Interview with Clyde MacDonald (2) by Mike Hastings

Biographical NoteClyde MacDonald, Jr. was born in 1929 in Old Orchard Beach, Maine, to Nellie MacDonald and Clyde MacDonald, Sr., who were both of Canadian descent. The oldest of four children, Clyde enlisted in the Army and served in Germany during the Korean War. After his military discharge, he became interested in politics at the local level. He attended Portland Junior College for two years and then Bates College for two years. He later earned a doctorate at the University of Maine while teaching undergraduate classes there. During that period, he became active in local Democratic politics and found himself in more regular contact with Senator Muskie. He eventually went to work for Muskie, becoming an aide and close personal adviser. He subsequently transitioned to Senator Mitchell’s office, where he was the field representative in Bangor throughout Mitchell’s Senate career, hiring many Maine field office staff. SummaryInterview includes discussion of: the scope of his role as a field rep for Senator Mitchell in Bangor; the different kinds of issues he dealt with; opening the office in Presque Isle; hiring Julia Nault, Mary LeBlanc, Ida McDonald and Tom Bertocci and the important qualities to look for when hiring people for political jobs; Mitchell’s intellectual and physical energy; the aspects of traveling in the state that Mitchell did and did not enjoy; the food irradiation issue and Mitchell’s solution; Standard Metropolitan Statistical Areas (SMSA) and the work they did to designate Bangor as one; the relationship that Mitchell’s office and MacDonald personally had with the Bangor Daily News and Maine press in general; and the difference between print press and TV coverage

Interview with Clyde MacDonald (1) by Mike Hastings

Biographical NoteClyde MacDonald, Jr. was born in 1929 in Old Orchard Beach, Maine, to Nellie MacDonald and Clyde MacDonald, Sr., who were both of Canadian descent. The oldest of four children, Clyde enlisted in the Army and served in Germany during the Korean War. After his military discharge, he became interested in politics at the local level. He attended Portland Junior College for two years and then Bates College for two years. He later earned a doctorate at the University of Maine while teaching undergraduate classes there. During that period, he became active in local Democratic politics and found himself in more regular contact with Senator Muskie. He eventually went to work for Muskie, becoming an aide and close personal adviser. He subsequently transitioned to Senator Mitchell’s office, where he was the field representative in Bangor throughout Mitchell’s Senate career, hiring many Maine field office staff. SummaryInterview includes discussion of: family and educational background; introduction and expansion of the cranberry industry in Maine; involvement in Democratic politics since leaving Mitchell’s Senate staff; the Mikulski Commission; anti-war movement’s role in strengthening equality movements; an argument for proportional representation in the national Democratic primary; meeting Senator Mitchell; inheriting his political structure and increasing his involvement with politics; confronting Senator Muskie for support of an amendment; meeting with people to increase support for Senator Eugene McCarthy; the 1974 Maine gubernatorial campaign; relationship between Joe Brennan and George Mitchell; suggestions to increase Mitchell’s popularity; the 1982 Senate campaign; surprise in Brennan’s appointing Mitchell to the U.S. Senate; and Anita Jensen

A study of the development of the violoncello technique of the nineteenth and twentieth centuries through the treatises of Jean Louis Duport and Diran Alexanian.

Thesis (M.M)--Boston Universit

Flamingo Vol. IX N 6

McDonald, George. Cover. Picture. 0 Ohio State Sun Dial. Untitled. Prose. 1. Arizona Kittykat. Untitled. Prose. 1. Sour Owl. Untitled. Prose. 3. Dartmouth Jack O\u27Lantern. Untitled. Prose. 2. Brown Jug. Untitled. Prose. 3. Illinois Siren. Untitled. Prose. 3. Kitty-Kat. Untitled. Prose. 3. Ohio State Sun Dial. Untitled. Prose. 4. Wabash Caveman. Untitled. Prose. 4. Anonymous. Untitled. Prose. 4. McDonald, George. Untitled. Picture. 8. Anonymous. Flamingo Gripes and Groans . Prose. 9. Smrcina, Orville. Untitled. Picture. 10. Anonymous. A Little Vow For Leap Year . Prose. 10. Kline, I.D. Gwendolyn Strikes Out, or, Set \u27Em Up In The Other Alley . Prose. 10. Smrcina, Orville. Untitled. Picture. 11. Anonymous. Untitled. Prose. 11. Anonymous. Untitled. Prose. 12. Anonymous. Literal Young lady . Prose. 12. Anonymous. Four-Legged Cops . Prose. 12. Anonymous. Our Leap year Poem . Prose. 13. Anonymous. The Co-Ed Thorn . Prose. 13. Anonymous. Untitled. Prose. 13. McDonald, George. Untitled. Picture. 13. Anonymous. A Bird in the Hand is Worth About Ten on the Newsstand . Prose. 15. Anonymous. I Kidnapped And Murdered Her So I Could Go To College. Prose. 18. Smith, Reed. A Photo For The Visual Minded . Picture. 16. Anonymous. Untitled. Prose. 16. Anonymous. More Photos For The Visual-Minded . Prose. 16. Anonymous. Co-Eds Obtain long-Sought Privilege: A Clever Plot Unfolded . Prose. 16. Anonymous. Candy . Prose. 16. Anonymous. Introducing-Miss 1928 . Prose. 17. Jester. Untitled Prose. 18. Lord Jeff. Untitled Prose. 18. Whirlwind. Untitled Prose. 18. Sniper. Untitled Prose. 18. Purple Parrot. Untitled Prose. 18. Minnesota Ski-U-Mah. Untitled. Prose. 18. Siren. Untitled. Prose. 18. Mink. Untitled. Prose. 18. Gargoyle. Untitled. Prose. 18. Center Colonel. Untitled. Prose. 18. Sun Dial. Untitled. Prose. 18. Anonymous. It\u27s A-Rainin\u27 Tonight . Prose. 19. Anonymous. Untitled. Prose. 19. Anonymous. The Passionate Plumber, or, Is It Cold Enough Out to Wear a Cane? . Prose. 19. McDonald, George. Untitled. Picture. 19. Anonymous. Untitled. Prose. 20. Bibby, Eugenia. The Separation of Hans and Feet Part III . Prose. 20. Smrcina, Orville. Untitled. Picture. 20. Anonymous. Untitled. Prose. 21. Anonymous. Le Quarantine Ballade . Poem. 20. Anonymous. L\u27envoi . Poem. 20. Anonymous. Book Nook . Prose. 22. Anonymous. Untitled. Prose. 23. Anonymous. Age Wisdom . Prose. 23. Brown Jug. Wrecked Romance . Prose. 24. Anonymous. Untitled. Prose. 24. Satyr. Untitled Prose. 24. Lord Jeff. Untitled Prose. 25. Mink. Have You Heard This One? Prose. 27. California Pelican. Subject to Change . Prose. 28. Yale Record. Logical . Prose. 28. Minnesota. Untitled. Prose. 28. Western Reserve Red Cat. Wotta Sight! . Prose. 29. Texas Ranger. Untitled. Prose. 29. Sniper. Untitled. Prose. 29. Anonymous. Mon Dieu . Poem. 31. Anonymous. Untitled. Poem. 31. College Humor. Untitled. Prose. 31. Kitty-Kat. Untitled. Prose. 32. Anonymous. Untitled. Prose. 32. The Old Maid. Untitled. Poem. 32

E-cigarette use in prisons with recently established smokefree policies:a qualitative interview study with people in custody in Scotland

Introduction E-cigarettes were one measure introduced to help people in custody (PiC) to prepare for and cope with implementation of comprehensive smokefree policies in Scottish prisons. Our earlier study explored experiences of vaping when e-cigarettes were first introduced and most participants were dual tobacco and e-cigarette users. Here we present findings of a subsequent study of vaping among a different sample of PiC when use of tobacco was prohibited in prison, and smokefree policy had become the norm. Methods Twenty eight qualitative interviews were conducted with PiC who were current or former users of e-cigarettes in prison, 6-10 months after implementation of a smokefree policy. Data were managed and analysed using the framework approach. Results PiC reported that vaping helped with mandated smoking abstinence. However, findings suggest that some PiC may be susceptible to heavy e-cigarette use potentially as a consequence of high nicotine dependence and situational factors such as e-cigarette product choice and availability in prisons; issues with nicotine delivery; prison regimes; and use of e-cigarettes for managing negative emotions. These factors may act as barriers to cutting down or stopping use of e-cigarettes by PiC who want to make changes due to dissatisfaction with vaping or lack of interest in continued use of nicotine, cost and/or health concerns. Conclusions E-cigarettes helped PiC to cope with smokefree rules, although concerns about e-cigarette efficacy, cost and safety were raised. PiC may desire or benefit both from conventional smoking cessation programmes, and interventions to support reduction, or cessation, of vaping. Implications Findings highlight successes, challenges and potential solutions in respect of use of e-cigarettes to cope with mandated smoking abstinence in populations with high smoking prevalence and heavy nicotine dependence. Experiences from prisons in Scotland may be of particular interest to health and/or justice services in other jurisdictions, with similar legislation on e-cigarettes to the UK, who are planning for institutional smokefree policies in their prisons or inpatient mental health settings in the future

Community-based environmental management for malaria control: evidence from a small-scale intervention in Dar es Salaam, Tanzania

Historically, environmental management has brought important achievements in malaria control and overall improvements of health conditions. Currently, however, implementation is often considered not to be cost-effective. A community-based environmental management for malaria control was conducted in Dar es Salaam between 2005 and 2007. After community sensitization, two drains were cleaned followed by maintenance. This paper assessed the impact of the intervention on community awareness, prevalence of malaria infection, and Anopheles larval presence in drains. A survey was conducted in neighbourhoods adjacent to cleaned drains; for comparison, neighbourhoods adjacent to two drains treated with larvicides and two drains under no intervention were also surveyed. Data routinely collected by the Urban Malaria Control Programme were also used. Diverse impacts were evaluated through comparison of means, odds ratios (OR), logistic regression, and time trends calculated by moving averages. Individual awareness of health risks and intervention goals were significantly higher among sensitized neighbourhoods. A reduction in the odds of malaria infection during the post-cleaning period in intervention neighbourhoods was observed when compared to the pre-cleaning period (OR = 0.12, 95% CI 0.05-0.3, p < 0.001). During the post-cleaning period, a higher risk of infection (OR = 1.7, 95% CI 1.1-2.4, p = 0.0069) was observed in neighbourhoods under no intervention compared to intervention ones. Eighteen months after the initial cleaning, one of the drains was still clean due to continued maintenance efforts (it contained no waste materials and the water was flowing at normal velocity). A three-month moving average of the percentage of water habitats in that drain containing pupae and/or Anopheles larvae indicated a decline in larval density. In the other drain, lack of proper resources and local commitment limited success. Although environmental management was historically coordinated by authoritarian/colonial regimes or by industries/corporations, its successful implementation as part of an integrated vector management framework for malaria control under democratic governments can be possible if four conditions are observed: political will and commitment, community sensitization and participation, provision of financial resources for initial cleaning and structural repairs, and inter-sectoral collaboration. Such effort not only is expected to reduce malaria transmission, but has the potential to empower communities, improve health and environmental conditions, and ultimately contribute to poverty alleviation and sustainable development

Gene Circuit Analysis of the Terminal Gap Gene huckebein

The early embryo of Drosophila melanogaster provides a powerful model system to study the role of genes in pattern formation. The gap gene network constitutes the first zygotic regulatory tier in the hierarchy of the segmentation genes involved in specifying the position of body segments. Here, we use an integrative, systems-level approach to investigate the regulatory effect of the terminal gap gene huckebein (hkb) on gap gene expression. We present quantitative expression data for the Hkb protein, which enable us to include hkb in gap gene circuit models. Gap gene circuits are mathematical models of gene networks used as computational tools to extract regulatory information from spatial expression data. This is achieved by fitting the model to gap gene expression patterns, in order to obtain estimates for regulatory parameters which predict a specific network topology. We show how considering variability in the data combined with analysis of parameter determinability significantly improves the biological relevance and consistency of the approach. Our models are in agreement with earlier results, which they extend in two important respects: First, we show that Hkb is involved in the regulation of the posterior hunchback (hb) domain, but does not have any other essential function. Specifically, Hkb is required for the anterior shift in the posterior border of this domain, which is now reproduced correctly in our models. Second, gap gene circuits presented here are able to reproduce mutants of terminal gap genes, while previously published models were unable to reproduce any null mutants correctly. As a consequence, our models now capture the expression dynamics of all posterior gap genes and some variational properties of the system correctly. This is an important step towards a better, quantitative understanding of the developmental and evolutionary dynamics of the gap gene network

Platform for Plasmodium vivax vaccine discovery and development

Plasmodium vivax is the most prevalent malaria parasite on the American continent. It generates a global burden of 80-100 million cases annually and represents a tremendous public health problem, particularly in the American and Asian continents. A malaria vaccine would be considered the most cost-effective measure against this vector-borne disease and it would contribute to a reduction in malaria cases and to eventual eradication. Although significant progress has been achieved in the search for Plasmodium falciparum antigens that could be used in a vaccine, limited progress has been made in the search for P. vivax components that might be eligible for vaccine development. This is primarily due to the lack of in vitro cultures to serve as an antigen source and to inadequate funding. While the most advanced P. falciparum vaccine candidate is currently being tested in Phase III trials in Africa, the most advanced P. vivax candidates have only advanced to Phase I trials. Herein, we describe the overall strategy and progress in P. vivax vaccine research, from antigen discovery to preclinical and clinical development and we discuss the regional potential of Latin America to develop a comprehensive platform for vaccine development

SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

Kidney failure is frequently observed during and after COVID-19, but it remains elusive whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects kidney cells and is associated with increased tubule-interstitial kidney fibrosis in patient autopsy samples. To study direct effects of the virus on the kidney independent of systemic effects of COVID-19, we infected human-induced pluripotent stem-cell-derived kidney organoids with SARS-CoV-2. Single-cell RNA sequencing indicated injury and dedifferentiation of infected cells with activation of profibrotic signaling pathways. Importantly, SARS-CoV-2 infection also led to increased collagen 1 protein expression in organoids. A SARS-CoV-2 protease inhibitor was able to ameliorate the infection of kidney cells by SARS-CoV-2. Our results suggest that SARS-CoV-2 can directly infect kidney cells and induce cell injury with subsequent fibrosis. These data could explain both acute kidney injury in COVID-19 patients and the development of chronic kidney disease in long COVID