Intrinsic Properties of steady Diabatic Complex Lamellar Gas Flows

Considering the Beltrami surfaces of revolution obtained by revolving a system of confocal hyperbolae in the meridian plane, various kinetic and kinematic properties of steady diabatic complex lamellar gas flows have been studied

Geometry of the Vortexline in Complex Lamellar Steady Diabatic Gas Flows

Considering the geometry of triply orthogonal spatial curves of congruences in Euclidean space E/Sup3, formed by a vortexline and its principal normal and binormal, various kinematic and kinetic properties of an inviscid diabatic steady gas flow are examined. Extending the same technique complex-lamellar flows are studied

Geometry of Magnetohydrodynamic Flow

The geometry of streamline and magnetic lines have been considered to study the various kinematic and kinetic properties of magnetohydrodynamic flows

Vorticity in Diabatic Steady Gas Flows

Various kinematic and kinetic properties of steady diabatic gas flows are studied considering the geometry of triply orthogonal spatial curves of congruences one related to the vortexlines and the other to their principal normals and binormals

Standardized method to extract phenolic compounds from Lagerstroemia speciosa L. (Jarul) for enhanced antioxidant activity

Phenolic compounds contribute to the antioxidant property of plants and the efficient extraction of plant phenolics could enhance its antioxidant potential. Lagerstroemia speciosa (L.) Pers. has been investigated for its pharmacological activities, but comparing its antioxidant activities of phenolics derived from its various parts has a key role in developing natural antioxidants. This study was conducted to standardize the extraction of phenolics from leaves, pods and branches of L. speciosa plant, followed by determination of antioxidant activities of their solvent fractions. Phenolic compounds were extracted from the leaves, pods and branches under different parameters such as temperature, pH, type of solvent and volume of the solvent. The extracted phenolic compounds were subjected to solvent fractions and antioxidant assays were performed. Among the various extraction methods tested, the best method was 50% ethanol +1% HCl, refluxing temperature, 100 ml of solvent and 1 hour extraction time. The best solvent fractions were determined as NaHCO3 + ethyl acetate for pods and ethyl acetate alone for leaves and branches with extracted phenolics content of 150.2 mg/g, 136.2 mg/g and 82.9 mg/g, respectively. The chloroform fraction was best among the fractions with maximum ascorbic acid equivalent (ASE) in all the parts of L. speciosa tested. Ferrous ion chelating capacity indicated that butanol fraction had the highest chelation and the same was recorded in ferric ion chelating assay with an EC50 value of 28.2. Hydroxyl radical scavenging activity of the fractions indicated that NaHCO3 + EtOAc fraction of pods had potential activity. Thus, the phenolic compounds from L. speciosa are excellent sources for future investigation on potent natural antioxidant compounds

Asynchronous Games over Tree Architectures

We consider the task of controlling in a distributed way a Zielonka asynchronous automaton. Every process of a controller has access to its causal past to determine the next set of actions it proposes to play. An action can be played only if every process controlling this action proposes to play it. We consider reachability objectives: every process should reach its set of final states. We show that this control problem is decidable for tree architectures, where every process can communicate with its parent, its children, and with the environment. The complexity of our algorithm is l-fold exponential with l being the height of the tree representing the architecture. We show that this is unavoidable by showing that even for three processes the problem is EXPTIME-complete, and that it is non-elementary in general

Quaternary Geology and Geomorphology of Terna River Basin in West Central India

Im vorgelegten Artikel werden die Morphostratigraphie, Lithostratigraphie sowie die Sedimentstrukturen des Terna Beckens in der Deccan Basaltic Province (DBP) im westlichen Zentralindien vorgestellt. Die Quartärablagerungen können in drei große Einheiten unterteilt werden (i) dunkelgraue Schluffablagerungen – Spätes Holozän, (ii) hellgraue Schluffablagerungen – Frühes Holozän, (iii) dunkelgrau-braune Schluffablagerungen – Spätpleistozän mit altquartären alluvialen Absätzen mit oberpleistozänen Altern. Die feinen tonig-schluffigen Ablagerungen im Unterlauf des Flusses deuten auf ruhige Ablagerungsbedingungen und einen sinusartigen Abfluss hin. Der Fluss zeigt Tendenzen zu abschwemmungsbedingten Gerinneverlagerungen, die wiederum durch vorhandene Bruchlinien gesteuert wurden. Entlang des Terna-Flusses konnten weiterhin Paläouferrücken in Form von 4–5 m hohen Rücken nachgewiesen werden, hier vor allem im Bereich der OrtschaftenTer, Killari, Sastur, Dhuta und Makni. Einige nachgewiesene Bruchlinien treten vor allem in NE-SE, NW-SE, E-W und WNW-ESE-Richtung auf und bestimmen die Struktur des Grundgebirges im Untersuchungsgebiet. Die TSI-Werte (Topographic Sinousity Index) verdeutlichen einen Erosionswechsel im Untersuchungsgebiet mit einer Verstärkung des topographischen Einflusses auf die Ausformung der Abflussbahnen. Die im Profil sichtbare Geländekante zeugt weiterhin von einer tektonischen Hebung des Gebietes im Quartär. Radiokohlenstoffdatierungen, die an einigen Holzkohlefragmenten durchgeführt wurden, die aus gefalteten Ablagerungen entnommen wurden, deuten darauf hin, dass eine seismische Aktivität in der Zeitspanne zwischen 120–1671 n. Chr. stattgefunden haben kann.researc

Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1) deficiency is linked to aggressive breast cancer and predicts response to adjuvant therapy

Uracil in DNA is an important cause of mutagenesis. SMUG1 is a uracil DNA glycosylase that removes uracil through base excision repair. SMUG1 also processes radiation induced oxidative base damage as well as 5-fluorouracil incorporated into DNA during chemotherapy. We investigated SMUG1 mRNA expression in 249 primary breast cancers. SMUG1 protein expression was investigated in 1165 breast tumours randomised into two cohorts [training set (n=583) and test set (n=582)]. SMUG1 and chemotherapy response was also investigated in a series of 315 ER negative tumours (n=315). For mechanistic insights, SMUG1 was correlated to biomarkers of aggressive phenotype, DNA repair, cell cycle and apoptosis. Low SMUG1 mRNA expression was associated with adverse disease specific survival (p=0.008) and disease free survival (p=0.008). Low SMUG1 protein expression (25%) was associated with high histological grade (p<0.0001), high mitotic index (p<0.0001), pleomorphism (p<0.0001), glandular de-differentiation (p=0.0001), absence of hormonal receptors (ER-/PgR-/AR) (p<0.0001), presence of basal-like (p<0.0001) and triple negative phenotypes (p<0.0001). Low SMUG1 protein expression was associated with loss of BRCA1 (p<0.0001), ATM (p<0.0001) and XRCC1 (p<0.0001). Low p27 (p<0.0001), low p21 (p=0.023), mutant p53 (p=0.037), low MDM2 (p<0.0001), low MDM4 (p=0.004), low Bcl-2 (p=0.001), low Bax (p=0.003) and high MIB1 (p<0.0001) were likely in low SMUG1 tumours. Low SMUG1 protein expression was associated with poor prognosis in univariate (p<0.001) and multivariate analysis (p<0.01). In ER+ cohort that received adjuvant endocrine therapy, low SMUG1 protein expression remains associated with poor survival (p<0.01). In ER- cohort that received adjuvant chemotherapy, low SMUG1 protein expression is associated with improved survival (p=0.043). Our study suggests that low SMUG1 expression may correlate to adverse clinicopathological features and predict response to adjuvant therapy in breast cancer

Capacity-aware Control Topology in MANET

The wireless mobile adhoc networks are dynamically Varying, the network performance may change by different unknown parameters such as the total number of nodes in the network, the transmission power range of the network and area of deployment of the network. The main aim is to increase the efficiency of the system through dynamically changing the trasmission range on every node of the network.contention index is the network performance factor is considered. we presented a study of the effects of contention index on the network performance, considering capacity of the network and efficiency of the power. The result is that the capacity is a concave function of the contention index. if the contention index is large the impact of node mobility is minimal on the network performance. we presented GridMobile, a distributed Network topology algorithm that attempts to shows the best possiblity, by maintaining optimal contention index by dynamically adjusting the transmission range on every nodes in the network

DNA polymerase B deficiency is linked to aggressive breast cancer: a comprehensive analysis of gene copy number, mRNA and protein expression in multiple cohorts

Short arm of chromosome 8 is a hot spot for chromosomal breaks, losses and amplifications in breast cancer. Although such genetic changes may have phenotypic consequences, the identity of candidate gene(s) remains to be clearly defined. Pol β gene is localized to chromosome 8p12 - p11 and encodes a key DNA base excision repair protein. Pol β may be a tumour suppressor and involved in breast cancer pathogenesis. We conducted the first and the largest study to comprehensively evaluate pol β in breast cancer. We investigated pol β gene copy number changes in two cohorts (n=128 & n=1952), pol β mRNA expression in two cohorts (n=249 & n=1952) and pol β protein expression in two cohorts (n=1406 & n=252). Artificial neural network analysis for pol β interacting genes was performed in 249 tumours. For mechanistic insights, pol β gene copy number changes, mRNA and protein levels were investigated together in 1 28 tumours and validated in 1952 tumours. Low pol β mRNA expression as well as low pol β protein expression was associated high grade, lymph node positivity, pleomorphism, triple negative, basal - like phenotypes and poor survival (ps<0.001). In oestrogen receptor (ER) positive sub - group that received tamoxifen, low pol β protein remains associated with aggressive phenotype and poor survival (ps<0.001). Artificial neural network analysis revealed ER as a top pol β interacting gene. Mechanistically, there was strong positive correlation between pol β gene copy number changes and pol β mRNA expression (p<0.0000001) and between pol β mRNA and pol β protein expression (p<0.0000001). This is the first study to provide evidence that pol β deficiency is linked to aggressive breast cancer and may have prognostic and predictive significance in patients