Interpreting the evolution of galaxy colours from z=8z = 8 to z=5z = 5

We attempt to interpret existing data on the evolution of the UV luminosity function and UV colours, $\beta$, of galaxies at $5 \leq z \leq 8$, to improve our understanding of their dust content and ISM properties. To this aim, we post-process the results of a cosmological hydrodynamical simulation with a chemical evolution model, which includes dust formation by supernovae and intermediate mass stars, dust destruction in supernova shocks, and grain growth by accretion of gas-phase elements in dense gas. We find that observations require a steep, Small Magellanic Cloud-like extinction curve and a clumpy dust distribution, where stellar populations younger than 15 Myr are still embedded in their dusty natal clouds. Investigating the scatter in the colour distribution and stellar mass, we find that the observed trends can be explained by the presence of two populations: younger, less massive galaxies where dust enrichment is mainly due to stellar sources, and massive, more chemically evolved ones, where efficient grain growth provides the dominant contribution to the total dust mass. Computing the IR-excess - UV color relation we find that all but the dustiest model galaxies follow a relation shallower than the Meurer et al. (1999) one, usually adopted to correct the observed UV luminosities of high-$z$ galaxies for the effects of dust extinction. As a result, their total star formation rates might have been over-estimated. Our study illustrates the importance to incorporate a proper treatment of dust in simulations of high-$z$ galaxies, and that massive, dusty, UV-faint galaxies might have already appeared at $z \lesssim 7$.Comment: accepted in MNRA

The dust mass in z > 6 normal star forming galaxies

We interpret recent ALMA observations of z > 6 normal star forming galaxies by means of a semi-numerical method, which couples the output of a cosmological hydrodynamical simulation with a chemical evolution model which accounts for the contribution to dust enrichment from supernovae, asymptotic giant branch stars and grain growth in the interstellar medium. We find that while stellar sources dominate the dust mass of small galaxies, the higher level of metal enrichment experienced by galaxies with Mstar > 10^9 Msun allows efficient grain growth, which provides the dominant contribution to the dust mass. Even assuming maximally efficient supernova dust production, the observed dust mass of the z = 7.5 galaxy A1689-zD1 requires very efficient grain growth. This, in turn, implies that in this galaxy the average density of the cold and dense gas, where grain growth occurs, is comparable to that inferred from observations of QSO host galaxies at similar redshifts. Although plausible, the upper limits on the dust continuum emission of galaxies at 6.5 < z < 7.5 show that these conditions must not apply to the bulk of the high redshift galaxy populationComment: 5 pages, 2 figures, accepted for publication as a Letter to MNRA

Electrode displacement after intracerebral hematoma as a complication of a deep brain stimulation procedure

Domenico Servello1, Marco Sassi1, Stefano Bastianello2, Guy Umberto Poloni2, Francesca Mancini3, Claudio Pacchetti31Functional Neurosurgery Unit, Istituto di Ricovero e Cura a Carattere Scientifico Galeazzi, Milan, Italy; 2Neuroradiology Unit; 3Parkinson Disease and Movement Disorder Unit, Istituto di Ricovero e Cura a Carattere Scientifico Mondino, Institute of Neurology, Pavia, Italy Objectives: Deep brain stimulation (DBS) is nowadays considered a safe and effective procedure for various movement disorders in which conservative treatments have failed to show significant therapeutic results. One of the most common complications of definitive electrode positioning is intraparenchymal hemorrhage.Materials and methods: Authors report the case of a 55-year-old female patient treated for&amp;nbsp;Parkinson&amp;rsquo;s disease in which intraparenchymal hemorrhage developed after DBS procedure, leading to significant (about 8 mm at the neuroradiological controls) displacement of an otherwise correctly positioned DBS electrode.Results: After conservative management, the hematoma spontaneously resolved. Late neuroradiological controls documented correct, symmetrically positioned electrodes, comparable to the immediate postoperative controls.Conclusions: Six months follow-up endpoint results of the DBS treatment were considered satisfying by an independent neurologist, with modest residual neurological deficits, demonstrating that re-positioning of the electrode was unnecessary in this rare complication.Keywords: deep brain stimulation, electrodes, outcomes, implant, case repor

Immune dyscrasia in adult growth hormone deficiency: Evaluation of hemolytic complement activity (CH50) and IgG subclasses.

CH50 is a screening assay for the activation of the classical complement pathway, the immunoglobulins-mediated one, activated in several inflammatory diseases. Adult growth hormone deficiency (aGHD) is recognized as a chronic inflammatory condition, although poorly evaluated under the profile of inflammatory biomarkers. The aim of this case-control observational study is to analyze CH50 and immunoglobulins G (IgG) subclasses production in aGHD, comparing this condition to healthy controls.38 subjects were included and divided as follows: aGHD (n = 18, 6 females and 12 males); healthy controls (n = 20, 10 females and 10 males). GHD was diagnosed with dynamic test using Growth Hormone-Releasing Hormone (GHRH 50 μg i.v. + arginine 0,5 g/Kg), with a peak GH response 30 kg/m2. The two groups were evaluated for hormonal and metabolic parameters, CH50 and IgG subtypes.IgG1 and IgG2 were significantly higher in controls than in aGHD, while IgG3 and IgG4 showed a trend to higher levels in controls, although not significant. Furthermore, CH50 levels were significantly higher in aGHD.These data substantiate the hypothesis of a dyscrasia in IgG subclasses production in aGHD. As IgG levels decrease, CH50 levels do not

COVID-19 and Youth Psychopathological Distress in Umbria, Central Italy: A 2-Year Observational Study in a Real-World Setting

IntroductionAdolescents and young adults represent a vulnerable population in the context of the Coronavirus disease 2019 (COVID-19) pandemic. The present retrospective study aims to investigate the pandemic's psychological impact on adolescents and young adults by analyzing data from an outpatient mental health service dedicated to youths in Umbria, central Italy. Materials and MethodsThe clinical charts of subjects aged 14-24 who first accessed the service in the timeframe between March 1st, 2019, and February 28th, 2021, were reviewed. Subjects were divided into two subgroups according to the period of time when they accessed the service (pre-COVID-19 vs. during- COVID-19 outbreak). Bivariate analyses were performed using the Chi-square test and the Welch's t-test. A secondary analysis was performed considering only subjects suffering from psychiatric disorders. Furthermore, data concerning individuals who were already followed by the service before the pandemic were analyzed by the McNemar's test and the t-paired test to assess changes in treatment features. ResultsThe number of new accesses during the pandemic period remained stable. After the emergency onset, youths accessing the service showed a higher prevalence of anxiety disorders (p = 0.022). During the COVID-19 period, services were more frequently delivered by using a digital mental health approach (p = 0.001). Psychopharmacological treatment was more frequently prescribed among subjects that were referred to the service after the pandemic onset (p = 0.033). As for substance use, a highly significant reduction in opioid use was observed (p = 0.003). Family therapy was delivered less frequently in the during-COVID-19 subgroup, especially in the subpopulation of subjects suffering from psychiatric disorders (p = 0.013). When considering subjects referred to the service in the pre-COVID-19 period, the number of interventions provided to this population increased after the pandemic outbreak (p = 0.038). ConclusionIn the context of the COVID-19-related public health crisis, youths represent an at-risk population for which pathways to care should be reinforced, and targeted interventions, including psychosocial treatments, should be implemented

Social assessment of raw materials supply chains: A life-cycle-based analysis

The value chains of raw materials and semi-finished products can create both positive and negative impacts in society, local communities, consumers, and workers. Raw materials have also a strategic importance for enhancing the competitiveness of the European industry, and creating employment (EC - European Commission, 2017a). At European level, the secure and sustainable supply of raw materials from domestic sources and international markets are key objectives of the Raw Materials Initiative (EC - European Commission, 2008a). The relationship between low security of supply and poor governance in supplier countries is acknowledged and captured in the list of Critical Raw Materials for the EU (EC - European Commission, 2017b). Internationally, many of the Sustainable Development Goals launched by the United Nations in 2015 (UN General Assembly, 2015) address, directly or indirectly, the social dimension of sustainable development and, hence, are linked to the supply of raw materials, under several aspects. In the context of sustainability assessment, Life Cycle Thinking is a well-known concept. Social Life Cycle Assessment (SLCA) evaluates social and socio-economic impacts along the life cycle of products (from the raw materials extraction, processing, manufacture, use, end of life) using a mix of generic and site specific data. Studies can be focused on a specific supply chain, or they can look at different sectors in an entire economy. In this study, we used a SLCA database for assessing and comparing the social risks associated with the supply chain of raw materials sectors at the macro scale in EU, and in a set of extra-EU countries. Negative social impacts are expressed in terms of potential risk to be exposed to negative social conditions while potential positive contributions are expressed using an opportunity evaluation. The economic sectors under investigation are those producing primary raw materials and semi-finished products, both from abiotic and biotic resources. According to the Eurostat NACE classification they are defined as: mining and quarrying; manufacture of basic metals; manufacture of non-metallic mineral products; forestry and logging; manufacture of paper and paper products; manufacture of wood and of products of wood. A set of social aspects (called subcategories, or areas of concern) was selected from those available in the database, according to criteria of relevance, data quality, etc. These include health and safety; freedom of association and collective bargaining; child labour; fair salary; working time (for the stakeholders category “workers”); respect of indigenous rights and migration (for the stakeholders category “local community”); corruption (for the stakeholders category “actors in the value chain”) and contribution to economic development (for the stakeholders category “society”). While the latter is a positive impact, the others are negative impacts occurring in the value chain. The initial results of the analysis compare social risk in the European raw materials supply chain with those of six extra-EU countries, for the set of selected social aspects. The contribution analysis shows social hotspots within a supply chain, highlighting sectors and locations that are mostly contributing to social risk in a certain subcategory. Data quality and sources of uncertainty are also discussed. As a general remark from the results of the preliminary international comparison, the social performance appears to be linked to socio-economic conditions of the country where the production activity occurs. Social risk seems to reflect also the development of a country and, to some extent, its governance. Given the granularity of the data used to assess social aspects (mostly at country, or macro-sector level), specific features of raw materials sectors are likely not captured in this analysis. This macro-scale assessment provides a first-screening assessment of supply chains, which can be used for prioritizing areas for more detailed investigation and for supporting due diligence operations at macro/sectorial scales. However, it should be complemented with bottom-up analyses in order to get a better understanding of the social consequences of more specific economic activities.JRC.D.3-Land Resource

Effects of Reactive Oxygen Species on Mitochondrial Content and Integrity of Human Anastomotic Colorectal Dehiscence: A Preliminary DNA Study

BACKGROUND: Anastomotic dehiscence is one of the most severe complications of colorectal surgery. Gaining insight into the molecular mechanisms responsible for the development of anastomotic dehiscence following colorectal surgery is important for the reduction of postoperative complications. OBJECTIVE: Based on the close relationship between surgical stress and oxidative stress, the present study aimed to determine whether a correlation exists between increased levels of reactive oxygen species and colorectal anastomotic dehiscence. METHODS: Patients who underwent surgical resection for colorectal cancer were divided into three groups: patients with anastomotic dehiscence (group 1); patients without dehiscence who underwent neoadjuvant radiochemotherapy (group 2); and patients without anastomotic dehiscence who did not undergo neoadjuvant radiochemotherapy (group 3). Quantitative polymerase chain reaction and real-time polymerase chain reaction assays were performed to measure nuclear DNA and mitochondrial DNA (mtDNA) content, and possible oxidative damage to nonmalignant colon and rectal tissues adjacent to the anastomoses. RESULTS: mtDNA content was reduced in the colon tissue of patients in groups 1 and 2. Rectal mtDNA was found to be more damaged than colonic mtDNAs in all groups. The 4977 bp common deletion was observed in the mtDNA of tissues from both the colon and rectum of all patients. DISCUSSION: Patients in groups 1 and 2 were more similar to one another than to group 3, probably due to higher levels of reactive oxygen species in the mitochondria; the greater damage found in the rectum suggests that dehiscence originates primarily from the rectal area. CONCLUSIONS: The present study of mtDNA analyses of normal human colon and rectal tissues from patients with colorectal cancer is among the first of its kind

Raw Materials Information System (RMIS): 2019 Roadmap & Progress Report - Context, content & foreseen priorities

The European Commission's (EC) Raw Materials Initiative (RMI) emphasises that raw materials are essential for the sound and sustainable functioning of Europe’s industries and, in a broader context, of Europe’s economy and society. The EC is committed to promote the competitiveness of industries related to raw materials. These industries play an important role in many downstream sectors in the European Union (EU) such as construction, chemicals, automotive, aerospace, machinery, pharmacy, equipment, renewable energy devices, and defence. These sectors have a combined added-value of around EUR 1,000 billion and provide employment for some 30 million people. Securing an undistorted supply of raw materials and, in particular, Critical Raw Materials (CRMs) is thus crucial and requires a sound and continuously developed knowledge base, namely the European Union Raw Materials Knowledge Base (EURMKB), as highlighted in the Strategic Implementation Plan (SIP) of the European Innovation Partnership (EIP) on Raw Materials. In this context, and responding to a specific action of the 2015 Circular Economy Communication, the JRC is further advancing the EC's Raw Materials Information System (RMIS), which was first released in March 2015. The markedly upgraded second version (hereinafter “RMIS 2.0”, or simply “RMIS”) was announced in the 2017 JRC “RMIS Roadmap & Progress Report” and officially launched during the 2017 “Raw Materials Week”, organised by DG GROW in Brussels. RMIS 2.0 broadened goal and scope of the first version, significantly expanded the network of its knowledge providers, and responded – often in quantitative terms – to the latest policy and knowledge needs on raw materials. In particular, important thematic sections such as “raw materials’ profiles”, “country profiles”, “supply chain viewer” and “raw materials knowledge gateway” were included. Since its conception and first release in 2015, RMIS has been developed in close cooperation with DG GROW. DG GROW helps the JRC to recognise policy and knowledge needs related to raw materials, and supports the JRC in identifying how RMIS can best meet these needs. RMIS development is supported by (and should be intended as part of) a well-established and extensive network of knowledge providers in the area of raw materials, which includes – among others – EC-funded projects, European Agencies (EASME, EEA, etc.), academia, European Geological Surveys, industry and business associations. Interactions and knowledge exchanges among the various stakeholders of this network are promoted in the yearly “RMIS Workshop” events, held at the JRC in Ispra, Italy, which attracts every year an increasing number of participants. Today, the RMIS is the EC’s reference web-based knowledge platform on non-fuel, non-agriculture raw materials from primary (extracted/harvested) and secondary (recycled/recovered) sources. RMIS responds to the need of strengthening the European Union Raw Materials Knowledge Base (EURMKB) and acts as the core access point to such knowledge and as interface for policy support. The knowledge accessible through RMIS is, to the extent possible, made available for the European Union (from regional, national and EU data), with the ambition of providing it in a harmonized way. This 2019 “RMIS Roadmap & Progress Report” presents RMIS in its latest form, highlights the progress made since 2017, connects this with most recent and relevant policy and knowledge needs on raw materials, and provides an overview of the development goals that could help fulfil such needs.JRC.D.3-Land Resource

Valutazione di Health Technology Assessment del sistema di sanificazione biologico a base di probiotici del genere Bacillus (PCHS)

Le infezioni correlate all’assistenza: priorità per la salute pubblica Epidemiologia delle infezioni correlate all’assistenza in Italia e loro impatto per la salute pubblica Sistemi di sanificazione attualmente disponibili in Italia Il Probiotic Cleaning Hygiene System (PCHS): caratteristiche della tecnologia, aspetti di efficacia e sicurezza Un sistema di sanificazione a base di probiotici per la riduzione delle infezioni correlate all’assistenza e la resistenza antimicrobica: analisi dell’impatto sul budget Impatto ambientale per la salute pubblica degli attuali sistemi di sanificazione di ambienti/superfici in setting assistenziale e comunitario e potenziali benefici dei nuovi sistemi innovativi Analisi delle principali raccomandazioni nazionali su sanificazione e disinfezione degli ambienti sanitari Valutazione etica dell’utilizzo del Probiotic Cleaning Hygiene System (PCHS) in Italia Elementi chiave per il processo decisional