The Effects of Parental Engagement Programs on Grades 3-5 Milestones Student Achievement

Although the Every Student Succeeds Act sets the parameters for parents and families to be involved in their children’s education, there are no specified guidelines on how that involvement should be designed to best impact student achievement. The purpose of this study was to compare Grade 3-5 students’ mean Milestones test scores in English Language Arts, mathematics, and science (dependent variables) at two Southeastern United States elementary schools which offered parental involvement/parental engagement programs—a nonmandatory or mandatory program (independent variable), represented by School A and B, respectively. The theoretical foundations of the study were the social and human capital theory and the school, family, and community partnership framework. The seven research questions compared student achievement scores for Grades 3-5 English Language Arts and mathematics and for Grade 5 science between schools. A quantitative design, using ex post facto data from the 2018-2019 school year (n = 1076), included seven independent samples t tests to determine statistically significant differences in mean Milestones test scores among students at School A and B. The results indicated a significant difference in all three grades, across all three subject areas. Students from School B with the mandatory parental engagement program experienced higher achievement in all subjects than students at School A with nonmandatory engagement. These results support the need for mandatory parent involvement programs that guide parents in how to support their children’s achievement. This study may contribute to positive social change by encouraging educators to promote new strategies and partnerships with parents and families specifically designed to improve student achievement

Discussion forum rubrics: Using rubrics to enhance and increase project management students' participation in online discussions

This paper examines the impact of using a discussion forum grading rubric to encourage and enhance discussions (posts) in an online introduction to project management course. The study consists of 53 Master of Business Administration (MBA) students enrolled in three sections of the course from October 2010 to May 2011. A control group of 20 students was compared to two experimental groups of 16 and 17 students respectively. The two experimental groups were given the specific grading rubric and instructions designed to encourage online conversation; the control group was not. The results indicate that there was a statistical difference in average postings per student between the two experimental groups and the control group but no statistical difference between the two experimental groups. The results suggest that the use of a rubric specifically designed to engage the student and expand the student's learning experience can increase online classroom participation and, as a consequence, enhance the educational experience for the online project management student and strengthen the university's MBA program

Increased Tolerance to Abiotic Stresses in Tobacco Plants Expressing a Barley Cell Wall Peroxidase

This study aimed to explore the prospects for enhancing abiotic stress tolerance through expression of a cell wall-targeted peroxidase in transgenic plants. Abiotic stresses result in the production of several Reactive Oxygen Species (ROS), including hydrogen peroxide (H2O2), in higher plants. H2O2 is highly diffusible and has a stress signalling role, but is also the source, through Fenton reactions, of highly destructive hydroxyl free radicals. Type III peroxidases, a family of heme-containing proteins which oxidise a range of substrates using H2O2 as oxidant, are capable of depleting H2O2 levels in several cellular compartments and specific peroxidases have been linked to stress defences. In the present study, we demonstrate expression of a pathogen-induced apoplastic barley peroxidase in transgenic tobacco plants and show that it confers improved tolerance to several abiotic stresses, including high and low temperatures, salinity, metal ion and osmotic stress

Increased Tolerance to Abiotic Stresses in Tobacco Plants Expressing a Barley Cell Wall Peroxidase

This study aimed to explore the prospects for enhancing abiotic stress tolerance through expression of a cell wall-targeted peroxidase in transgenic plants. Abiotic stresses result in the production of several Reactive Oxygen Species (ROS), including hydrogen peroxide (H2O2), in higher plants. H2O2 is highly diffusible and has a stress signalling role, but is also the source, through Fenton reactions, of highly destructive hydroxyl free radicals. Type III peroxidases, a family of heme-containing proteins which oxidise a range of substrates using H2O2 as oxidant, are capable of depleting H2O2 levels in several cellular compartments and specific peroxidases have been linked to stress defences. In the present study, we demonstrate expression of a pathogen-induced apoplastic barley peroxidase in transgenic tobacco plants and show that it confers improved tolerance to several abiotic stresses, including high and low temperatures, salinity, metal ion and osmotic stress

Novel ETHE1 mutation in a carrier couple having prior offspring affected with ethylmalonic encephalopathy: Genetic analysis, clinical management and reproductive outcome.

Ethylmalonic encephalopathy (EE) is an autosomally recessive inherited disorder with a relentlessly progressive decline in neurological function, usually fatal by the age of ten. It is characterised by generalised hypotonia, psychomotor regression, spastic tetraparesis, dystonia, seizures and, eventually, global neurological failure. Approximately 50 reports have been published worldwide describing this devastating disease, most involving patients of Mediterranean or Arab origin. The fundamental defect in EE likely involves the impairment of a mitochondrial sulphur dioxygenase coded by the ETHE1 gene responsible for the catabolism of sulphide, which subsequently accumulates to toxic levels. A diagnosis of EE should initiate careful genetic evaluation and counselling, particularly if the parents intend to have additional offspring. The present report describes the diagnosis of EE in a reproductive endocrinology context, where both members of a non-consanguineous couple were confirmed to be carriers of an identical A↷G mutation. This previously unknown mutation at nucleotide position c.494 resulted in an amino acid substitution, p.Asp165Gly. Although consideration was given to in vitro fertilisation, embryo biopsy and single gene pre-implantation genetic diagnosis, the couple decided to first utilise a less aggressive therapeutic approach with donor sperm insemination. Pregnancy with a low risk of EE was indeed achieved; however, the infant was affected with a different anomaly (hypoplastic left heart). As this case demonstrates, prior to the initiation of fertility therapy, genetic analysis may be used to provide a confirmatory diagnosis when EE is suspected

Early Negative Affect Predicts Anxiety, not Autism, in Preschool Boys with Fragile X Syndrome

Children with fragile X syndrome (FXS) face high risk for anxiety disorders, yet no studies have explored FXS as a high-risk sample for investigating early manifestations of anxiety outcomes. Negative affect is one of the most salient predictors of problem behaviors and has been associated with both anxiety and autistic outcomes in clinical and non-clinical pediatric samples. In light of the high comorbidity between autism and anxiety within FXS, the present study investigates the relationship between longitudinal trajectories of negative affect (between 8 and 71 months) and severity of anxiety and autistic outcomes in young males with FXS (n= 25). Multilevel models indicated associations between elevated anxiety and higher fear and sadness, lower soothability, and steeper longitudinal increases in approach. Autistic outcomes were unrelated to negative affect. These findings suggest early negative affect differentially predicts anxiety, not autistic symptoms, within FXS. Future research is warranted to determine the specificity of the relationship between negative affect and anxiety, as well as to explore potential moderators. Characterizing the relationship between early negative affect and anxiety within FXS may inform etiology and treatment considerations specific to children with FXS, as well as lend insight into precursors of anxiety disorders in other clinical groups and community samples

First trimester diagnosis and screening for fetal aneuploidy

Maternal serum screening for neural tube defects and fetal aneuploidy in the second trimester has been incorporated into obstetrical practice over the past two decades. Now, as a result of several multicenter trials, first trimester screening between 11 and 14 weeks has been shown to be an effective and reliable screening test for Down syndrome and trisomy 18. Benefits of first trimester screening include earlier identification of the pregnancy at risk for fetal aneuploidy and anatomic defects, in particular, cardiac anomalies, and the option of earlier diagnosis by chorionic villus sampling, if available. This policy updates the American College of Medical Genetics policy statement entitled Second Trimester Maternal Serum Screening for Fetal Open Neural Tube Defects and Aneuploidy (2004) and complements the sections of American College of Medical Genetic’s Standards and Guidelines for Clinical Genetics Laboratories entitled “Prenatal screening for Down syndrome that includes first trimester biochemistry and/or ultrasound measurements.

High-throughput manufacturing of size-tuned liposomes by a new microfluidics method using enhanced statistical tools for characterization

Microfluidics has recently emerged as a new method of manufacturing liposomes, which allows for reproducible mixing in miliseconds on the nanoliter scale. Here we investigate microfluidics-based manufacturing of liposomes. The aim of these studies was to assess the parameters in a microfluidic process by varying the total flow rate (TFR) and the flow rate ratio (FRR) of the solvent and aqueous phases. Design of experiment and multivariate data analysis were used for increased process understanding and development of predictive and correlative models. High FRR lead to the bottom-up synthesis of liposomes, with a strong correlation with vesicle size, demonstrating the ability to in-process control liposomes size; the resulting liposome size correlated with the FRR in the microfluidics process, with liposomes of 50 nm being reproducibly manufactured. Furthermore, we demonstrate the potential of a high throughput manufacturing of liposomes using microfluidics with a four-fold increase in the volumetric flow rate, maintaining liposome characteristics. The efficacy of these liposomes was demonstrated in transfection studies and was modelled using predictive modeling. Mathematical modelling identified FRR as the key variable in the microfluidic process, with the highest impact on liposome size, polydispersity and transfection efficiency. This study demonstrates microfluidics as a robust and high-throughput method for the scalable and highly reproducible manufacture of size-controlled liposomes. Furthermore, the application of statistically based process control increases understanding and allows for the generation of a design-space for controlled particle characteristics

Inter-team Coordination in Large-Scale Agile Development: A Case Study of Three Enabling Mechanisms

Agile methods are increasingly used in large development projects, with multiple development teams. A central question is then what is needed to coordinate feature teams efficiently. This study exam- ines three mechanisms for coordination: Shared mental models, commu- nication and trust in a large-scale development project with 12 feature teams running over a four-year period. We analyse the findings in rela- tion to suggested frameworks for large-scale agile development and a theory on coordination, and provide new recommendations for practice and theory.Inter-team Coordination in Large-Scale Agile Development: A Case Study of Three Enabling MechanismspublishedVersio

Challenges to undertaking randomised trials with looked after children in social care settings.

BACKGROUND: Randomised controlled trials (RCTs) are widely viewed as the gold standard for assessing effectiveness in health research; however many researchers and practitioners believe that RCTs are inappropriate and un-doable in social care settings, particularly in relation to looked after children. The aim of this article is to describe the challenges faced in conducting a pilot study and phase II RCT of a peer mentoring intervention to reduce teenage pregnancy in looked after children in a social care setting. METHODS: Interviews were undertaken with social care professionals and looked after children, and a survey conducted with looked after children, to establish the feasibility and acceptability of the intervention and research design. RESULTS: Barriers to recruitment and in managing the intervention were identified, including social workers acting as informal gatekeepers; social workers concerns and misconceptions about the recruitment criteria and the need for and purpose of randomisation; resource limitations, which made it difficult to prioritise research over other demands on their time and difficulties in engaging and retaining looked after children in the study. CONCLUSIONS: The relative absence of a research infrastructure and culture in social care and the lack of research support funding available for social care agencies, compared to health organisations, has implications for increasing evidence-based practice in social care settings, particularly in this very vulnerable group of young people