Modelling noise propagation generated by forest operations: a case study in Southern Italy

Noise is defined as an undesired sound that constitutes an unwarranted disturbance potentiality modifying animal behaviour or normal functioning. Forest operations commonly involve the use of equipment and machines that can produce noise and be a potential permanent or temporary disturbance for the wildlife. This study simulates noise propagation in a natural area generated during coppice stand harvesting by direct field noise measurements and the application of a specific GIS model. Two working phases were investigated: felling and yarding operations. Two potential systems were analyzed for the yarding operations: a) yarding by mobile cable yarder and b) skidding by tractor with a three point log grapple. The results are reported in terms of excess noise area for the third-octave bandwidths with the centre in 500 Hz, 1000 Hz and 2000 Hz. Felling by chainsaws presented the largest area where noise exceeds the ambient natural noise, while in the case of yarding, mobile cable yarding operations presented a smaller area of excess noise than skidding by tractor

Early-Middle Pleistocene benthic turnover and oxygen isotope stratigraphy from the Central Mediterranean (Valle di Manche, Crotone Basin, Italy): data and trends

Ostracod faunal turnover and oxygen isotope data (foraminifera) along the Valle di Manche (VdM) section are herein compiled. Specifically, the material reported in this work includes quantitative palaeoecological data and patterns of ostracod fauna framed within a high-resolution oxygen isotope stratigraphy (δ18O) from Uvigerina peregrina. In addition, the multivariate ostracod faunal stratigraphic trend (nMDS axis-1 sample score) is calibrated using bathymetric distributions of extant molluscs sampled from the same stratigraphic intervals along the VdM section. Data and analyses support the research article “Dynamics of benthic marine communities across the Early-Middle Pleistocene boundary in the Mediterranean region (Valle di Manche, Southern Italy): biotic and stratigraphic implications” Rossi et al. [1]

Management of an invasive plant in a Mediterranean Protected Area: the experience of Senecio deltoideus in Italy

Biological invasions are one of the most serious threats to global biodiversity and ecosystem integrity. The problem is growing year by year and a large number of protected areas worldwide are today invaded by at least one exotic species. In this study, we tested the eco-friendly and cost-effective weeding control of Senecio deltoideus in a Regional Protected Area in the North Mediterranean region. During a two years experiment, four techniques compatible with the local laws on protected areas (natural-herbicide, flame-weeding, mulching and mowing) were applied five times a season on sixty plots, compared with fifteen untreated controls. All techniques were effective in reducing Senecio covering: after the first year the maximum covering was limited to 37.93% (flame weeding) with a mean value of 10%; after second year the covering was further reduced (17.02% max; 2% mean). Interestingly, during the second year all plots submitted to a one-year treatment showed an enduring control of S. deltoideus covering (40.73% max; 20% mean). Taking into account feasibility and their impact on the environment, the weeding control recommendable for S. deltoideus is mowing. In a long-time management strategy, the selected treatment could be applied every two years with a drastic reduction in costs for the manager of the protected area

Reproductive traits of the invasive species Acacia dealbata Link. in the northern Mediterranean basin

Among the many exotic plants introduced in the last two centuries in Northern Mediterranean Basin Acacia dealbata Link. is one of the most invasive. Despite its presence in the region since many years, it has not yet been investigated how the species has established itself and has formed small forests. In this study, we aimed to gather data on reproductive trait of the invasive species A. dealbata at the northern limit of the Mediterranean bioclimatic region. In six naturalized populations, fruit and seed set were estimated and seed germination was tested in laboratory. Two out of the six populations failed to set fruits, and the fruit set was always low as observed in other invaded areas of the world. Only three populations produced germinating seeds whose rates were comparable to other invasive areas. The seeds may constitute a long-lasting seed bank that may favour the colonization of the species in areas disturbed by external factors. In conclusion, the reproductive system may contributes only partially to the spread and invasiveness of the species in the Northern Mediterranean basin, while the plant to spread itself adopts also other vegetative strategies

Extraskeletal myxoid chondrosarcoma: a case report with adjuvant intraoperative treatment

Extraskeletal myxoid chondrosarcoma is a rare form of malignant mesenchymal neoplasm mainly localized into the limbs, particularly in the thigh and popliteal fossa. It has been classified as a low-grade sarcoma so far, but it shows a tendency to relapse and metastasize. In the early stage of disease, surgery represents the only chance of cure. In case of diffuse metastatic disease, systemic chemotherapy with anthracyclines is the standard of care. In this paper, we present a case of a patient affected by this rare disease and the analysis of radiological, surgical and histopathological aspects

Neonatal corticosterone mitigates autoimmune neuropsychiatric disorders associated with streptococcus in mice

Increased glucocorticoid concentrations have been shown to favor resilience towards autoimmune phenomena. Here, we addressed whether experimentally induced elevations in circulating glucocorticoids mitigate the abnormalities exhibited by an experimental model of Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus (PANDAS). This is a pathogenic hypothesis linking repeated exposures to Group-A-beta-hemolytic streptococcus (GAS), autoantibodies targeting selected brain nuclei and neurobehavioral abnormalities. To persistently elevate glucocorticoid concentrations, we supplemented lactating SJL/J mice with corticosterone (CORT; 80\u2009mg/L) in the drinking water. Starting in adolescence (postnatal day 28), developing offspring were exposed to four injections - at bi-weekly intervals - of a GAS homogenate and tested for behavioral, immunological, neurochemical and molecular alterations. GAS mice showed increased perseverative behavior, impaired sensorimotor gating, reduced reactivity to a serotonergic agonist and inflammatory infiltrates in the anterior diencephalon. Neonatal CORT persistently increased circulating glucocorticoids concentrations and counteracted these alterations. Additionally, neonatal CORT increased peripheral and CNS concentrations of the anti-inflammatory cytokine IL-9. Further, upstream regulator analysis of differentially expressed genes in the striatum showed that the regulatory effect of estradiol is inhibited in GAS-treated mice and activated in GAS-treated mice exposed to CORT. These data support the hypothesis that elevations in glucocorticoids may promote central immunomodulatory processes

Mice repeatedly exposed to Group-A \u3b2-Haemolytic Streptococcus show perseverative behaviors, impaired sensorimotor gating, and immune activation in rostral diencephalon

Repeated exposure to Group-A \u3b2-Haemolytic Streptococcus (GAS) may constitute a vulnerability factor in the onset and course of pediatric motor disturbances. GAS infections/colonization can stimulate the production of antibodies, which may cross the blood brain barrier, target selected brain areas (e.g. basal ganglia), and exacerbate motor alterations. Here, we exposed developing SJL male mice to four injections with a GAS homogenate and evaluated the following domains: motor coordination; general locomotion; repetitive behaviors; perseverative responses; and sensorimotor gating (pre-pulse inhibition, PPI). To demonstrate that behavioral changes were associated with immune-mediated brain alterations, we analyzed, in selected brain areas, the presence of infiltrates and microglial activation (immunohistochemistry), monoamines (HPLC), and brain metabolites (in vivo Magnetic Resonance Spectroscopy). GAS-exposed mice showed increased repetitive and perseverative behaviors, impaired PPI, and reduced concentrations of serotonin in prefrontal cortex, a brain area linked to the behavioral domains investigated, wherein they also showed remarkable elevations in lactate. Active inflammatory processes were substantiated by the observation of infiltrates and microglial activation in the white matter of the anterior diencephalon. These data support the hypothesis that repeated GAS exposure may elicit inflammatory responses in brain areas involved in motor control and perseverative behavior, and result in phenotypic abnormalities

Clinical and molecular epidemiology of erythropoietic protoporphyria in Italy

Background: Erythropoietic protoporphyria (EPP) is a rare inherited disease associated with heme metabolism, characterized by severe life-long photosensitivity and liver involvement. Objectives: To provide epidemiological data of EPP in Italy. Materials and Methods: Prospective/retrospective data of EPP patients were collected by an Italian network of porphyria specialist centres (Gruppo Italiano Porfiria, GrIP) over a 20-year period (1996-2017). Results: In total, 179 patients (79 females) with a clinical and biochemical diagnosis of EPP were assessed, revealing a prevalence of 3.15 cases per million persons and an incidence of 0.13 cases per million persons/year. Incidence significantly increased after 2009 (due to the availability of alfa-melanotide, which effectively limits skin photosensitivity). Mean age at diagnosis was 28 years, with only 22 patients (12.2%) diagnosed 6410 years old. Gene mutations were assessed in 173 (96.6%) patients; most (164; 91.3%) were FECH mutations on one allele in association with the hypomorphic variant, c.315-48C, on the other (classic EPP), and nine (5.2%) were ALAS2 mutations (X-linked EPP). Only one case of autosomal recessive EPP was observed. Of the 42 different FECH mutations, 15 are novel, three mutations collectively accounted for 45.9% (75/164) of the mutations (c.215dupT [27.2%], c.901_902delTG [11.5%] and c.67\u2009+\u20095G\u2009>\u2009A [7.2%]), and frameshift mutations were prevalent (33.3%). A form of light protection was used by 109/179 (60.8%) patients, and 100 (56%) had at least one \u3b1-melanotide implant. Three cases of severe acute liver involvement, requiring OLT, were observed. Conclusions: These data define, for the first time, the clinical and molecular epidemiology of EPP in Italy

Conventional CT versus Dedicated CT Angiography in DIEP Flap Planning: A Feasibility Study

The deep inferior epigastric perforator (DIEP) flap is used with increasing frequency in post-mastectomy breast reconstruction. Preoperative mapping with CT angiography (CTa) is crucial in reducing surgical complications and optimizing surgical techniques. Our study\u2019s goal was to investigate the accuracy of conventional CT (cCT), performed during disease staging, compared to CTa in preoperative DIEP flap planning. In this retrospective, single-center study, we enrolled patients scheduled for mastectomy and DIEP flap breast reconstruction, subjected to cCT within 24 months after CTa. We included 35 patients in the study. cCT accuracy was 95% (CI 0.80\u20130.98) in assessing the three largest perforators, 100% (CI 0.89\u2013100) in assessing the dominant perforator, 93% (CI 0.71\u20130.94) in assessing the perforator intramuscular course, and 90.6% (CI 0.79\u20130.98) in assessing superficial venous communications. Superficial inferior epigastric artery (SIEA) caliber was recognized in 90% of cases (CI 0.84\u20130.99), with an excellent assessment of superficial inferior epigastric vein (SIEV) integrity (96% of cases, CI 0.84\u20130.99), and a lower accuracy in the evaluation of deep inferior epigastric artery (DIEA) branching type (85% of cases, CI 0.69\u20130.93). The mean X-ray dose spared would have been 788 \ub1 255 mGy/cm. Our study shows that cCT is as accurate as CTa in DIEP flap surgery planning