourists’ demands for a safe journey. Research results indicate statistically significant differences in the attitudes of respondents in relation to age, gender and education, but most respondents believe that it is necessary for the state to invest more in tourist infrastructure and to adjust pricing policy to remain competitive domestic destinations after Covid-19.Publishe

Assessing the effects of hydrological and chemical stressors on macroinvertebrate community in an Alpine river: the Adige river as a case study

In this study, the combined effects of hydrological and chemical stressors on benthic macroinvertebrates were evaluated in order to explore the response of the biological community to multiple stressors. The Adige River, located in the south‐eastern Alps, was selected as a case study because representative of the situation of a large river in which the variety of stressors present in the Alpine region act simultaneously. As expected, streamflow showed a seasonal pattern, with high flows in the spring-summer period; however, locally, the natural hydrological regime was altered by the presence of hydropower systems, which chiefly affected low flows. Multivariate analysis showed seasonal and spatial patterns in both chemical and hydrological parameters with a clear gradient in the concentration of nitrate, personal care, and pharmaceutical products moving from headwaters to the main stem of the river. The macroinvertebrate community composition was significantly different in summer and winter and between up and downstream sites. Streamflow alteration chiefly due to water use by hydropower affected community composition but not richness or diversity. Gammarus sp., Hirudinea, and Psychomyia sp., were positively correlated with flow variability, increasing their densities in the sites with higher streamflow variability because of hydropeaking. The results obtained in this study show that the composition of the macroinvertebrate community responded to seasonality and to changes in the main stressors along the river and highlights the importance of the spatial and temporal variability of stressors in this Alpine river. Taking into account, this variability will help the decision‐making process for improving basin management

Relapse in resected lung cancer revisited: does intensified follow up really matter? A prospective study

<p>Abstract</p> <p>Background</p> <p>beside the well known predominance of distant vs. loco-regional relapse, several aspects of the relapse pattern still have not been fully elucidated.</p> <p>Methods</p> <p>prospective, controlled study on 88 patients operated for non-small cell lung cancer (NSCLC) in a 15 months period. Stage IIIA existed in 35(39.8%) patients, whilst stages IB, IIA and IIB existed in 10.2%, 4.5% and 45.5% patients respectively. Inclusion criteria: stage I-IIIA, complete resection, systematic lymphadenectomy with at least 6 lymph node groups examined, no neoadjuvant therapy, exact data of all aspects of relapse, exact data about the outcome of the treatment.</p> <p>Results</p> <p>postoperative lung cancer relapse occurred in 50(56.8%) patients. Locoregional, distant and both types of relapse occurred in 26%, 70% and 4% patients respectively. Postoperative cancer relapse occurred in 27/35(77.1%) pts. in the stage IIIA and in 21/40(52.55) pts in the stage IIB. In none of four pts. in the stage IIA cancer relapse occurred, unlike 22.22% pts. with relapse in the stage IB. The mean disease free interval in the analysed group was 34.38 ± 3.26 months.</p> <p>The mean local relapse free and distant relapse free intervals were 55 ± 3.32 and 41.62 ± 3.47 months respectively Among 30 pts. with the relapse onset inside the first 12 month after the lung resection, in 20(66.6%) pts. either T3 tumours or N2 lesions existed. In patients with N0, N1 and N2 lesions, cancer relapse occurred in 30%, 55.6% and 70.8% patients respectively</p> <p>Radiographic aspect T stage, N stage and extent of resection were found as significant in terms of survival. Related to the relapse occurrence, although radiographic aspect and extent of resection followed the same trend as in the survival analysis, only T stage and N stage were found as significant in the same sense as for survival. On multivariate, only T and N stage were found as significant in terms of survival.</p> <p>Specific oncological treatment of relapse was possible in 27/50(54%) patients.</p> <p>Conclusion</p> <p>the intensified follow up did not increase either the proportion of patients detected with asymptomatic relapse or the number of patients with specific oncological treatment of relapse.</p

NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation

NKp46/NCR1 is an activating NK-cell receptor implicated in the control of various viral and bacterial infections. Recent findings also suggest that it plays a role in shaping the adaptive immune response to pathogens. Using NCR1-deficient (NCR1(gfp/gfp)) mice, we provide evidence for the role of NCR1 in antibody response to mouse cytomegalovirus infection (MCMV). The absence of NCR1 resulted in impaired maturation, function and NK-cell migration to regional lymph nodes. In addition, CD4(+) T-cell activation and follicular helper T-cell (Tfh) generation were reduced, leading to inferior germinal center (GC) B-cell maturation. As a consequence, NCR1(gfp/gfp) mice produced lower amounts of MCMV-specific antibodies upon infection, which correlated with lower number of virus-specific antibody secreting cells in analyzed lymph nodes