Détection de sinusoïdes noyées dans du bruit par les régions d'inclusion des valeurs propres

- Les régions d'inclusion des valeurs propres permettent l'élaboration de critères d'estimation du nombre de sinusoïdes efficaces. Pour exploiter ces régions, une transformation préalable de la matrice de covariance est nécessaire. Aussi, nous proposons une transformation reposant sur une approximation de valeurs et vecteurs propres afin d'obtenir les rayons et les centres des disques de Gerschgôrin, les disques étant les régions d'inclusion étudiées. Nous montrons que l'introduction des informations rayons et centres dans les critères de détection améliore considérablement leurs performances. Un nouveau critère utilisant la distance euclidienne, appelé GDEdist, est ainsi proposé

An elitist approach for extracting automatically well-realized speech sounds with high confidence

This paper presents an ëlitist approach\" for extracting automatically well-realized speech sounds with high confidence. The elitist approach uses a speech recognition system based on Hidden Markov Models (HMM). The HMM are trained on speech sounds which are systematically well-detected in an iterative procedure. The results show that, by using the HMM models defined in the training phase, the speech recognizer detects reliably specific speech sounds with a small rate of errors

Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe

SVD-Based Optimal Filtering Technique for Noise Reduction in Hearing Aids Using Two Microphones

<p/> <p>We introduce a new SVD-based (Singular value decomposition) strategy for noise reduction in hearing aids. This technique is evaluated for noise reduction in a behind-the-ear (BTE) hearing aid where two omnidirectional microphones are mounted in an endfire configuration. The behaviour of the SVD-based technique is compared to a two-stage adaptive beamformer for hearing aids developed by Vanden Berghe and Wouters (1998). The evaluation and comparison is done with a performance metric based on the speech intelligibility index (SII). The speech and noise signals are recorded in reverberant conditions with a signal-to-noise ratio of <inline-formula><graphic file="1687-6180-2002-852365-i1.gif"/></inline-formula> and the spectrum of the noise signals is similar to the spectrum of the speech signal. The SVD-based technique works without initialization nor assumptions about a look direction, unlike the two-stage adaptive beamformer. Still, for different noise scenarios, the SVD-based technique performs as well as the two-stage adaptive beamformer, for a similar filter length and adaptation time for the filter coefficients. In a diffuse noise scenario, the SVD-based technique performs better than the two-stage adaptive beamformer and hence provides a more flexible and robust solution under speaker position variations and reverberant conditions.</p

Association Rules and Statistics

4 pages - ISBN : 1-59140-557-2In this paper, the two kinds of knowledge extracted by Statistics and by Association Rules, both working on the same data structured in tables [Objects *x* Properties], are compared. These two methods establish the links between properties of objects. When the amount of data properties increases, Statistics may be replaced by Association rules for better performance. Pros and cons of using Association rules instead of Statistics are described in this paper

Digital hearing aids and future directions for hearing aids

In recent years many technical evolutions have been applied in hearing aids. In this paper differences between analog, programmable and fully digital hearing aids, the basic and supplementary functions of a hearing aid, and some important issues and future directions for digital hearing aids will be mentioned.status: publishe

Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

Lithium is a first-line medication for bipolar disorder (BD), but only one in three patients respond optimally to the drug. Since evidence shows a strong clinical and genetic overlap between depression and bipolar disorder, we investigated whether a polygenic susceptibility to major depression is associated with response to lithium treatment in patients with BD. Weighted polygenic scores (PGSs) were computed for major depression (MD) at different GWAS p value thresholds using genetic data obtained from 2586 bipolar patients who received lithium treatment and took part in the Consortium on Lithium Genetics (ConLi+Gen) study. Summary statistics from genome-wide association studies in MD (135,458 cases and 344,901 controls) from the Psychiatric Genomics Consortium (PGC) were used for PGS weighting. Response to lithium treatment was defined by continuous scores and categorical outcome (responders versus non-responders) using measurements on the Alda scale. Associations between PGSs of MD and lithium treatment response were assessed using a linear and binary logistic regression modeling for the continuous and categorical outcomes, respectively. The analysis was performed for the entire cohort, and for European and Asian sub-samples. The PGSs for MD were significantly associated with lithium treatment response in multi-ethnic, European or Asian populations, at various p value thresholds. Bipolar patients with a low polygenic load for MD were more likely to respond well to lithium, compared to those patients with high polygenic load [lowest vs highest PGS quartiles, multi-ethnic sample: OR = 1.54 (95% CI: 1.18–2.01) and European sample: OR = 1.75 (95% CI: 1.30–2.36)]. While our analysis in the Asian sample found equivalent effect size in the same direction: OR = 1.71 (95% CI: 0.61–4.90), this was not statistically significant. Using PGS decile comparison, we found a similar trend of association between a high genetic loading for MD and lower response to lithium. Our findings underscore the genetic contribution to lithium response in BD and support the emerging concept of a lithium-responsive biotype in BD