Many-Body Superconformal Systems from Hamiltonian Reductions

We propose a new reduction mechanism which allows one to construct n-particle (super)conformal theories with pairwise interaction starting from a composite system involving n(n-1)/2+1 copies of the ordinary (super)conformal mechanics. Applications of the scheme include an N=4 superconformal extension for a complexification of the Calogero model and a D(2,1|\alpha)-invariant n-particle system.Comment: 12 pages, no figures. v2: Title changed. New material and acknowledgements adde

Supersymmetry for Fermion Masses

It is proposed that supersymmetry (SUSY) maybe used to understand fermion mass hierarchies. A family symmetry Z_{3L} is introduced, which is the cyclic symmetry among the three generation SU(2) doublets. SUSY breaks at a high energy scale ~ 10^{11} GeV. The electroweak energy scale ~ 100 GeV is unnaturally small. No additional global symmetry, like the R-parity, is imposed. The Yukawa couplings and R-parity violating couplings all take their natural values which are about (10^0-10^{-2}). Under the family symmetry, only the third generation charged fermions get their masses. This family symmetry is broken in the soft SUSY breaking terms which result in a hierarchical pattern of the fermion masses. It turns out that for the charged leptons, the tau mass is from the Higgs vacuum expectation value (VEV) and the sneutrino VEVs, the muon mass is due to the sneutrino VEVs, and the electron gains its mass due to both Z_{3L} and SUSY breaking. The large neutrino mixing are produced with neutralinos playing the partial role of right-handed neutrinos. |V_{e3}| which is for nu_e-nu_{tau} mixing is expected to be about 0.1. For the quarks, the third generation masses are from the Higgs VEVs, the second generation masses are from quantum corrections, and the down quark mass due to the sneutrino VEVs. It explains m_c/m_s, m_s/m_e, m_d > m_u and so on. Other aspects of the model are discussed.Comment: 25 pages, 3 figures, revtex4; neutrino oscillation and many discussions added, smallness of the electron mass due to supersymmetry pointed out; v3: numerical errors correcte

A Randomized Phase III Trial Investigating 2 Gy TBI Vs. Flu/2 Gy TBI Conditioning for HLA-Matched Related Donor Hematopoietic Cell Transplantation (HCT): Tempo of CD3 and NK Cell Engraftment Determines Relapse and Progression Free Survival in Patients with Hematologic

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Supersymmetric Unification Without Low Energy Supersymmetry And Signatures for Fine-Tuning at the LHC

The cosmological constant problem is a failure of naturalness and suggests that a fine-tuning mechanism is at work, which may also address the hierarchy problem. An example -- supported by Weinberg's successful prediction of the cosmological constant -- is the potentially vast landscape of vacua in string theory, where the existence of galaxies and atoms is promoted to a vacuum selection criterion. Then, low energy SUSY becomes unnecessary, and supersymmetry -- if present in the fundamental theory -- can be broken near the unification scale. All the scalars of the supersymmetric standard model become ultraheavy, except for a single finely tuned Higgs. Yet, the fermions of the supersymmetric standard model can remain light, protected by chiral symmetry, and account for the successful unification of gauge couplings. This framework removes all the difficulties of the SSM: the absence of a light Higgs and sparticles, dimension five proton decay, SUSY flavor and CP problems, and the cosmological gravitino and moduli problems. High-scale SUSY breaking raises the mass of the light Higgs to about 120-150 GeV. The gluino is strikingly long lived, and a measurement of its lifetime can determine the ultraheavy scalar mass scale. Measuring the four Yukawa couplings of the Higgs to the gauginos and higgsinos precisely tests for high-scale SUSY. These ideas, if confirmed, will demonstrate that supersymmetry is present but irrelevant for the hierarchy problem -- just as it has been irrelevant for the cosmological constant problem -- strongly suggesting the existence of a fine-tuning mechanism in nature.Comment: Typos and equations fixed, references adde

Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer

FEN1 has key roles in Okazaki fragment maturation during replication, long patch base excision repair, rescue of stalled replication forks, maintenance of telomere stability and apoptosis. FEN1 may be dysregulated in breast and ovarian cancers and have clinicopathological significance in patients. We comprehensively investigated FEN1 mRNA expression in multiple cohorts of breast cancer [training set (128), test set (249), external validation (1952)]. FEN1 protein expression was evaluated in 568 oestrogen receptor (ER) negative breast cancers, 894 ER positive breast cancers and 156 ovarian epithelial cancers. FEN1 mRNA overexpression was highly significantly associated with high grade (p= 4.89 x 10 - 57) , high mitotic index (p= 5.25 x 10 - 28), pleomorphism (p= 6.31 x 10-19), ER negative (p= 9.02 x 10-35 ), PR negative (p= 9.24 x 10-24 ), triple negative phenotype (p= 6.67 x 10-21) , PAM50.Her2 (p=5.19 x 10-13 ), PAM50.Basal (p=2.7 x 10-41), PAM50.LumB (p=1.56 x 10-26), integrative molecular cluster 1 (intClust.1) ( p=7.47 x 10-12), intClust.5 (p=4.05 x 10-12) and intClust. 10 (p=7.59 x 10-38 ) breast cancers. FEN1 mRNA overexpression is associated with poor breast cancer specific survival in univariate (p=4.4 x 10-16) and multivariate analysis (p=9.19 x 10-7). At the protein level, in ER positive tumours , FEN1 overexpression remains significantly linked to high grade, high mitotic index and pleomorphism (ps< 0.01). In ER negative tumours, high FEN1 is significantly associated with pleomorphism, tumour type, lymphovascular invasion, triple negative phenotype, EGFR and HER2 expression (ps<0.05). In ER positive as well as in ER negative tumours, FEN1 protein over expression is associated with poor survival in univariate and multivariate analysis (ps<0.01). In ovarian epithelial cancers , similarly, FEN1 overexpression is associated with high grade, high stage and poor survival (ps<0.05). We conclude that FEN1 is a promising biomarker in breast and ovarian epithelial cancer

170: Long-Term Outcome of Nonmyeloalative Allografting from HLA-Identical Sibling for Multiple Myeloma (MM)

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Ultraluminous Infrared Galaxies

Ever since their discovery in the 1970's, UltraLuminous InfraRed Galaxies (ULIRGs; classically Lir>10^12Lsun) have fascinated astronomers with their immense luminosities, and frustrated them due to their singularly opaque nature, almost in equal measure. Over the last decade, however, comprehensive observations from the X-ray through to the radio have produced a consensus picture of local ULIRGs, showing that they are mergers between gas rich galaxies, where the interaction triggers some combination of dust-enshrouded starburst and AGN activity, with the starburst usually dominating. Very recent results have thrown ULIRGs even further to the fore. Originally they were thought of as little more than a local oddity, but the latest IR surveys have shown that ULIRGs are vastly more numerous at high redshift, and tantalizing suggestions of physical differences between high and low redshift ULIRGs hint at differences in their formation modes and local environment. In this review we look at recent progress on understanding the physics and evolution of local ULIRGs, the contribution of high redshift ULIRGs to the cosmic infrared background and the global history of star formation, and the role of ULIRGs as diagnostics of the formation of massive galaxies and large-scale structures.Comment: Review article, published in "Astrophysics Update 2 - topical and timely reviews on astronomy and astrophysics". Ed. John W. Mason. Springer/Praxis books. ISBN: 3-540-30312-X. 53 pages, 5 figures. Higher quality figures available on reques

Volume I. Introduction to DUNE

The preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay—these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. The Deep Underground Neutrino Experiment (DUNE) is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. This TDR is intended to justify the technical choices for the far detector that flow down from the high-level physics goals through requirements at all levels of the Project. Volume I contains an executive summary that introduces the DUNE science program, the far detector and the strategy for its modular designs, and the organization and management of the Project. The remainder of Volume I provides more detail on the science program that drives the choice of detector technologies and on the technologies themselves. It also introduces the designs for the DUNE near detector and the DUNE computing model, for which DUNE is planning design reports. Volume II of this TDR describes DUNE\u27s physics program in detail. Volume III describes the technical coordination required for the far detector design, construction, installation, and integration, and its organizational structure. Volume IV describes the single-phase far detector technology. A planned Volume V will describe the dual-phase technology

Overview of the Alaskan Layered Pollution and Chemical Analysis (ALPACA) Field Experiment

The Alaskan Layered Pollution And Chemical Analysis (ALPACA) field experiment was a collaborative study designed to improve understanding of pollution sources and chemical processes during winter (cold climate and low-photochemical activity), to investigate indoor pollution, and to study dispersion of pollution as affected by frequent temperature inversions. A number of the research goals were motivated by questions raised by residents of Fairbanks, Alaska, where the study was held. This paper describes the measurement strategies and the conditions encountered during the January and February 2022 field experiment, and reports early examples of how the measurements addressed research goals, particularly those of interest to the residents. Outdoor air measurements showed high concentrations of particulate matter and pollutant gases including volatile organic carbon species. During pollution events, low winds and extremely stable atmospheric conditions trapped pollution below 73 m, an extremely shallow vertical scale. Tethered-balloon-based measurements intercepted plumes aloft, which were associated with power plant point sources through transport modeling. Because cold climate residents spend much of their time indoors, the study included an indoor air quality component, where measurements were made inside and outside a house to study infiltration and indoor sources. In the absence of indoor activities such as cooking and/or heating with a pellet stove, indoor particulate matter concentrations were lower than outdoors; however, cooking and pellet stove burns often caused higher indoor particulate matter concentrations than outdoors. The mass-normalized particulate matter oxidative potential, a health-relevant property measured here by the reactivity with dithiothreiol, of indoor particles varied by source, with cooking particles having less oxidative potential per mass than pellet stove particles