Modern Code Reviews: Preliminary Results of an Analysis of the State of the Art with Respect to the Role Played by Human Factors

Modern Code Reviewing has shown to be an effective mechanism to identify bugs in the code; however, given their intrinsic subjectivity, they can be significantly affected by human factors such as interpersonal relationships. This paper focuses on exploring such issues, with specific attention to social iterations and personal factors. Future work includes experimental evaluations to verify the research hypothesis related to improving the quality of the process under the study

Apoptosis regulates notochord development in Xenopus

AbstractThe notochord is the defining characteristic of the chordate embryo and plays critical roles as a signaling center and as the primitive skeleton. In this study we show that early notochord development in Xenopus embryos is regulated by apoptosis. We find apoptotic cells in the notochord beginning at the neural groove stage and increasing in number as the embryo develops. These dying cells are distributed in an anterior to posterior pattern that is correlated with notochord extension through vacuolization. In axial mesoderm explants, inhibition of this apoptosis causes the length of the notochord to approximately double compared to controls. In embryos, however, inhibition of apoptosis decreases the length of the notochord and it is severely kinked. This kinking also spreads from the anterior with developmental stage such that, by the tadpole stage, the notochord lacks any recognizable structure, although notochord markers are expressed in a normal temporal pattern. Extension of the somites and neural plate mirrors that of the notochord in these embryos, and the somites are severely disorganized. These data indicate that apoptosis is required for normal notochord development during the formation of the anterior–posterior axis, and its role in this process is discussed

How social interactions can affect Modern Code Review

Introduction: Modern Code Review (MCR) is a multistage process where developers evaluate source code written by others to enhance the software quality. Despite the numerous studies conducted on the effects of MCR on software quality, the non-technical issues in the MCR process have not been extensively studied. This study aims to investigate the social problems in the MCR process and to find possible ways to prevent them and improve the overall quality of the MCR process.Methodology: To achieve the research objectives, we applied the grounded theory research shaped by GQM approach to collect data on the attitudes of developers from different teams toward MCR. We conducted interviews with 25 software developers from 13 companies to obtain the information necessary to investigate how social interactions affect the code reviewing process.Results: Our findings show that interpersonal relationships within the team can have significant consequences on the MCR process. We also received a list of possible strategies to overcome these problems.Discussion: Our study provides a new perspective on the non-technical issues in the MCR process, which has not been extensively studied before. The findings of this study can help software development teams to address the social problems in the MCR process and improve the overall quality of their software products.Conclusion: This study provides valuable insights into the non-technical issues in the MCR process and the possible ways to prevent them. The findings of this study can help software development teams to improve the MCR process and the quality of their software products. Future research could explore the effectiveness of the identified strategies in addressing the social problems in the MCR process

Background and the beginning of trade relations on the Silk Road

The relevance to research the beginning of trade relations on the ancient Silk Road was determined by the growing interest in the “revival” of the Silk Road. China is striving to develop the concept of “One Belt, One Road”, namely the “Silk Road Economic Belt”, which aims is a new transport system, that will improve trade relations between the countries and accelerate the supply of goods through Central Asia along the historical trade routes. This initiative is supported by many CIS states and countries whose history is directly related to the history of the Silk Road. The study of the prerequisites for the formation and initial stage of trade relations along the “Route” will allow us to assess the experience and potential of the regions related to this issue for building new effective models of cooperation

AI MENTORING AS A FORM AKMEOLOGICHESKOJ ORIENTED PROFESSIONAL INTERACTION

Optimization of professional relationships in the "mentor- apprentice" promotes the formation of a professional orientation akmeologicheskoj both subjects interaction. On the one hand , mentoring is one of the oldest and most effective ways to acquire knowledge and skills of young employees of the company in the process of adapting to a new team . On the other - allows teacher to identify their professional and personal opportunities and consciously decide to choose the optimum time of interaction with the students, based on their individual characteristics, as well as improve their own skills.Оптимизация профессиональных взаимоотношений в системе «наставник – ученик» способствует формированию акмеологической профессиональной направленности у обоих субъектов взаимодействия. Наставничество является одним из самых старых и эффективных способов приобретения знаний и навыков молодыми сотрудниками предприятия в процессе их адаптации в новом коллективе; позволяет наставнику выявить свои профессионально-личностные возможности и осознанно определиться в выборе оптимального стажа взаимодействия с учениками, с учетом их индивидуальных особенностей, а также повысить уровень собственного мастерства

Selective inhibitor of histone deacetylase 6 (tubastatin A) suppresses proliferation of hepatitis C virus replicon in culture of human hepatocytes

Acetylation of α-tubulin was studied in cultures of human hepatocytes under the influence of selective inhibitors of histone deacetylases HDAC6 and SIRT-2 - tubastatin A and 2-(3-phenethoxyphenylamino)benzamide, respectively. It was found that in hepatocyte cell line HepG2 acetylated α-tubulin is accumulated preferentially on inhibition of HDAC6 but not of SIRT-2. Under the same conditions, no acetylation of α-tubulin was observed in hepatocyte cell line Huh7. However, the inhibition of HDAC6 with tubastatin A led to hyperacetylation of α-tubulin and simultaneously to decrease in viral RNA concentration in hepatocyte cell line Huh7-luc/neo, which supports propagation of the full genome replicon of hepatitis C virus. The correlation between these two processes points to HDAC6 as a promising cellular target for therapy of hepatitis C. © 2014 Pleiades Publishing, Ltd

Research of intelligent methods of software testing

This article presents the examination of several techniques and tools used in the automated software testing process. Considering the ever-growing importance of software testing, several possible implications of implementation of artificial intelligence into this area are also discussed. The main objective of this study is to examine the field of test automation by categorising related test activities, to which artificial intelligence tools can be applied for increased efficiency, and evaluate the impact of the application. The main software testing methods are white-box, black-box, and grey-box methods; an effort has been made to determine a connection between the given testing methods and artificial intelligence methods. A brief summary of several artificial intelligence engine tools used to automate testing was also provided. Lastly, the possible future benefits from usage of AI in software testing was investigated

Purification and characterization of a subtilisin-like proteinases secreted in the stationary growth phase of Bacillus amyloliquefaciens H2

Proteinases secreted during the early and late stationary phases have been isolated from the culture liquid of Bacillus amyloliquefaciens H2 using CM-cellulose ion-exchange chromatography with subsequent FPLC on a Mono S column. Considering the character of hydrolysis of specific chromogenic substrates and the type of inhibition, these enzymes were identified as subtilisin-like proteinases. The molecular weight of both proteinases is 29 kD. The proteolytic activity of the proteinases secreted during the early and late stationary phases towards the synthetic substrate Z-Ala-Ala-Leu-pNA was maximal at pH 8.5 and 9.0, respectively. The maximal activity of both proteinases was observed at 37°C, and the proteins were stable within the pH range of 7.2-9.5. The subtilisin-like proteinases from B. amyloliquefaciens were shown to catalyze synthesis of peptide bonds. © Nauka/Interperiodica 2007

Subtilisin-like proteinase secreted by the Bacillus pumilus KMM 62 strain at different growth stages

Proteinase secreted in the environment by bacilli on different growth stages was isolated by ion chromatography from the culture medium of Bacillus pumilus KMM 62. According to the hydrolysis character of specific chromogenic substrates and inhibition type, the enzyme belongs to subtilisin-like serine proteinases. The isolated proteinase with the molecular mass of 30 kDa displays maximum activity on hydrolysis of the peptide substrate Z-Ala-Ala-Leu-pNA at pH 8.0 - 8.5 and temperature 30°C. The protein is stable in the range of pH 7.5 - 10.0. It was shown that subtilisin-like serine proteinase from B. pumilus KMM 62 possessed thrombolytic activity. © Pleiades Publishing, Ltd., 2012