Boosting 5G Through Ethernet: How Evolved Fronthaul Can Take Next-Generation Mobile to the Next Level

Current approaches to the fronthaul for centralized- or Cloud-Radio Access Networks (C-RANs) need to be revised to meet the requirements of next-generation mobile networks. There are two major challenges: first, fronthaul signals need to be transported over public fixed access networks, such as passive optical networks (PONs), typically sharing them with other services; second, higher data rates must be catered for due to larger radio bandwidths and greater use of multi-antenna techniques, such as massive MIMO. Using Ethernet as a new transport protocol for the fronthaul allows statistical multiplexing and enables convergence between fixed and mobile services. This new approach more easily benefits from common developments being made for service level agreements, functional virtualization and software-defined networking. Higher data rates will be supported by the move to new, and possibly flexible, functional split points inside the radio access network (RAN) protocol stack of the processing located in the central and distributed units, as is being investigated by a number of bodies. However, there are technical challenges with regard to latency and packet delay variation. This article summarizes the benefits of an Ethernet-based fronthaul for the next generation of mobile networks, its main challenges and how these may be overcome

Concepts and requirements for the Ethernet-based evolved fronthaul

The use of Ethernet in the fronthaul permits convergence and exploitation of statistical multiplexing gains of the new interfaces, but minimum latency and latency variation requirements may become challenging. The techniques proposed to meet these challenges are summarized

Semen May Harbor HIV Despite Effective HAART: Another Piece in the Puzzle

The risk of male-to-female intravaginal HIV-1 transmission is estimated at about 1 event per 200–2000 coital acts. The aim of this study was to assess the residual risk of HIV presence in semen in patients under HAART therapy.The study took place in France from October 2001 to March 2009. 394 paired blood and semen samples were provided from 332 HIV-1 infected men. The Roche Cobas AMPLICOR Monitor HIV assay was used to quantify HIV-1 RNA in blood and in seminal plasma. Three percent of 394 HIV-1 infected men enrolled in an assisted reproductive technology program harbored detectable HIV-1 RNA in semen, although they had no other sexually transmitted disease and their blood viral load was undetectable for at least 6 months under antiretroviral treatment.These data suggest that undetectable plasma HIV RNA means a lower risk of viral transmission through seminal fluid on a population level, but not necessarily at the level of the individual

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk of one in 350 people and an unmet need for disease-modifying therapies. We conducted a cross-ancestry genome-wide association study (GWAS) including 29,612 patients with ALS and 122,656 controls, which identified 15 risk loci. When combined with 8,953 individuals with whole-genome sequencing (6,538 patients, 2,415 controls) and a large cortex-derived expression quantitative trait locus (eQTL) dataset (MetaBrain), analyses revealed locus-specific genetic architectures in which we prioritized genes either through rare variants, short tandem repeats or regulatory effects. ALS-associated risk loci were shared with multiple traits within the neurodegenerative spectrum but with distinct enrichment patterns across brain regions and cell types. Of the environmental and lifestyle risk factors obtained from the literature, Mendelian randomization analyses indicated a causal role for high cholesterol levels. The combination of all ALS-associated signals reveals a role for perturbations in vesicle-mediated transport and autophagy and provides evidence for cell-autonomous disease initiation in glutamatergic neurons. A cross-ancestry genome-wide association meta-analysis of amyotrophic lateral sclerosis (ALS) including 29,612 patients with ALS and 122,656 controls identifies 15 risk loci with distinct genetic architectures and neuron-specific biology

The HIV-1 transmission bottleneck

It is well established that most new systemic infections of HIV-1 can be traced back to one or a limited number of founder viruses. Usually, these founders are more closely related to minor HIV-1 populations in the blood of the presumed donor than to more abundant lineages. This has led to the widely accepted idea that transmission selects for viral characteristics that facilitate crossing the mucosal barrier of the recipient’s genital tract, although the specific selective forces or advantages are not completely defined. However, there are other steps along the way to becoming a founder virus at which selection may occur. These steps include the transition from the donor’s general circulation to the genital tract compartment, survival within the transmission fluid, and establishment of a nascent stable local infection in the recipient’s genital tract. Finally, there is the possibility that important narrowing events may also occur during establishment of systemic infection. This is suggested by the surprising observation that the number of founder viruses detected after transmission in intravenous drug users is also limited. Although some of these steps may be heavily selective, others may result mostly in a stochastic narrowing of the available founder pool. Collectively, they shape the initial infection in each recipient

Too much or not enough: Reflection on two contrasting perspectives on soil biodiversity

International audienc

Lower Sebtides Neogene exhumationand uplift in Ceuta and Cabo Negro areas(Internal Rif, Northern Morocco) : insightsfrom medium- and low-temperaturethermochronology

International audienceThe Rif Chain (Northern Morocco) belongs, with the Betic Cordillera(Southern Spain), to the western termination of the Alpine belt. Deepestunits of the Rif Internal Zones (i.e. Lower Sebtides) outcrop in three areas, from North to South : Ceuta, Cabo Negro and Beni Bousera.The quick exhumation of these units during the Late Oligocene-EarlyMiocene is related with a crustal thinning and the Alboran Sea rifting.Despite Beni Bousera massif has been well investigated, no data areavailable in Ceuta and Cabo Negro areas. This study aims to constrainthe last steps of cooling and exhumation in the Lower Sebtides usingmedium- and low-temperature thermochronological data. Combinationof Ar-Ar on micas, fission tracks and (U-Th)/He on apatites (respectivelyAFT and AHe) from high-grade rocks allows understanding thermalhistory between 450-350°C and surface temperatures. These datasuggest a similar cooling evolution of the Ceuta and Cabo Negro units.Ages obtained with all these methods are comprised in the same interval,between 22 and 18 Ma. These data record an almost instantaneouscooling (between 50 and 200°C/Ma) associated to final exhumation afterthe Oligo-Miocene thermal event affecting these units at shallowdepths (10 km). Low-temperature data suggest that Ceuta and CaboNegro units cooled at surface temperatures before Beni Bousera ones.Since the end of Burdigalian, the Rif internal zones vertical movementsdid not exceed 1km, even during the Messinian Salinity. AFT and AHeages in the whole Sebtides are also slightly older than these obtainedin their Spanish equivalent (Alpujarrides). The Gibraltar arc is dividedinto several independent crustal blocks separated by major fault zonesperpendicular to the coast that could have induced independent verticalmovements during the entire Neogen