636 research outputs found
Looking Through Whiteness: Objectivity, Racism, Method, and Responsibility
Does a white philosopher have anything of value to offer to the philosophy of race and racism? If this philosophical subfield must embrace subjective experience, why should we value the perspective of white philosophers whose racial identity is often occluded by racial normativity and who lack substantive experiences of being on the receiving end of racism? Further, if we should be committed to experience, in what sense can the philosophy of race and racism be “objective”? What should that word mean?Tackling this question first, “objective” should at least mean general, that the ideas of the literature can be coherently integrated. An objective take on racism brings together a plurality of perspectives. What’s wrong with just a plurality of satellite ideas? It implies a fragmented approach to ameliorating racism, where different specialists have different recommendations. How can racism, generally, be lessened? If major views of racism are unifiable, then we have a general method to ameliorate racism. This project might appear tone-deaf: a white philosopher unifying things by reducing ideas to some central notion. But this unity isn’t about reducing things but rather integrating them in a way that respects difference. Yet, there’s a reason we should be interested in the white perspective. Whites can speak about racism from a participatory perspective. If whites are knowledgeable, and believe themselves to have no implicit bias, they may suppose they’re “beyond” racism or no longer at risk for perpetuating it. I explore this idea in a psychologically realistic way via my notion of overlooking, where ameliorating racism from the white perspective is an ongoing project. I end by considering how racism is applicable to other philosophical ideas beyond its typical or circumscribed purview. Here, I re-frame responsibility, arguing that we needn’t be forced to choose between responsibility models divided into individual versus social camps. We ought to instead think of responsibility in terms of power, which provides a realistic lens by which persons and groups are held to account. In being more generally convincing, it might actually get folks to take responsibility where they might not otherwise—theory in service of praxis
The Starry Heavens Above Me and the Starmaking Power Within Me
The worldmaking thesis stands as a contentious view of reality. Its primary tenet, that we play a role in cognitively making objects, properties, facts, and thereby the world, is dismissed by many philosophers as an incoherent and misguided position. In this paper I critically discuss the thesis and defend it against several criticisms: that (1) it is cosmologically incoherent, (2) raises a problem of causation, (3) implies subjectivism, (4) commits a use-mention fallacy, and (5) it commits the problem of disagreement. I show that these criticisms are not ultimately deleterious to the thesis. Furthermore, I explore ways in which worldmaking constitutes a more satisfactory account of objects, properties, and facts over and against competing views, viz., metaphysical realism
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Everolimus Exposure as a Predictor of Toxicity in Renal Cell Cancer Patients in the Adjuvant Setting: Results of a Pharmacokinetic Analysis for SWOG S0931 (EVEREST), a Phase III Study (NCT01120249).
BackgroundS0931 is assessing recurrence-free survival in renal cell carcinoma (RCC) patients randomized to receive everolimus (EVE) versus placebo for one year following nephrectomy. Due to a higher than expected dropout rate, we assessed EVE trough levels in the adjuvant setting to evaluate the relationship between EVE exposure and probability of toxicity.MethodsPatients received 10 mg daily EVE for nine 6-week cycles. Pre-dose whole blood samples were collected pre-cycle 2 and pre-cycle 3 and analyzed for EVE. Patients with pre-cycle 2 and/or pre-cycle 3 EVE results were used in the analysis. Patients were segregated into quartiles (Q) based on EVE levels and logistic regression was used to model the most common adverse event outcomes using EVE trough as a predictor. Hazard and odds ratios were adjusted for age, BMI and performance status.ResultsA total of 467 patients were included in this analysis. Quartiles normalized to an EVE dose of 10 mg/day were < 9.0, 9.0-12.9, 12.9-22.8, and > 22.8 ng/mL, respectively. EVE trough levels increased with increasing age (p < 0.001). Furthermore, EVE trough levels were higher in men than women (19.4 versus 15.4 ng/mL, p = 0.01). Risk of grade 2 + triglycerides was increased in Q2 and Q3 vs Q1 (OR = 2.08; p = 0.02 and OR = 2.63; p = 0.002). Risk of grade 2 + rash was increased in Q2 and Q4 vs Q1 (OR = 2.99; p = 0.01 and OR = 2.90; p = 0.02). There was also an increased risk of any grade 3 + tox in Q2 vs Q1 (OR = 1.71; p = 0.05).ConclusionsWe identified significant gender and age-related differences in EVE trough levels in patients receiving adjuvant treatment for RCC. Furthermore, our analysis identified significant associations between EVE exposure and probability of toxicity
Awareness and use of motivational interviewing reported by Canadian university sport coaches
Motivational Interviewing (MI) is a communication strategy to facilitate behaviour change yet MI research in sport is scant. This study investigated awareness and use of MI by coaches in Canadian university sport using a non-experimental design. Less than one-third of the male (30.2%) and one-quarter of the female (20.0%) coaches reported awareness of MI with a similar pattern noted for male (32.0%) and female (25.8%) coaches’ reported use of MI. No sex-based differences in MI awareness and use were evident (p's > .05). Overall, low awareness and use of MI reported by coaches have implications for designing coach education programs
New N=2 Superconformal Field Theories in Four Dimensions
New examples of N=2 supersymmetric conformal field theories are found as
fixed points of SU(2) N=2 supersymmetric QCD. Relations among the scaling
dimensions of their relevant chiral operators, global symmetries, and Higgs
branches are understood in terms of the general structure of relevant
deformations of non-trivial N=2 conformal field theories. The spectrum of
scaling dimensions found are all those compatible with relevant deformations of
a y^2 = x^3 singular curve.Comment: 17 pages, harvma
Supersymmetry and Strongly Coupled Gauge Theories
I briefly review how supersymmetry helps in the extraction of exact
nonperturbative information from field theories, and then discuss some open
problems in strongly coupled gauge theories. (Talk given at ``30 Years of
Supersymmetry'' symposium in Minneapolis, Minnesota on October 15, 2000.)Comment: 8 pages, 2 figure
The ACS Nearby Galaxy Survey Treasury IX. Constraining asymptotic giant branch evolution with old metal-poor galaxies
In an attempt to constrain evolutionary models of the asymptotic giant branch
(AGB) phase at the limit of low masses and low metallicities, we have examined
the luminosity functions and number ratio between AGB and red giant branch
(RGB) stars from a sample of resolved galaxies from the ACS Nearby Galaxy
Survey Treasury (ANGST). This database provides HST optical photometry together
with maps of completeness, photometric errors, and star formation histories for
dozens of galaxies within 4 Mpc. We select 12 galaxies characterized by
predominantly metal-poor populations as indicated by a very steep and blue RGB,
and which do not present any indication of recent star formation in their
color--magnitude diagrams. Thousands of AGB stars brighter than the tip of the
RGB (TRGB) are present in the sample (between 60 and 400 per galaxy), hence the
Poisson noise has little impact in our measurements of the AGB/RGB ratio. We
model the photometric data with a few sets of thermally pulsing AGB (TP-AGB)
evolutionary models with different prescriptions for the mass loss. This
technique allows us to set stringent constraints to the TP-AGB models of
low-mass metal-poor stars (with M<1.5 Msun, [Fe/H]<~-1.0). Indeed, those which
satisfactorily reproduce the observed AGB/RGB ratios have TP-AGB lifetimes
between 1.2 and 1.8 Myr, and finish their nuclear burning lives with masses
between 0.51 and 0.55 Msun. This is also in good agreement with recent
observations of white dwarf masses in the M4 old globular cluster. These
constraints can be added to those already derived from Magellanic Cloud star
clusters as important mileposts in the arduous process of calibrating AGB
evolutionary models.Comment: To appear in ApJ, a version with better resolution is in
http://stev.oapd.inaf.it/~lgirardi/rgbagb.pd
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