95 research outputs found
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Markov sequential pattern recognition : dependency and the unknown class.
The sequential probability ratio test (SPRT) minimizes the expected number of observations to a decision and can solve problems in sequential pattern recognition. Some problems have dependencies between the observations, and Markov chains can model dependencies where the state occupancy probability is geometric. For a non-geometric process we show how to use the effective amount of independent information to modify the decision process, so that we can account for the remaining dependencies. Along with dependencies between observations, a successful system needs to handle the unknown class in unconstrained environments. For example, in an acoustic pattern recognition problem any sound source not belonging to the target set is in the unknown class. We show how to incorporate goodness of fit (GOF) classifiers into the Markov SPRT, and determine the worse case nontarget model. We also develop a multiclass Markov SPRT using the GOF concept
Improving mental health literacy in Year 9 high school children across Wales: A protocol for a randomised control treatment trial (RCT) of a mental health literacy programme across an entire country.
Background
Adolescence is a crucial period for developing and maintaining good habits for mental health and well-being. This is important for future mental health, as most mental health problems manifest during adolescence. Mental health literacy is the foundation for mental health prevention, stigma reduction, and increased help-seeking efficacy particularly among adolescents. The mental health literacy programme âThe Guideâ, which was developed in Canada, has shown success in increasing mental health literacy in North American 16â17âyear olds. âThe Guide Cymruâ is an adaptation of The Guide designed for a younger age group (13â14âyear olds) and for the Welsh culture and context and is being offered to all state schools in Wales.
Methods
This two-armed cluster randomised control trial (RCT) will evaluate the effectiveness of The Guide Cymru. All 205 secondary schools in Wales will be invited to take part, involving up to 30,000âyear 9 pupils. Schools will be randomised to either the immediate implementation of The Guide Cymru or to a wait-list control. The wait-list control will receive The Guide Cymru around 12âweeks later. Measures of mental health literacy (assessed via the Knowledge and Attitudes to Mental Health scale) and mental health problems (via the PedsQL and Strengths and Difficulties Questionnaire) will be taken at baseline (pre-intervention), 12âweeks later (after the active group has received The Guide Cymru), and 24âweeks later (after the wait-list control has received The Guide Cymru).
Discussion
The trial aims to evaluate if The Guide Cymru increases mental health literacy, including reduced stigma to others and to the self, and increased levels of good mental health behaviours and help-seeking for mental health problems
First Trimester Prediction of Uteroplacental Disease- Results of the Prospective Handle Study
To assess the ability of non-invasive cardiac output monitoring (NICOM), a novel method of non-invasive maternal hemodynamic assessment using bioreactance, in combination with first trimester biomarkers to predict the evolution of gestational hypertension (GH), pre-eclampsia (PE) and normotensive fetal growth restriction (FGR)
Variability in the study quality appraisals reported in systematic reviews on the acute:chronic workload ratio and injury risk
Patient-Specific Metrics of Invasiveness Reveal Significant Prognostic Benefit of Resection in a Predictable Subset of Gliomas
Object
Malignant gliomas are incurable, primary brain neoplasms noted for their potential to extensively invade brain parenchyma. Current methods of clinical imaging do not elucidate the full extent of brain invasion, making it difficult to predict which, if any, patients are likely to benefit from gross total resection. Our goal was to apply a mathematical modeling approach to estimate the overall tumor invasiveness on a patient-by-patient basis and determine whether gross total resection would improve survival in patients with relatively less invasive gliomas.
Methods
In 243 patients presenting with contrast-enhancing gliomas, estimates of the relative invasiveness of each patient's tumor, in terms of the ratio of net proliferation rate of the glioma cells to their net dispersal rate, were derived by applying a patient-specific mathematical model to routine pretreatment MR imaging. The effect of varying degrees of extent of resection on overall survival was assessed for cohorts of patients grouped by tumor invasiveness.
Results
We demonstrate that patients with more diffuse tumors showed no survival benefit (Pâ=â0.532) from gross total resection over subtotal/biopsy, while those with nodular (less diffuse) tumors showed a significant benefit (Pâ=â0.00142) with a striking median survival benefit of over eight months compared to sub-totally resected tumors in the same cohort (an 80% improvement in survival time for GTR only seen for nodular tumors).
Conclusions
These results suggest that our patient-specific, model-based estimates of tumor invasiveness have clinical utility in surgical decision making. Quantification of relative invasiveness assessed from routinely obtained pre-operative imaging provides a practical predictor of the benefit of gross total resection
Spenser and Shakespeare: Bards of a feather?
This chapter examines the latticework of links between Shakespeare and Spenser, sifting the available evidence to establish key points of contact within the Irish colonial context. It tells a tale of two writers, one who goes to London to become poet and playwright, the other to Dublin with dreams of a dramatic career, where he finds his theatre of worldlings is a theatre of war. If Spenserâs influence on Shakespeare, especially early Shakespeare, is seldom discussed, Shakespeareâs influence on Spenser remains an even more neglected topic. Shifting from an Anglocentric to an Anglo-Irish focus aids our understanding of the creative context from which Shakespeare took wing. Spenser is crucial here, since that poetâs Irish residence necessitates a broadening of horizons, and he is viewed as part of a recognizable circle. Shakespeare was a lifelong co-author and collaborator influenced by several of Spenserâs Irish contemporaries â Lodowick Bryskett, Geoffrey Fenton, Barnabe Googe, Thomas North, Barnaby Rich, and Petruccio Ubaldini â yet he is more often read in isolation. These writers and translators, part of an expansive English literary circle in Ireland, offer a rich resource for understanding and enhancing the âShakespeare Circleâ that has recently received some critical attention, albeit within a restricted English milieu. From the Spenser-Harvey correspondence and the early histories onwards, this study tracks the collaborative underpinnings of both writersâ work, charting their influences from a shared reliance on Holinshed to a common concern with innovation in form and genre
Height, selected genetic markers and prostate cancer risk:Results from the PRACTICAL consortium
Background: Evidence on height and prostate cancer risk is mixed, however, recent studies with large data sets support a
possible role for its association with the risk of aggressive prostate cancer.
Methods: We analysed data from the PRACTICAL consortium consisting of 6207 prostate cancer cases and 6016 controls and a
subset of high grade cases (2480 cases). We explored height, polymorphisms in genes related to growth processes as main effects
and their possible interactions.
Results: The results suggest that height is associated with high-grade prostate cancer risk. Men with height 4180cm are at a 22%
increased risk as compared to men with height o173cm (OR 1.22, 95% CI 1.01â1.48). Genetic variants in the growth pathway gene
showed an association with prostate cancer risk. The aggregate scores of the selected variants identified a significantly increased
risk of overall prostate cancer and high-grade prostate cancer by 13% and 15%, respectively, in the highest score group as
compared to lowest score group.
Conclusions: There was no evidence of gene-environment interaction between height and the selected candidate SNPs. Our
findings suggest a role of height in high-grade prostate cancer. The effect of genetic variants in the genes related to growth is
seen in all cases and high-grade prostate cancer. There is no interaction between these two exposures.</p
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