275 research outputs found
Features of myelin oligodendrocyte glycoprotein (MOG) required for the detection of autoantibodies from patients with MOG-antibody-associated disorders
Privacy Considerations for Online Advertising: A Stakeholder’s Perspective to Programmatic Advertising
Purpose
Privacy considerations have become a topic with increasing interest from academics, industry leaders and regulators. In response to consumers’ privacy concerns, Google announced in 2020 that Chrome would stop supporting third-party cookies in the near future. At the same time, advertising technology companies are developing alternative solutions for online targeting and consumer privacy controls. This paper aims to explore privacy considerations related to online tracking and targeting methods used for programmatic advertising (i.e. third-party cookies, Privacy Sandbox, Unified ID 2.0) for a variety of stakeholders: consumers, AdTech platforms, advertisers and publishers. Design/methodology/approach
This study analyzes the topic of internet user privacy concerns, through a multi-pronged approach: industry conversations to collect information, a comprehensive review of trade publications and extensive empirical analysis. This study uses two methods to collect data on consumer preferences for privacy controls: a survey of a representative sample of US consumers and field data from conversations on web-forums created by tech professionals. Findings
The results suggest that there are four main segments in the US internet user population. The first segment, consisting of 26% of internet users, is driven by a strong preference for relevant ads and includes consumers who accept the premises of both Privacy Sandbox and Unified ID (UID) 2.0. The second segment (26%) includes consumers who are ambivalent about both sets of premises. The third segment (34%) is driven by a need for relevant ads and a strong desire to prevent advertisers from aggressively collecting data, with consumers who accept the premises of Privacy Sandbox but reject the premises of UID 2.0. The fourth segment (15% of consumers) rejected both sets of premises about privacy control. Text analysis results suggest that the conversation around UID 2.0 is still nascent. Google Sandbox associations seem nominally positive, with sarcasm being an important factor in the sentiment analysis results. Originality/value
The value of this paper lies in its multi-method examination of online privacy concerns in light of the recent regulatory legislation (i.e. General Data Protection Regulation and California Consumer Privacy Act) and changes for third-party cookies in browsers such as Firefox, Safari and Chrome. Two alternatives proposed to replace third-party cookies (Privacy Sandbox and Unified ID 2.0) are in the proposal and prototype stage. The elimination of third-party cookies will affect stakeholders, including different types of players in the AdTech industry and internet users. This paper analyzes how two alternative proposals for privacy control align with the interests of several stakeholders.
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O diferencial no atendimento online : a experiência bem-sucedida da startup Nubank
Trabalho de Conclusão de Curso (graduação)—Universidade de Brasília, Faculdade de Comunicação, Departamento de Comunicação Organizacional, 2019.Este trabalho se propõe a analisar o fenômeno da startup banco digital Nubank, uma organização genuinamente brasileira criada em maio de 2013. Atualmente, a empresa está presente em todo o Brasil, contabilizando mais de 8 milhões de clientes e considerada a principal fintech da América Latina. As perguntas de pesquisa que orientam este trabalho são: os canais e estratégias de atendimento do Nubank, que já conta com 8 milhões de clientes em sua carteira, são eficientes?; como os clientes percebem o atendimento na organização? A metodologia usada no estudo foi a pesquisa bibliográfica utilizando autores de comunicação organizacional, marketing, atendimento, Serviço de Atendimento Online – SAC, bem como a pesquisa documental do Nubank. Foi feita ainda, uma pesquisa de opinião com um levantamento a respeito da percepção dos serviços e produtos da organização por parte de seus usuários na utilização cotidiana dos canais de comunicação digitais. Um questionário estruturado, com quinze perguntas ficou disponível online aos clientes da instituição, no período compreendido entre 14 de maio e 02 de junho de 2019. O objetivo do questionário foi avaliar o serviço de atendimento oferecido pelo banco ao consumidor online e ainda o que os atuais clientes esperam da organização nos próximos anos, em termos de bens e serviços. Na análise descritiva e quantitativa das 408 respostas recebidas, observou-se a satisfação de 83,82% dos serviços e atendimento ora entregues. Do mesmo modo, os clientes solicitaram melhorias para os próximos anos como, por exemplo, a criação de programas de milhagem, opções de investimento e aumento no limite de crédito. Isto posto, espera-se que esse estudo contribua para ampliar as discussões a respeito do Serviço de Atendimento online.This paper proposes an analysis on the phenomenon of the startup Nubank, which is a genuinely Brazilian digital bank created in May 2013. Currently, the company operates all over Brazil, accounting for more than 8 million customers and considered the main fintech in Latin America. The inquiries that guide this work are: The customer service channels and strategies apply to Nubank, that already has 8 million people, are efficient?; How do customers perceive the attendance on the organization? The methodology used in the study was a bibliographic research of organizational communication, marketing, attendance and online SAC authors, as well as a documentary research of Nubank. An opinion survey was also made regarding the perception of the services and products of the organization by its users in the daily use of its digital communication channels. A structured questionnaire with 15 questions was made available online to the clients of the institution, from May 14 to June 2, 2019. The objective of the questionnaire was to evaluate the customer service offered by the bank to the online consumers and still what current customers expect from the organization in the coming years in terms of goods and services. In the descriptive and quantitative analysis of the 408 responses received, a satisfaction of 83.82% of the services and attendance delivered was observed. In the same way, customers have requested improvements for the coming years, such as the creation of mileage programs, investment options and an increase in the credit limit. That said, it is hoped that this study will contribute to broaden the discussions about the Online Helpdesk
Extracts from Amazonian plants have inhibitory activity against tyrosinase: an in vitro evaluation
Dermatological disorders related to pigmentation result in tenuous hyper or hypopigmentation Cosmetic and pharmaceutical products containing depigmenting substances are used in the treatment of patients who have high pigmentation disorders, such as melasma or chloasma, post-inflammatory hyperpigmentation, senile lentigo and ephelides. Skin lightening agents are not yet totally effective or safe and therefore intensive research for the discovery of new agents is continuous. Enzyme inhibitors involved in melanogenesis, such as tyrosinase, have been discovered in Asian countries, including those isolated from plant extracts. The Brazilian flora has the highest species diversity in the world, and the chemical, pharmacological and cosmetic potential for the discovery of new skin whitening agents is in proportion with this biodiversity. For these reasons, 25 aqueous and 24 organic extracts obtained from 19 plants native to the Amazon rain forest and to the Atlantic forest, belonging to 11 different families, were evaluated as tyrosinase inhibitors. Nine out of 49 extracts showed inhibitory activity in the screening process. The 50% inhibitory activity (IA50) was calculated, revealing that the most active extracts were the organic extracts from the leaves and stem of Ruprechtia sp. (IA50 33.76 mg.mL-1) and the organic extract from the aerial organs of Rapanea parviflora (IA50 64.19 mg.mL-1).Problemas dermatológicos relacionados com a pigmentação resultam em hiperpigmentações ou hipopigmentação cutâneas. Produtos cosméticos e farmacêuticos com atividade despigmentante são utilizados para o tratamento de pacientes que apresentam distúrbios de hiperpigmentação, tais como melasma ou cloasma, hiperpigmentação pós-inflamatória, lentigem senil e efélides. Os despigmentantes atualmente utilizados não são totalmente eficazes ou seguros, razão pela qual há intensa pesquisa, principalmente em países asiáticos, com a finalidade de se obter novos agentes com esta ação, em especial inibidores de enzimas envolvidas na melanogênese, como a tirosinase. Considerando-se que algumas substâncias obtidas de plantas apresentam essa atividade, a flora brasileira constitui-se uma fonte potencial de obtenção de novos despigmentantes. Por essa razão, 25 extratos aquosos e 24 orgânicos obtidos de 19 plantas da Floresta Amazônica e Mata Atlântica, provenientes de 11 diferentes famílias, foram avaliados quanto à atividade de inibição da tirosinase. Do total de 49 extratos testados, 9 mostraram atividade. Os valores de concentração da atividade inibitória 50% (AI 50%), foram calculados e o mais ativo foi o extrato orgânico das folhas e caule de Ruprechtia sp. (AI50 33,76 mg.mL-1) seguido do extrato orgânico dos órgãos aéreos de Rapanea parviflora (AI50 64,19 mg.mL-1)
“The tasks that are women´s, now I do too”. Masculinities and cares in times of pandemic
Enmarcado en el campo de investigación de
las masculinidades, el presente artículo
expone, desde una perspectiva de género, el
análisis de los resultados surgidos de la
indagación acerca de los cambios producidos
en la cotidianeidad de los varones
autopercibidos como tales, durante la
aplicación de las medidas preventivas de
aislamiento social determinadas por el
gobierno nacional, en el tránsito de la
pandemia provocada por el Covid-19.
Basado en la aplicación de una encuesta no
probabilística, este estudio analiza las
respuestas de 1.006 varones residentes de
todo el país, comprendidos en un rango de
edades que oscila entre los 18 y 79 años. La
recolección de información se realizó
mediante un cuestionario compuesto por
preguntas abiertas y cerradas centradas en
aspectos relacionados a la salud, trabajo, vida
cotidiana, relaciones intrafamiliares, prácticas
sexuales y la valoración sobre las ventajas y
desventajas que la permanencia en sus
hogares les ha ocasionado.
Desde el Trabajo Social entendemos como
necesidad implicar a aquellos varones que se
autoperciben como tales en el debate
público, a fin de problematizar y promover la asunción de roles de cuidado compartidos
entre feminidades, masculinidades y
disidencias, cuestión sobre la que se aprecian
altos niveles de desigualdad intergéneros.Framed in the field of investigation of
masculinities, this article presents, from a gender
perspective, the analysis of the results arising
from the investigation about the changes
produced in the daily lives of self-perceived
males during the application of preventive
isolation measures determined by the national
government in the transit of the pandemic
caused by Covid-19.
Based on the application of a non-probabilistic
survey, this study analyzes the responses of
1.006 males residents from all over the country,
comprised in an age range that oscillates
between 18 and 79 years. The information
collection was carried out through a
questionnaire composed of open and closed
questions focused on aspects related to health,
work, daily life, intrafamily relationships, sexual
practices and the assessment of the advantages
and disadvantages that staying in their homes
has caused them.
From Social Work we understand as a need to
involve self-perceived males as such in public
debate in order to problematize and promote the
assumption of shared care roles between
femininity, masculinities and dissidents, an issue
on which high levels of intergender inequality are
observed.publishedVersionFil: Robles, Claudio. Universidad de Buenos Aires; Argentina.Fil: Robles, Claudio. Universidad Nacional de La Matanza; Argentina.Fil: Macrini, Patricia. Universidad Nacional de La Matanza; Argentina.Fil: Robledo, Sandra. Universidad Nacional de La Matanza; Argentina
Evidências neuroquímicas e comportamentais do efeito ansiogênico da deltametrina em ratos
Pyrethroid insecticides are extensively used for pest control around the house, flea prevention for pets, and plant sprays for the home and in agriculture. Deltamethrin (DTM) is a Type II pyrethroid insecticide used to control a variety of insects in agriculture and domestic environments. The present study investigated the possible anxiogenic effects of DTM (1, 3, and 10 mg/kg) in rats using behavioral and neurochemical methods. We assessed general locomotor activity and behavior in the elevated plus maze and open field test. Striatal and hippocampal neurotransmitter and metabolite levels were also measured. DTM (i) reduced locomotion and rearing frequency, (ii) slightly increased the duration of immobility, (iii) reduced the time engaged in social interaction, (iv) reduced the percentage of entries into and time spent on the open arms of the elevated plus maze, (v) reduced the number of center crossings in the elevated plus maze, (vi) Striatal and hippocampal neurotransmitter and metabolite levels were also measured. DTM (i) reduced locomotion and rearing frequency, (ii) slightly increased the duration of immobility, (iii) reduced the time engaged in social interaction, (iv) reduced the percentage of entries into and time spent on the open arms of the elevated plus maze, (v) reduced the number of center crossings in the elevated plus maze, (vi) increased striatal serotonin neurotransmitter and its metabolite, and (vii) did not alter motor coordination on the rotarod, grooming duration in the open field test, rectal temperature, or hippocampal neurotransmitter levels. These data suggest that DTM at the present doses and under these experimental conditions presented a similar profile to that of anxiogenic drugs, unrelated with the increased serotonin neurotransmission.Inseticidas piretróides são amplamente utilizados para controle de pragas, como na prevenção de pulgas em animais de estimação e sprays de plantas para a casa e na agricultura. Deltametrina (DTM) é um inseticida piretróide tipo II usado para controlar uma variedade de insetos na agricultura e ambientes domésticos. O presente estudo investigou os possíveis efeitos ansiogênicos de DTM (1, 3 e 10 mg/kg) em ratos, utilizando métodos comportamentais e neuroquímicos. Foi avaliada a atividade locomotora geral e comportamento no labirinto em cruz elevado e teste de campo aberto. Os níveis de neurotransmissores e metabólitos no estriado e hipocampo também foram mensurados. DTM (i) reduziu a locomoção e a frequência de levantar, (ii) aumentou da duração da imobilidade, (iii) reduziu o tempo de interação social, (iv) reduziu a percentagem de entradas e tempo gasto nos braços abertos do elevado labirinto em cruz, (v) reduziu o número de cruzamentos no centro do labirinto em cruz elevado, (vi) aumentou neurotransmissor serotonina e de seu metabólito estriatal, e (vii) não alterou a coordenação motora no rotarod, duração do grooming no teste de campo aberto, temperatura retal, ou níveis de neurotransmissores do hipocampo. Estes dados sugerem que DTM nas presentes doses e sob estas condições experimentais apresentaram um perfil semelhante ao de drogas ansiogénicas, não relacionados ao aumento da serotonina estriatal
Informal Trade of Psychoactive Herbal Products in the City of Diadema, SP, Brazil: Quality and Potential Risks
The present study aimed to assess the quality and risks involved in the consumption of psychoactive herbal products (PHs) that are available through informal commerce in the city of Diadema, SP, Brazil. Methods of ethnography were used to conduct the fieldwork during which four dealers were selected to record the collection, handling, packaging, types of PHs marketed, and their therapeutic purposes. in addition, lots of the PHs selected were purchased from the dealers and analyzed using microbiology and pharmacognosy techniques. 217 PHs were recorded and categorized into two main groups: stimulants (67%) and depressants (27%) of the central nervous system; sixteen of them were selected, and their 52 lots were acquired. the deficiencies observed in handling and packaging these lots by dealers were confirmed by microbiological analysis; 80.8% of them presented risk according to the indicators defined by the Brazilian Pharmacopoeia. the pharmacognostic analysis confirmed the authenticity of only 9 to 16 PHs analyzed. in addition, descriptions of contraindications, adverse reactions, and drug interactions were found in the literature for the PHs. the results of this study allow the observation of the priorities for the sanitary adequacy of the popular trade of herbs.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)AFIP-Associacao Fundo de Incentivo a PesquisaUniversidade Federal de São Paulo, Dept Med Prevent, BR-04038034 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Ciencias Biol, Ctr Estudos Etnobot & Etnofarmacol, BR-09972270 Diadema, SP, BrazilUniv São Paulo, Dept Farm, BR-05508000 São Paulo, BrazilAdolfo Lutz Inst, Ctr Medicamentos Cosmet & Saneantes, BR-01246902 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psicobiol, BR-04023062 São Paulo, BrazilUniv Bandeirante Anhanguera, BR-02071013 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Ciencias Biol, BR-09972270 Diadema, SP, BrazilUniversidade Federal de São Paulo, Dept Med Prevent, BR-04038034 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Ciencias Biol, Ctr Estudos Etnobot & Etnofarmacol, BR-09972270 Diadema, SP, BrazilUniversidade Federal de São Paulo, Dept Psicobiol, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Ciencias Biol, BR-09972270 Diadema, SP, BrazilWeb of Scienc
Clinical results with the 31 mm CoreValve™ in large aortic annuli: The importance of implantation technique
The CoreValve Revalving System (CRS) (Medtronic Inc., Minneapolis, MN, USA) is currently available in four sizes: 23 mm, 26 mm, 29 mm and 31 mm. Aim of our study was to assess the acute clinical results after implantation of a 31 mm CRS
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