106 research outputs found
Kältevasokonstriktion, Kältedilatation und reaktive Hyperämie der Haut, dargestellt anhand der Laser-Doppler-Flußmessung
Der Einsatz der Laser-Doppler-Flußmessung hat sich auch in der hydrotherapeutischen
Forschung zur Frage der Objektivierung von thermisch ausgelösten Effekten im kutanen
Gefäßsystem bewährt. Die in der vorliegenden Arbeit dargestellten Versuchsergebnisse
beruhen auf kleinflächigen lokalen Abkühlungen mittels einer mit verschieden temperiertem
Wasser perfundierten Thermode. Dabei wurden an definierten Meßstellen periphere gefäßregulatorische
Vorgänge, wie Kältevasokonstriktion, -dilatation und reaktive Hyperämie,
sowie Durchblutungsgrad und Vasomotion an 10 gesunden Versuchspersonen untersucht
Zur Wirkung von Moorpackungen auf das Kontraktionsverhalten der Skelettmuskulatur (EMG-Untersuchung)
Eligibility for allogeneic transplantation in very high risk childhood acute lymphoblastic leukemia: the impact of the waiting time.
The advantage of allogeneic transplant from compatible related donors versus chemotherapy in children with very-high-risk acute lymphoblastic leukemia in first complete remission was previously demonstrated in an international prospective trial. This study quantified the impact of time elapsed in first remission in the same cohort. Of 357 pediatric patients with very-high-risk acute lymphoblastic leukemia, 259 received chemotherapy, 55 transplantation from compatible related and 43 from unrelated donors. The 5-year disease-free survival was 44.2% overall and 42.5% for chemotherapy only patients. The chemotherapy conditional 5-year disease-free survival increased to 44.4%, 47.6%, 51.7%, and 60.4% in patients who maintained their first remission for at least 3, 6, 9, and 12 months respectively. The overall outcome was superior to that obtained with chemotherapy-only at any time-point. The relative advantage of transplant from compatible related donors in very-high-risk childhood acute lymphoblastic leukemia was consistent for any time elapsed in first remission
Gyermekkori Langerhans-sejtes histiocytosissal szerzett magyarországi tapasztalataink
BACKGROUND: Langerhans cell histiocytosis (LCH) in children is
relatively rare, and the long-term analysis of therapy results
has not been done yet in Hungary. PURPOSE: In this review we
summarise the incidence, clinical features, prognostic risk
factors and treatment results of children's LCH in Hungary,
using data from the National Childhood Cancer Registry in
Hungary in a 20-year period between 1981 and 2000. RESULTS: From
January 1981 to December 2000, 111 children under 18 years of
age were newly diagnosed with LCH in Hungary. The male-female
ratio was 1.36:1, the mean age: 4 years 11 months. The minimal
and median follow-up time was 3.48 years and 10.98 years
respectively. 38 children had single-system disease, while in 73
cases we found systemic dissemination already at the time of
diagnosis. Twenty-two patients were treated only by local
surgery, 7 by surgery with local irradiation and 5 children
received only local irradiation. In two cases remission was
obtained with local steroid administration. 75 patient received
chemotherapy. During the twenty years 14 children died, 9 due to
the progression of the disease. Sixteen of the 111 patients had
relapse with a mean of 2.16+/-1.29 years after the first
diagnosis. Three patients with relapse got chemotherapy
generally used in lymphoma and remission was achieved. The
overall survival of all patients (n=111) was 88.3+/-3.1% at 5
years and 87.3+/-3.2% at 10 and 20 years. CONCLUSION: Childhood
LCH is a well treatable disease and the survival rate is high.
Even disseminated diseases have a quite good prognosis in
childhood
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