Long noncoding RNAs in prostate cancer: overview and clinical implications.

Prostate cancer is the second most common cause of cancer mortality among men in the United States. While many prostate cancers are indolent, an important subset of patients experiences disease recurrence after conventional therapy and progresses to castration-resistant prostate cancer (CRPC), which is currently incurable. Thus, there is a critical need to identify biomarkers that will distinguish indolent from aggressive disease, as well as novel therapeutic targets for the prevention or treatment of CRPC. In recent years, long noncoding RNAs (lncRNAs) have emerged as an important class of biological molecules. LncRNAs are polyadenylated RNA species that share many similarities with protein-coding genes despite the fact that they are noncoding (not translated into proteins). They are usually transcribed by RNA polymerase II and exhibit the same epigenetic signatures as protein-coding genes. LncRNAs have also been implicated in the development and progression of variety of cancers, including prostate cancer. While a large number of lncRNAs exhibit tissue- and cancer-specific expression, their utility as diagnostic and prognostic biomarkers is just starting to be explored. In this review, we highlight recent findings on the functional role and molecular mechanisms of lncRNAs in the progression of prostate cancer and evaluate their use as potential biomarkers and therapeutic targets

Numerical simulation of Goertler/Tollmien-Schlichting wave-interaction

The problem of nonlinear development of Goertler vortices and interaction with Tollmien-Schlichting (TS) waves is considered within the framework of incompressible Navier-Stokes equations which are solved by a Fourier-Chebyshev spectral method. It is shown that two-dimensional waves can be excited in the flow modulated by Goertler vortices. Due to nonlinear effects, this interaction further leads to the development of oblique waves with spanwise wavelength equal to the Goertler vortex wavelength. Interaction is also considered of oblique waves with spanwise wavelength twice that of Goertler vortices

Germanium-on-silicon mid-infrared waveguides and Mach-Zehnder interferometers

In this paper we describe Ge-on-Si waveguides and Mach-Zehnder interferometers operating in the 5.2 - 5.4 mu m wavelength range. 3dB/cm waveguide losses and Mach-Zehnder interferometers with 20dB extinction ratio are presented

Computer Simulation of Current Forces on Motion of Floating Production Storage and Offloading in Irregular Waves

This paper presents the effect of current forces on the motion of forces on Floating Production Storage and Offloading (FPSO) in irregular waves. The objective of this research is to compute the motion of FPSO in irregular waves by time domain simulation including the effect of current forces. A study is made on the slowly varying oscillations of a moored single body system in a current and waves. Linear potential theory is used to describe the fluid motion, and three-dimensional source distribution techniques are applied to obtain the hydrodynamic forces and transfer function of the wave exciting forces. OCIMF (1994) data are used for estimation of the current forces. The non-linear time domain simulations have been carried out in irregular waves. Based on it, slowly varying motion responses are examined including the effect of the current forces. Several environmental conditions, such as the current angle of attack, current velocity, significant wave height and mean wave period are considered, which may significantly affect FPSO motion in surge, sway and yaw moments. It is found that the effect of current forces is quite significant when the current velocity is increased. In this simulation, while the current velocity is increased to 3.0 meter/seconds, the impact on FPSO motion is quite significant, which should be taken into consideration from the point of view of safety, failure of mooring systems, operating responses and the dynamic positioning of the FPSO

Characterization of ash derived from combustion of paper mill waste sludge: Comparison with municipal solid waste incinerator ash

Fly ash derived from incineration of Malaysian paper mill waste sludge (PMWS) was physically and chemically characterized in order to determine its potential toxicity as well as its application as cement replacement material. The results were compared with results obtained from similar characterization on Malaysian municipal solid waste incineration (MSWI) bottom ash. Principal analyses conducted include particle size distribution, elemental analysis, toxicity characteristic leaching procedure (TCLP) as well as thermogravimetric, x-ray diffractometry and FTIR analyses. TCLP result indicated that both the PMWS and MSWI ashes should not be classified as hazardous wastes in terms of heavy metal leachability, since leachable copper, cadmium, lead and nickel concentrations were detected below the stipulated leachability limits. Both ashes could be reused as cement replacement materials since both contained SiO2 which is one of the main building components in cement and concrete utilizations. Nonetheless, PMWS ash could be more suitable as a cement replacement material as compared to MSWI ash, as the former had significantly smaller particle size distribution and lower organic content

Effects of prostaglandin analog therapy on the ocular surface of glaucoma patients

Michael B Horsley, Malik Y KahookRocky Mountain Lions Eye Institute, Department of Ophthalmology, University of Colorado Denver, Aurora, CO, USAPurpose: To quantify changes in tear break-up time (TBUT), corneal staining and ocular surface disease index (OSDI) in glaucoma patients after switching therapy from latanoprost with 0.02% benzalkonium chloride (BAK) to travoprost with sofZia™.Methods: Prospective consecutive case series evaluating patients before and 8 weeks after switching from latanoprost with BAK to travoprost with sofZia™ in patients with baseline TBUT less than 6 seconds.Results: Forty eyes of 20 consecutive patients using latanoprost with BAK were switched to travoprost with sofZia™. Mean TBUT prior to starting travoprost was 2.02 ± 0.71 seconds and increased to 6.34 ± 1.31 seconds 8 weeks after the switch (p < 0.001). Mean inferior corneal staining scores decreased from 2.40 ± 0.87 to 1.38 ± 0.59 (p < 0.001). Mean OSDI scores decreased from 26.31 ± 8.25 to 16.56 ± 6.19 (p < 0.001).Discussion: This report focuses on the status of the ocular surface, as documented by TBUT, corneal staining and OSDI, in patients switched from latanoprost with BAK to travoprost without BAK. The switch resulted in a statistically significant increase in TBUT and decreases in corneal staining and OSDI in patients with low baseline TBUT values.Conclusion: BAK, a common preservative for glaucoma drops, may increase OSD by disrupting the tear film and increasing conjunctival inflammation. In this study, a change from a BAK-preserved prostaglandin analog (PGA) to a non-BAK-preserved PGA resulted in a measurable improvement of TBUT, corneal staining and OSDI. Further studies are needed to better understand the impact of BAK-preserved medications on the ocular surface.Keywords: ocular surface, glaucoma, benzalkonium chloride, prostaglandin analo

Performance Enhancement of Wideband Reflectarray Antennas Embedded on Paper Substrate Materials

This research presents an innovative solution to address the bandwidth limitation of microstrip reflectarray antennas. Organic substrate materials with controlled compositions have been characterized to be employed as substrate materials for microstrip reflectarrays. The three proposed materials show low dielectric permittivity values of 1.81, 1.64 and 1.84 along with loss tangents of 0.053, 0.047 and 0.057 respectively. The proposed substrate materials have been verified by modelling reflectarray unit elements in CST MWS and measured using a waveguide simulator technique. The comparison between measured and simulated results show a good agreement with promising broadband performance of 312, 340 and 207 MHz for S1, S2 and S3 substrate materials respectively

New Lie group of transformation for the non-Newtonian fluid flow narrating differential equations

In this endeavour, a new Lie point of transformation for the fluid flow narrating differential equations are proposed. For this purpose a non-Newtonian fluid named tangent hyperbolic fluid is considered towards the flat surface in a magnetized flow field. In addition, equation of concentration admits the role of chemically reactive species. A mathematical model in terms of the coupled PDE’s is constructed. Lie group of analysis is implemented to yield the new Lie point of transformation for tangent hyperbolic fluid flow narrating differential equations when the heat and mass transfer individualities are considered. The resultant system of PDE’s is reduced into system of ODE’s via obtained set of transformation. The self-coded computational scheme is accomplished and the outcomes are reported by way of graphs. It is noticed that tangent hyperbolic fluid velocity, temperature and concentration is decreasing function of magnetic field parameter, Prandtl number and chemical reaction parameter respectively