Representação Política:: significação de representatividade política para o vereador no município de fortaleza

O presente trabalho tem como objetivo investigar os significados de representação política para o vereador do Município de Fortaleza, estudando o conceito de representação a partir de autores clássicos e contemporâneos em conjunto com os dados estatísticos retirados do site do Tribunal Regional Eleitoral do Ceará e das informações extraídas dos arquivos da Câmara de Vereadores de Fortaleza. Procurar-se-á construir o perfil dos vereadores a partir da análise de suas proposições legislativas e da fala de alguns entrevistados durante a pesquisa investigando qual o papel que o vereador acredita desempenhar junto ao corpo de eleitores que o escolheu e perante a cidade em que ele trabalha

Advanced Glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1

<p>Abstract</p> <p>Background</p> <p>Advanced glycation end products (AGE) alter lipid metabolism and reduce the macrophage expression of ABCA-1 and ABCG-1 which impairs the reverse cholesterol transport, a system that drives cholesterol from arterial wall macrophages to the liver, allowing its excretion into the bile and feces. Oxysterols favors lipid homeostasis in macrophages and drive the reverse cholesterol transport, although the accumulation of 7-ketocholesterol, 7alpha- hydroxycholesterol and 7beta- hydroxycholesterol is related to atherogenesis and cell death. We evaluated the effect of glycolaldehyde treatment (GAD; oxoaldehyde that induces a fast formation of intracellular AGE) in macrophages overloaded with oxidized LDL and incubated with HDL alone or HDL plus LXR agonist (T0901317) in: 1) the intracellular content of oxysterols and total sterols and 2) the contents of ABCA-1 and ABCG-1.</p> <p>Methods</p> <p>Total cholesterol and oxysterol subspecies were determined by gas chromatography/mass spectrometry and HDL receptors content by immunoblot.</p> <p>Results</p> <p>In control macrophages (C), incubation with HDL or HDL + T0901317 reduced the intracellular content of total sterols (total cholesterol + oxysterols), cholesterol and 7-ketocholesterol, which was not observed in GAD macrophages. In all experimental conditions no changes were found in the intracellular content of other oxysterol subspecies comparing C and GAD macrophages. GAD macrophages presented a 45% reduction in ABCA-1 protein level as compared to C cells, even after the addition of HDL or HDL + T0901317. The content of ABCG-1 was 36.6% reduced in GAD macrophages in the presence of HDL as compared to C macrophages.</p> <p>Conclusion</p> <p>In macrophages overloaded with oxidized LDL, glycolaldehyde treatment reduces the HDL-mediated cholesterol and 7-ketocholesterol efflux which is ascribed to the reduction in ABCA-1 and ABCG-1 protein level. This may contribute to atherosclerosis in diabetes mellitus.</p

INPUTS OPTIMIZATION IN THE SEEDLINGS PRODUCTION OF Corymbia citriodora E Eucalyptus dunnii

Corymbia citriodora and Eucalyptus dunnii are species of relevant importance due to the quality of the wood and growth potential in Southern Brazil. Therefore, we aimed to identify containers and doses of controlled-release fertilizer capable of enhancing the morphophysiological quality and growth of these species in the nursery, aiming for the proper management of these inputs. The seedlings were produced in two volumes of containers (50 e 110 cm³), filled with Sphagnum peat-based substrate, mixed with different doses of controlled-release fertilizer (CRF) NPK 15-09-12 (0, 3, 6, 9 e 12 g L-1 of substrates). In addition, the morphological (height, stem diameter, leaf area, dry weight of shoot, root, and total) and physiological (chlorophyll a and b index and quantum yield of the photosystem II) attributes were evaluated. The morphological attributes proved to be suitable indicators of the quality of C. citriodora and E. dunnii seedlings, allowing to recommend the container of 50 cm³ and the doses of 9.0 g L-1 of controlled-release fertilizer for both species. At the same time, the physiological variables evaluated were not responsive to the effect of the treatments

Validation of a quality of life questionnaire (King's Health Questionnaire) in Brazilian women with urinary incontinence

Universidade Federal de São Paulo, São Paulo, BrazilUniversidade Federal de São Paulo, São Paulo, BrazilWeb of Scienc

Transtorno de Ansiedade Social: um estudo de caso

Social Anxiety Disorder is the most common anxiety disorder and it shows high prevalence rates, with significant functional impairment, requiring long-term therapeutic approaches in more severe cases. The aim of the present study is to describe a case study with cognitive-behavioral intervention without associated psychotropic treatment on a young adult male with this diagnosis. In the intervention, distributed in initial evaluation, intervention, final evaluation and follow up, DSM-5 diagnostic criteria and cognitive-behavioral techniques were used. In the initial evaluation the psychotherapist identified difficulties in several social situations, difficulties in writing the final paper of his college studies and in seeking desired job opportunities. Results obtained at the final evaluation and at the six months follow up indicated considerable improvement of the initial complaints, reduction of social anxiety, correction of incorrect beliefs, development of social skills and reduction of safety strategies and of inhibitory behaviors. It is important that more case studies with male individuals are carried out, enabling a better understanding of the treatment of patients with Social Anxiety Disorder through cognitive and behavioral techniques. Considering that several techniques have been indicated as important in the treatment of these patients, it is essential to consider them in clinical practice.Keywords: Social Anxiety Disorder, treatment, cognitive-behavior therapy.O Transtorno de Ansiedade Social é o transtorno de ansiedade mais comum e apresenta elevadas taxas de prevalência, com prejuízos funcionais importantes, demandando abordagens terapêuticas de longa duração em casos de maior gravidade. O objetivo do presente estudo é relatar um estudo de caso com intervenção cognitivo-comportamental, sem o uso associado de psicofármacos, em um adulto jovem do sexo masculino com esse diagnóstico. No tratamento, distribuído em avaliação inicial, intervenção, avaliação final e seguimento, foram utilizados critérios diagnósticos do DSM-5 e técnicas cognitivo-comportamentais. Na avaliação inicial, identificaram-se dificuldades em diversas situações sociais, em realizar o trabalho de conclusão de curso de sua faculdade e em buscar oportunidades de trabalho desejadas. Os resultados obtidos na avaliação final e no seguimento de seis meses indicaram melhora considerável das queixas iniciais, redução da ansiedade social, correção de crenças errôneas, desenvolvimento de habilidades sociais, redução de estratégias de segurança e de comportamentos inibitórios. É importante que mais estudos de caso com indivíduos do sexo masculino sejam realizados, possibilitando o melhor entendimento do tratamento de pacientes com Transtorno de Ansiedade Social através de técnicas cognitivas e comportamentais. Uma vez que diversas técnicas vêm sendo indicadas como importantes no tratamento desses pacientes, é essencial considerá-las na prática clínica.Palavras-chave: Transtorno de Ansiedade Social, tratamento, terapia cognitivo- comportamental

Feasibility, safety and accuracy of dobutamine/atropine stress echocardiography for the detection of coronary artery disease in renal transplant candidates

OBJECTIVE: To evaluate the feasibility, safety and accuracy of dobutamine/atropine stress echocardiography (DASE) for the detection of coronary artery desease (CAD) in renal transplant candidates. METHODS: Patients candidates to renal transplant were submitted consecutively to DASE and coronary angiography. The adopted angiographic criteria for CAD were an obstructive lesion of > 50% and > 70%. RESULTS: 148 patients underwent the DASE and the coronary angiography. Mean age was 52 ± 9 years, 69% of the patients were males; 27% had diabetic nephropathy and 73% had LVH; 63% were asymptomatic; 36% and 22% presented coronary obstructions > 50% and 70%, respectively. The DASE performance was 91% and major complication rate was 2.7%. The sensibility, specificity and accuracy for the diagnosis of coronary obstruction > 50% were 53% (CI:45-61), 87% (CI:81-93), and 75% (CI:63-83) respectively. For coronary obstruction > 70% these values were, respectively, 71% (CI:64-92), 85% (CI:79-91) and 81% (CI:75-87). The sensibility to detect univessel and multivessel disease was 41% (CI:19-63) and 78% (CI:64-92), respectively. CONCLUSION: The DASE was practical and safe; however, it presented a poor result for the detection of CAD regarding obstructions > 50%. It can be a useful screening for the detection of CAD in candidates with obstructions > 70% and multivessel disease.OBJETIVO: Avaliar a exeqüibilidade, a segurança e a acurácia diagnóstica do ecocardiograma sob estresse (EEDA) com dobutamina/atropina em candidatos a transplante renal. MÉTODOS: Pacientes candidatos a transplante renal com e sem nefropatia diabética realizaram EEDA e cineangiocoronariografia. Consideraram-se dois pontos de corte para doença arterial coronariana (DAC): > 50% e > 70% de obstrução de uma artéria epicárdica. RESULTADOS: Cento e quarenta e oito pacientes realizaram o EEDA e a angiografia coronariana. A média de idade foi de 52±9 anos, 69% eram do sexo masculino, 27% tinham nefropatia diabética, e 73%, HVE; 63% estavam assintomáticos, 36% e 22% apresentaram obstruções coronarianas > 50% e > 70%, respectivamente. A exeqüibilidade foi de 91% e houve 2,7% de complicações maiores. Obtiveram-se as seguintes médias de sensibilidade, especificidade e acurácia, considerando obstrução coronariana > 50%: 53% (IC:45-61), 87% (IC:81-93), e 75% (IC:63-83), respectivamente. Para obstrução >70%, 71% (IC:64-92), 85% (IC:79-91) e 81% (IC:75-87). A sensibilidade para diagnosticar doença uniarterial foi 41% (IC:19-63) e doença multiarterial, 78% (IC:64-92). CONCLUSÃO: O EEDA foi exeqüível e seguro; entretanto, foi ineficiente para rastreamento de DAC, considerando obstruções > 50%, mas pode ser útil para detecção de DAC em pacientes com obstruções > 70% e doença multiarterial.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Hospital do Rim e HipertensãoUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Hospital São PauloUNIFESP, EPM, Hospital do Rim e HipertensãoUNIFESP, EPM, Hospital São PauloSciEL

Redox markers and inflammation are differentially affected by atorvastatin, pravastatin or simvastatin administered before endotoxin-induced acute lung injury

AbstractStatins are standard therapy for the treatment of lipid disorders, and the field of redox biology accepts that statins have antioxidant properties. Our aim in this report was to consider the pleiotropic effects of atorvastatin, pravastatin and simvastatin administered prior to endotoxin-induced acute lung injury. Male mice were divided into 5 groups and intraperitoneally injected with LPS (10mg/kg), LPS plus atorvastatin (10mg/kg/day; A+LPS group), LPS plus pravastatin (5mg/kg/day; P+LPS group) or LPS plus simvastatin (20mg/kg/day; S+LPS group). The control group received saline. All mice were sacrificed one day later. There were fewer leukocytes in the P+LPS and S+LPS groups than in the LPS group. MCP-1 cytokine levels were lower in the P+LPS group, while IL-6 levels were lower in the P+LPS and S+LPS groups. TNF-α was lower in all statin-treated groups. Levels of redox markers (superoxide dismutase and catalase) were lower in the A+LPS group (p<0.01). The extent of lipid peroxidation (malondialdehyde and hydroperoxides) was reduced in all statin-treated groups (p<0.05). Myeloperoxidase was lower in the P+LPS group (p<0.01). Elastance levels were significantly greater in the LPS group compared to the statin groups. Our results suggest that atorvastatin and pravastatin but not simvastatin exhibit anti-inflammatory and antioxidant activity in endotoxin-induced acute lung injury

ANÁLISE QUALI-QUANTITATIVA DA FLORA PRESENTE NAS PRAÇAS DO CENTRO COMERCIAL DA CIDADE DE TERESINA, PIAUÍ

Objetivou-se neste trabalho investigar a diversidade florística e o estado fitossanitário das espécies vegetais presente nas praças do centro comercial de Teresina-PI. Para isso foram realizadas visitas semanais nas 12 praças do centro de Teresina durante o período de outubro de 2019 a março de 2020. Em nossa pesquisa encontramos 110 espécies distribuídas em 92 gêneros, 40 famílias e 2677 indivíduos. Dentre as praças, a que apresentou a maior diversidade foi a praça João Luís, as famílias mais representativas foram Fabaceae, Anacardiaceae, Arecaceae, Asparagaceae e Apocynaceae. As espécies que tiveram maior abundância foram C. prunifera, M. tomentosa, A. indica e M. indica, com 328, 305, 212 e 122 indivíduos, respectivamente. A maior parte da vegetação nas praças é formada por indivíduos de grande porte e 54% das espécies são de origem exótica. Em suma, se faz necessário em um futuro próximo que os representantes do poder público adotem medidas para influenciar o plantio de mais espécies nativas para que a discrepância entre espécies exóticas versus nativas seja maior, deixando tais praças com as características ecológicas presente em nosso bioma, situação que se espera que mude por meio de estudos como este