Los mayores y las nuevas tecnologías de la comunicación

[Resumen] Fundamentos: En una sociedad envejecida es necesario establecer nuevas alternativas que de alguna manera traten de satisfacer las necesidades de las personas mayores, a la vez que incrementen su calidad de vida percibida. En este sentido, las nuevas tecnologías, como la informática, se han convertido en una herramienta básica de nuestra sociedad, de la que los mayores, sin ninguna duda, podrán beneficiarse. El objetivo del presente trabajo es conocer la opinión de los mayores acerca de temas relacionados con la informática e Internet, así como su capacidad de acceso a las nuevas tecnologías y los conocimientos con los que cuentan. Métodos: Se realiza una entrevista estandarizada, de diseño propio, a una muestra de 105 personas mayores con una edad media de 73 años, residentes en la ciudad de A Coruña. Resultados: De los resultados obtenidos se constata que aunque la mayoría de las personas mayores no cuenta con ordenador personal ni ha trabajado con aplicaciones informáticas, les gustaría aprender más sobre este campo. Además, cuando se conectan a Internet lo hacen desde centros sociales y/o educativos, no encontrando excesivos problemas en su manejo y navegación. Conclusiones: Es necesario fomentar el uso de la informática por parte de los mayores, ya que en un futuro puede constituir una herramienta imprescindible en la intervención sobre problemas inherentes al envejecimiento como son el aislamiento o la soledad entre otros.[Abstract] new alternatives, that somehow try to satisfy the needs of elderly people and that at the same time increase their quality of life. On this sense, the new technologies, such as computer science, have become a basic tool of our society, and the elderly, without no doubt will be able to benefit from it. The objective of the present work is to know what the elderly think about themes related to computer science and internet, as well as their capacity of accessing to new technologies, and the knowledge that they have about them. Methods: A standarized interview has been made, it´s self designed, to a sample of 105 elderly people living in the city of A Coruña. Results: Although most elderly people don´t have a personal computer neither have worked with a computer application, would like to learn more about this field. When they are connected to internet they do it from social and/or educative centres, not having great problems neither in its handling or navigation. Conclusions: It´s necessary to promote the use of computer science on the elderly people, since in a future it can constitute an essential tool in the intervention on inherent problems to aging such as isolation or loneliness among others

Spatiotemporal Characteristics of the Largest HIV-1 CRF02_AG Outbreak in Spain: Evidence for Onward Transmissions

Background and Aim: The circulating recombinant form 02_AG (CRF02_AG) is the predominant clade among the human immunodeficiency virus type-1 (HIV-1) non-Bs with a prevalence of 5.97% (95% Confidence Interval-CI: 5.41–6.57%) across Spain. Our aim was to estimate the levels of regional clustering for CRF02_AG and the spatiotemporal characteristics of the largest CRF02_AG subepidemic in Spain.Methods: We studied 396 CRF02_AG sequences obtained from HIV-1 diagnosed patients during 2000–2014 from 10 autonomous communities of Spain. Phylogenetic analysis was performed on the 391 CRF02_AG sequences along with all globally sampled CRF02_AG sequences (N = 3,302) as references. Phylodynamic and phylogeographic analysis was performed to the largest CRF02_AG monophyletic cluster by a Bayesian method in BEAST v1.8.0 and by reconstructing ancestral states using the criterion of parsimony in Mesquite v3.4, respectively.Results: The HIV-1 CRF02_AG prevalence differed across Spanish autonomous communities we sampled from (p < 0.001). Phylogenetic analysis revealed that 52.7% of the CRF02_AG sequences formed 56 monophyletic clusters, with a range of 2–79 sequences. The CRF02_AG regional dispersal differed across Spain (p = 0.003), as suggested by monophyletic clustering. For the largest monophyletic cluster (subepidemic) (N = 79), 49.4% of the clustered sequences originated from Madrid, while most sequences (51.9%) had been obtained from men having sex with men (MSM). Molecular clock analysis suggested that the origin (tMRCA) of the CRF02_AG subepidemic was in 2002 (median estimate; 95% Highest Posterior Density-HPD interval: 1999–2004). Additionally, we found significant clustering within the CRF02_AG subepidemic according to the ethnic origin.Conclusion: CRF02_AG has been introduced as a result of multiple introductions in Spain, following regional dispersal in several cases. We showed that CRF02_AG transmissions were mostly due to regional dispersal in Spain. The hot-spot for the largest CRF02_AG regional subepidemic in Spain was in Madrid associated with MSM transmission risk group. The existence of subepidemics suggest that several spillovers occurred from Madrid to other areas. CRF02_AG sequences from Hispanics were clustered in a separate subclade suggesting no linkage between the local and Hispanic subepidemics

Effect of the ImPACT intervention on preterm children with autism spectrum disorder: a follow-up study

[ENG]BACKGROUND: Globally, 15 million babies are born prematurely (<37 weeks' gestation) each year (Blencowe et al., 2012). Advances in intensive neonatal care have greatly improved the survival rate of preterm infants. However, the incidence of neurodevelopmental disorders in this group, such as autism, is one of these behavioral conditions observed. There is scarce evidence of programs that monitor and teach parents about the development of this group when the first developmental concerns appear until the diagnosis is finally confirmed and not many studies report follow-up results. OBJECTIVES: To this end, we conducted the ImPACT (Improving Parents As a Communication Teachers) intervention (Ingersoll & Wainer, 2013) aimed to investigate results in broader gains in social, cognitive, language and adaptive functioning in young preterm children with a higher probability to have autism (measured with ADOS and M-CHAT-R/F) 6 months after finishing intervention. Moreover, this is the first study to use individual change indices in a pre-post-follow-up design with preterm infants with ASD, a comparison group, and a control group. METHODS: Eighteen children between the ages of 18 and 20 months and their families participated in the study. Children were recruited from a developmental disorder diagnostic and rehabilitation centre and from the Salamanca Clinical Hospital, and allocated to the three groups in accordance with the respective inclusion criteria: (1) preterm children at risk for autism who received intervention (experimental), (2) full-term children at risk for autism who received intervention (comparison), and (3) preterm children (control). In the intervention, children and their parents participated in fifteen weekly individualized 2-h session with a researcher that emphasized embedding strategies targeting imitation, joint attention and play into everyday routines and play activities. Children were evaluated 6 months after the end of the intervention. RESULTS: Findings indicate that children in the intervention groups maintained the improvements showed post-intervention. There were significant differences in imitation skills (.045), joint attention (.031), and play (.025) in the follow-up results compared to post-intervention. There were no significant differences between preterm and term children with autism in any area. Individual analyses showed similar results, except for ADOS-T module results and cognitive functioning, in which the mean of preterm children with autism showed reliable changes maintained 6 months after finishing intervention. CONCLUSIONS: These results shows that change can be made and maintained in core developmental areas for preterm children with a higher probability to develop autism, when applying a low-intensity intervention targeting social and communication skills. Even though such core areas of impairment are not easy to change, the intervention had an appreciable effect. Most of the participants improved significantly in socio-communicative skills, cognitive development, language, and adaptive behavior, and ASD signs were reduced. Thus, this study emphasized the need for further research and implementation of early interventions in young preterm children with autism and their parents when targeting social-communication skills as a main objective for intervention.Grants PID2019-107177RB-I00 and TED2021-129301B-I00 funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”, by the “European Union” and by the “European Union NextGenerationEU/PRTR

Effect of a Focused Social and Communication Intervention on Preterm Children with ASD: A Pilot Study

While advances in intensive neonatal care have greatly improved survival rates among preterm infants, incidence of neurodevelopmental disorders in this group is still high, with autism spectrum disorder (ASD) being one of the most frequent. To this end, we conducted a social-communication intervention aimed at investigating efficacy in social-communicative skills. Eighteen children (preterm and full-term with ASD and preterm children) aged 18 through 20 months participated in the study. Our findings indicate that most participants in the intervention groups registered significant improvements in terms of socio-communicative skills, cognitive development, and language. Accordingly, these pilot data underscore the need for further research and implementation of early interventions in young preterm children with ASD.Grants PID2019-107177RB-I00 and TED2021-129301B-I00 funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”, by the “European Union” and by the “European Union NextGenerationEU/PRTR

Discovering HIV related information by means of association rules and machine learning

Acquired immunodeficiency syndrome (AIDS) is still one of the main health problems worldwide. It is therefore essential to keep making progress in improving the prognosis and quality of life of affected patients. One way to advance along this pathway is to uncover connections between other disorders associated with HIV/AIDS-so that they can be anticipated and possibly mitigated. We propose to achieve this by using Association Rules (ARs). They allow us to represent the dependencies between a number of diseases and other specific diseases. However, classical techniques systematically generate every AR meeting some minimal conditions on data frequency, hence generating a vast amount of uninteresting ARs, which need to be filtered out. The lack of manually annotated ARs has favored unsupervised filtering, even though they produce limited results. In this paper, we propose a semi-supervised system, able to identify relevant ARs among HIV-related diseases with a minimal amount of annotated training data. Our system has been able to extract a good number of relationships between HIV-related diseases that have been previously detected in the literature but are scattered and are often little known. Furthermore, a number of plausible new relationships have shown up which deserve further investigation by qualified medical experts

How do women living with HIV experience menopause? Menopausal symptoms, anxiety and depression according to reproductive age in a multicenter cohort

CatedresBackground: To estimate the prevalence and severity of menopausal symptoms and anxiety/depression and to assess the differences according to menopausal status among women living with HIV aged 45-60 years from the cohort of Spanish HIV/AIDS Research Network (CoRIS). Methods: Women were interviewed by phone between September 2017 and December 2018 to determine whether they had experienced menopausal symptoms and anxiety/depression. The Menopause Rating Scale was used to evaluate the prevalence and severity of symptoms related to menopause in three subscales: somatic, psychologic and urogenital; and the 4-item Patient Health Questionnaire was used for anxiety/depression. Logistic regression models were used to estimate odds ratios (ORs) of association between menopausal status, and other potential risk factors, the presence and severity of somatic, psychological and urogenital symptoms and of anxiety/depression. Results: Of 251 women included, 137 (54.6%) were post-, 70 (27.9%) peri- and 44 (17.5%) pre-menopausal, respectively. Median age of onset menopause was 48 years (IQR 45-50). The proportions of pre-, peri- and post-menopausal women who had experienced any menopausal symptoms were 45.5%, 60.0% and 66.4%, respectively. Both peri- and post-menopause were associated with a higher likelihood of having somatic symptoms (aOR 3.01; 95% CI 1.38-6.55 and 2.63; 1.44-4.81, respectively), while post-menopause increased the likelihood of having psychological (2.16; 1.13-4.14) and urogenital symptoms (2.54; 1.42-4.85). By other hand, post-menopausal women had a statistically significant five-fold increase in the likelihood of presenting severe urogenital symptoms than pre-menopausal women (4.90; 1.74-13.84). No significant differences by menopausal status were found for anxiety/depression. Joint/muscle problems, exhaustion and sleeping disorders were the most commonly reported symptoms among all women. Differences in the prevalences of vaginal dryness (p = 0.002), joint/muscle complaints (p = 0.032), and sweating/flush (p = 0.032) were found among the three groups. Conclusions: Women living with HIV experienced a wide variety of menopausal symptoms, some of them initiated before women had any menstrual irregularity. We found a higher likelihood of somatic symptoms in peri- and post-menopausal women, while a higher likelihood of psychological and urogenital symptoms was found in post-menopausal women. Most somatic symptoms were of low or moderate severity, probably due to the good clinical and immunological situation of these women

COVID-19 in hospitalized HIV-positive and HIV-negative patients : A matched study

CatedresObjectives: We compared the characteristics and clinical outcomes of hospitalized individuals with COVID-19 with [people with HIV (PWH)] and without (non-PWH) HIV co-infection in Spain during the first wave of the pandemic. Methods: This was a retrospective matched cohort study. People with HIV were identified by reviewing clinical records and laboratory registries of 10 922 patients in active-follow-up within the Spanish HIV Research Network (CoRIS) up to 30 June 2020. Each hospitalized PWH was matched with five non-PWH of the same age and sex randomly selected from COVID-19@Spain, a multicentre cohort of 4035 patients hospitalized with confirmed COVID-19. The main outcome was all-cause in-hospital mortality. Results: Forty-five PWH with PCR-confirmed COVID-19 were identified in CoRIS, 21 of whom were hospitalized. A total of 105 age/sex-matched controls were selected from the COVID-19@Spain cohort. The median age in both groups was 53 (Q1-Q3, 46-56) years, and 90.5% were men. In PWH, 19.1% were injecting drug users, 95.2% were on antiretroviral therapy, 94.4% had HIV-RNA < 50 copies/mL, and the median (Q1-Q3) CD4 count was 595 (349-798) cells/μL. No statistically significant differences were found between PWH and non-PWH in number of comorbidities, presenting signs and symptoms, laboratory parameters, radiology findings and severity scores on admission. Corticosteroids were administered to 33.3% and 27.4% of PWH and non-PWH, respectively (P = 0.580). Deaths during admission were documented in two (9.5%) PWH and 12 (11.4%) non-PWH (P = 0.800). Conclusions: Our findings suggest that well-controlled HIV infection does not modify the clinical presentation or worsen clinical outcomes of COVID-19 hospitalization