Inconstancy of finite and infinite sequences

In order to study large variations or fluctuations of finite or infinite sequences (time series), we bring to light an 1868 paper of Crofton and the (Cauchy-)Crofton theorem. After surveying occurrences of this result in the literature, we introduce the inconstancy of a sequence and we show why it seems more pertinent than other criteria for measuring its variational complexity. We also compute the inconstancy of classical binary sequences including some automatic sequences and Sturmian sequences.Comment: Accepted by Theoretical Computer Scienc

Plastic Surgery After Ablative Cancer Surgery

Plastic and reconstructive surgery often is conceptualized either as "cosmetic” or as involving complex operations with massive flaps or time-consuming and difficult microsurgery. A number of personal cases are used to illustrate that reconstruction after cancer surgery, even reconstruction of some large tumors, can be performed with modern modifications of classic local flaps, but that sound knowledge and skill in basic surgical and plastic techniques are inescapable prerequisite

From selection to cultivation with the support of all stakeholders: first registration in France of two bread wheat varieties after VCU in organic farming system

As bread wheat is the most important cash crops for French organic farmers, the question of the kind of varieties farmers should be using is therefore very important. Most of varieties available were bred for intensive “conventional” farming systems (with high inputs of mineral fertilizers and pesticides), also screening current varieties for organic conditions becomes a necessity to identifiy suitable varieties for organic farming conditions in a short term experiment. After 20 years of selection and screening combined in two different crop management systems, low inputs and organic, two lines, Hendrix and Skerzzo, have been registered in the official catalogue with the special mention « organic farming ». For the second year of seed production, 150 hectares were sown in autumn 2013 to be sell to organic farmers in 2014. This successful process was possible with the support of all the agricultural organic sector associated in the initiative

Mathématiques, musique et émotion

L’émotion ne serait-elle pas une différence irréductible entre mathématiques et musique ?An irreducible difference between mathematics, and music might be emotion

Flat Peach SUBLOR and SUBLIM and Flat Nectarine PERLA Series

Flat peach and flat nectarine (Prunus persica L. Batsch.) production in Spain started from local cultivars at marginal sites, mainly in the Ebro Valley and Murcia regions. At the end of the 1990s, the introduction of improved cultivars from France and Italy, with more red skin color coverage and better regular shape, fruit size, and stylar cavity closure, together with superior handling and transport conditions led the Spanish peach sector to develop this fruit type on a commercial scale. Currently, Spain is the largest European producer and exporter of flat peach and nectarine, offering a wide range of cultivars covering the producing period from May to September. In 2020, a total of 10.200 ha for flat peach and 481 ha for flat nectarine together produced 263.651 t (20% of the total peach production) (MAPAMA, 2022). To guarantee adaptation to local growing conditions (Font i Forcada et al., 2021a), several national breeding programs started to develop new flat peach and flat nectarine cultivars. One of these breeding programs is the ASF-IRTA breeding program, which is located at Gimenells (Lleida) in the Ebro Valley (northeastern Spain), which is a major region of peach production in Spain (Batlle et al., 2012; Cantín et al., 2017). It was started in 2004, with the objective of developing new cultivars adapted to chilling between 1000 and 1500 chill units or between 42 and 75 chill portions and warm conditions similar to the Mediterranean area (32 °C mean daily summer temperature and 300–400 mm of annual rainfall). It aimed to produce high-quality fruits, both at harvest and after cold storage, with the ultimate goal of satisfying consumers (Font i Forcada et al., 2021a, 2021b). As a result of this collaborative effort, the ASF-IRTA scion peach breeding program has already released the SUBLOR (one flat yellow-fleshed peach), SUBLIM (six flat white-fleshed peach), and PERLA (two flat white-fleshed nectarine) series. These nine new flat peach and nectarine cultivars produce highly attractive yellow-fleshed or white-fleshed fruits with high coverage of red skin, a balanced or acid flavor, sweet taste, and good flesh firmness. The harvesting calendar of these series will be progressively completed with new future releases.info:eu-repo/semantics/publishedVersio

HIV-1/M+O INTERGROUP DUAL INFECTIONS AND ASSOCIATED HIV-MO RECOMBINANTS IN FRANCE FROM 2004 TO 2014

International audienc

039: Platelet reactivity predicts both ischemic and bleeding events at one year follow-up in acute coronary syndome patients receiving prasugrel

There are evidences of a link between platelet reactivity inhibition and thrombotic and bleeding events. We have previously demonstrated that PR after prasugrel loading dose (LD) predicts short-term thrombotic events. We aimed to further investigate the relationship between PR under prasugrel and one-year thrombotic and bleeding events.MethodPatients were prospectively included in this multicentre study if they had a successful PCI for an acute coronary syndrome (ACS) and received prasugrel. Vasodilator-Stimulated Phosphoprotein (VASP index) was measured after prasugrel LD. Endpoint included the rate of thrombotic events (cardiovascular death, myocardial infarction and stent thrombosis) and bleeding events (TIMI) at one year.ResultsThree hundreds and one patients were enrolled. Nine patients (3%) were lost to follow-up at one year. The rates of thrombotic and bleeding events at one year were 7.5 and 6.8% respectively. The mean VASP index after a 60mg LD of prasugrel was 34}23% and 76 patients (25%) were considered as having high on-treatment platelet reactivity (HTPR). Patients with HTPR had a higher rate of thrombotic events compared to good responders (19.7 vs 3.1%;p<0.001). Patients with a minor or major non-CABG related TIMI bleeding had lower PR compared to patients with no bleeding events (21}18 vs 35}23%;p=0.008). In multivariate analysis, the VASP index predicted both thrombotic and bleeding events (OR: 1.44 (95% CI: 1.2–1.72; p<0.001 and 0.75 (95% CI: 0.59–0.96;p=0.024 (respectively, per 10% increase)).ConclusionPlatelet reactivity measurement after prasugrel LD predicts both ischemic and bleedings events at one year follow-up for ACS patients undergoing PCI

Does Plasminogen Activator Inhibitor-1 Drive Lymphangiogenesis?

The purpose of this study is to explore the function of plasminogen activator inhibitor-1 (PAI-1) during pathological lymphangiogenesis. PAI-1, the main physiological inhibitor of plasminogen activators is involved in pathological angiogenesis at least by controlling extracellular proteolysis and by regulating endothelial cell survival and migration. Protease system's role in lymphangiogenesis is unknown yet. Thus, based on its important pro-angiogenic effect, we hypothesized that PAI-1 may regulate lymphangiogenesis associated at least with metastatic dissemination of cancer cells. To address this issue, we studied the impact of PAI-1 deficiency in various murine models of tumoral lymphangiogenesis. Wild-type PAI-1 proficient mice were used as controls. We provide for the first time evidence that PAI-1 is dispensable for tumoral lymphangiogenesis associated with breast cancers either induced by mammary carcinoma cell injection or spontaneously appearing in transgenic mice expressing the polyomavirus middle T antigen (PymT) under the control of a mouse mammary tumor virus long-terminal repeat promoter (MMTV-LTR). We also investigated inflammation-related lymphatic vessel recruitment by using two inflammatory models. PAI-1 deficiency did neither affect the development of lymphangioma nor burn-induced corneal lymphangiogenesis. These novel data suggest that vascular remodelling associated with lymphangiogenesis and angiogenesis involve different molecular determinants. PAI-1 does not appear as a potential therapeutic target to counteract pathological lymphangiogenesis

Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease.

Chronic graft-versus-host disease (cGVHD) is a leading cause of morbidity and mortality following allotransplant. Activated donor effector T cells can differentiate into pathogenic T helper (Th)-17 cells and germinal center (GC)-promoting T follicular helper (Tfh) cells, resulting in cGVHD. Phosphoinositide-3-kinase-δ (PI3Kδ), a lipid kinase, is critical for activated T cell survival, proliferation, differentiation, and metabolism. We demonstrate PI3Kδ activity in donor T cells that become Tfh cells is required for cGVHD in a nonsclerodermatous multiorgan system disease model that includes bronchiolitis obliterans (BO), dependent upon GC B cells, Tfhs, and counterbalanced by T follicular regulatory cells, each requiring PI3Kδ signaling for function and survival. Although B cells rely on PI3Kδ pathway signaling and GC formation is disrupted resulting in a substantial decrease in Ig production, PI3Kδ kinase-dead mutant donor bone marrow-derived GC B cells still supported BO cGVHD generation. A PI3Kδ-specific inhibitor, compound GS-649443, that has superior potency to idelalisib while maintaining selectivity, reduced cGVHD in mice with active disease. In a Th1-dependent and Th17-associated scleroderma model, GS-649443 effectively treated mice with active cGVHD. These data provide a foundation for clinical trials of US Food and Drug Administration (FDA)-approved PI3Kδ inhibitors for cGVHD therapy in patients