Kältevasokonstriktion, Kältedilatation und reaktive Hyperämie der Haut, dargestellt anhand der Laser-Doppler-Flußmessung

Der Einsatz der Laser-Doppler-Flußmessung hat sich auch in der hydrotherapeutischen Forschung zur Frage der Objektivierung von thermisch ausgelösten Effekten im kutanen Gefäßsystem bewährt. Die in der vorliegenden Arbeit dargestellten Versuchsergebnisse beruhen auf kleinflächigen lokalen Abkühlungen mittels einer mit verschieden temperiertem Wasser perfundierten Thermode. Dabei wurden an definierten Meßstellen periphere gefäßregulatorische Vorgänge, wie Kältevasokonstriktion, -dilatation und reaktive Hyperämie, sowie Durchblutungsgrad und Vasomotion an 10 gesunden Versuchspersonen untersucht

Eligibility for allogeneic transplantation in very high risk childhood acute lymphoblastic leukemia: the impact of the waiting time.

The advantage of allogeneic transplant from compatible related donors versus chemotherapy in children with very-high-risk acute lymphoblastic leukemia in first complete remission was previously demonstrated in an international prospective trial. This study quantified the impact of time elapsed in first remission in the same cohort. Of 357 pediatric patients with very-high-risk acute lymphoblastic leukemia, 259 received chemotherapy, 55 transplantation from compatible related and 43 from unrelated donors. The 5-year disease-free survival was 44.2% overall and 42.5% for chemotherapy only patients. The chemotherapy conditional 5-year disease-free survival increased to 44.4%, 47.6%, 51.7%, and 60.4% in patients who maintained their first remission for at least 3, 6, 9, and 12 months respectively. The overall outcome was superior to that obtained with chemotherapy-only at any time-point. The relative advantage of transplant from compatible related donors in very-high-risk childhood acute lymphoblastic leukemia was consistent for any time elapsed in first remission

Gyermekkori Langerhans-sejtes histiocytosissal szerzett magyarországi tapasztalataink

BACKGROUND: Langerhans cell histiocytosis (LCH) in children is relatively rare, and the long-term analysis of therapy results has not been done yet in Hungary. PURPOSE: In this review we summarise the incidence, clinical features, prognostic risk factors and treatment results of children's LCH in Hungary, using data from the National Childhood Cancer Registry in Hungary in a 20-year period between 1981 and 2000. RESULTS: From January 1981 to December 2000, 111 children under 18 years of age were newly diagnosed with LCH in Hungary. The male-female ratio was 1.36:1, the mean age: 4 years 11 months. The minimal and median follow-up time was 3.48 years and 10.98 years respectively. 38 children had single-system disease, while in 73 cases we found systemic dissemination already at the time of diagnosis. Twenty-two patients were treated only by local surgery, 7 by surgery with local irradiation and 5 children received only local irradiation. In two cases remission was obtained with local steroid administration. 75 patient received chemotherapy. During the twenty years 14 children died, 9 due to the progression of the disease. Sixteen of the 111 patients had relapse with a mean of 2.16+/-1.29 years after the first diagnosis. Three patients with relapse got chemotherapy generally used in lymphoma and remission was achieved. The overall survival of all patients (n=111) was 88.3+/-3.1% at 5 years and 87.3+/-3.2% at 10 and 20 years. CONCLUSION: Childhood LCH is a well treatable disease and the survival rate is high. Even disseminated diseases have a quite good prognosis in childhood

Perorvoslatok a polgári peres eljárásban és összehasonlítás a szovjet eljárási joggal

INST: L_08