302 research outputs found
Localized Endomorphisms of the Chiral Ising Model
Based on the treatment of the chiral Ising model by Mack and Schomerus, we
present examples of localized endomorphisms and
. It is shown that they lead to the same
superselection sectors as the global ones in the sense that unitary equivalence
and holds. Araki's formalism of the selfdual CAR algebra is
used for the proof. We prove local normality and extend representations and
localized endomorphisms to a global algebra of observables which is generated
by local von Neumann algebras on the punctured circle. In this framework, we
manifestly prove fusion rules and derive statistics operators.Comment: 41 pages, latex2
Conformal Maxwell theory as a singleton field theory on AdS_5, IIB three-branes and duality
We examine the boundary conditions associated with extended supersymmetric
Maxwell theory in 5-dimensional anti-De Sitter space. Excitations on the
boundary are identical to those of ordinary 4-dimensional conformal invariant
super electrodynammics. Extrapolations of these excitations give rise to a
5-dimensional topological gauge theory of the singleton type. The possibility
of a connection of this phenomenon to the world volume theory of 3-branes in
IIB string theory is discussed.Comment: 19 pages, TeX, no figures; v2: misprints corrected, references added,
discussion on Chern-Simons couplings revised. v3: References added, misprints
corrected and a discussion in section 2 revised. v4: Typos corrected and
reference adde
Superconformal symmetry and maximal supergravity in various dimensions
In this paper we explore the relation between conformal superalgebras with 64
supercharges and maximal supergravity theories in three, four and six
dimensions using twistorial oscillator techniques. The massless fields of N=8
supergravity in four dimensions were shown to fit into a CPT-self-conjugate
doubleton supermultiplet of the conformal superalgebra SU(2,2|8) a long time
ago. We show that the fields of maximal supergravity in three dimensions can
similarly be fitted into the super singleton multiplet of the conformal
superalgebra OSp(16|4,R), which is related to the doubleton supermultiplet of
SU(2,2|8) by dimensional reduction. Moreover, we construct the ultra-short
supermultiplet of the six-dimensional conformal superalgebra OSp(8*|8) and show
that its component fields can be organized in an on-shell superfield. The
ultra-short OSp(8*|8) multiplet reduces to the doubleton supermultiplet of
SU(2,2|8) upon dimensional reduction. We discuss the possibility of a chiral
maximal (4,0) six-dimensional supergravity theory with USp(8) R-symmetry that
reduces to maximal supergravity in four dimensions and is different from
six-dimensional (2,2) maximal supergravity, whose fields cannot be fitted into
a unitary supermultiplet of a simple conformal superalgebra. Such an
interacting theory would be the gravitational analog of the (2,0) theory.Comment: 54 pages, PDFLaTeX, Section 5 and several references added. Version
accepted for publication in JHE
Beryllium-specific CD4\u3csup\u3e+\u3c/sup\u3e T cells induced by chemokine neoantigens perpetuate inflammation
Discovering dominant epitopes for T cells, particularly CD4+ T cells, in human immune-mediated diseases remains a significant challenge. Here, we used bronchoalveolar lavage (BAL) cells from HLA-DP2–expressing patients with chronic beryllium disease (CBD), a debilitating granulomatous lung disorder characterized by accumulations of beryllium-specific (Be-specific) CD4+ T cells in the lung. We discovered lung-resident CD4+ T cells that expressed a disease-specific public CDR3β T cell receptor motif and were specific to Be-modified self-peptides derived from C-C motif ligand 4 (CCL4) and CCL3. HLADP2–CCL/Be tetramer staining confirmed that these chemokine-derived peptides represented major antigenic targets in CBD. Furthermore, Be induced CCL3 and CCL4 secretion in the lungs of mice and humans. In a murine model of CBD, the addition of LPS to Be oxide exposure enhanced CCL4 and CCL3 secretion in the lung and significantly increased the number and percentage of CD4+ T cells specific for the HLA-DP2–CCL/Be epitope. Thus, we demonstrate a direct link between Be-induced innate production of chemokines and the development of a robust adaptive immune response to those same chemokines presented as Be-modified self-peptides, creating a cycle of innate and adaptive immune activation
Beryllium-specific CD4+ T cells induced by chemokine neoantigens perpetuate inflammation
Discovering dominant epitopes for T cells, particularly CD4+ T cells, in human immune-mediated diseases remains a significant challenge. Here, we used bronchoalveolar lavage (BAL) cells from HLA-DP2-expressing patients with chronic beryllium disease (CBD), a debilitating granulomatous lung disorder characterized by accumulations of beryllium (Be)-specific CD4+ T cells in the lung. We discovered lung resident CD4+ T cells that expressed a disease-specific public CDR3β T cell receptor motif and were specific to Be-modified self-peptides derived from C-C motif ligands 4 (CCL4) and 3 (CCL3). HLA-DP2-CCL/Be tetramer staining confirmed that these chemokine-derived peptides represented major antigenic targets in CBD. Furthermore, Be induced CCL3 and 4 secretion in the lungs of mice and humans. In a murine model of CBD, the addition of LPS to Be oxide exposure enhanced CCL4 and CCL3 secretion in the lung and significantly increased the number and percentage of CD4+ T cells specific for the HLA-DP2-CCL/Be epitope. Thus, we demonstrate a direct link between Be-induced innate production of chemokines and the development of a robust adaptive immune response to those same chemokines presented as Be-modified self-peptides, creating a vicious cycle of innate and adaptive immune activation
Radio spectra and polarisation properties of a bright sample of Radio-Loud Broad Absorption Line Quasars
The origin of broad-absorption-line quasars (BAL QSOs) is still an open
issue. Accounting for ~20% of the QSO population, these objects present broad
absorption lines in their optical spectra generated from outflows with
velocities up to 0.2c. In this work we present the results of a multi-frequency
study of a well-defined radio-loud BAL QSO sample, and a comparison sample of
radio-loud non-BAL QSOs, both selected from the Sloan Digital Sky Survey
(SDSS).
We aim to test which of the currently-popular models for the BAL phenomenon -
`orientation' or 'evolutionary' - best accounts for the radio properties of BAL
quasars. Observations from 1.4 to 43 GHz have been obtained with the VLA and
Effelsberg telescopes, and data from 74 to 408 MHz have been compiled from the
literature.
The fractions of candidate GHz-peaked sources are similar in the two samples
(36\pm12% vs 23\pm8%), suggesting that BAL QSOs are not generally younger than
non-BAL QSOs. BAL and non-BAL QSOs show a large range of spectral indices,
consistent with a broad range of orientations. There is weak evidence (91%
confidence) that the spectral indices of the BAL QSOs are steeper than those of
non-BAL QSOs, mildly favouring edge-on orientations. At a higher level of
significance (\geq97%), the spectra of BAL QSOs are not flatter than those of
non-BAL QSOs, which suggests that a polar orientation is not preferred.Comment: Accepted by A&
CD4\u3csup\u3e+\u3c/sup\u3e T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitope
Löfgren’s syndrome (LS) is an acute form of sarcoidosis characterized by a genetic association with HLA-DRB1*03 (HLA-DR3) and an accumulation of CD4+ T cells of unknown specificity in the bronchoalveolar lavage (BAL). Here, we screened related LS-specific TCRs for antigen specificity and identified a peptide derived from NAD-dependent histone deacetylase hst4 (NDPD) of Aspergillus nidulans that stimulated these CD4+ T cells in an HLA-DR3–restricted manner. Using ELISPOT analysis, a greater number of IFN-γ– and IL-2–secreting T cells in the BAL of DR3+ LS subjects compared with DR3+ control subjects was observed in response to the NDPD peptide. Finally, increased IgG antibody responses to A. nidulans NDPD were detected in the serum of DR3+ LS subjects. Thus, our findings identify a ligand for CD4+ T cells derived from the lungs of LS patients and suggest a role of A. nidulans in the etiology of LS
Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease
Chronic beryllium disease (CBD) is a granulomatous disorder characterized by an influx of beryllium (Be)-specific CD4+ T cells into the lung. The vast majority of these T cells recognize Be in an HLA-DP–restricted manner, and peptide is required for T cell recognition. However, the peptides that stimulate Be-specific T cells are unknown. Using positional scanning libraries and fibroblasts expressing HLA-DP2, the most prevalent HLA-DP molecule linked to disease, we identified mimotopes and endogenous self-peptides that bind to MHCII and Be, forming a complex recognized by pathogenic CD4+ T cells in CBD. These peptides possess aspartic and glutamic acid residues at p4 and p7, respectively, that surround the putative Be-binding site and cooperate with HLA-DP2 in Be coordination. Endogenous plexin A peptides and proteins, which share the core motif and are expressed in lung, also stimulate these TCRs. Be-loaded HLA-DP2–mimotope and HLA-DP2–plexin A4 tetramers detected high frequencies of CD4+ T cells specific for these ligands in all HLA-DP2+ CBD patients tested. Thus, our findings identify the first ligand for a CD4+ T cell involved in metal-induced hypersensitivity and suggest a unique role of these peptides in metal ion coordination and the generation of a common antigen specificity in CBD
Noncommutative Sp(2,R) Gauge Theories - A Field Theory Approach to Two-Time Physics
Phase-space and its relativistic extension is a natural space for realizing
Sp(2,R) symmetry through canonical transformations. On a Dx2 dimensional
covariant phase-space, we formulate noncommutative field theories, where
Sp(2,R) plays a role as either a global or a gauge symmetry group. In both
cases these field theories have potential applications, including certain
aspects of string theories, M-theory, as well as quantum field theories. If
interpreted as living in lower dimensions, these theories realize Poincare'
symmetry linearly in a way consistent with causality and unitarity. In case
Sp(2,R) is a gauge symmetry, we show that the spacetime signature is determined
dynamically as (D-2,2). The resulting noncommutative Sp(2,R) gauge theory is
proposed as a field theoretical formulation of two-time physics: classical
field dynamics contains all known results of `two-time physics', including the
reduction of physical spacetime from D to (D-2) dimensions, with the associated
`holography' and `duality' properties. In particular, we show that the solution
space of classical noncommutative field equations put all massless scalar,
gauge, gravitational, and higher-spin fields in (D-2) dimensions on
equal-footing, reminiscent of string excitations at zero and infinite tension
limits.Comment: 32 pages, LaTe
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