Equation of State and Isentropic Releasem of Aluminum Foam and Fluoropolymer Composites

There is considerable interest in developing a better understanding of the dynamic behavior of heterogeneous materials. This study investigates and compares the dynamic response of 20 and 47% dense aluminum foam systems with and without a polytetrafluoroethylene (PTFE or Teflon) fill. Experiments on 47% foam were conduced in a 60 mm bore gun in a reverse ballistic configuration at velocities ranging from 350 m/s to 2.5 km/s. The particle velocity of the backside of the anvil was monitored with a VISAR system. Mesoscale simulations are in good agreement with the available experimental data. Both the experimental and simulated data are in good agreement with an analytic release isentrope when released from Hugoniot stress levels less than 5 GPa. However there is significant deviation from the analytic isentrope as the Hugoniot stress level is increased

TIME AND BIOGRAPHY IN DIABETIC EXPERIENCE

This paper offers a preliminary analysis of temporality in the lives of diabetics. It is argued that time unites the various aspects of diabetic experience, including the disease itself, and the social, emotional, institutional, and technological arenas of that experience. A depiction of diabetic experience is rendered by focusing on family life, time in the individuals' sense of being, and biographical time. It is concluded that diabetes transforms time for the person and for patterns ofgroup life

Elements of the Perpetuation of Dependency in a Psychiatric Halfway House

Halfway houses are intended as helping institutions for those who are attempting to make the transition from institutionalized mental health facilities to autonomous living in the community. In spite of the manifest goal to produce independence for its residents, however, the halfway house contributes to patterns of dependency. In addition to the network nature of mental health care, we identify three dependency-perpetuating elements: role commitments, language, and mixed messages. These elements are analyzed as both social organizational and social psychological processes, and their implications are discussed

The case of the singing vortex’.

A relatively high amplitude, discrete tone is radiated from fully developed tip vortex cavitation under certain conditions. The phenomenon of the "singing vortex" was first reported b

Comparison of traditional intranasal and aerosol inhalation inoculation of mice with influenza A viruses

AbstractIntranasal instillation of virus in a liquid suspension (IN) is the most frequently employed method to inoculate small mammalian models with influenza virus, but does not reflect a natural route of exposure. In contrast, inoculation via aerosol inhalation (AR) more closely resembles human exposure to influenza virus. Studies in mice have yielded conflicting results regarding virulence induced by virus inoculated by these routes, and have not controlled for potential strain-specific differences, or examined contemporary influenza viruses and avian viruses with pandemic potential. We used a whole-body AR inoculation method to compare infectivity and disease progression of a highly pathogenic H5N1, a low pathogenic H7N9, and a 2009 H1N1 virus with traditional IN inoculation in the mouse model. Generally comparable levels of morbidity and mortality were observed with all viruses examined using either inoculation route, indicating that both IN and AR delivery are appropriate for murine studies investigating influenza virus pathogenicity

Effect of high pressure on the vibrational modes and the energy gap of ZnP₂

The pressure dependence of the vibrational modes in ZnP2 has been investigated by Raman Spectroscopy using a diamond anvil cell, up to 150 kbar pressure. The intrachain phosphorus modes exhibit a strong pressure dependence whereas the low frequency Zn-P modes soften very slightly under pressure. For a crystal which is treated as a molecular crystal this is an unexpected result. It is suggested that the behaviour may be due to a buckling of the phosphorus chain, or due to a double bond promotion between P atoms, or a charge transfer under pressure. The shift in the energy gap has also been measured to 100 kbar hydrostatic pressure. There is a small initial blue shift which gradually changes over to a red shift. However the whole shift in 100 kbar is quite small. Combining the (dEg/dP) T with the published (dEg/dT) P the thermal expansion contribution and the electron-phonon interaction contribution were evaluated. The latter dominates the total (dEg/dT) P of ZnP2

Emerging role of tumor-associated macrophages as therapeutic targets in patients with metastatic renal cell carcinoma.

Tumor-associated macrophages (TAMs) derived from peripheral blood monocytes recruited into the renal cell carcinoma (RCC) microenvironment. In response to inflammatory stimuli, macrophages undergo M1 (classical) or M2 (alternative) activation. M1 cells produce high levels of inflammatory cytokines, such as tumor necrosis factor-α, interleukin (IL)-12, IL-23 and IL-6, while M2 cells produce anti-inflammatory cytokines, such as IL-10, thus contributing to RCC-related immune dysfunction. The presence of extensive TAM infiltration in RCC microenvironment contributes to cancer progression and metastasis by stimulating angiogenesis, tumor growth, and cellular migration and invasion. Moreover, TAMs are involved in epithelial-mesenchymal transition of RCC cancer cells and in the development of tumor resistance to targeted agents. Interestingly, macrophage autophagy seems to play an important role in RCC. Based on this scenario, TAMs represent a promising and effective target for cancer therapy in RCC. Several strategies have been proposed to suppress TAM recruitment, to deplete their number, to switch M2 TAMs into antitumor M1 phenotype and to inhibit TAM-associated molecules. In this review, we summarize current data on the essential role of TAMs in RCC angiogenesis, invasion, impaired anti-tumor immune response and development of drug resistance, thus describing the emerging TAM-centered therapies for RCC patients