Oncología pediátrica

Cancer in chilhood is becoming increasingly important in the field of Pediatrics; among other reasons as it the second cause of infant mortality. The possibility of detecting genetic and molecular alterations in tumoral cells can allow the patient´s risk to be individualized and, as a consequence, treatments which are just as effective but less toxic to be used. Although over recent years we have seen a spectacular advance in the survival of cancer in chilhood and few specialties have attained similar results, it is probably that a new era in research on and treatment of tumors in the infant has begun

El proceso de comprensión lectora en alumnos de tercero de secundaria

El presente artículo describe el proceso lector seguido por estudiantes de tercero de secundaria para abordar un texto con el propósito de comprenderlo. Se utilizó un método de investigación mixto secuencial cuantitativo/cualitativo. En la fase cuantitativa se seleccionó una muestra de altos y bajos lectores, que fueron observados durante la ejecución de dos tareas, mediante las cuales se evidenció el proceso que siguieron al intentar comprender diversos textos. Los datos recabados en la fase cualitativa evidenciaron que no todos los alumnos siguen el mismo camino para lograr el propósito mencionado, por lo que se presenta un modelo que muestra las diferentes rutas seguidas y se identifica un conjunto de factores que intervienen en la elección de la ruta lectora, entre ellos el pensamiento metacognitivo y las creencias acerca de la lectura. The present article describes the reading process ninth-graders follow to address a text with the purpose of understanding it. A sequential mixed quantitative/qualitative method was used. In the quantitative phase, a sample of high and low readers was selected; these readers were observed while performing two tasks, which revealed the process they followed while attempting to understand diverse texts. The data compiled in the qualitative phase showed that not all students follow the same path to attain the designated purpose. A model is presented to show the different paths followed, and a set of factors that intervene in selecting the reading path is identified. These factors include metacognitive thinking and beliefs about reading.ITESO, A.C

Los últimos años del adelantado

Mucho se ha escrito del fundador de Bogotá. Abundan relatos en forma novelada llamados biografías, de los cuales han publicado los periódicos en estos días algunos capítulos para solaz de sus lectores

Oncología pediátrica

Cancer in chilhood is becoming increasingly important in the field of Pediatrics; among other reasons as it the second cause of infant mortality. The possibility of detecting genetic and molecular alterations in tumoral cells can allow the patient´s risk to be individualized and, as a consequence, treatments which are just as effective but less toxic to be used. Although over recent years we have seen a spectacular advance in the survival of cancer in chilhood and few specialties have attained similar results, it is probably that a new era in research on and treatment of tumors in the infant has begun

Application of oncoproteomics to aberrant signalling networks in changing the treatment paradigm in acute lymphoblastic leukaemia

Oncoproteomics is an important innovation in the early diagnosis, management and development of personalized treatment of acute lymphoblastic leukaemia (ALL). As inherent factors are not completely known – e.g. age or family history, radiation exposure, benzene chemical exposure, certain viral exposures such as infection with the human T-cell lymphoma/leukaemia virus-1, as well as some inherited syndromes may raise the risk of ALL – each ALL patient may modify the susceptibility of therapy. Indeed, we consider these unknown inherent factors could be explained via coupling cytogenetics plus proteomics, especially when proteins are the ones which play function within cells. Innovative proteomics to ALL therapy may help to understand the mechanism of drug resistance and toxicities, which in turn will provide some leads to improve ALL management. Most important of these are shotgun proteomic strategies to unravel ALL aberrant signalling networks. Some shotgun proteomic innovations and bioinformatic tools for ALL therapies will be discussed. As network proteins are distinctive characteristics for ALL patients, unrevealed by cytogenetics, those network proteins are currently an important source of novel therapeutic targets that emerge from shotgun proteomics. Indeed, ALL evolution can be studied for each individual patient via oncoproteomicsDr. E. López Villar is supported by Spanish Health System SNS ISCIII-BOE 2012. This work is supported by Project FIS PI13/02475

Performance of a behavioral model with long-term memory effects

This paper presents a new behavioral model for power amplifiers that accomplishes the capture of nonlinear low-frequency memory effects with reduced complexity and superior precision. It has been extensively evaluated with a commercial amplifier using wideband code-division multiple-access (WCDMA)-like modulated data with symbol rates in the range of 2 ksym/s to 1 Msym/s, and it is shown that the first dynamic reduction of the proposed model is successfully compared with other highly efficient methods in terms of complexity and generalization capacity.CICYT TEC2011-23559Junta de Andalucía P11-TIC-786