Management techniques for Effective Teaching

Discipline and management are frequently cited as the greatest dilemma facing public schools today. In the Annual Gallop Poll of Public\u27s Attitudes Toward the Public Schools, respondents consistently ranked discipline as the major problem confronting American education. For 16 of the 17 years, the United States public has ranked school discipline as the number-one educational problem in the public school system. School teachers in the United States reported that discipline interfered with their teaching to a moderate or great extent (Bauer, 1985). Brophy and Putnam (1978) listed classroom management as the first or second major concern among teachers. Studies indicate that few teachers feel prepared to deal with the issues of maintaining and organizing a classroom so that it operates smoothly (Brophy & Putnam, 1978; Emmer, et al., 1979; Paine, 1983)

Shear History Extensional Rheology Experiment: A Proposed ISS Experiment

The Shear History Extensional Rheology Experiment (SHERE) is a proposed International Space Station (ISS) glovebox experiment designed to study the effect of preshear on the transient evolution of the microstructure and viscoelastic tensile stresses for monodisperse dilute polymer solutions. Collectively referred to as Boger fluids, these polymer solutions have become a popular choice for rheological studies of non-Newtonian fluids and are the non-Newtonian fluid used in this experiment. The SHERE hardware consists of the Rheometer, Camera Arm, Interface Box, Cabling, Keyboard, Tool Box, Fluid Modules, and Stowage Tray. Each component will be described in detail in this paper. In the area of space exploration, the development of in-situ fabrication and repair technology represents a critical element in evolution of autonomous exploration capability. SHERE has the capability to provide data for engineering design tools needed for polymer parts manufacturing systems to ensure their rheological properties have not been impacted in the variable gravity environment and this will be briefly addressed

Shear History Extensional Rheology Experiment II (SHERE II) Microgravity Rheology with Non-Newtonian Polymeric Fluids

The primary objective of SHERE II is to study the effect of torsional preshear on the subsequent extensional behavior of filled viscoelastic suspensions. Microgravity environment eliminates gravitational sagging that makes Earth-based experiments of extensional rheology challenging. Experiments may serve as an idealized model system to study the properties of lunar regolith-polymeric binder based construction materials. Filled polymeric suspensions are ubiquitous in foods, cosmetics, detergents, biomedical materials, etc

Hepatocyte nuclear receptor SHP suppresses inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis

This research was originally published in the Journal of Biological Chemistry. An Zou, Nancy Magee, Fengyan Deng, Sarah Lehn, Cuncong Zhong, Yuxia Zhang. Hepatocyte nuclear receptor SHP suppresses inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis. J. Biol. Chem. 2018; Vol:pp-pp. © The American Society for Biochemistry and Molecular Biology. This work is licensed under a Creative Commons Attribution 4.0 International License.Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem worldwide, ranging from nonalcoholic fatty liver (NAFL, steatosis without hepatocellular injury) to the more aggressive nonalcoholic steatohepatitis (NASH, steatosis with ballooning, inflammation, or fibrosis). Although many studies have greatly contributed to the elucidation of NAFLD pathogenesis, the disease progression from NAFL to NASH remains incompletely understood. Nuclear receptor small heterodimer partner (Nr0b2, SHP) is a transcriptional regulator critical for the regulation of bile acid, glucose, and lipid metabolism. Here, we show that SHP levels are decreased in the livers of patients with NASH and in diet-induced mouse NASH. Exposing primary mouse hepatocytes to palmitic acid and lipopolysaccharide in vitro, we demonstrated that the suppression of Shp expression in hepatocytes is due to c-Jun N-terminal kinase (JNK) activation, which stimulates c-Jun–mediated transcriptional repression of Shp. Interestingly, in vivo induction of hepatocyte-specific SHP in steatotic mouse liver ameliorated NASH progression by attenuating liver inflammation and fibrosis, but not steatosis. Moreover, a key mechanism linking the anti-inflammatory role of hepatocyte-specific SHP expression to inflammation involved SHP-induced suppression of NF-κB p65-mediated induction of chemokine (C–C motif) ligand 2 (CCL2), which activates macrophage proinflammatory polarization and migration. In summary, our results indicate that a JNK/SHP/NF-κB/CCL2 regulatory network controls communications between hepatocytes and macrophages and contributes to the disease progression from NAFL to NASH. Our findings may benefit the development of new management or prevention strategies for NASH

Preliminary Findings from the SHERE ISS Experiment

The Shear History Extensional Rheology Experiment (SHERE) is an International Space Station (ISS) glovebox experiment designed to study the effect of preshear on the transient evolution of the microstructure and viscoelastic tensile stresses for monodisperse dilute polymer solutions. The SHERE experiment hardware was launched on Shuttle Mission STS-120 (ISS Flight 10A) on October 22, 2007, and 20 fluid samples were launched on Shuttle Mission STS-123 (ISS Flight 10/A) on March 11, 2008. Astronaut Gregory Chamitoff performed experiments during Increment 17 on the ISS between June and September 2008. A summary of the ten year history of the hardware development, the experiment's science objectives, and Increment 17's flight operations are discussed in the paper. A brief summary of the preliminary science results is also discussed

The Ursinus Weekly, October 10, 1974

Gov. candidate Drew Lewis fields questions at U.C. • Achatz discusses news media role at Ursinus forum • Parents\u27 Day events slated • USGA continues action policy • Editorial: Ursinus was a people place • Pages from Ursinus past: Radical changes in store for Ursinus by year 1970! • Pumpkin eater\u27s greenery • Personals • A letter to the Weekly • Institute helps pre-meds abroad • Ursinus student publishes histories • Story leaks out • X-country defeated by King\u27s College • Bears will win Saturday! • Hockey team plans tour of Englandhttps://digitalcommons.ursinus.edu/weekly/1021/thumbnail.jp

Identification of PKD1L1 Gene Variants in Children with the Biliary Atresia Splenic Malformation Syndrome

Biliary atresia (BA) is the most common cause of end‐stage liver disease in children and the primary indication for pediatric liver transplantation, yet underlying etiologies remain unknown. Approximately 10% of infants affected by BA exhibit various laterality defects (heterotaxy) including splenic abnormalities and complex cardiac malformations — a distinctive subgroup commonly referred to as the biliary atresia splenic malformation (BASM) syndrome. We hypothesized that genetic factors linking laterality features with the etiopathogenesis of BA in BASM patients could be identified through whole exome sequencing (WES) of an affected cohort. DNA specimens from 67 BASM subjects, including 58 patient‐parent trios, from the NIDDK‐supported Childhood Liver Disease Research Network (ChiLDReN) underwent WES. Candidate gene variants derived from a pre‐specified set of 2,016 genes associated with ciliary dysgenesis and/or dysfunction or cholestasis were prioritized according to pathogenicity, population frequency, and mode of inheritance. Five BASM subjects harbored rare and potentially deleterious bi‐allelic variants in polycystin 1‐like 1, PKD1L1, a gene associated with ciliary calcium signaling and embryonic laterality determination in fish, mice and humans. Heterozygous PKD1L1 variants were found in 3 additional subjects. Immunohistochemical analysis of liver from the one BASM subject available revealed decreased PKD1L1 expression in bile duct epithelium when compared to normal livers and livers affected by other non‐cholestatic diseases. Conclusion WES identified bi‐allelic and heterozygous PKD1L1 variants of interest in 8 BASM subjects from the ChiLDReN dataset. The dual roles for PKD1L1 in laterality determination and ciliary function suggest that PKD1L1 is a new, biologically plausible, cholangiocyte‐expressed candidate gene for the BASM syndrome

Observations of the low-luminosity Type Iax supernova 2019gsc: a fainter clone of SN 2008ha?

We present optical photometric and spectroscopic observations of the faint-and-fast evolving Type Iax supernova (SN) 2019gsc, extending from the time of g-band maximum until about 50 d post-maximum, when the object faded to an apparent r-band magnitude m(r )= 22.48 +/- 0.11 mag. SN 2019gsc reached a peak luminosity of only M-g = -13.58 +/- 0.15 mag, and is characterized with a post-maximum decline rate Delta m(15)(g) = 1.08 +/- 0.14 mag. These light curve parameters are comparable to those measured for SN 2008ha of M-g = -13.89 +/- 0.14 mag at peak and Delta m(15)(g) =1.80 +/- 0.03 mag. The spectral features of SN 2019gsc also resemble those of SN 2008ha at similar phases. This includes both the extremely low ejecta velocity at maximum, similar to 3000 km s(-1) and at late-time (phase +54 d) strong forbidden iron and cobalt lines as well as both forbidden and permitted calcium features. Furthermore, akin to SN 2008ha, the bolometric light curve of SN 2019gsc is consistent with the production of approximate to 0.003 +/- 0.001 M-circle dot of Ni-56. The explosion parameters, M-ej approximate to 0.13 M-circle dot and E-k approximate to 12 x 10(48) erg, are also similar to those inferred for SN 2008ha. We estimate a subsolar oxygen abundance for the host galaxy of SN 2019gsc (12 + log(10)(O/H) =8.10 +/- 0.18 dex), consistent with the equally metal-poor environment of SN 2008ha. Altogether, our data set for SN 2019gsc indicates that this is a member of a small but growing group of extreme SN Iax that includes SN 2008ha and SN 2010ae