26 research outputs found

    Metabolic labeling of DNA by purine analogs in vivo

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    The 2′-deoxyadenosine analogue “EdA” efficiently labels newly synthesized DNA with alkyne groups in vivo without inhibiting cell cycle progression or embryonic development. This provides the first demonstration that a bio-orthogonal functional group can be metabolically incorporated into DNA through endogenous pathways by addition of a purine analogue to cells
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