Effect of Delta Operator on Umbral Composition in Finite Operator calculus

The main objective of this paper is to propose the matrix representation of umbral composition and investigate the effect of delta operator on umbral composition by using the sequential representation of delta operator in finite operator calculus

Analytical method development and validation for simultaneous estimation of Moxifloxacin Hydrochloride and Ketorolac Tromethamine by using RP-HPLC

The main objectives of the present research were to develop the new method for the simultaneous estimation and validation of Moxifloxacin HCl and Ketorolac Tromethamine in pure form and in pharmaceutical dosage form by RP-HPLC. The chromatogram of Moxifloxacin HCl and Ketorolac Tromethamine was developed through column (Inertsil ODS C18), UV detection at 304 nm at a flow rate of 1.0 ml/min with Buffer (pH 4.0):Acetonitrile:Methanol (50:30:20) V/V as mobile phase. The method was validated by various validation parameters such as accuracy, precision, linearity, specificity as per the ICH guidelines. A linearity range of Moxifloxacin HCl and Ketorolac Tromethamine was found to be 60 to 140 µg/ml and 48 to 112 µg/ml respectively. The retention time of Moxifloxacin HCl and Ketorolac Tromethamine was found to be 2.07 min and 4.06 min respectively. % RSD of retention time and peak areas obtained in system precision for Moxifloxacin HCl was 0.21 and 0.80 respectively and for Ketorolac Tromethamine were 0.90 and 1.06 respectively. The % recovery of standard Moxifloxacin HCl and Ketorolac Tromethamine was found to be 100.18 to 100.08% and 99.97 to 99.93% respectively. The % recovery of Moxifloxacin HCl and Ketorolac Tromethamine in dosage form was found to be 98.73 to 100.92% and 98.10 to 100.77% respectively. This method was simple, accurate, precise, and sensitive. Hence, the developed method was employed for the routine analysis of Tenofovir in the pharmaceutical dosage form

Measuring Scalability of Resource Management Systems

Scalability refers to the extent of configuration modifications over which a system continues to be economically deployable. Until now, scalability of resource management systems (RMSs) has been examined implicitly by studying different performance measures of the RMS designs for different parameters. However, a framework is yet to be developed for quantitatively evaluating scalability to unambiguously examine the trade-offs among the different RMS designs. In this paper, we present a methodology to study scalability of RMSs based on overhead cost estimation. First, we present a performance model for a managed distributed system (e.g., Grid computing system) that separates the manager and managee. Second, based on the performance model we present a metric used to quantify the scalability of a RMS. Third, simulations are used to apply the proposed scalability metric to selected RMSs from the literature. The results show that the proposed metric is useful in quantifying the scalabilities of the RMSs

Empirical Implications of Arbitrage-Free Asset Markets

The martingale-equivalence condition delivered by a non-arbitrage assumption in complete asset markets has implications for fine-time-unit asset price behavior that can be rejected with finite spans of data. A class of stochastic processes that could model such deviations from martingale-equivalence is proposed.Asset market, asset pricing

Simultaneous determination of levocetrizine and phenylpropanolamine hydrocholride by RP-HPLC

The aim of the present study was to develop the simple, selective, rapid, precise and economical reverse phase-high performance liquid chromatography (RP-HPLC) method for the simultaneous estimation of levocetirizine and phenylpropanolamine HCl in solid dosage forms. The method was carried out on a Phenomenex Luna C18 (25 cm × 4.6 mm i.d., 5 μ) column with a mobile phase consisting of acetonitrile: 0.5% triethylamine (70:30 v/v, pH 3.0) at a flow rate of 1.2 mL/min. Detection was carried out at 220 nm. The retention time (RT) 1.8 min and 2.6 min for phenylpropanolamine hydrocholride and levocetrizine respectively. The % recovery of standard phenylpropanolamine hydrocholride and levocetrizine was found to be 98.17 to 103.56 and 98.893 to 10.422 respectively. The % recovery of sample phenylpropanolamine hydrocholride and levocetrizine was found to be 101.30 and 100.63 respectively. The validation of the proposed method was also carried out. The proposed method can be used for the estimation of these drugs in combined dosage forms

A new RP-HPLC method for the determination of Tenofovir Disoproxil Fumarate in pure form and pharmaceutical formulation

The present study aimed to develop the new method for the estimation and validation of tenofovir in pure form and in pharmaceutical dosage form by RP-HPLC. The chromatogram of tenofovir was developed through column (Hyper ODS2 C18), UV detection at 260 nm at a flow rate of 1.2 ml/min with Methanol and Phosphate buffer (90:10) as mobile phase. The method was validated by various validation parameters such as accuracy, precision, linearity, specificity as per the ICH guidelines. A linearity range and retention time of Tenofovir were found to be 20-110 µg/ml and 2.1 min respectively. The % RSD of the Tenofovir was found to be 0.7. The % recovery was obtained as 99.7% for standard and 96.32% for tablets. This method was simple, accurate, precise and sensitive. Hence, the developed method was employed for the routine analysis of Tenofovir in the pharmaceutical dosage form

Population-level linkages between urban greenspace and health inequality : the case for using multiple indicators of neighbourhood greenspace

Exposure to greenspace in urban environments is associated with a range of improved health and well-being outcomes. There is a need to understand which aspects of greenspace influence which components of health. We investigate the relationship of indicators of greenspace quantity (total and specific types of greenspace), accessibility and quality with poor general health, depression, and severe mental illness, in the city of Sheffield, UK. We find complex relationships with multiple greenspace indicators that are different for each health measure, highlighting a need for future studies to include multiple, nuanced indicators of neighbourhood greenspace in order to produce results that can inform planning and policy guidance

Trends in alcohol-related admissions to hospital by age, sex and socioeconomic deprivation in England, 2002/03 to 2013/14

List of conditions by outcome measure. (DOCX 21 kb

Magnetic Rotator Winds and Keplerian Disks of Hot Stars

We consider rotating magnetic stars with winds and disks. We establish a theorem that relates the angular velocity of a disk region with no meridional motion to the angular velocity of the star. Also, we show that for a given value of the magnetic field strength, if the rotation rate is too high or the flow velocity into the shock boundary is too low, a Keplerian disk region will not be formed. We develop a model for the formation of disks in magnetic rotators through the processes of fill-up and diffusion into Keplerian orbits. At the end of the fill-up stage the density of the disk increases significantly and the magnetic force in the disk becomes negligible. We derive analytical expressions for the inner and outer radii of Keplerian disks in terms of the stellar rotation rate. A disk can form if the meridional component Bm of the field at the stellar surface is larger than a minimum value. The radial extent of the Keplerian region becomes larger for larger values of Bm and is largest when Bm equals an optimal value. The strengths of the minimum fields required for Keplerian disk formation in B-type stars varies from order 1G to 10G. In O-type stars they must be of order 500G. Also, we suggest that the stellar magnetic fields may be affected by rotationally driven meridional circulation leading to some of the the observed variations of disks with time.Comment: 44 pages, 1 figure, accepted by Ap

Intra annual Variability of the Arabian Sea high salinity water mass in the South Eastern Arabian Sea during 2016 17

Intra-annual variability of the Arabian Sea high salinity water mass (ASHSW) in the South Eastern Arabian Sea (SEAS) and Gulf of Mannar (GoM) are addressed in this paper by utilisng the monthly missions carried out onboard INS Sagardhwani during 2016-17. Our observations revealed that the ASHSW was evident along the SEAS irrespective of seasons, whereas in the GoM the presence of ASHSW was observed during winter. The processes such as downwelling/up-welling, coastal currents, intrusion of low saline waters, stratification are clearly affects the spreading of the ASHSW. The characteristics such as core salinity value, depth and thickness of ASHSW exhibited remarkable spatio-temporal variability. Lateral mixing with the low saline waters in the region during winter reduces its core salinity. The intrusion of low saline waters was clearly seen upto 15 ON but the intrusion of low saline waters is not flowing through the GoM. The interface between the ASHSW and the prevailing low saline waters showed strong horizontal gradients of salinity. The presence of the ASHSW makes difference in the SLD and the below layer gradient which is sufficient to complicate or influence sound transmission. The spatio temporal variability of the ASHSW and its acoustic relevance are documented in this paper