How platforms govern users’ copyright-protected content: exploring the power of private ordering and its implications

Online platforms provide primary points of access to information and other content in the digital age. They foster users’ ability to share ideas and opinions while offering opportunities for cultural and creative industries. In Europe, ownership and use of such expressions is partly governed by a complex web of legislation, sectoral self- and co-regulatory norms. To an important degree, it is also governed by private norms defined by contractual agreements and informal relationships between users and platforms. By adopting policies usually defined as Terms of Service and Community Guidelines, platforms almost unilaterally set use, moderation and enforcement rules, structures and practices (including through algorithmic systems) that govern the access and dissemination of protected content by their users. This private governance of essential means of access, dissemination and expression to (and through) creative content is hardly equitable, though. In fact, it is an expression of how platforms control what users – including users-creators – can say and disseminate online, and how they can monetise their content. As platform power grows, EU law is adjusting by moving towards enhancing the responsibility of platforms for content they host. One crucial example of this is Article 17 of the new Copyright Directive (2019/790), which fundamentally changes the regime and liability of “online content-sharing service providers” (OCSSPs). This complex regime, complemented by rules in the Digital Services Act, sets out a new environment for OCSSPs to design and carry out content moderation, as well as to define their contractual relationship with users, including creators. The latter relationship is characterized by significant power imbalance in favour of platforms, calling into question whether the law can and should do more to protect users-creators. This article addresses the power of large-scale platforms in EU law over their users’ copyright-protected content and its effects on the governance of that content, including on its exploitation and some of its implications for freedom of expression. Our analysis combines legal and empirical methods. We carry our doctrinal legal research to clarify the complex legal regime that governs platforms’ contractual obligations to users and content moderation activities, including the space available for private ordering, with a focus on EU law. From the empirical perspective, we conducted a thematic analysis of most versions of the Terms of Services published over time by the three largest social media platforms in number of users – Facebook, Instagram and YouTube – so as to identify and examine the rules these companies have established to regulate user-generated content, and the ways in which such provisions shifted in the past two decades. In so doing, we unveil how foundational this sort of regulation has always been to platforms’ functioning and how it contributes to defining a system of content exploitation.info:eu-repo/semantics/publishedVersio

As bases sociais dos partidos portugueses

Este texto foi publicado como Working Paper e é essa a versão disponibilizada em acesso aberto, que deve ser citada como: Cancela, J., Magalhães, P. (2020). As bases sociais dos partidos portugueses.Working Paper 60/2020. IPRI - Instituto Português de Relações Internacionais. Universidade Nova de Lisboa. https://doi.org/10.23906/wp60/2020Este estudo examina os inquéritos pós-eleitorais de 2002 a 2019 para determinar as principais características sociais dos eleitorados dos principais partidos portugueses e analisar em que medida ocorreram transformações relevantes do longo deste período. Existem traços importantes de continuidade desde 2002 até hoje: a ausência de uma relação entre o sexo dos inquiridos e as suas opções de voto; uma relação forte entre a intensidade da religiosidade e da prática religiosa e as opções pelo voto à direita do espectro partidário; e a inexistência de uma clivagem esquerda-direita do ponto de vista da instrução. Por outro lado, existem também sinais de mudança. Há uma relação cada vez mais forte entre quer o sexo dos inquiridos quer o seu rendimento e a participação eleitoral, com os homens e aqueles com rendimentos mais elevados a absterem-se menos. Além disso, a partir de 2015, o centro-direita (PSD+CDS) começa a mostrar dificuldades em atrair o voto dos mais velhos. Por fim, se até 2009 ter rendimentos mais elevados não aumentava significativamente a propensão para votar nos partidos de centro-direita, essa relação intensifica-se a partir das eleições de 2011.info:eu-repo/semantics/publishedVersio

Conceiving a Digital Twin for a Flexible Manufacturing System

Digitization and virtualization represent key factors in the era of Industry 4.0. Digital twins (DT) can certainly contribute to increasing the efficiency of various productive sectors as they can contribute to monitoring, managing, and improvement of a product or process throughout its life cycle. Although several works deal with DTs, there are gaps regarding the use of this technology when a Flexible Manufacturing System (FMS) is used. Existing work, for the most part, is concerned with simulating the progress of manufacturing without providing key production data in real-time. Still, most of the solutions presented in the literature are relatively expensive and may be difficult to implement in most companies, due to their complexity. In this work, the digital twin of an FMS is conceived. The specific module of an ERP (Enterprise Resources Planning) system is used to digitize the physical entity. Production data is entered according to tryouts performed in the FMS. Sensors installed in the main components of the FMS, CNC (computer numerical control) lathe, robotic arm, and pallet conveyor send information in real-time to the digital entity. The results show that simulations using the digital twin present very satisfactory results compared to the physical entity. In time, information such as production rate, queue management, feedstock, equipment, and pallet status can be easily accessed by operators and managers at any time during the production process, confirming the MES (manufacture execution system) efficiency. The low-cost hardware and software used in this work showed its feasibility. The DT created represents the initial step towards designing a metaverse solution for the manufacturing unit in question, which should operate in the near future as a smart and autonomous factory model.Thanks are due to Elkartek 2022 project LANVERSO, and in some sections (simulations) to Basque government university group IT 1573-22

Role of malnutrition and parasite infections in the spatial variation in children’s anaemia risk in Northern Angola

Anaemia has a significant impact on child development and mortality and is a severe public health problem in most countries in sub-Saharan Africa. Nutritional and infectious causes of anaemia are geographically variable and anaemia maps based on information on the major aetiologies of anaemia are important for identifying communities most in need and the relative contribution of major causes. We investigated the consistency between ecological and individual-level approaches to anaemia mapping, by building spatial anaemia models for children aged ≤15 years using different modeling approaches. We aimed to a) quantify the role of malnutrition, malaria, Schistosoma haematobium and soil-transmitted helminths (STH) for anaemia endemicity in children aged ≤15 years and b) develop a high resolution predictive risk map of anaemia for the municipality of Dande in Northern Angola. We used parasitological survey data on children aged ≤15 years to build Bayesian geostatistical models of malaria (PfPR≤15), S. haematobium, Ascaris lumbricoides and Trichuris trichiura and predict small-scale spatial variation in these infections. The predictions and their associated uncertainty were used as inputs for a model of anemia prevalence to predict small-scale spatial variation of anaemia. Stunting, PfPR≤15, and S. haematobium infections were significantly associated with anaemia risk. An estimated 12.5%, 15.6%, and 9.8%, of anaemia cases could be averted by treating malnutrition, malaria, S. haematobium, respectively. Spatial clusters of high risk of anaemia (>86%) were identified. Using an individual-level approach to anaemia mapping at a small spatial scale, we found that anaemia in children aged ≤15 years is highly heterogeneous and that malnutrition and parasitic infections are important contributors to the spatial variation in anemia risk. The results presented in this study can help inform the integration of the current provincial malaria control program with ancillary micronutrient supplementation and control of neglected tropical diseases, such as urogenital schistosomiasis and STH infection

Local environment and fragmentation by drought and damming shape different components of native and non-native fish beta diversity across pool refuges

Pool refuges are critical for maintaining stream fish diversity in increasingly intermittent streams. Yet, the patterns and drivers of beta diversity of native and non-native fish in pool refuges remain poorly known. Focusing on Mediterranean streams, we decomposed beta diversity of native and non-native fish into richness difference (RichDiff) and species replacement (Repl), and local (LCBD, LCBDRichDiff and LCBDRepl) and species (SCBD) contributions. We assessed the influence of environmental and spatial factors associated with drought and damming fragmentations on beta diversity components and LCBDs, and of local species richness and occupancy on LCBDs and SCBD, respectively. Overall, non-native species showed a more limited occupancy of pool refuges than native fish. RichDiff dominated beta diversity, though it was influenced by drought and damming fragmentations for native fish and local environment for non-native fish. Repl for native fish was slightly influenced by local environment, but for non-native fish was largely driven by drought and damming, albeit with a contribution of local environment as well. LCBD and LCBDRichDiff increased in pools in low order streams for native fish and at low elevations for non-native fish, and with high or low species richness. SCBD was higher for native species with intermediated pool occupancy, but for non-native species with low occupancy. Our results suggest that stream fragmentation may drive native species loss and non-native species replacement in pool refuges, and that environmental filtering may shape non-native species loss. Pools in lower order streams har bouring unique species-rich or species-poor assemblages should be prioritize for conservation and restoration, respectively, and pools at low elevation with unique non-native assemblages should deserve control efforts. We encourage the partitioning of beta diversity and individual analysis of native and non-native fish in intermittent streams, which may be key in stressing the importance of pool refuges in safeguarding native fish diversity.Fundação para a Ciência e a Tecnologiainfo:eu-repo/semantics/publishedVersio

Initial screening of poly(ethylene glycol) amino ligands for affinity purification of plasmid DNA in aqueous two-phase systems

Gene therapy and DNA vaccination are among the most expected biotechnological and medical advances for the coming years. However, the lack of cost-effective large-scale production and purification of pharmaceutical-grade plasmid DNA (pDNA) still hampers their wide application. Downstream processing, which is mainly chromatography-based, of pDNA remains the key manufacturing step. Despite its high resolution, the scaling-up of chromatography is usually difficult and presents low capacity, resulting in low yields. Alternative methods that are based on aqueous two-phase systems (ATPSs) have been studied. Although higher yields may be obtained, its selectivity is often low. In this work, modified polymers based on poly(ethylene glycol) (PEG) derivatisation with amino groups (PEGamine) or conjugation with positively charged amino acids (PEGlysine, PEGarginine, and PEGhistidine) were studied to increase the selectivity of PEGdextran systems towards the partition of a model plasmid. A two-step strategy was employed to obtain suitable pure formulations of pDNA. In the first step, a PEGdextran system with the addition of the affinity ligand was used with the recovery of the pDNA in the PEG-rich phase. Then, the pDNA was re-extracted to an ammonium-sulphate-rich phase in the second step. After removing the salt, this method yielded a purified preparation of pDNA without RNA and protein contamination.Thanks are due to the Fundação para a Ciência e Tecnologia (FCT, Portugal) for financial support to the NMR Portuguese network (PTNMR, Bruker Avance III 400-Univ. Minho) and strategic funding for CQUM (UID/QUI/00686/2020).info:eu-repo/semantics/publishedVersio

Overweight, central obesity and abdominal obesity in middle-age adults in an inland region of northeast Portuguese: a pilot study

The prevalence of central and abdominal obesity has been increasing over last decades in developed countries. As well, the high prevalence of obesity in Portugal has already been documented, however it is need to better understand the prevalence in each region of the country. Thus, the aim of this study was to evaluate the prevalence of the overweight, central obesity and abdominal obesity in middleage in an inland region of Northeast Portuguese. Methods: A descriptive and cross-sectional community sample was collected from two Portuguese primary health care centres between January 2019 and December 2020. A total of 673 individuals aged 40–65 years were included for analysis, among which 400 women (53.34 ± 7.33 years) and 273 men (53.01 ± 7.20 years). Prevalence of overweight, central obesity and abdominal obesity were analysed across sexes using body mass index and waist circumference. Categorical variables were expressed by counts and proportions with a 95% confidence interval (CI). Chi-squared test or fisher exact test were applied whenever appropriate. To compare continuous variables independent sample t-test or Mann-Whitney U test were used. Statistical significance was set at p < 0.05. Results: The prevalence of overweight, central obesity and abdominal obesity in this cross-sectorial sample were 41.01%, 30.61% and 67.20%, respectively. Significant differences among men and women were found for abdominal obesity (p < 0.001). Women presented a higher prevalence of abdominal obesity (67.5%). Men have higher prevalence of overweight (48.72%) and central obesity (31.14%) than women (35.75% and 30.25%, respectively). However, differences were not statistically significant between sexes for overweight and central obesity (p ≥ 0.05). Conclusion: A higher prevalence of overweight, central obesity and abdominal obesity was reported for middle-age adults in this inland region of Northeast Portuguese. Our data suggest a higher prevalence of all three clinical conditions, comparing previous Portuguese epidemiological studies. Current report provides the study pilot for a more detailed epidemiological research. Also, preliminary findings emphasise the importance of implementing physical activity programmes and promoting healthy lifestyles to tackling this growing public health problem.info:eu-repo/semantics/publishedVersio

Adjuvant Hyperthermic Intravesical Chemotherapy in Intermediate- and High-Risk Non-muscle Invasive Bladder Cancer

Introduction: Non-muscle invasive bladder cancer (NMIBC) is a frequently diagnosed neoplasm, which is typically managed with transurethral resection of bladder tumor (TURBT) eventually followed by intravesical therapies. Bacillus Calmette-Guérin (BCG) is used as first-line adjuvant treatment in high- (HR) and intermediate-risk (IR) NMIBC, although, in the latter, mitomycin C (MMC) may also be used. Multiple limitations to the use of BCG encouraged the search for therapeutic alternatives. In this context, hyperthermic intravesical chemotherapy with MMC (HIVEC-MMC) emerged as a promising therapy in the adjuvant setting for NMIBC. The aim of our study was to evaluate the tolerability, compliance, and survival outcomes of HIVEC-MMC in patients with IR- and HR-NMIBC. Material and methods: This was a single-center retrospective analysis of IR- and HR- NMIBC patients who received HIVEC-MMC after TURBT between August 2018 and August 2022. Levels of risk stratification were defined using the European Association of Urology (EAU) criteria. The protocol consisted of four weekly HIVEC-MMC instillations (induction) followed by six monthly instillations (maintenance). The primary outcomes were to evaluate the tolerability and compliance with the HIVEC-MMC protocol and secondary outcomes were disease-free survival (DFS) and overall survival (OS). For the purpose of statistical analysis, methods of descriptive statistics, survival analysis (Kaplan-Meier estimation), and multivariate analysis (Cox regression, and binary logistic regression) were used. Results: Fifty-seven patients were enrolled with a median age of 67.9 (34.4-83.5) years old. In this cohort, 40 patients (70.2%) had primary tumors. At the time of referral for HIVEC-MMC, the majority of the patients had IR-NMIBC (n= 33, 57.9%). A total of 41 patients (71.9%) completed the HIVEC-MMC protocol. Disease recurrence and adverse events (AEs) were the most common reasons to stop the protocol. After a median follow-up of 31 months (95% CI, 5.0-54.0), 32 patients (61.4%) were disease-free, 22 (38.6%) experienced recurrent disease and six patients (10.5%) died, although only one death was directly attributable to bladder cancer. The median DFS was 42 months (95% CI, 28.0-56.0). Completion of the HIVEC-MMC maintenance phase protocol stood as a predictive factor for DFS (44 months, 95% CI 29.1-58.9 vs. 14 months, 95% CI 0.0-29.6, p < 0.001; HR 4.48, 95% CI 1.65-12.15). The median OS was not reached; the 24- and 48-month OS were 92.6% and 82.7%, respectively. EAU risk group, ECOG-PS, and completion of HIVEC protocol were found to be significant predictive factors of OS but lost their significance on multivariate analysis. However, if we exclude those who experienced recurrence during the maintenance phase protocol, treatment completion had a significant positive impact on OS (HR: 42.8, 95% CI 1.75-1045.072, p= 0.021). Conclusions: Our study suggests that HIVEC is a secure and well-tolerated treatment with promising efficacy data, making this therapeutic approach a feasible option in IR- and HR-NMIBC patients, mainly in those who cannot tolerate or have contraindications to BCG therapy, but also as an alternative during BCG shortages.info:eu-repo/semantics/publishedVersio