International Earth Science Constellation (ESC) Introduction

No abstract availabl

Options for the Continuing Evolution of the Earth Science Constellation

No abstract availabl

Leverage Your Science Data Return by Flying with the International Earth Science Constellation (ESC)

Constellations have proven to be an effective and efficient way to acquire earth science data. By flying together, sensors on all satellites in a constellation take measurements of the same air, water, or land mass at essentially the same time. The sensors form a single "virtual satellite". The key to making a constellation effective and efficient is keeping the operations as independent as possible in order to minimize the operational burden and costs. The Earth Science Constellation (ESC) has been successful on all counts and continues to welcome new missions to continue its 18+ year record of coincidental earth science observations. The ESC also serves as a model for future constellation designs. This paper describes the ESC and its evolution from its initial launches in 1999 through the present and how new missions might benefit from joining the ESC

Invariant classification and the generalised invariant formalism: conformally flat pure radiation metrics, with zero cosmological constant

Metrics obtained by integrating within the generalised invariant formalism are structured around their intrinsic coordinates, and this considerably simplifies their invariant classification and symmetry analysis. We illustrate this by presenting a simple and transparent complete invariant classification of the conformally flat pure radiation metrics (except plane waves) in such intrinsic coordinates; in particular we confirm that the three apparently non-redundant functions of one variable are genuinely non-redundant, and easily identify the subclasses which admit a Killing and/or a homothetic Killing vector. Most of our results agree with the earlier classification carried out by Skea in the different Koutras-McIntosh coordinates, which required much more involved calculations; but there are some subtle differences. Therefore, we also rework the classification in the Koutras-McIntosh coordinates, and by paying attention to some of the subtleties involving arbitrary functions, we are able to obtain complete agreement with the results obtained in intrinsic coordinates. In particular, we have corrected and completed statements and results by Edgar and Vickers, and by Skea, about the orders of Cartan invariants at which particular information becomes available.Comment: Extended version of GRG publication, with some typos etc correcte

Social and Nonsocial Content Differentially Modulates Visual Attention and Autonomic Arousal in Rhesus Macaques

The sophisticated analysis of gestures and vocalizations, including assessment of their emotional valence, helps group-living primates efficiently navigate their social environment. Deficits in social information processing and emotion regulation are important components of many human psychiatric illnesses, such as autism, schizophrenia and social anxiety disorder. Analyzing the neurobiology of social information processing and emotion regulation requires a multidisciplinary approach that benefits from comparative studies of humans and animal models. However, many questions remain regarding the relationship between visual attention and arousal while processing social stimuli. Using noninvasive infrared eye-tracking methods, we measured the visual social attention and physiological arousal (pupil diameter) of adult male rhesus monkeys (Macaca mulatta) as they watched social and nonsocial videos. We found that social videos, as compared to nonsocial videos, captured more visual attention, especially if the social signals depicted in the videos were directed towards the subject. Subject-directed social cues and nonsocial nature documentary footage, compared to videos showing conspecifics engaging in naturalistic social interactions, generated larger pupil diameters (indicating heightened sympathetic arousal). These findings indicate that rhesus monkeys will actively engage in watching videos of various kinds. Moreover, infrared eye tracking technology provides a mechanism for sensitively gauging the social interest of presented stimuli. Adult male rhesus monkeys' visual attention and physiological arousal do not always trend in the same direction, and are likely influenced by the content and novelty of a particular visual stimulus. This experiment creates a strong foundation for future experiments that will examine the neural network responsible for social information processing in nonhuman primates. Such studies may provide valuable information relevant to interpreting the neural deficits underlying human psychiatric illnesses such as autism, schizophrenia and social anxiety disorder

Leverage Your Science Data Return by Flying with the International Earth Science Constellation (ESC)

Constellations have proven to be an effective and efficient way to acquire earth science data. By flying together, sensors on all satellites in a constellation take measurements of the same air, water, or land mass at essentially the same time. The sensors form a single "virtual satellite". The key to making a constellation effective and efficient is keeping the operations as independent as possible in order to minimize the operational burden and costs. The Earth Science Constellation (ESC) has been successful on all counts and continues to welcome new missions to continue its 18+ year record of coincidental earth science observations. The ESC also serves as a model for future constellation designs. This paper describes the ESC and its evolution from its initial launches in 1999 through the present and how new missions might benefit from joining the ESC

The Legacy and Future of the International Earth Science Constellation (ESC)

The most recent Decadal Survey placed high value on continuing constellation science. The ESC has evolved by seeing new missions joining and old missions retiring. Most recently, GCOM-W1, Landsat-8, and OCO-2 joined during 2012-2014. Landsat-9 is set to join in 2020. Each new mission provides new and improved suite of sensors. The new sensors also benefit both from the multitude of other existing on-orbit sensors as well as from the long-term cross-calibrated climate observations from the sensors that preceded them. At the same time, existing missions leave the constellation due to low fuel reserves or aging spacecraft subsystems. For example, CloudSat and CALIPSO left the ESC orbits in 2018, although they plan to continue making coordinated science observations at their new lower altitudes. This ESC evolution is expected to continue and this paper will discuss the opportunities for other new missions to join the ESC

Optimization and analysis of a quantitative real-time PCR-based technique to determine microRNA expression in formalin-fixed paraffin-embedded samples

<p>Abstract</p> <p>Background</p> <p>MicroRNAs (miRs) are non-coding RNA molecules involved in post-transcriptional regulation, with diverse functions in tissue development, differentiation, cell proliferation and apoptosis. miRs may be less prone to degradation during formalin fixation, facilitating miR expression studies in formalin-fixed paraffin-embedded (FFPE) tissue.</p> <p>Results</p> <p>Our study demonstrates that the TaqMan Human MicroRNA Array v1.0 (Early Access) platform is suitable for miR expression analysis in FFPE tissue with a high reproducibility (correlation coefficients of 0.95 between duplicates, p < 0.00001) and outlines the optimal performance conditions of this platform using clinical FFPE samples. We also outline a method of data analysis looking at differences in miR abundance between FFPE and fresh-frozen samples. By dividing the profiled miR into abundance strata of high (Ct<30), medium (30≤Ct≤35), and low (Ct>35), we show that reproducibility between technical replicates, equivalent dilutions, and FFPE <it>vs</it>. frozen samples is best in the high abundance stratum. We also demonstrate that the miR expression profiles of FFPE samples are comparable to those of fresh-frozen samples, with a correlation of up to 0.87 (p < 0.001), when examining all miRs, regardless of RNA extraction method used. Examining correlation coefficients between FFPE and fresh-frozen samples in terms of miR abundance reveals correlation coefficients of up to 0.32 (low abundance), 0.70 (medium abundance) and up to 0.97 (high abundance).</p> <p>Conclusion</p> <p>Our study thus demonstrates the utility, reproducibility, and optimization steps needed in miR expression studies using FFPE samples on a high-throughput quantitative PCR-based miR platform, opening up a realm of research possibilities for retrospective studies.</p

Mutations in FRMD7, a newly identified member of the FERM family, cause X-linked idiopathic congenital nystagmus.

Idiopathic congenital nystagmus is characterized by involuntary, periodic, predominantly horizontal oscillations of both eyes. We identified 22 mutations in FRMD7 in 26 families with X-linked idiopathic congenital nystagmus. Screening of 42 singleton cases of idiopathic congenital nystagmus (28 male, 14 females) yielded three mutations (7%). We found restricted expression of FRMD7 in human embryonic brain and developing neural retina, suggesting a specific role in the control of eye movement and gaze stability