New method for critical failure prediction of complex systems

Rigorous analytical technique, called criticality determination methodology /or CD technique/ determines the probability that a given complex system will successfully achieve stated objectives. The CD technique identifies critical elements of the system by a failure mode and effects analysis

Constraints on the three-fluid model of curvaton decay

A three fluid system describing the decay of the curvaton is studied by numerical and analytical means. We place constraints on the allowed interaction strengths between the fluids and initial curvaton density by requiring that the curvaton decays before nucleosynthesis while nucleosynthesis, radiation-matter equality and decoupling occur at correct temperatures. We find that with a continuous, time-independent interaction, a small initial curvaton density is naturally preferred along with a low reheating temperature. Allowing for a time-dependent interaction, this constraint can be relaxed. In both cases, a purely adiabatic final state can be generated, but not without fine-tuning. Unlike in the two fluid system, the time-dependent interactions are found to have a small effect on the curvature perturbation itself due to the different nature of the system. The presence of non-gaussianity in the model is discussed.Comment: 9 pages, 10 figure

Nucleotide specificity of the enzymatic and motile activities of dynein, kinesin, and heavy meromyosin.

The substrate specificities of dynein, kinesin, and myosin substrate turnover activity and cytoskeletal filament-driven translocation were examined using 15 ATP analogues. The dyneins were more selective in their substrate utilization than bovine brain kinesin or muscle heavy meromyosin, and even different types of dyneins, such as 14S and 22S dynein from Tetrahymena cilia and the beta-heavy chain-containing particle from the outer-arm dynein of sea urchin flagella, could be distinguished by their substrate specificities. Although bovine brain kinesin and muscle heavy meromyosin both exhibited broad substrate specificities, kinesin-induced microtubule translocation varied over a 50-fold range in speed among the various substrates, whereas heavy meromyosin-induced actin translocation varied only by fourfold. With both kinesin and heavy meromyosin, the relative velocities of filament translocation did not correlate well with the relative filament-activated substrate turnover rates. Furthermore, some ATP analogues that did not support the filament translocation exhibited filament-activated substrate turnover rates. Filament-activated substrate turnover and power production, therefore, appear to become uncoupled with certain substrates. In conclusion, the substrate specificities and coupling to motility are distinct for different types of molecular motor proteins. Such nucleotide "fingerprints" of enzymatic activities of motor proteins may prove useful as a tool for identifying what type of motor is involved in powering a motility-related event that can be reconstituted in vitro

Nonlinear superhorizon perturbations of non-canonical scalar field

We develop a theory of non-linear cosmological perturbations at superhorizon scales for a scalar field with a Lagrangian of the form $P(X,\phi)$, where $X=-\partial^{\mu}\phi\partial_{\mu}\phi$ and $\phi$ is the scalar field. We employ the ADM formalism and the spatial gradient expansion approach to obtain general solutions valid up to the second order in the gradient expansion. This formulation can be applied to, for example, DBI inflation models to investigate superhorizon evolution of non-Gaussianities. With slight modification, we also obtain general solutions valid up to the same order for a perfect fluid with a general equation of state $P=P(\rho)$.Comment: 14 page

Structural and magnetic properties of E-Fe_{1-x}Co_xSi thin films deposited via pulsed laser deposition

We report pulsed laser deposition synthesis and characterization of polycrystalline Fe1-xCox Si thin films on Si (111). X-ray diffraction, transmission electron, and atomic force microscopies reveal films to be dense, very smooth, and single phase with a cubic B20 crystal structure. Ferromagnetism with significant magnetic hysteresis is found for all films including nominally pure FeSi films in contrast to the very weak paramagnetism of bulk FeSi. For Fe1-xCoxSi this signifies a change from helimagnetism in bulk, to ferromagnetism in thin films. These ferromagnetic thin films are promising as a magnetic-silicide/silicon system for polarized current production, manipulation, and detection.Comment: 12 pages, 4 figures accepted in the Applied Physics Letter

Uniqueness of the gauge invariant action for cosmological perturbations

In second order perturbation theory different definitions are known of gauge invariant perturbations in single field inflationary models. Consequently the corresponding gauge invariant cubic actions do not have the same form. Here we show that the cubic action for one choice of gauge invariant variables is unique in the following sense: the action for any other, non-linearly related variable can be brought to the same bulk action, plus additional boundary terms. These boundary terms correspond to the choice of hypersurface and generate extra, disconnected contributions to the bispectrum. We also discuss uniqueness of the action with respect to conformal frames. When expressed in terms of the gauge invariant curvature perturbation on uniform field hypersurfaces the action for cosmological perturbations has a unique form, independent of the original Einstein or Jordan frame. Crucial is that the gauge invariant comoving curvature perturbation is frame independent, which makes it extremely helpful in showing the quantum equivalence of the two frames, and therefore in calculating quantum effects in nonminimally coupled theories such as Higss inflation.Comment: 27 page

Non-linear isocurvature perturbations and non-Gaussianities

We study non-linear primordial adiabatic and isocurvature perturbations and their non-Gaussianity. After giving a general formulation in the context of an extended delta N-formalism, we analyse in detail two illustrative examples. The first is a mixed curvaton-inflaton scenario in which fluctuations of both the inflaton and a curvaton (a light isocurvature field during inflation) contribute to the primordial density perturbation. The second example is that of double inflation involving two decoupled massive scalar fields during inflation. In the mixed curvaton-inflaton scenario we find that the bispectrum of primordial isocurvature perturbations may be large and comparable to the bispectrum of adiabatic curvature perturbations.Comment: 24 pages, typos corrected, references adde

Classification of Normal and Crackles Respiratory Sounds into Healthy and Lung Cancer Groups

Lung cancer is the most common cancer worldwide and the third most common cancer in Malaysia. Due to its high prevalence worldwide and in Malaysia, it is an utmost importance to have the disease detected at an early stage which would result in a higher chance of cure and possibly better survival. The current methods used for lung cancer screening might not be simple, inexpensive and safe and not readily accessible in outpatient clinics. In this paper, we present the classification of normal and crackles sounds acquired from 20 healthy and 23 lung cancer patients, respectively using Artificial Neural Network. Firstly, the sounds signals were decomposed into seven different frequency bands using Discrete Wavelet Transform (DWT) based on two different mother wavelets namely Daubechies 7 (db7) and Haar. Secondly, mean, standard deviation and maximum PSD of the detail coefficients for five frequency bands (D3, D4, D5, D6, and D7) were calculated as features. Fifteen features were used as input to the ANN classifier. The results of classification show that db7 based performed better than Haar with perfect 100% sensitivity, specificity and accuracy for testing and validation stages when using 15 nodes at the hidden layer. While for Haar, only testing stage shows the perfect 100% for sensitivity, specificity, and accuracy when using 10 nodes at the hidden layer