Efecto de un programa de ejercicio aeróbico en la composición corporal y somatotipo de un obeso mórbido infantil

La obesidad representa un problema de salud que suele iniciarse en la infancia y la adolescencia, por un desequilibrio entre la ingesta y el gasto energético, derivando en niveles altos de grasa corporal y grados peligrosos de adiposidad relativa. Por tanto, la inactividad física es un factor de riego que favorece el sobrepeso y la obesidad. El objetivo fue diseñar y aplicar un programa de ejercicio aeróbico y evaluar su efecto en la composición corporal y somatotipo en un niño con obesidad mórbida. Se abordó como un estudio de caso, con pre-test y post-test, en un niño de 10 años, con peso corporal de 88.9 kg, estatura de 158.5 cm, un IMC clasificado de obeso mórbido, no practicante de algún deporte o actividad física regular. El programa fue de 12 semanas, 5 sesiones por semana y una duración de 30-60 min por sesión y una intensidad del 55- 70% de Fcmax. La composición corporal y el somatotipo se obtuvo por mediciones de variables antropométricas. El componente graso a través de la medición de pliegues. En los resultados destacan la diferencia en el pre-test y pos-test de los pliegues: bíceps (dif. 0.0 mm), tríceps (dif. -1.2 mm), subescapular (dif. -1.0 mm.) y suprailiaco (dif. -3.2 mm). Se encontraron pequeñas diferencias en el componente graso (dif. -1.05%) y peso graso (dif. -800 grs). Con respecto a la somaocarta, la distancia de dispersión del somatotipo no mostró valores relevantes. El efecto del programa no alcanzó niveles significativos y el sujeto aún permanece en estado de alto riesgo de saludObesity represents a health problem that usually starts in childhood and adolescence, by an imbalance between the consumption and the energy use, deriving in high levels of body fat and dangerous degrees of relative adiposity. Thus, the physical inactivity is a risk factor that favours overweight and obesity. The objective was to design and apply a program of aerobic exercises and to evaluate its effect on body composition and somatotype in a child with morbid obesity. It was addressed as a case study, with pre-test and post-test, in a 10-year-old child, with a body weight of 88.9 kg, a height of 158.5 cm, a BMI classified as morbidly obese, not practicing a sport or physical activity regularly. The program was 12 weeks, 5 sessions per week and a duration of 30-60 minutes per session and an intensity of 55-70% of Fcmax. Body composition and somatotype were obtained by measuring the anthropometric variables. The fat component through the measurement of folds. The results highlight the difference in the pre-test and post-test of the folds: biceps (diff. 0.0 mm.), triceps (diff. -1.2 mm.), subscapular (diff. -1.0 mm.) and suprailiac (diff -3.2 mm.). Small differences in the fat component (diff -1.05%) and the fat weight (diff. -800 grs.) were found. Regarding the somacarta the dispersal distance of the somatotype did not show relevant values. The effect of the program did not reach significant levels and the subject remains in a state of high health risk

Comparison the efficacy of three positive pressure ventilation devices used by medicine students on a neonatal resuscitation simulators

8 páginasBackground: Positive pressure ventilation is the most frequently used intervention for the resuscitation of newborns. It should guarantee pressures and volumes in safe and effective ranges to establish appropriate pulmonary ventilation and prevent pulmonary injury. The objective of this study was to compare the efficacy of ventilation of three manual PPV devices used on a neonatal resuscitation simulator by medical students. Methods: An experimental two-factor (device and student) study design with several replications of the experiment (a ventilation cycle performed by a student in one minute with each device) was used. Students in their last year of school of medicine at the Universidad de La Sabana were included. The data were collected using a pressure sensor. The peak inspiratory pressure (PIP), the positive end-expiratory pressure (PEEP) by ventilation, and the respiratory rate per minute were recorded for each participant. Pressure in safety range was used as efficacy endpoint. Results: 30 students were included in the study. With the self-inflating bag (SIB) and the flow-inflating bag, a higher percentage of PIP and PEEP was found to be ineffective. No device exceeded the maximum PIP. The use of the disposable T-piece resuscitator resulted in PIP within the safety range 3.20 times more frequently and in PEEP within the safety range 963.8 times more frequently compared with the SIB. Conclusions: The disposable T-piece resuscitator was found to be the most efficacy device for manual ventilation, when used by inexperienced personnel for neonatal resuscitation

How Far Are Non-Viral Vectors to Come of Age and Reach Clinical Translation in Gene Therapy?

Efficient delivery of genetic material into cells is a critical process to translate gene therapy into clinical practice. In this sense, the increased knowledge acquired during past years in the molecular biology and nanotechnology fields has contributed to the development of different kinds of non-viral vector systems as a promising alternative to virus-based gene delivery counterparts. Consequently, the development of non-viral vectors has gained attention, and nowadays, gene delivery mediated by these systems is considered as the cornerstone of modern gene therapy due to relevant advantages such as low toxicity, poor immunogenicity and high packing capacity. However, despite these relevant advantages, non-viral vectors have been poorly translated into clinical success. This review addresses some critical issues that need to be considered for clinical practice application of non-viral vectors in mainstream medicine, such as efficiency, biocompatibility, long-lasting effect, route of administration, design of experimental condition or commercialization process. In addition, potential strategies for overcoming main hurdles are also addressed. Overall, this review aims to raise awareness among the scientific community and help researchers gain knowledge in the design of safe and efficient non-viral gene delivery systems for clinical applications to progress in the gene therapy field.This work was supported by the Basque Country Government (Department of Education, University and Research, Consolidated Groups IT907-16) and by the Spanish Ministry of Science and Innovation (Grant PID2019-106199RB-C21). I.V.B. and M.S.R. thank the University of the Basque Country (UPV/EHU) for the granted postdoctoral fellowship (ESPDOC19/47) and the granted pre-doctoral fellowship (PIF17/79), respectively. Additional funding was provided by the CIBER of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), an initiative of the Carlos III Health Institute (ISCIII)

Caracterización sobre la toma de decisiones éticas en las unidades de cuidado neonatal por parte de pediatras y neonatólogos

The survival of critically ill neonates has increased, which has led to professional caregivers of these babies to face ethical decisions about it. This paper outlines the aim of characterizing ethical situations that caregivers face, the criterion they use and how decisions on ethical dilemmas are taken by Pediatricians and Neonatologists. Methodology: A cross-sectional study was performed. 87 neonatologists and/or Pediatricians, who work in neonatal care units in Chia and Bogota between October 1 of 2014 and January 31 of 2015, were invited to participate and answer a characterization survey voluntarily, but only 45 professionals (51.7%) agreed to take part in it. An exploratory data analysis was performed by using descriptive statistics. Results: Professionals who answered the survey, 100.0% of them has faced ethical problems, 60.0% of them has received some training in bioethics, 33.0% relies on ethics committee, 98.0% has a viability limit to start reanimating and 93.0% has limited the therapeutic effort; 98.0% includes parents in decisions and registers the decision in the medical record. Conclusions: Ethical conflicts in the neonatal care unit are frequent. Most professionals have training and an ethics committee for decision-making. Among the specialists there are heterogeneous views on certain ethical problems in neonatal care units. [Agudelo-Pérez SI, MaldonadoCalderón MJ, Pinzón-Flórez C, Pérez-Barreto C, Mazzantidi-Ruggiero M. Characterization of making ethical decisions in neonatal care units by pediatricians and neonatologists. MedUNAB 2016; 19(1): 9-17]Introducción: Ha aumentado la sobrevida de los neonatos críticamente enfermos, lo que ha llevado a los profesionales encargados del cuidado de estos bebés a enfrentar frecuentemente decisiones éticas. En el presente trabajo se plantea el objetivo de caracterizar las situaciones éticas que enfrentan, el criterio que utilizan y la forma en que se toman las decisiones en los dilemas éticos por parte de los pediatras y neonatólogos. Métodos: Se realizó un estudio de corte transversal. Se invitaron a participar 87 neonatólogos y/o pediatras que quisieran contestar de forma voluntaria la encuesta para la caracterización y trabajaran en unidades neonatales de Chía y Bogotá entre el 1 de octubre de 2014 y 31 de enero de 2015, de los cuales aceptaron participar 45 profesionales (51.7%). Se realizó un análisis exploratorio de los datos, utilizando estadística descriptiva. Resultados: De los profesionales que contestaron la encuesta, el 100.0% se ha enfrentado a problemas éticos, el 60.0% han recibido algún tipo de capacitación en bioética, 33.0% se apoya en comités de ética, 98.0% tienen algún límite de viabilidad para iniciar reanimar y el 93.0% ha limitado el esfuerzo terapéutico; el 98.0% incluye a los padres en las decisiones y registra la decisión en la historia clínica. Conclusiones: Son frecuentes los conflictos éticos en la unidad neonatal. La mayoría cuenta con capacitación y comité de ética para la toma de decisiones. Entre los especialistas hay opiniones heterogéneas sobre ciertos problemas éticos en las unidades neonatales. [Agudelo-Pérez SI, Maldonado-Calderón MJ, Pinzón-Flórez C, Pérez-Barreto C, Mazzanti-di-Ruggiero M. Caracterización sobre la toma de decisiones éticas en las unidades de cuidado neonatal por parte de pediatras y neonatólogos. MedUNAB 2016; 19(1): 9-17

Assessment of Different Niosome Formulations for Optogenetic Applications: Morphological and Electrophysiological Effects

Gene therapy and optogenetics are becoming promising tools for treating several nervous system pathologies. Currently, most of these approaches use viral vectors to transport the genetic material inside the cells, but viruses present some potential risks, such as marked immunogenicity, insertional mutagenesis, and limited insert gene size. In this framework, non-viral nanoparticles, such as niosomes, are emerging as possible alternative tools to deliver genetic material, avoiding the aforementioned problems. To determine their suitability as vectors for optogenetic therapies in this work, we tested three different niosome formulations combined with three optogenetic plasmids in rat cortical neurons in vitro. All niosomes tested successfully expressed optogenetic channels, which were dependent on the ratio of niosome to plasmid, with higher concentrations yielding higher expression rates. However, we found changes in the dendritic morphology and electrophysiological properties of transfected cells, especially when we used higher concentrations of niosomes. Our results highlight the potential use of niosomes for optogenetic applications and suggest that special care must be taken to achieve an optimal balance of niosomes and nucleic acids to achieve the therapeutic effects envisioned by these technologies.This research was funded in part by grants RTI2018-098969-B-I00, PRE2019-087693, DTS19/00175, and PDC2022-133952-100 from the Spanish “Ministerio de Ciencia, Innovación y Universidades” and by the European Union’s Horizon 2020 Research and Innovation Programme under Grant Agreement No. 899287 (NeuraViPeR)

Temas Socio-Jurídicos. Volumen 30 No. 61 Diciembre de 2011

El Centro de Investigaciones Socio-Jurídicas de la UNABse complace en presentar la edición número 61 de su revista Temas Socio-jurídicos, con gran satisfacción y el firme propósito de dar continuidad a un legado que nos dejará nuestro reconocido maestro y entrañable amigo, Laureano Gómez.The Center for Socio-Legal Research of UNAB is pleased to present the 61st edition of its magazine Temas Socio-jurídicos, with great satisfaction and the firm intention of continuing a legacy that our renowned teacher and dear friend, Laureano Gómez, will leave us

Frequency and Characteristics of familial melanoma in Spain: the FAM-GEM-1 Study.

Familial history of melanoma is a well-known risk factor for the disease, and 7% melanoma patients were reported to have a family history of melanoma. Data relating to the frequency and clinical and pathological characteristics of both familial and non-familial melanoma in Spain have been published, but these only include patients from specific areas of Spain and do not represent the data for the whole of Spain. PATIENTS AND METHODS: An observational study conducted by the Spanish Group of Melanoma (GEM) analyzed the family history of patients diagnosed with melanoma between 2011 and 2013 in the dermatology and oncology departments. RESULTS: In all, 1047 patients were analyzed, and 69 (6.6%) fulfilled criteria for classical familial melanoma (two or more first-degree relatives diagnosed with melanoma). Taking into account other risk factors for familial melanoma, such as multiple melanoma, pancreatic cancer in the family or second-degree relatives with melanoma, the number of patients fulfilling the criteria increased to 165 (15.8%). Using a univariate analysis, we determined that a Breslow index of less than 1 mm, negative mitosis, multiple melanoma, and a history of sunburns in childhood were more frequent in familial melanoma patients, but a multivariate analysis revealed no differences in any pathological or clinical factor between the two groups. CONCLUSIONS: Similar to that observed in other countries, familial melanoma accounts for 6.6% of melanoma diagnoses in Spain. Although no differences in the multivariate analysis were found, some better prognosis factors, such as Breslow index, seem more frequent in familial melanoma, which reflect a better early detection marker and/or a different biological behavior

Análisis de la opinión de estudiantes sobre conductas de riesgo de jóvenes en Puerto Rico

The main purpose of the study was to analyze the opinion that students of the University of Puerto Rico, Río Piedras Campus (UPRRP) have about some risk behaviors in teenagers of both genders between the ages of 13-18. We administered an online survey, which was taken by 1,836 students enrolled during the first semester of the 2017-18 academic year. We used mixed methods: descriptive statistics analysis and content analysis. The findings reveal that the opinion of students is that youth is a stage of confusion and turbulence; that some risk behaviors have increased during the past five years and that it tends to be associated to male youth. These results suggest that university students tend to reproduce the dominant social imaginary in terms of risk behavior in youth. Further investigations should take into consideration the consequences of youth stigmatization, since this is a heterogeneous and diverse group.El objetivo de nuestro estudio fue analizar la opinión que tienen los/as estudiantes de la Universidad de Puerto Rico, Recinto de Río Piedras (UPRRP), sobre algunas conductas de riesgo en jóvenes de ambos géneros, de 13-18 años.  Administramos un cuestionario en línea que fue contestado por 1,836 estudiantes matriculados/as durante el primer semestre del año académico 2017-18. Utilizamos un método mixto: análisis estadístico descriptivo y análisis de contenido. Los hallazgos revelan que la opinión de la mayoría de los/as estudiantes universitarios/as es que la juventud es una etapa de confusión y turbulencia; que algunas conductas de riesgo han aumentado durante los pasados cinco años y que se asocian más con los jóvenes que con las jóvenes. Estos hallazgos sugieren que los/as estudiantes tienden a reproducir los imaginarios sociales dominantes sobre la conducta de riesgo en jóvenes entre las edades de 13-18 años. Futuros trabajos deben considerar las consecuencias de la estigmatización hacia los/as jóvenes, ya que este es un grupo heterogéneo y variado