16 research outputs found
Performance analysis of packet layer FEC codes and interleaving in FSO channels
The combination of forward-error-correction (FEC) and interleaving can be used to improve free-space optical (FSO) communication systems. Recent research has optimized the codeword length and interleaving depth under the assumption of a fixed buffering size, however, how the buffering size influences the system performance remains unsolved. This paper models the system performance as a function of buffering size and FEC recovery threshold, which allows system designers to determine optimum parameters in consideration of the overhead. The modelling is based on statistics of temporal features of correct data reception and burst error length through the measurement of the channel good time and outage time. The experimental results show good coherence with the theoretical values. This method can also be applied in other channels if a Continuous-Time-Markov-Chain (CTMC) model of the channel can be derive
Second harmonics and compensation effect in ceramic superconductors
A three-dimensional lattice of the Josephson junctions with a finite
self-conductance is employed to model the ceramic superconductors. The
nonlinear ac susceptibility and the compensation effect are studied by Monte
Carlo simulations in this model. The compensation effect is shown to be due to
the existence of the chiral glass phase. We demonstrate, in agreement with
experiments, that this effect may be present in the ceramic superconductors
which show the paramagnetic Meissner effect.Comment: 6 pages, latex, 4 figures, Phys. Rev. B (accepted
Combination Antifungal Therapy for Cryptococcal Meningitis
Background
Combination antifungal therapy (amphotericin B deoxycholate and flucytosine) is the recommended treatment for cryptococcal meningitis but has not been shown to reduce mortality, as compared with amphotericin B alone. We performed a randomized, controlled trial to determine whether combining flucytosine or high-dose fluconazole with high-dose amphotericin B improved survival at 14 and 70 days.
Methods
We conducted a randomized, three-group, open-label trial of induction therapy for cryptococcal meningitis in patients with human immunodeficiency virus infection. All patients received amphotericin B at a dose of 1 mg per kilogram of body weight per day; patients in group 1 were treated for 4 weeks, and those in groups 2 and 3 for 2 weeks. Patients in group 2 concurrently received flucytosine at a dose of 100 mg per kilogram per day for 2 weeks, and those in group 3 concurrently received fluconazole at a dose of 400 mg twice daily for 2 weeks.
Results
A total of 299 patients were enrolled. Fewer deaths occurred by days 14 and 70 among patients receiving amphotericin B and flucytosine than among those receiving amphotericin B alone (15 vs. 25 deaths by day 14; hazard ratio, 0.57; 95% confidence interval [CI], 0.30 to 1.08; unadjusted P=0.08; and 30 vs. 44 deaths by day 70; hazard ratio, 0.61; 95% CI, 0.39 to 0.97; unadjusted P=0.04). Combination therapy with fluconazole had no significant effect on survival, as compared with monotherapy (hazard ratio for death by 14 days, 0.78; 95% CI, 0.44 to 1.41; P=0.42; hazard ratio for death by 70 days, 0.71; 95% CI, 0.45 to 1.11; P=0.13). Amphotericin B plus flucytosine was associated with significantly increased rates of yeast clearance from cerebrospinal fluid (−0.42 log10 colony-forming units [CFU] per milliliter per day vs. −0.31 and −0.32 log10 CFU per milliliter per day in groups 1 and 3, respectively; P<0.001 for both comparisons). Rates of adverse events were similar in all groups, although neutropenia was more frequent in patients receiving a combination therapy.
Conclusions
Amphotericin B plus flucytosine, as compared with amphotericin B alone, is associated with improved survival among patients with cryptococcal meningitis. A survival benefit of amphotericin B plus fluconazole was not found
Conjugated Polyelectrolyte Graphene Hetero Bilayer Nanocomposites Exhibit Temperature Switchable Type of Conductivity
Conjugated polyelectrolytes CPEs comprise an electronically delocalized backbone that is rendered soluble in high dielectric media through the incorporation of side groups bearing ionic functionalities. This combination of structural components yields soft materials capable of integrating the optoelectronic features of organic semiconductors with the ability of polyelectrolytes to modulate physical properties through electrostatic forces. CPEs have been used to control charge injection barriers in organic optoelectronic devices through interfacial phenomena in which electrostatic dipoles modify the effective work function of adjacent metallic electrodes. Doping preferences of the backbone can also be influenced by the choice of the charged group closest to the backbone, as demonstrated by narrow bandgap molecular frameworks that spontaneously p dope in water when containing anionic side groups, but remain undoped in the case of the cationic counterparts. These doping preferences also extend to single walled carbon nanotube SWNT composites, where the cationic anionic CPE yields n type p type nanocomposites, despite that the same conjugated framework is utilize